CN203619562U - Double-wavelength difference near-infrared non-invasive blood glucose meter - Google Patents
Double-wavelength difference near-infrared non-invasive blood glucose meter Download PDFInfo
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- CN203619562U CN203619562U CN201320467753.4U CN201320467753U CN203619562U CN 203619562 U CN203619562 U CN 203619562U CN 201320467753 U CN201320467753 U CN 201320467753U CN 203619562 U CN203619562 U CN 203619562U
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- laser instrument
- blood glucose
- near infrared
- dual
- glucose meter
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Abstract
The utility model discloses a double-wavelength difference near-infrared non-invasive blood glucose meter which comprises a first laser (11), a first plane mirror (12), a protecting layer (13), a sample (14), a function generator (15), a second laser (16), an optical neutral density filter (17), a first parabolic mirror (18), a second plane mirror (19), a phase-locking amplifier (110), a broadband optical near-infrared detector (111), a double-channel optical filter (112) and a second parabolic mirror (113). Power of the second laser (16) can be adjusted through the optical neutral density filter (17), so that the output power ratio of the first laser (11) and the second laser (16) can be adjusted. The phase difference can be controlled through the function generator (15) and the phase-locking amplifier (110). Combining the amplitude with the phase characteristic of near-infrared light and adopting variation difference of peaks and troughs of the absorption spectrum, the double-wavelength difference near-infrared non-invasive blood glucose meter has the capability of non-invasive detection and is high in measurement accuracy especially in the range of hypoglycemia, and skin tissue can be prevented from being accidentally injured by the lasers by the arrangement of the protecting layer.
Description
Technical field
This utility model relates to a kind of measuring instrument that detects blood sugar in diabetic patients level for medical science, is specifically related to a kind of dual-wavelength difference near infrared no-wound and hinders blood glucose meter.
Background technology
China has become the country that global diabetics is maximum, total patient of diabetes patient number nearly 100,000,000, and prediabetes number reaches 1.5 hundred million left and right.And diabetics is in order to control its PD, need to measure incessantly its blood sugar level, make blood glucose value remain on the object of normal range to reach.At present conventional blood glucose monitoring system is all traumatic clinically, brings certain misery to patient.Simultaneously, we notice that people are developing non-invasive determination method of blood sugar and detecting instrument, and multinomial patent disclosed, as " Noninvasive near-infrared electronic blood-glucose meter " (CN102198004A) utilizes infrared light supply (600～2500nm) transmission hands to refer to, according to the absorption spectrum of blood glucose, the Mixture of expert algorithm that utilizes neutral net is weighted after average and obtains blood glucose value the signal of each sensor in infrared sensing array, the shortcoming of this patent of invention is that the spectral region of considering is too wide, will certainly be subject to coming from like this skin, water, the impact of the composition such as fat and protein, " Non-invasive blood sugar monitor " thus (CN201295231Y) be the blood glucose value that the capacitance of two electrode measurement patients by contacting with patient skin obtains patient, " self-service non-wound blood sugar measurer " is (CN1271562A) to utilize infrared light emission pipe as infrared light supply (wavelength: 1000～2900nm), adopt transmission-type measuring blood value, it is divided into two-way by light path and enters the same position of human body by different optical filters, calibrates the blood glucose value of measuring patient.
These above-mentioned technology, all measuring amplitude obtains corresponding blood glucose value bar none, but is limited to the impact of its hetero-organization (skin, fat etc.), makes accuracy not high, in order to improve accuracy, reduces the impact of its hetero-organization.Patent of the present invention adopts differential mode to measure near infrared light amplitude and phase place combines, and reduces the impact of its hetero-organization, thereby obtains blood glucose value accurately.
Utility model content
Problem to be solved in the utility model is: provide a kind of for medical science detect blood sugar in diabetic patients level without wound measuring instrument, specifically improve noinvasive and hinder the accuracy within the scope of accuracy of detection, the especially hypoglycemia of blood glucose meter.
Technical problem provided by the utility model is to solve like this: provide a kind of dual-wavelength difference near infrared no-wound to hinder blood glucose meter, it is characterized in that: comprise laser instrument 1, plane mirror 1, coupling material 13, sample 14, functional generator 15, laser instrument 2 16, optics neutral-density filter 17, throwing face mirror 1, plane mirror 2 19, lock-in amplifier 110, Reflection Optical Thin Film near infrared detector 111, dual pathways optical filter 110, throwing face mirror 2 113, wherein optics neutral-density filter 17 can regulate the power of laser instrument 2 16, thereby adjust the output ratio of laser instrument A and laser instrument B, phase contrast is controlled by functional generator 15 and lock-in amplifier 110,
The center of described laser instrument 1, plane mirror 1, protective layer 13, sample 14, laser instrument 2 16, optics neutral-density filter 17, throwing face mirror 1, plane mirror 2 19 and the face of throwing mirror 2 113 is in same level, and functional generator 15 is connected with laser instrument 2 16 with laser instrument 1 respectively and laser instrument 1 and laser instrument 2 16 are modulated; Functional generator 15 is connected with lock-in amplifier 110 and as being input to reference to signal in lock-in amplifier 110; Reflection Optical Thin Film near infrared detector 111 is connected with dual pathways optical filter 112, and dual pathways optical filter 112 is connected with lock-in amplifier 110, and the optical signal that Reflection Optical Thin Film near infrared detector 111 is detected is input in lock-in amplifier 110.
Further, described laser instrument 1 and laser instrument 2 16 are LED laser instrument, can be also semiconductor lasers, and centre wavelength scope is: 930～1300nm.
Further, described optics neutral-density filter 17 can regulate the power of laser instrument 2 16, thereby adjust the output ratio of laser instrument 1 and laser instrument 2 16, make two laser output powers than near 1, concrete excursion is between 0.98～1.02.
Further, described functional generator 15 and lock-in amplifier 110 can locked lasers 1 and the phase contrast of laser instrument 2 16, and phase contrast is near 180 degree, and concrete excursion is between 179.9～180.1.
Further, the filter wavelength of described dual pathways optical filter 112 is consistent with the operation wavelength of laser instrument 1 and laser instrument 2 16 respectively.
Further, described protective layer 13 is to be made up of flexible PVC colloidal sol, has isotropic feature, and thickness is less than 0.2mm.
Further, the operating wavelength range of described Reflection Optical Thin Film near infrared detector 111 at least comprises 900～1100nm.
The utility model proposes a kind of dual-wavelength difference near infrared no-wound and hinder blood glucose meter, the beneficial effects of the utility model are:
(1) not only have the ability that noinvasive triage is surveyed, and certainty of measurement height is especially within the scope of hypoglycemia, the method that employing amplitude and phase place combine, can effectively improve accuracy of detection, and certainty of measurement is reached more than 98.5%.
(2) carry protective layer simultaneously, avoid laser instrument to accidentally injure skin histology.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the absorption spectrum of the glucose solution of two kinds of variable concentrations;
Fig. 3 is power ratio R=1.004 and phase contrast dP=179.56 °, the graph of a relation of blood glucose density and measuring amplitude;
Fig. 4 is power ratio R=0.988 and phase contrast dP=179.56 °, blood glucose density and the graph of a relation of measuring phase place.
Wherein, 11, laser instrument one; 12, plane mirror one; 13, protective layer; 14, sample; 15, functional generator; 16, laser instrument two; 17, optics neutral-density filter; 18, throw face mirror one; 19, plane mirror two; 110, lock-in amplifier; 111, Reflection Optical Thin Film near infrared detector; 110, dual pathways optical filter; 113, throw face mirror two.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is further described, a kind of dual-wavelength difference near infrared no-wound is hindered blood glucose meter:
This utility model main feature is that two laser instrument of use are laser instrument 1 and laser instrument 2 16, utilize optics neutral-density filter 17 to make the emergent light power of two laser instrument consistent, use lock-in amplifier 110 and functional generator 15 to make the single spin-echo of two laser instrument simultaneously, be phase contrast near 180 degree, concrete excursion is between 179.9～180.1.
Because the work phase place of two-laser is just in time contrary, in theory at whole cycle 0≤t≤τ
0in the luminous power that incides on sample can be expressed as:
Wherein A
afor the luminous power of laser instrument 1, A
bfor the luminous power of laser instrument 2 16.
dP＝p
oA-p
oB
Wherein p
oAfor the initial phase of laser instrument 1, p
oBfor the initial phase of laser instrument 2 16.
ΔA
AB＝A
DA-A
DB
Wherein A
dAfor Reflection Optical Thin Film near infrared detector 111 detects the luminous power of laser instrument 1, A
dBfor Reflection Optical Thin Film near infrared detector 111 detects the luminous power of laser instrument 2 16.
Δp
AB＝p
DA-p
DB
Wherein p
dAfor Reflection Optical Thin Film near infrared detector 111 detects phase place corresponding to laser instrument one 11 wavelength, p
dBfor Reflection Optical Thin Film near infrared detector 111 detects phase place corresponding to laser instrument 2 16 wavelength.
As shown in Figure 1, laser instrument 1 and laser instrument 2 16 are subject to the impulse modulation of functional generator 15, make the phase contrast of laser instrument 1 and laser instrument 2 16, just in time near 180 degree, laser instrument 2 16 is subject to the modulation of optics neutral-density filter 17 simultaneously, making the light beam of laser instrument 1 and laser instrument 2 16 see through the power ratio of the rear arrival sample 14 of protective layer 13 is near 1, concrete excursion is between 0.98～1.02, two-beam arrives after measurement point, after throwing face mirror 2 113, received by Reflection Optical Thin Film near infrared detector 111 by dual pathways optical filter 110 is rear again, amplitude difference and the phase contrast of the light by measuring two bundle different wave lengths carry out measuring blood value.
In Fig. 2, provide the absorption spectrum of the glucose solution of two kinds of variable concentrations, can find out at 900～1100nm from absorption spectrum, at least there are two absworption peaks, exist simultaneously and absorb trough, select the optical maser wavelength of two different absorptances can realize the object of Measurement accuracy blood glucose value.
Fig. 3 has provided respectively different R ratio and phase contrast dp is 179.56 degree, the graph of a relation of the amplitude difference detecting and phase contrast and blood glucose density to Fig. 4.From scheming, can find out that amplitude difference and phase contrast and blood glucose density have extraordinary linear relationship.
Subtract each other by amplitude, the impact that comes from the compositions such as skin, water, fat and protein can be offseted.By setting up under different R ratio and phase contrast dp, the corresponding form of amplitude difference and phase contrast, can measure blood glucose value exactly like this, and certainty of measurement reaches more than 98.5%.
Be to be understood that the above embodiments are only for illustrating that the technical solution of the utility model is not intended to limit.Therefore, this utility model should comprise change, the modifications and variations of all that within the scope of appended claims.
Claims (7)
1. a dual-wavelength difference near infrared no-wound is hindered blood glucose meter, it is characterized in that: comprise laser instrument one (11), plane mirror one (12), protective layer (13), sample (14), functional generator (15), laser instrument two (16), optics neutral-density filter (17), throwing face mirror one (18), plane mirror two (19), lock-in amplifier (110), Reflection Optical Thin Film near infrared detector (111), dual pathways optical filter (112), throwing face mirror two (113), wherein optics neutral-density filter (17) can regulate the power of laser instrument two (16), thereby adjust the output ratio of laser instrument one (11) and laser instrument two (16), phase contrast is controlled by functional generator (15) and lock-in amplifier (110),
The center of described laser instrument one (11), plane mirror one (12), protective layer (13), sample (14), laser instrument two (16), optics neutral-density filter (17), throwing face mirror one (18), plane mirror two (19) and the face of throwing mirror two (113) is in same level, and functional generator (15) is connected with laser instrument two (16) with laser instrument one (11) respectively and laser instrument one (11) and laser instrument two (16) are modulated; Functional generator (15) is connected with lock-in amplifier (110) and as being input to reference to signal in lock-in amplifier (110); Reflection Optical Thin Film near infrared detector (111) is connected with dual pathways optical filter (112), dual pathways optical filter (112) is connected with lock-in amplifier (110), and the optical signal that Reflection Optical Thin Film near infrared detector (111) is detected is input in lock-in amplifier (110).
2. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: described laser instrument one (11) and laser instrument two (16) can be LED laser instrument, also can be semiconductor laser, centre wavelength scope be: 900～1100nm.
3. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: described optics neutral-density filter (17) can regulate the power of laser instrument two (16), thereby adjust the output ratio of laser instrument one (11) and laser instrument two (16), make two laser output powers than near 1, concrete excursion is between 0.98～1.02.
4. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: described functional generator (15) and lock-in amplifier (110) can locked lasers one (11) and the phase contrast of laser instrument two (16), phase contrast is near 180 degree, and concrete excursion is between 179.9～180.1.
5. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: the filter wavelength of described dual pathways optical filter (112) is consistent with the operation wavelength of laser instrument one (11) and laser instrument two (16) respectively.
6. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: described protective layer (13) is to be made up of flexible PVC colloidal sol, has isotropic feature, and thickness is less than 0.2mm.
7. a kind of dual-wavelength difference near infrared no-wound according to claim 1 is hindered blood glucose meter, it is characterized in that: the operating wavelength range of described Reflection Optical Thin Film near infrared detector (111) at least comprises 900～1100nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320467753.4U CN203619562U (en) | 2013-08-01 | 2013-08-01 | Double-wavelength difference near-infrared non-invasive blood glucose meter |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320467753.4U CN203619562U (en) | 2013-08-01 | 2013-08-01 | Double-wavelength difference near-infrared non-invasive blood glucose meter |
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| CN203619562U true CN203619562U (en) | 2014-06-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974250A (en) * | 2019-12-27 | 2020-04-10 | 深圳市太赫兹科技创新研究院有限公司 | Terahertz spectrum-based blood glucose detection method and device and computer storage medium |
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2013
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974250A (en) * | 2019-12-27 | 2020-04-10 | 深圳市太赫兹科技创新研究院有限公司 | Terahertz spectrum-based blood glucose detection method and device and computer storage medium |
| CN110974250B (en) * | 2019-12-27 | 2024-01-16 | 深圳市华讯方舟光电技术有限公司 | Terahertz spectrum-based blood glucose detection method and device and computer storage medium |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160901 Address after: 610000, No. two, section 4, Jianshe North Road, Chengdu, Sichuan, Chenghua District Patentee after: Yang Lifeng Address before: 200237 No. 55, a village, Minhang District, Shanghai, Meilong 301 Patentee before: Zhao Wei |
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| DD01 | Delivery of document by public notice |
Addressee: Zhao Wei Document name: Notification of Passing Examination on Formalities |