CN203688274U - Tissue chip sampling gun - Google Patents
Tissue chip sampling gun Download PDFInfo
- Publication number
- CN203688274U CN203688274U CN201320717742.7U CN201320717742U CN203688274U CN 203688274 U CN203688274 U CN 203688274U CN 201320717742 U CN201320717742 U CN 201320717742U CN 203688274 U CN203688274 U CN 203688274U
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- China
- Prior art keywords
- gun
- piston
- protective cover
- sampling
- push rod
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- 238000005070 sampling Methods 0.000 title claims abstract description 34
- 230000001681 protective effect Effects 0.000 claims abstract description 22
- 238000005520 cutting process Methods 0.000 claims abstract description 3
- 210000004907 gland Anatomy 0.000 claims description 10
- 230000008520 organization Effects 0.000 claims description 9
- 239000000523 sample Substances 0.000 claims 4
- 239000013068 control sample Substances 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 11
- 239000002184 metal Substances 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 7
- 229910052755 nonmetal Inorganic materials 0.000 description 7
- 238000001514 detection method Methods 0.000 description 4
- 238000000018 DNA microarray Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 229910000737 Duralumin Inorganic materials 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000282376 Panthera tigris Species 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002500 microbody Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001141 propulsive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a tissue chip sampling gun, relates to a device is used for cutting off cylindrical samples from large pieces of embedded biological tissues and preparing biological tissue chips, and aims at solving the problems that the sampling length and the diameter of the traditional sampler are difficult to adjust, a gun head piston and a thin-wall slim tube are difficult to protect, loading positioning is inaccurate so as to scratch porous wax blocks and the like. The tissue chip sampling gun comprises a pressure cover, a gun body, a push rod, a stop collar, a connecting rod, a spring, a piston clamp, a piston, a tube knife, a tube knife holder and a protective cover, wherein the position of the tube knife holder can be adjusted. The position of the stop collar is adjusted to control the distance of travel of the piston pushed by the push rod, the tube knife holder is adjusted to control the extending length of the tube knife, and the protective cover is adjusted to control loading positioning. The sampling diameter can be changed by replacing the piston clamp, the piston, the tube knife holder, the tube knife and the protective cover of the sampling gun, so that one gun have multiple purposes. The diameter and the holding length of the sampling gun conform to most hand shapes.
Description
Technical field:
The present invention relates to the sampling of a kind of bulk biological tissue from embedding treatment the device for the preparation of biochip.
Background technology:
In the scientific research or clinical position of biological and medical field, to the tissue of several millimeters of the general needs of the Preliminary detection of biosome physiology or pathological tissue or centimeter scale.But in the time that depth detection and tissue are preserved, only need 1 millimeter or sample still less, and wish that multiple samples put together and be convenient to contrast, can improve like this detection efficiency and reduce retain costs.Developing rapidly of this demand computer technology and Measurement for Biotechnique, has caused comprising the appearance of the biochip of the long-pending and many kinds sample of microbody.Now, utilizing biochip to realize high-throughput automation detection becomes biological and medical field and carries out scientific research and the more and more important means of clinical position.Therefore, succinctly prepare efficiently biological tissue's chip and become the important step of this technology application.
Intercepting fritter sample from bulk biological tissue need to be by Special sampling device.The similar propelling pencil of this class device, is piston cylinder operator (" tissue chip sampler " that the patent No. is 02292520, the Korea S Quick-Ray of UNITMA company tissue arrayer).But there is following problem in this class formation: the one, and the pipe of front end is regular length, regulates sampling thickness inconvenience; The 2nd, while sample being added to micropore after sampling, front end does not stop location structure, is difficult to sample column accurately to be inserted in array hole; The 3rd, some similar structures can regulate sample length, but pipe inner carrier front end is always not concordant with the mouth of pipe, also easily batters the regular shape of array hole; The 4th, thin walled tube and the internal piston of sampler front end are more fragile, be easy to because of misoperation or touch because of carelessness bending deformation, and then impact is used.Similar techniques also has micro-fluidic chip card punch (Shanghai Wen Chang chip companies card punch), syringe and liquid pipettor, and they are all to adopt piston cylinder operator.Different, although single volume of liquid pipettor is adjustable, for solid, cannot contrast, the one, its rifle head tip is only applicable to liquid filling, and the 2nd, when single agent structure is constant, can not regulate solid sample column diameter; The gas propulsive formula structure of syringe is had a greatly reduced quality because the compressibility of air makes application of sample accuracy, and can not automatically reset; Chip card punch is the special designs that adopt hole one device also more.In a word, above similar device does not have the superiority that overcomes prior art defect.
Summary of the invention:
The problem to be solved in the present invention is the accuracy of sampler sample length and diameter adjustment, application of sample length and location, and most advanced and sophisticated safeguard protection.For solving the problems of the technologies described above, the present invention takes position adjustable protective cover and thin walled tube cutting knife technology and piston to advance spacing technology.After adopting above technology, in the time regulating sample length, can effectively overcome the consistency problem of sample length and piston extension elongation by upper and lower dual regulation, also play application of sample location and protection thin walled tube and piston and avoid collsion damage effect; Can realize the adjusting of sampling diameter by changing the parts such as piston and protective cover, accomplish that a rifle is multiplex.
On the pressing lever on sampling gun top, be carved with mark scale according to pressing depth, after this regulates, in succession regulate thin walled tube and the protective cover of sampling gun end, thereby guarantee to avoid accidents.
Accompanying drawing explanation:
Below in conjunction with the drawings and specific embodiments, the present invention is described in further details.
Fig. 1 is the axial section of organization chip sampling gun structure.
Fig. 2 is organization chip sampling gun appearance figure.
Embodiment:
Sampling gun shown in accompanying drawing 1 comprises that push rod 1, stop collar 2, gland 3, connecting rod 4, spring 5, the body of a gun 6, pipe tool rest 7, piston clip 8, piston 9, protective cover 10 and pipe cutter 11 form.
Push rod 1 is for metal or nonmetally make T-shaped structure, and tail end is processed with screw thread to be threaded connection with connecting rod 4, and push rod neck is portrayed the scale of mark distance.
Stop collar 2 is by metal or nonmetal making, be assembled together by screw thread and gland 3, overlap 2 by rotary stopper and can regulate its height that stretches out gland 3, and then the depression distance of push rod 1 is played to restriction effect, avoid pressing down and excessively make piston 9 stretch out long and damage porous wax-pattern.Preferably, design depression distance is between 2 millimeters to 10 millimeters.Stop collar 2 diameter larger side faces have non-slip groove or annular knurl.
Connecting rod 4, by metal or nonmetal making, is by screw thread, push rod 1 and piston clip 8 to be coupled together, on the other hand by step retainer spring 5 on the one hand.
The body of a gun 6 is by metal or nonmetal making, and outside surface has annular non-slip groove, and assemble by internal thread and gland 3 one end, and the other end assembles by internal thread and pipe tool rest 7 and protective cover 10.The inner different-diameter cylindrical cavity of the body of a gun 6 forms ring-shaped step and plays spring 6 position-limiting actions.Preferably, the body of a gun 6 duralumin manufacture, outside surface sandblast oxidation processes.
Pipe tool rest 7 is by metal or nonmetal making, by the extension elongation of external thread and the body of a gun 6 assemblings adjustable pipe cutter 11.Pipe tool rest 7 bottom apertures are for fixing thin walled tube cutter 11, and the aperture of different inner diameters can assemble the pipe cutter 11 of different thicknesses.There are non-slip groove or annular knurl in pipe tool rest 7 thinner end sides.
Piston clip 8 is by metal or nonmetal making, and assemble by external thread and connecting rod 4 one end, and other end aperture is for fixed piston 9, and the aperture of different inner diameters can assemble the piston of different-diameter.
Piston 9 is made up of low bulk corrosion resistant metal, and assemble by interference fit or cementing and piston clip 8 one end, other end Inserting Tube cutter 11 mesopores.Piston 9 is no more than 0.1 millimeter with pipe cutter 11 gaps.
Pipe tool rest 7, piston clip 8, protective cover 10, piston 9 and pipe cutter 11 are field-replaceable unit, and a sampling gun is equipped with the field-replaceable unit of several specifications, realize the adjusting of tissue sample thickness by changing different parts.
Accompanying drawing 2 is organization chip sampling gun appearance figure.Consider that staff grips length and thickness and aesthetic measure, the design of sampling gun external diameter within the scope of 30 millimeters, grips 80 millimeters to 120 millimeters of length at 20 millimeters, and whole rifle length is at 150 millimeters to 200 millimeters.
When use, regulate stop collar 2 to push rod 1 to expose the corresponding scale that necessarily presses down length, adjustable pipe tool rest 7 and protective cover 10 make pipe cutter 11 extend out to Len req, and head is concordant with the pipe edge of a knife while guaranteeing that piston 9 is depressed; In the time that push rod 1 is not depressed, hand-held sampling gun cuts tissue sample; Screwing out protective cover 10 makes 11 mouthfuls, its end face and pipe cutter concordant; The pipe edge of a knife is aimed to well, by lower push-rod 1.
Claims (5)
1. an organization chip sampling gun; comprise by connecting rod (4) and promote piston clip (8) and the push rod (1) of piston (9), make spring (5), the gripping body of a gun (6) of push rod (1) and piston (9) reset and organize cutting sampling pipe cutter (11); it is characterized in that: it also comprises that being enclosed within push rod (1) goes up and limit the stop collar (2) of its depression distance and be arranged in gland (3), stretch out the adjustable pipe tool rest (7) of the body of a gun (6) distance and the protective cover (10) that position is adjustable and end face is level and smooth.
2. according to organization chip sampling gun claimed in claim 1, it is characterized in that: stop collar (2) is enclosed within on push rod (1) by smooth through hole, by external thread and gland (3) combination, turn stop collar (2) can regulate the distance of its top to push rod (1) head, to realize quantification spacing by blocking scale on push rod (1) for stop collar (2), stop collar (2) is at sampling time control sample length processed, and control piston in the time of application of sample (9) extension elongation is to avoid destroying porous wax-pattern.
3. according to organization chip sampling gun claimed in claim 1, it is characterized in that: pipe tool rest (7) is the relative body of a gun (6) position adjustable structure, pipe tool rest (7) screws by external thread and the body of a gun (6) internal thread, the extension elongation that turn pipe tool rest (7) can adjustable pipe cutter (11) thereby control sample length.
4. according to organization chip sampling gun claimed in claim 1; it is characterized in that: protective cover (10) is enclosed within outside pipe tool rest (7); also screw by external thread and the body of a gun (6); regulate protective cover (10) precession length to control on the one hand sample length; protection tube cutter and piston on the other hand; location when the rear application of sample of the level and smooth end face structure control sampling of protective cover (10); protective cover (10) side has two windows, finger by window can turn inside pipe tool rest (7) and needn't unload protective cover (10).
5. according to organization chip sampling gun claimed in claim 1; it is characterized in that: pipe tool rest (7), piston clip (8), protective cover (10), piston (9) and pipe cutter (11) are field-replaceable unit; a sampling gun is equipped with the field-replaceable unit of several specifications, realizes tissue sample diameter adjustment by changing different parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320717742.7U CN203688274U (en) | 2013-11-15 | 2013-11-15 | Tissue chip sampling gun |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320717742.7U CN203688274U (en) | 2013-11-15 | 2013-11-15 | Tissue chip sampling gun |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203688274U true CN203688274U (en) | 2014-07-02 |
Family
ID=51010161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320717742.7U Expired - Fee Related CN203688274U (en) | 2013-11-15 | 2013-11-15 | Tissue chip sampling gun |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203688274U (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104266860A (en) * | 2014-10-16 | 2015-01-07 | 南通大学 | Spring type brain slice sampler and sampling method thereof |
| CN109121790A (en) * | 2018-10-15 | 2019-01-04 | 山东省果树研究所 | A kind of Cherry dwarf rootstock grafting tool |
| CN110411779A (en) * | 2019-06-17 | 2019-11-05 | 淮北矿业股份有限公司 | A kind of adjustable coal slime sampling spade of collection capacity |
| CN111397943A (en) * | 2020-04-20 | 2020-07-10 | 山东中医药大学附属医院 | Focal sampler for sampling adenomyosis specimen and sampling method |
| CN112964607A (en) * | 2021-02-26 | 2021-06-15 | 重庆国际复合材料股份有限公司 | Settlement observation instrument |
| CN114027888A (en) * | 2021-11-16 | 2022-02-11 | 重庆西山科技股份有限公司 | Windowing size adjusting method for sampling window of biopsy surgical device |
| CN114544230A (en) * | 2022-02-24 | 2022-05-27 | 浙江省工程物探勘察设计院有限公司 | Soil property detection device for geological survey engineering |
-
2013
- 2013-11-15 CN CN201320717742.7U patent/CN203688274U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104266860A (en) * | 2014-10-16 | 2015-01-07 | 南通大学 | Spring type brain slice sampler and sampling method thereof |
| CN109121790A (en) * | 2018-10-15 | 2019-01-04 | 山东省果树研究所 | A kind of Cherry dwarf rootstock grafting tool |
| CN109121790B (en) * | 2018-10-15 | 2023-09-15 | 山东省果树研究所 | Grafting tool for dwarfing stock of sweet cherry |
| CN110411779A (en) * | 2019-06-17 | 2019-11-05 | 淮北矿业股份有限公司 | A kind of adjustable coal slime sampling spade of collection capacity |
| CN111397943A (en) * | 2020-04-20 | 2020-07-10 | 山东中医药大学附属医院 | Focal sampler for sampling adenomyosis specimen and sampling method |
| CN112964607A (en) * | 2021-02-26 | 2021-06-15 | 重庆国际复合材料股份有限公司 | Settlement observation instrument |
| CN114027888A (en) * | 2021-11-16 | 2022-02-11 | 重庆西山科技股份有限公司 | Windowing size adjusting method for sampling window of biopsy surgical device |
| CN114544230A (en) * | 2022-02-24 | 2022-05-27 | 浙江省工程物探勘察设计院有限公司 | Soil property detection device for geological survey engineering |
| CN114544230B (en) * | 2022-02-24 | 2024-03-08 | 浙江省工程物探勘察设计院有限公司 | Soil property detection device for geological survey engineering |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140702 Termination date: 20191115 |