CN203619577U - Device for testing performance of SPECT pinhole collimator - Google Patents
Device for testing performance of SPECT pinhole collimator Download PDFInfo
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- CN203619577U CN203619577U CN201320853807.0U CN201320853807U CN203619577U CN 203619577 U CN203619577 U CN 203619577U CN 201320853807 U CN201320853807 U CN 201320853807U CN 203619577 U CN203619577 U CN 203619577U
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Abstract
The utility model discloses a device for testing the performance of an SPECT pinhole collimator. The device for testing the performance of the SPECT pinhole collimator comprises an SPECT detector, the pinhole collimator, a horizontally-moving table, a rotating table, a three-dimensional adjusting table, a base and a data acquisition system. The SPECT detector is arranged on the horizontally-moving table, a radioactive source is placed on the three-dimensional adjusting table, the pinhole collimator is arranged on the rotating table, the center of the radioactive source, the center of the pinhole collimator and the center of the SPECT detector are located on the same axis, and the SPECT detector is connected to the data acquisition system. The horizontally-moving table and the rotating table are adopted, on one hand, the image distance and the object distance can be continuously adjusted, in the other hand, variables affecting study reproducibility and quantifiability can be controlled, wherein the variables include the smoothness change of an optical table within a small range, mechanical errors accumulated by different mechanical fixing parts, rotating of a pinhole plane, and the like, and accuracy of geometric correction and ray detection is improved.
Description
Technical field
This utility model relates to biomedical imaging field, is specifically related to a kind of test set for assessment of SPECT pinhole collimator performance.
Background technology
Single photon emission computerized tomography technology (Single-Photon Emission Computed Tomography, SPECT) be to adopt Radioactive isotope technology, the ray of launching by the radiosiotope medicine that in detection organism, some organ is taken in obtains data for projection, again the data for projection obtaining is redeveloped into faultage image, and then obtains distribution situation and the metabolic information of the specific molecular in object under test.Toy SPECT video picture can accurately reflect that the medicine of active nucleus labelling absorbs in petty action object, the dynamic process of metabolism, the interference effect of monitor treatment method to disease.In addition, because SPECT video picture can be carried out continuous longitudinal study on same small animal model, therefore can get rid of the error causing because of animal individual difference, and direct experimental result class can be pushed into clinically, development and exploitation to people's kind new medicine have great importance.In recent years, along with detecting the appearance of SPECT probe of different molecular biological process, make toy SPECT have application prospect widely at the aspect such as noinvasive detection, oncobiology for the vitals such as heart and brain.
Sensitivity and spatial resolution are to weigh two important parameters of SPECT detector performance.The ability of effective counting that sensitivity sign SPECT detects in (under the low-activity) unit interval under given activity, the ability that spatial resolution characterizes SPECT system resolution rebuilds two adjacent point sources in image.Because the volume of laboratory animal is much smaller than the mankind, toy SPECT imaging requirements detector has higher sensitivity and spatial resolution, and this is also one of main direction of following toy SPECT development.At present, the high spatial resolution of toy SPECT (can reach 1mm following) can be by utilizing pinhole collimator (pin hole amplification imaging) or the higher detector of intrinsic resolution obtains, and pinhole collimator comes more economical compared with expensive high-resolution detector, the collimator in spininess hole can be taken into account detection efficient in improving spatial resolution simultaneously, has made up the too low shortcoming of single pin-hole collimator detection efficient.Holland Utrecht university has developed U-SPECT-II toy SPECT prototype and has used 75 aperture collimators of annular arrangement, and spatial resolution has reached 0.3mm.The NanoScanSPECT/CT that Mediso company of the U.S. produces has also adopted many pinhole collimators, can be to intravital mouse or rat body SPECT imaging, reach the spatial resolution of " submillimeter level ", even can realize the spatial resolution of 0.2mm at regional area.As can be seen here, in the research and development of toy SPECT, the application of pinhole collimator is vital to the spatial resolution that improves toy SPECT video picture, also has very much realistic meaning for the performance estimating method of pinhole collimator.
With positron emission tomography (Positron Emission Tomography, PET) difference, do not seek unity of standard for toy SPECT Evaluation of the function of the instrument at present.2002, professor S.D.Metzler of Duke Univ USA has proposed to come with theoretical model resolution and sensitivity (" Analytic Determination of the Pinhole Collimator ' sPoint-Spread Function and RMS Resolution With Penetration " [IEEE TRANSACTIONS ONMEDICAL IMAGING of matching pinhole collimator, VOL.21, NO.8, AUGUST2002]).But in actual applications exist machine error can cause radioactive source from axle offset, in image, form artifact.Therefore there is larger limitation in this Theoretical Calculation.National electrical manufacturers association (National Electrical Manufactures Association, NEMA) suggestion is the Performance Evaluation standard for clinical SPECT in conjunction with NEMA2012NU-1() with NEMA2008NU-4(for small animal position emission tomography (PET) Performance Evaluation standard) toy SPECT is carried out to Performance Evaluation.But current pin hole test platform space one-movement-freedom-degree deficiency, can not meet object distance, focal length, the amplification demand of adjusting continuously, has been difficult to the every test to pinhole collimator in NEMA testing standard.
Secondly, traditional pinhole collimator test platform can not be realized the location to radioactive source accurately at present, can not reflect the response of collimator to space gamma ray projector.Consider that gamma-ray penetrance is very strong, even if collimator uses highdensity shielding material, ray also can penetrate the edge of pin hole, thereby in image, produces artifact.Therefore, must carry out central visual field or the test of off-axis to pin hole with point source, line source, face radioactive source in actual applications, research radioactive source penetrates the impact that image is caused in collimator edge, could fundamentally reduce image artifacts.
Finally, comprise the impact of difformity pin hole on image sampling rate for the test of many pinhole collimators, but current test set adopts the method for directly replacing pinhole collimator.Because the material of collimator is high desnity metal, difficulty of processing is large, the cycle is longer, if often replaced, has caused the waste of resource.
Utility model content
This utility model provides a kind of follow-on pinhole collimator test set, possesses the features such as multiple degrees of freedom adjusting, has overcome the problems referred to above.
The purpose of this utility model is to provide a kind of SPECT pinhole collimator performance testing device.
SPECT pinhole collimator performance testing device of the present utility model comprises: SPECT detector, translation stage, pinhole collimator, turntable, three-dimensional regulation platform, base and data collecting system; Wherein, translation stage is fixed on one end of base, and SPECT detector is arranged on translation stage; Three-dimensional regulation platform is fixed on the other end of base, and radioactive source is placed on three-dimensional regulation platform; Between translation stage on base and three-dimensional regulation platform, fix turntable, pinhole collimator is arranged on turntable; Being centered close on same axis of radioactive source, pinhole collimator and SPECT detector, turntable is turning perpendicular to the plane internal rotation of pin hole axis, drives pinhole collimator at the rotation with in surface perpendicular to axis; SPECT detector is connected to data collecting system.
SPECT detector is fixed on translation stage, and detector is semiconductor detector array.Pinhole collimator is arranged between SPECT detector and search coverage, is made up of the gamma-ray high density material of maskable.The radioactive source being injected in body to be measured adopts single photon tracer, single photon tracer sends gamma-rays, these gamma-rays are received by quasiconductor (as tellurium zinc cadmium, cadmium telluride) detector through after pinhole collimator, directly gamma-rays is converted into the signal of telecommunication, is finally connected to data collecting system by data wire.
Radioactive source is by pin hole imaging on detector.Radioactive source is placed on three-dimensional regulation platform, can adjust the position of radioactive source, to reach coaxial with the center of pinhole collimator and SPECT detector.Adjust translation stage, regulate the distance between SPECT detector and pinhole detector, to regulate image distance; Coordinate three-dimensional regulation platform to regulate the distance between radioactive source and pinhole collimator, with instrumentality distance, thereby can control the imaging magnification of pinhole collimator.Turntable regulates pinhole collimator to turn at the plane internal rotation of vertical and pin hole axis, thereby can detect the sample rate of pinhole collimator, and regulates the position of radioactive source by three-dimensional regulation platform, detects the response to radioactive source (sensitivity) at space diverse location.
SPECT pinhole collimator performance test methods of the present utility model, comprises the following steps:
A) on turntable, change a pin hole that aperture is larger, then on three-dimensional regulation platform, place a cross aligner, by regulating three-dimensional regulation platform, make the center of cross aligner and the center of pin hole coaxial;
B) radioactive source is placed on to the center of the cross collimator of coarse adjustment, pinhole collimator to be measured is arranged on turntable, the center of pinhole collimator and the center superposition of pin hole, record the γ photon counting at the center of detector, the knob of fine setting translation stage, make the counting at center reach maximum, thereby realize being centered close on same axis of radioactive source, pinhole collimator and SPECT detector;
Detector has been arranged on translation stage, by regulating translation stage motion continuously in the horizontal direction, regulate the distance between pinhole collimator and detector, to regulate image distance u, coordinate three-dimensional regulation platform to regulate the distance between radioactive source and pinhole collimator, apart from v, realize the continuous adjusting to pin-hole imaging amplification, amplification with instrumentality
field range is
wherein, the area that S is detector;
A), for single pin-hole collimator, radioactive source, in the position of central point, records the data that detector is collected, and obtains the point spread function (being the resolution of single pin-hole collimator) of single pin-hole collimator at center position; Adjusting by three-dimensional regulation platform in horizontal plane and in the adjusting of vertical direction, radioactive source off-center point moves on three-dimensional, the distance of radioactive source off-center point is within sweep of the eye, collect data, obtain point source at counting rate curve within the vision, thereby obtain the sensitivity of single pin-hole collimator for space any point radioactive source;
B) for many pinhole collimators, by regulating turntable, pinhole collimator is turned at the plane internal rotation of vertical axial, collect data, can obtain the point spread function that radioactive source is arranged for different pin holes, thereby obtain the sample rate of many pinhole collimators.
Advantage of the present utility model:
This utility model adopts translation stage and turntable, has realized on the one hand the continuous adjusting of image distance and object distance; On the other hand can control effect research reproducibility and variable that can be quantitative, for example: the flatness of optical table in small scope changes, the machine error that different mechanical fixed parts are accumulated, the uncertain factors such as the rotation of pin hole plane, have improved the degree of accuracy of geometric correction and X-ray detection X.Secondly, most of device of the present utility model and mechanical part, without customization, can utilize conventional component of machine to carry out assembly and adjustment, and the method that different shapes or the pin hole in aperture also can directly be bolted is fixed on collimator, simple to operate, good economy performance.
Accompanying drawing explanation
Fig. 1 is the structural representation of SPECT pinhole collimator performance testing device of the present utility model;
Fig. 2 is that the SPECT detector of SPECT pinhole collimator performance testing device of the present utility model is arranged on the structural representation on translation stage, wherein, (A) is front view, is (B) side view, (C) is top view;
Fig. 3 is the structural representation of the three-dimensional regulation platform of SPECT pinhole collimator performance testing device of the present utility model, wherein, (A) is front view, is (B) side view, is (C) top view;
Fig. 4 is the schematic diagram of the pin hole of SPECT pinhole collimator performance testing device of the present utility model, wherein, (A), for the schematic diagram of pin-hole imaging, (B) is the schematic diagram of the shape of pin hole, is (C) schematic diagram of pin hole Plane Rotation;
Fig. 5 rotates many pinhole collimators to increase the schematic diagram of data sampling rate in SPECT pinhole collimator performance testing device of the present utility model;
Fig. 6 is the pinhole collimator of SPECT pinhole collimator performance testing device of the present utility model and the schematic diagram of cross aligner geometric correction, wherein, (A) be the schematic diagram on same axis that is centered close to of radioactive source, pinhole collimator and SPECT detector, (B) for placing the schematic diagram of a cross aligner on three-dimensional regulation platform, (C) be the coaxial schematic diagram at the center of cross aligner and the center of pin hole.
The specific embodiment
Below in conjunction with accompanying drawing, by embodiment, this utility model is described further.
As shown in Figure 1, the SPECT pinhole collimator performance testing device of the present embodiment comprises: SPECT detector 1, translation stage 2, pinhole collimator 3, turntable 4, three-dimensional regulation platform 5, base 6 and data collecting system; Wherein translation stage 2 is fixed on one end of base 6, and SPECT detector 1 is arranged on translation stage 2; Three-dimensional regulation platform 5 is fixed on the other end of base 6, and radioactive source is placed on three-dimensional regulation platform 5; Between translation stage 2 on base and three-dimensional regulation platform 5, fix turntable 4, pinhole collimator 3 is arranged on turntable 4; Being centered close on same axis of radioactive source, pinhole collimator and SPECT detector, turntable turns at the plane internal rotation perpendicular to axis, drives pinhole collimator at the rotation with in surface perpendicular to axis; SPECT detector is connected to data collecting system.Axis is positioned at X-axis, and base is positioned at XY plane, and pinhole collimator and SPECT detector are positioned at YZ plane, and turntable 4 drives pinhole collimator at YZ rotation with in surface.Body to be measured adopts experiment die body.Base 6 adopts optical table.Turntable 4 adopts position, angle platform.
As shown in Figure 2, translation stage 2 comprises right angle fixed block 201, translation plates 203 and the rotary screw 204 of L-type; Wherein, SPECT detector 1 is fixed in translation plates 203 by the right angle fixed block 201 of L-type; Rotary screw 204 connects one end of translation plates 203; By rotary screw 204, translation plates 203 can realize and moving continuously along X axis on horizontal plane, reaches the distance regulating between pinhole collimator 3 and detector 1, thereby regulates image distance, realizes the continuous adjusting to pin hole amplification.
As shown in Figure 3, three-dimensional regulation platform 5 comprises object stage 501, turntable 502, horizontal adjustment plate 503 and vertical adjustable plate 504; Wherein, horizontal adjustment plate 503 is arranged on base 6, can realize the movement in XY plane; Vertically adjustable plate 504 is arranged on horizontal adjustment plate 503, can realize the movement in Z-direction; Turntable 502 is arranged on vertical adjustable plate 504, and turntable can be realized 360 ° of rotations around Z axis; Object stage 501 is arranged on turntable 502; Inner incident has the experiment die body 505 of radioactive source to be placed in object stage 501; Turntable is connected to motor, and driven by motor turntable rotates.Object stage 501 is the hollow cylinder of internal diameter below 50mm, adopts low density material, is used for placing toy or experiment die body.Radioactive source to be measured is incident to experiment and is placed on three-dimensional regulation platform in die body 505, can gather by electric machine rotation the fault information of different directions, also can static placement gathers the projection information of a direction.
Radioactive source is imaged on SPECT detector 1 by pinhole collimator 3, forms pinhole imaging system, and the principle of imaging as shown in Figure 4 (A).Pinhole collimator 3 can adopt multiple difform pin hole form, comprises the one in the regular shape such as taper shape, pyramid and inclined hole form, as shown in Fig. 4 (B).Many pinhole collimators 3 planar rotate, and as shown in Fig. 4 (C), collect data, can obtain the point spread function that radioactive source is arranged for different pin holes, thereby obtain the sample rate of many pinhole collimators.
Fig. 5 (A) is the not schematic diagram of rotation of four pinhole collimators, and Fig. 5 (B) is the postrotational schematic diagram of four pinhole collimators, as shown in the figure, after many pinhole collimator rotations, has increased data sampling rate.
The SPECT pinhole collimator performance test methods of the present embodiment, comprises the following steps:
A) due to the aperture of pinhole collimator to be measured very little (being less than 1mm), therefore on turntable, change a pin hole (for example aperture is 3mm or 5mm) that aperture is larger, the center of pin hole and the center superposition of pinhole collimator, then on three-dimensional regulation platform, place a cross aligner, as shown in Fig. 6 (B), by regulating three-dimensional regulation platform, look over along pin hole face, make the center of cross aligner by the center of pin hole, thereby realize the coaxial of the center of cross aligner and the center of pin hole, as shown in Fig. 6 (C);
B) radioactive source is placed on to the center of the cross collimator of coarse adjustment, and pinhole collimator to be measured is arranged on turntable, the center of pinhole collimator and the center superposition of pin hole, record the γ photon counting at the center of detector, the knob of fine setting translation stage, make the counting at center reach maximum (generally, the counting of single pixel reaches more than 80, the signal to noise ratio that just can meet test requires), thereby realize being centered close on same axis of radioactive source, pinhole collimator and SPECT detector, as shown in Fig. 6 (A);
Detector has been arranged on translation stage, by regulating translation stage motion continuously in the horizontal direction, regulates the distance between pinhole collimator and detector, i.e. image distance u, realizes the continuous adjusting to pin hole amplification, amplification
wherein v be radioactive source to the distance between pinhole collimator, i.e. object distance, field range is
wherein, the area that S is detector;
A), for single pin-hole collimator, radioactive source, in the position of central point, records the data that detector is collected, and obtains the point spread function (being the resolution of pinhole collimator) of single pin-hole collimator at center position; Adjusting by three-dimensional regulation platform in horizontal plane (XY) and in the adjusting of vertical direction (Z axis), radioactive source off-center point moves on three-dimensional, the distance of radioactive source off-center point is within sweep of the eye, collect data, obtain the counting rate curve of point source in field range FOV, thereby obtain the sensitivity of single pin-hole collimator for space any point radioactive source;
B) for many pinhole collimators, four pinhole collimators as shown in Figure 4, by regulating turntable, pinhole collimator is turned at (YZ) of vertical axial plane internal rotation, collect data, can obtain the point spread function that radioactive source is arranged for different pin holes, thereby obtain the sample rate of many pinhole collimators.
Finally it should be noted that, the object of publicizing and implementing mode is to help further to understand this utility model, but it will be appreciated by those skilled in the art that: not departing from the spirit and scope of this utility model and appended claim, various substitutions and modifications are all possible.Therefore, this utility model should not be limited to the disclosed content of embodiment, and the scope that the claimed scope of this utility model defines with claims is as the criterion.
Claims (7)
1. a SPECT pinhole collimator performance testing device, it is characterized in that, described test set comprises: SPECT detector (1), translation stage (2), pinhole collimator (3), turntable (4), three-dimensional regulation platform (5), base (6) and data collecting system; Wherein, described translation stage (2) is fixed on one end of base (6), and described SPECT detector (1) is arranged on translation stage (2); Described three-dimensional regulation platform (5) is fixed on the other end of base (6), and radioactive source is placed on three-dimensional regulation platform (5); It is upper that described turntable (4) is fixed on base (6), and be positioned between translation stage (2) and three-dimensional regulation platform (5), and described pinhole collimator (3) is arranged on turntable (4); Being centered close on same axis of described radioactive source, pinhole collimator and SPECT detector, the surfaces of revolution of described turntable (4) is perpendicular to axis; Described SPECT detector is connected to data collecting system.
2. test set as claimed in claim 1, is characterized in that, described translation stage (2) comprises right angle fixed block (201), translation plates (203) and the rotary screw (204) of L-type; Wherein, described SPECT detector (1) is fixed in described translation plates (203) by the right angle fixed block (201) of L-type; Described rotary screw (204) connects one end of translation plates (203).
3. test set as claimed in claim 1, is characterized in that, described three-dimensional regulation platform (5) comprises object stage (501), turntable (502), horizontal adjustment plate (503) and vertical adjustable plate (504); Wherein, described horizontal adjustment plate (503) is arranged on base (6); Described vertical adjustable plate (504) is arranged on horizontal adjustment plate (503); Described turntable (502) is arranged on vertical adjustable plate (504); Described object stage (501) is arranged on turntable (502); Described turntable (502) is connected to motor.
4. test set as claimed in claim 1, is characterized in that, described detector is semiconductor detector array.
5. test set as claimed in claim 1, is characterized in that, described pinhole collimator adopts the gamma-ray high density material of maskable.
6. test set as claimed in claim 1, is characterized in that, described radioactive source adopts single photon tracer.
7. test set as claimed in claim 1, is characterized in that, described turntable (4) adopts position, angle platform.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103654835A (en) * | 2013-12-23 | 2014-03-26 | 北京大学 | Testing device and testing method for evaluating performance of SPECT pinhole collimator |
| CN106236121A (en) * | 2016-08-30 | 2016-12-21 | 武汉数字派特科技有限公司 | The aligning regulating device of a kind of multi-mode imaging system and alignment control method thereof |
| CN113693614A (en) * | 2021-08-26 | 2021-11-26 | 赛诺联合医疗科技（北京）有限公司 | PETCT system alignment device and alignment method thereof |
-
2013
- 2013-12-23 CN CN201320853807.0U patent/CN203619577U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103654835A (en) * | 2013-12-23 | 2014-03-26 | 北京大学 | Testing device and testing method for evaluating performance of SPECT pinhole collimator |
| CN106236121A (en) * | 2016-08-30 | 2016-12-21 | 武汉数字派特科技有限公司 | The aligning regulating device of a kind of multi-mode imaging system and alignment control method thereof |
| CN106236121B (en) * | 2016-08-30 | 2023-11-28 | 合肥锐世数字科技有限公司 | Alignment adjusting device and alignment adjusting method of multi-mode imaging system |
| CN113693614A (en) * | 2021-08-26 | 2021-11-26 | 赛诺联合医疗科技（北京）有限公司 | PETCT system alignment device and alignment method thereof |
| CN113693614B (en) * | 2021-08-26 | 2024-01-05 | 赛诺联合医疗科技（北京）有限公司 | PETCT system alignment device and alignment method thereof |
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