CN103584878A - Multi-mode registration test method and device - Google Patents
Multi-mode registration test method and device Download PDFInfo
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Abstract
The invention relates to a multi-mode registration test method and device. The method comprises the steps of point source preparation, imaging and data analysis. The invention further relates to the test device corresponding to the test method. The test device comprises a point source container and a point source support. According to the method, radioisotopes and contrast agents are mixed and then dropped into the point source container according to the point source preparation method to generate point sources, the multiple point sources are then placed on the point source support to form certain spatial arrangement, the point source support is placed on an examination table of a multi-mode imaging device to conduct two different modes of imaging on the point sources, analysis and calculation are conducted on the two kinds of images to obtain the position deviation of the point sources in the two kinds of images, and the position deviation serves as a quantitative test index of multi-mode registration.
Description
Technical field
The present invention relates in a kind of multi-mode imaging system the method for testing of registration and corresponding testing equipment between different modalities imaging, belong to assessment measuring method and the equipment of medical imaging system.
Background technology
Multi-modality imaging equipment can be used the image that carrys out acquisition target such as two or more different image modes of CT, PET, SPECT, MRI.
SPECT (single photon emission tomographic imaging) is a kind of conventional nuclear medical imaging device, is mainly used in the functional imaging of live body patient's whole body skeleton and cardiac system etc., is a kind of important clinical diagnosis imaging tool.In order better SPECT image and anatomic image to be merged, pathological changes is accurately located, and to carrying out quantitative correction for attenuation with SPECT image, SPECT equipment can be combined with CT (computer tomography) equipment, obtains SPECT/CT imaging system.
Shown in Fig. 1 is a kind of SPECT/CT system of the prior art, comprise CT frame (1), SPECT frame (2), one or more SPECT probes (3), examinating couch (4) comprises examinating couch bed board (5) that can horizontal movement, and control station and image workstation.By the horizontal movement of bed board, the patient body position of needs inspection can be transported under SPECT probe (3) or CT scan plane (6), carry out SPECT and CT imaging.The SPECT obtaining and CT transfer of data are rebuild and merge to control station or image workstation.
In SPECT/CT system, the precision of SPECT and CT image co-registration registration has material impact to pathological changes location and correction for attenuation, and the assessment that therefore need to carry out standardization and quantification to it is measured.Till now, still do not have in the world registration apparatus, method and the index definition of the measurement standard ，Ge manufacturer of SPECT/CT registration to be not quite similar, cannot carry out lateral comparison.
Summary of the invention
For above-mentioned technical problem of the prior art, the object of the present invention is to provide and a kind ofly can carry out the method and apparatus that standardization and quantitative evaluation are measured to the precision of SPECT/CT registration.
The present invention realizes by the following technical solutions.
A registration testing equipment, comprising:
Point source support, its examinating couch that is suitable for being placed on described multi-mode imaging system carries out multi-modality imaging near the top of frame;
At least one some source container, its can be detachably and adjustable ground be positioned described point source support;
At least one point source, it is suitable for being placed in described some source container, and can in the image that each mode imaging obtains, can form with object around enough large contrast.
Preferably, described some source container is by making gamma light and the lower material of X-ray absorption, and shape is inverted cone wide at the top and narrow at the bottom.
Preferably, described point source support is comprised of laminate and column, and described laminate and column all, by gamma light and the lower material of X-ray absorption are made, have perforate for fixing described some source container so that imaging on laminate.
Preferably, described multi-mode imaging system system comprises any two in CT, MRI, PET, SPECT.
Preferably, described point source is liquid.
Preferably, described multi-mode imaging system is SPECT/CT imaging system, and described point source merges preparation by radioisotope solution and CT contrast agent.
Preferably, described point source is not less than 5mCi/ml's by radioactivity
99mtc solution, fully mixes according to volume ratio 4:1 with the CT contrast agent based on iodine.
Meanwhile, the present invention also provides a kind of multi-mode imaging system registration method of testing, comprises the steps:
By point source stentplacement in the examinating couch of described multi-mode imaging system the top near frame;
By a source container can be detachably and adjustable ground be positioned described point source support;
Point source is positioned in described some source container, and described point source can form with object around enough large contrast in the image that each mode imaging obtains;
Use described multi-mode imaging system to carry out multi-modality imaging to described point source;
Imaging results is carried out to data analysis, obtain the position deviation of point source in each image.
Preferably, described multi-mode imaging system is SPECT/CT imaging system.
Preferably, the described step that imaging results is carried out to data analysis comprises:
Read SPECT and CT view data;
Obtain the point source approximate location in image;
Calculate point source along X, Y, the intensity distributions of tri-directions of Z;
Calculate point source exact position;
Calculation level source position deviation, calculates respectively its other absolute value of alternate position spike in SPECT figure and CT figure to each point source and each direction, then calculates in three directions the maximum of deviation in all point sources.
By above technical scheme, the present invention can carry out standardization and quantitative evaluation measurement to the precision of the registration of the SPECT/CT equipment of various different vendors.
Accompanying drawing explanation
Fig. 1 is SPECT/CT system structure schematic diagram of the prior art;
Fig. 2 is of the present invention some source container and point source structural representation;
Fig. 3 is measurement device structural representation of the present invention.
Wherein each Reference numeral implication is as follows:
1, CT frame; 2, SPECT frame; 3, SPECT probe; 4, examinating couch; 5, examinating couch bed board; 6, CT scan plane; 7, some source container; 8,9, laminate; 10, perforate; 11, column; 12, cross groove; 13, unnecessary perforate.
The specific embodiment
A SPECT/CT registration method of testing, and necessary measurement device.The SPECT/CT method of testing of the present invention's design, comprises point source preparation method, formation method and data analysing method; The measurement device of the present invention's design comprises a source container and point source support.
The point source of the present invention's design merges preparation by radioisotope solution and CT contrast agent, makes it in SPECT and CT image, can form larger contrast with object (some source container, support, bed board etc.) around.In the embodiment recommending, by radioactivity, be not less than 5mCi/ml's
99mtc solution, fully mixes according to volume ratio 4:1 with the CT contrast agent based on iodine.
The point source container (7) of the present invention's design is by making gamma light and the lower material of X-ray absorption, and shape is inverted cone wide at the top and narrow at the bottom.Container upper end opening injects for solution, lower end closed camber.Container upper end opening has outstanding edge, is convenient to stable being placed on point source support.In the embodiment recommending, some source container is made of plastics, and lower end can hold the drop of approximately 5 μ l, and subsidiary stopper can, at filling liquid rear enclosed container, avoid liquid to flow out or volatilization.
The point source support of the present invention design is comprised of laminate (8,9) and column (11), and laminate and support be all by making gamma light and the lower material of X-ray absorption, on laminate, have perforate (10) for fixed point sources container so that imaging.In the embodiment recommending, point source support has four root posts and two laminates, and every layer has a round hole at 4 jiaos, and size is consistent with point source container upper end opening, altogether can place 8 point sources, and point source position is distributed as the cube of length of side 20cm.In the embodiment recommending, laminate has cross groove (12) for imaging device location on center, has a plurality of unnecessary perforates (13) to be convenient to point source preparation on top plate.
The formation method of the present invention design comprises: point source carries out SPECT and CT imaging at the examinating couch of SPECT/CT system near the top of frame by stentplacement after preparing and being placed on support.According to the method in clinical application of manufacturer's recommended, data acquisition can first be measured SPECT and be surveyed CT again, also can first CT after SPECT.Imaging need to carry out twice, once on examinating couch, does not add any counterweight, and another time need to be close within the scope of the 1.5m that the position of support starts and evenly place the mass that is no less than 135kg from bed board.In the embodiment recommending, CT should adopt axle to sweep mode and minimum scanning bed thickness, and image spacing is identical with bed thickness, with basic filter, carries out filtered back projection's reconstruction, and reconstruction matrix is 512 * 512; SPECT scanning should be selected amplification 1, and reconstruction matrix 512 * 512, carries out filtered back projection's reconstruction with ramp wave filter.
The data analysing method of the present invention's design comprises:
Read SPECT and CT view data (image is DICOM form in preferred embodiment)
The point source approximate location of obtaining in image (in the first embodiment, is shown to user by image, by user, with mouse, is delineated and determine point source position; In the second embodiment, according to the threshold value of user's input, automatically search point source position; In the third embodiment, for the support of two-layer laminate, eight point sources, by image, at X, Y, tri-direction deciles of Z, are divided into eight by image space, the max pixel value in automatically searching every is as point source position)
Calculate point source along X, Y, the intensity distributions of tri-directions of Z (in the first embodiment, cross point source approximate location, along X, Y, tri-directions of Z are drawn straight line, and the pixel value on cut-off line distributes; In the second embodiment, choose in the ，Ci region of interest, a cube region of interest that comprises point source, to the pixel value summation in each Y-Z plane, the one dimension that obtains directions X distributes, and obtains the distribution of Y and Z direction with same method; In the third embodiment, on the basis of the second embodiment, first all pixels that are less than given threshold value in region of interest are set to zero Computation distribution again, to eliminate foreign material and effect of noise)
Calculating point source exact position (in the first embodiment, carries out gaussian curve approximation to above-mentioned distribution and asks for center; In the second embodiment, find the maximum of points distributing, add the point of its both sides, these three points are done to fitting of parabola, using parabola peak as point source center)
Calculation level source position deviation, to each point source and each direction (X, Y or Z), calculates respectively its other absolute value of alternate position spike in SPECT figure and CT figure, then calculates in three directions the maximum of deviation in all point sources.
Equipment of the present invention and method not only can be applied to SPECT/CT system, and for example, the isotope solution of point source or CT contrast agent can replace with the contrast agent of MRT, PET as required.In addition, the form of point source also can be selected solid-state or solid-liquid mixing as required.
The foregoing is only several specific embodiment of the present invention, above embodiment is only for explaining and unrestricted claim scope of the present invention technical scheme of the present invention and inventive concept.All technical staff in the art on inventive concept of the present invention basis in conjunction with prior art, by the available other technologies scheme of logical analysis, reasoning or limited experiment, within also should being considered to drop on claim protection domain of the present invention.
Claims (10)
1. a multi-mode imaging system registration testing equipment, comprising:
Point source support, its examinating couch that is suitable for being placed on described multi-mode imaging system carries out multi-modality imaging near the top of frame;
At least one some source container, its can be detachably and adjustable ground be positioned described point source support;
At least one point source, it is suitable for being placed in described some source container, and can in the image that each mode imaging obtains, can form with object around enough large contrast.
2. testing equipment according to claim 1, is characterized in that, described some source container is by making gamma light and the lower material of X-ray absorption, and shape is inverted cone wide at the top and narrow at the bottom.
3. testing equipment according to claim 1, it is characterized in that, described point source support is comprised of laminate and column, and described laminate and column all, by gamma light and the lower material of X-ray absorption are made, have perforate for fixing described some source container so that imaging on laminate.
4. testing equipment according to claim 1, is characterized in that, described multi-mode imaging system system comprise in CT, MRI, PET, SPECT image mode any two or more.
5. testing equipment according to claim 1, is characterized in that, described point source is liquid.
6. testing equipment according to claim 5, is characterized in that, described multi-mode imaging system is SPECT/CT imaging system, and described point source merges preparation by radioisotope solution and CT contrast agent.
7. testing equipment according to claim 6, is characterized in that, described point source is not less than 5mCi/ml's by radioactivity
99mtc solution, fully mixes according to volume ratio 4:1 with the CT contrast agent based on iodine.
8. a multi-mode imaging system registration method of testing, comprises the steps:
By point source stentplacement in the examinating couch of described multi-mode imaging system the top near frame;
By a source container can be detachably and adjustable ground be positioned described point source support;
Point source is positioned in described some source container, and described point source can form with object around enough large contrast in the image that each mode imaging obtains;
Use described multi-mode imaging system to carry out multi-modality imaging to described point source;
Imaging results is carried out to data analysis, obtain point source and become the position deviation in image in each mode.
9. method of testing according to claim 8, is characterized in that, described multi-mode imaging system is SPECT/CT imaging system.
10. method of testing according to claim 9, is characterized in that, the described step that imaging results is carried out to data analysis comprises:
Read SPECT and CT view data;
Obtain the point source approximate location in image;
Calculate point source along X, Y, the intensity distributions of tri-directions of Z;
Calculate point source exact position;
Calculation level source position deviation, calculates respectively its other absolute value of alternate position spike in SPECT figure and CT figure to each point source and each direction, then calculates in three directions the maximum of deviation in all point sources.
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| CN104665857A (en) * | 2013-11-28 | 2015-06-03 | 上海联影医疗科技有限公司 | Multi-mode imaging system registering method |
| CN104840212A (en) * | 2014-02-14 | 2015-08-19 | 上海联影医疗科技有限公司 | Registering test equipment and method for multi-mode imaging system |
| CN105193441A (en) * | 2015-08-17 | 2015-12-30 | 中国科学院高能物理研究所 | Radioactive point source positioning method and system |
| CN106890000A (en) * | 2016-12-28 | 2017-06-27 | 赛诺联合医疗科技（北京）有限公司 | The coordinate registration die body of multi-modal detection system |
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| CN116115245A (en) * | 2023-02-14 | 2023-05-16 | 重庆全景红岭医学影像诊断中心有限公司 | Stereotactic frame for fusion of abdominal basin PET, CT and MR images |
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| CN106890000A (en) * | 2016-12-28 | 2017-06-27 | 赛诺联合医疗科技（北京）有限公司 | The coordinate registration die body of multi-modal detection system |
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| CN107374656A (en) * | 2017-05-26 | 2017-11-24 | 赛诺联合医疗科技（北京）有限公司 | The coordinate registration die body of multi-modal detection system |
| CN107374656B (en) * | 2017-05-26 | 2019-12-03 | 赛诺联合医疗科技（北京）有限公司 | The coordinate registration die body of multi-modal detection system |
| CN116115245A (en) * | 2023-02-14 | 2023-05-16 | 重庆全景红岭医学影像诊断中心有限公司 | Stereotactic frame for fusion of abdominal basin PET, CT and MR images |
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