CN203665949U - Biological 3d printing device - Google Patents
Biological 3d printing device Download PDFInfo
- Publication number
- CN203665949U CN203665949U CN201320802256.5U CN201320802256U CN203665949U CN 203665949 U CN203665949 U CN 203665949U CN 201320802256 U CN201320802256 U CN 201320802256U CN 203665949 U CN203665949 U CN 203665949U
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- Prior art keywords
- biological
- shower nozzle
- printing
- printing equipment
- print platform
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- Expired - Lifetime
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- 238000007639 printing Methods 0.000 title claims abstract description 27
- 230000007246 mechanism Effects 0.000 claims abstract description 48
- 230000033001 locomotion Effects 0.000 claims abstract description 37
- 238000010146 3D printing Methods 0.000 claims abstract description 15
- 238000004321 preservation Methods 0.000 claims abstract description 13
- 239000012809 cooling fluid Substances 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 5
- 239000012620 biological material Substances 0.000 abstract description 21
- 239000000463 material Substances 0.000 abstract description 16
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 210000000056 organ Anatomy 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- KLLGGXNLLYKQQW-UHFFFAOYSA-K [C+4].P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2] Chemical compound [C+4].P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2] KLLGGXNLLYKQQW-UHFFFAOYSA-K 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000004078 cryogenic material Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 229940014259 gelatin Drugs 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 229960002442 glucosamine Drugs 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- -1 ossein Polymers 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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Abstract
The utility model relates to a biological 3D printing device which comprises a printing platform, a triaxial movement mechanism, a thread extruding mechanism, a nozzle, and a heat preservation mechanism, wherein the triaxial movement mechanism and the printing platform are mounted on the baseplate of the printing device respectively; the thread extruding mechanism and the triaxial movement mechanism are connected with each other; the nozzle is mounted on the thread extruding mechanism, and points downwards to the printing platform; the heat preservation mechanism is arranged on the printing platform. The nozzle of the biological 3D printing device provided by the utility model is convenient to dismount and mount; different nozzles can be selected according to different printing materials; the printing platform has the heat preservation function, so as to be used for heating as well as refrigerating to satisfy the printing requirement of both high-temperature materials and low-temperature materials; the biological 3D printing device can position and assemble biomaterials or living cells, manufacture artificially implanted brackets, tissue organs, medical auxiliary tools and other biomedical products, is flexible to use, and is wide in application range.
Description
Technical field
The utility model relates to a kind of printing device, relates in particular to biological 3D printing equipment.
Background technology
3D printing technique is the rapid shaping technique of any complicated shape three dimensional physical of a quick manufacture entity directly being driven by digital model, and its general principle all adopts the manufacture thought of " layering manufacture, successively stack ".The modern means such as it can computer, laser, precision drive and numerical control, CAD and computer-aided manufacturing are integrated in one, according to the threedimensional model of constructing on computers, can within very short time, directly produce outturn sample, mechanical processing machine that need not be traditional and mould, have the plurality of advantages such as cost is low, the cycle is short, amendment is simple, dimensionally stable.But current 3D printer, is subject to the restriction of structure and material, generally all can only print metal or alloy material, be substantially used in field of machining and machinebuilding technology, cannot realize the printing of biomaterial, there is limitation in the scope of application.
Summary of the invention
The utility model mainly solves original 3D printer generally all can only print metal or alloy material, is substantially used in field of machining and machinebuilding technology, cannot realize the printing of biomaterial, and the scope of application exists circumscribed technical problem; A kind of biological 3D printing equipment is provided, and it can print biomaterial, prints and needs replaceable different shower nozzles according to difference, uses flexibly, and the scope of application is extensive.
Above-mentioned technical problem of the present utility model is mainly solved by following technical proposals: the utility model comprises print platform, three-axis moving mechanism, wire squeeze mechanism, shower nozzle and heat preservation mechanism, three-axis moving mechanism and print platform are arranged on respectively on the chassis of printing equipment, wire squeeze mechanism is connected with three-axis moving mechanism, described shower nozzle is arranged in described wire squeeze mechanism, and shower nozzle points to described print platform down, heat preservation mechanism is located on described print platform.Three-axis moving mechanism can drive shower nozzle to do the movement of X to, Y-direction and three directions of Z-direction, thereby the biomaterial in can extruding jet is sprayed onto smoothly biomaterial print platform, to complete on request print out task in shower nozzle by wire squeeze mechanism.Heat preservation mechanism plays insulation effect to print platform and the biomaterial that prints on print platform, can heat also and can freeze according to the needs of printed biomaterial, and minimum temperature can reach 0 DEG C.The printable multiple biomaterial of the utility model, as: hydroxyapatite, titanium , tricalcium phosphate carbon etc. are for the material of bore regenerating, polycaprolactone, PLA, poly lactic coglycolic acid etc. are for the material of medicine controlled releasing, agar, poly glucosamine, alginate, gelatin, ossein, cellulose etc. are for the material of soft tissue biological structure and Organ printing, and polyurethane, silicone etc. are for the material of conceptual model.The utility model can orientation assemble biomaterial or living cells, and the biomedical products such as manufacture of intraocular implant frame, histoorgan and medical auxiliary tool use flexibly, and the scope of application is extensive.
As preferably, the piston that described wire squeeze mechanism comprises installing rack, is located at the pushing block that is subject to Electric Machine Control on installing rack and is connected by connecting rod with pushing block, described shower nozzle is arranged on the bottom of installing rack, and described piston is located in described shower nozzle.Motor forward or reverse, drive pushing block to rise or decline, pushing block is driven piston to rise or is declined by connecting rod, when piston declines, extruding is installed at the biomaterial in shower nozzle, make biomaterial along with the movement of shower nozzle is flowed out and is sprayed onto on print platform from shower nozzle, thereby complete the 3D printing of biomaterial.
As preferably, described shower nozzle is high temp. jetting nozzle or low temperature shower nozzle.Shower nozzle is arranged in wire squeeze mechanism removably, as adopted interface arrangment or being fixedly connected with by screw.Can choice for use high temp. jetting nozzle or low temperature shower nozzle according to different biomaterials, then keep shower nozzle to maintain design temperature by temperature control system.High temp. jetting nozzle can adopt heating rod to heat, and low temperature shower nozzle can adopt in its peripheral runner realization refrigeration that is connected with cooling fluid that arranges.High temp. jetting nozzle print temperature is at 60～260 DEG C, and low temperature shower nozzle print temperature is at 0～60 DEG C.Meet the needs of different biomaterials, use flexibly, the scope of application is extensive.
As preferably, described heat preservation mechanism comprises heat exchange coil, and the surrounding of described print platform is provided with coaming plate, and the coaming plate of left side, right side and rear side and the back side of print platform are equipped with heat exchange coil, in heat exchange coil, have hot fluid or cooling fluid, heat exchange coil is connected with heat exchanger.While printing high-temperature material, in heat exchange coil, be hot fluid, print platform is heated; While printing cryogenic material, in heat exchange coil, be cooling fluid, print platform is freezed.Certainly, also can heat print platform by infrared ray, laser or microwave etc.
As preferably, the coaming plate of described print platform front side is piece transparent panel.By transparent panel, can see print path and the lamination process of biomaterial clearly.
As preferably, described three-axis moving mechanism comprises that Y-direction motion, X are to motion and Z-direction motion, Y-direction motion is located at left side and the right side on the chassis of printing equipment, one vertically disposed platform is installed on Y-direction motion, X is located at table top to motion, X is provided with a back-up block on motion, and described Z-direction motion is located on described back-up block, and described wire squeeze mechanism is arranged on Z-direction motion.Y-direction motion, X can adopt guide rail leading screw to realize to motion and Z-direction motion.Vertically disposed platform moves as Y-direction, and gripper shoe is made X to movement, and wire squeeze mechanism moves as Z-direction, thereby drives shower nozzle to complete three-axis moving.Simple in structure, reliability is high.
The beneficial effects of the utility model are: shower nozzle easy accessibility, can select to install different shower nozzles according to different printed materials, print platform has heat insulation function, both can heat also and can freeze, meet the printing requirement of high-temperature material and cryogenic material, can orientation assemble biomaterial or living cells, the biomedical products such as manufacture of intraocular implant frame, histoorgan and medical auxiliary tool, use flexibly, the scope of application is extensive.
Brief description of the drawings
Fig. 1 is a kind of perspective view of the present utility model.
Fig. 2 is a kind of perspective view of print platform and coaming plate in the utility model.
Fig. 3 is the main TV structure schematic diagram of the one of coaming plate in the utility model.
Fig. 4 is the main TV structure schematic diagram of the one of wire squeeze mechanism in the utility model.
1. print platforms in figure, 2. wire squeeze mechanism, 3. shower nozzle, 4. installing rack, 5. motor, 6. pushing block, 7. connecting rod, 8. heat exchange coil, 9. transparent panel, 10.Y direction guiding rail, 11.X direction guiding rail, 12.Z direction guiding rail, 13. chassis, 14. platforms, 15. back-up blocks, 16. coaming plates.
Detailed description of the invention
Below by embodiment, and by reference to the accompanying drawings, the technical solution of the utility model is described in further detail.
Embodiment: the biological 3D printing equipment of the present embodiment, as shown in Figure 1, comprises print platform 1, three-axis moving mechanism, wire squeeze mechanism 2, shower nozzle 3 and heat preservation mechanism.Three-axis moving mechanism and print platform 1 are arranged on respectively on the chassis 13 of printing equipment, three-axis moving mechanism comprises that Y-direction motion 10, X are to motion 11 and Z-direction motion 12, Y-direction motion is arranged on left side and the right side on the chassis 13 of printing equipment, one vertically disposed platform 14 is installed on Y-direction motion 10, X is arranged on platform 14 tops to motion 11, X is provided with a back-up block 15 on motion 11, Z-direction motion 12 is arranged on back-up block 15, and wire squeeze mechanism 2 is arranged on Z-direction motion 12.As shown in Figure 4, wire squeeze mechanism 2 comprises installing rack 4, be installed on and be subject to the pushing block 6 that motor 5 controls and the piston being connected by connecting rod 7 with pushing block 6 on installing rack 4, installing rack 4 is arranged on Z-direction motion 12, shower nozzle 3 is arranged on the bottom of installing rack 4, piston is arranged in shower nozzle 3, and shower nozzle 3 points to print platform 1 down.Shower nozzle 3 adopts Demountable, can choice for use high temp. jetting nozzle or low temperature shower nozzle according to the needs of printed material, and high temp. jetting nozzle heats by heating rod, and low temperature shower nozzle arranges by periphery the runner that is connected with cooling fluid and realizes refrigeration.High temp. jetting nozzle print temperature is at 60～260 DEG C, low temperature shower nozzle print temperature is at 0～60 DEG C, heat preservation mechanism is arranged on print platform 1, as Fig. 2, shown in Fig. 3, heat preservation mechanism comprises heat exchange coil 8, the surrounding of print platform 1 respectively has a coaming plate 16, the coaming plate of front side is piece transparent panel 9, left side, the coaming plate of right side and rear side and the back side of print platform are all provided with heat exchange coil 8, in heat exchange coil 8, stream has heat-exchange carrier, need to heat time, it in heat exchange coil, is hot fluid, need to freeze time, it in heat exchange coil, is cooling fluid, the import of heat exchange coil 8, outlet is connected with heat exchanger respectively.
While printing low-temperature biological material, adopt low temperature shower nozzle, in the coaming plate of low temperature shower nozzle and print platform, pass to the cooling fluid of uniform temperature, thereby ensure print temperature; While printing high-temperature biological material, adopt high temp. jetting nozzle, high temp. jetting nozzle heats separately, passes to the hot fluid of uniform temperature in the coaming plate of print platform, thereby ensures print temperature.
The biomaterial kind that the utility model can be printed is many, as: hydroxyapatite, titanium , tricalcium phosphate carbon etc. are for the material of bore regenerating, polycaprolactone, PLA, poly lactic coglycolic acid etc. are for the material of medicine controlled releasing, agar, poly glucosamine, alginate, gelatin, ossein, cellulose etc. are for the material of soft tissue biological structure and Organ printing, and polyurethane, silicone etc. are for the material of conceptual model.The utlity model has characteristic quick, accurate, personalized and that be good at manufacture complicated shape, can be for the specific anatomic construction of patient, physiological function and Treatment need, taking electronic 3-D model as basis, the method of and numerical control moulding discrete by software hierarchy, at spray in head localization assembling biomaterial or living cells, produce the biomedical products such as Artificial Intervention support, histoorgan and medical auxiliary tool by printing, thereby provide new technology possibility for developing breakthrough therapeutic treatment means.The utility model is easy to operate, uses flexibly, and the scope of application is wide, and low to cellular damage rate, printing precision is high.
Claims (6)
1. a biological 3D printing equipment, it is characterized in that comprising print platform (1), three-axis moving mechanism, wire squeeze mechanism (2), shower nozzle (3) and heat preservation mechanism, three-axis moving mechanism and print platform (1) are arranged on respectively on the chassis (13) of printing equipment, wire squeeze mechanism (2) is connected with three-axis moving mechanism, described shower nozzle (3) is arranged in described wire squeeze mechanism (2), and shower nozzle (3) points to described print platform (1) down, heat preservation mechanism is located on described print platform (1).
2. biological 3D printing equipment according to claim 1, it is characterized in that described wire squeeze mechanism (2) comprises installing rack (4), is located at the pushing block (6) that is subject to motor (5) control on installing rack (4) and the piston being connected by connecting rod (7) with pushing block (6), described shower nozzle (3) is arranged on the bottom of installing rack (4), and described piston is located in described shower nozzle (3).
3. biological 3D printing equipment according to claim 1, is characterized in that described shower nozzle (3) is high temp. jetting nozzle or low temperature shower nozzle.
4. according to the biological 3D printing equipment described in claim 1 or 2 or 3, it is characterized in that described heat preservation mechanism comprises heat exchange coil (8), the surrounding of described print platform (1) is provided with coaming plate (16), left side, right side and the coaming plate of rear side and the back side of print platform are equipped with described heat exchange coil (8), heat exchange coil has hot fluid or cooling fluid in (8), and heat exchange coil (8) is connected with heat exchanger.
5. biological 3D printing equipment according to claim 4, is characterized in that the coaming plate of described print platform (1) front side is piece transparent panel (9).
6. according to the biological 3D printing equipment described in claim 1 or 2 or 3, it is characterized in that described three-axis moving mechanism comprises Y-direction motion (10), X is to motion (11) and Z-direction motion (12), Y-direction motion (10) is located at left side and the right side on the chassis (13) of printing equipment, one vertically disposed platform (14) is installed on Y-direction motion (10), X is located at platform (14) top to motion (11), X is provided with a back-up block (15) on motion (11), described Z-direction motion (12) is located on described back-up block (15), described wire squeeze mechanism (2) is arranged on Z-direction motion (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320802256.5U CN203665949U (en) | 2013-12-06 | 2013-12-06 | Biological 3d printing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320802256.5U CN203665949U (en) | 2013-12-06 | 2013-12-06 | Biological 3d printing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203665949U true CN203665949U (en) | 2014-06-25 |
Family
ID=50962281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320802256.5U Expired - Lifetime CN203665949U (en) | 2013-12-06 | 2013-12-06 | Biological 3d printing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203665949U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104441654A (en) * | 2014-10-27 | 2015-03-25 | 清华大学深圳研究生院 | Three-dimensional biological printing device and method |
| CN104999668A (en) * | 2015-06-25 | 2015-10-28 | 浙江大学 | Rotary type tubular tissue biological 3D printing device and method thereof |
| CN104552956B (en) * | 2015-01-26 | 2016-09-07 | 杭州捷诺飞生物科技有限公司 | A kind of biomaterial printing head |
-
2013
- 2013-12-06 CN CN201320802256.5U patent/CN203665949U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104441654A (en) * | 2014-10-27 | 2015-03-25 | 清华大学深圳研究生院 | Three-dimensional biological printing device and method |
| CN104441654B (en) * | 2014-10-27 | 2016-08-24 | 清华大学深圳研究生院 | A kind of three dimensional biological printing equipment and method |
| CN104552956B (en) * | 2015-01-26 | 2016-09-07 | 杭州捷诺飞生物科技有限公司 | A kind of biomaterial printing head |
| CN104999668A (en) * | 2015-06-25 | 2015-10-28 | 浙江大学 | Rotary type tubular tissue biological 3D printing device and method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Hangzhou City, Zhejiang province Xiaoshan District 310000 North Street five Hing Road No. 237 Patentee after: REGENOVO BIOTECHNOLOGY Co.,Ltd. Address before: Hangzhou City, Zhejiang province Xiaoshan District 310000 North Street five Hing Road No. 237 Patentee before: HANGZHOU REGENOVO BIOTECHNOLOGY Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140625 |