CN203569103U - Temperature control type cell printing nozzle - Google Patents

Temperature control type cell printing nozzle Download PDF

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Publication number
CN203569103U
CN203569103U CN201320668491.8U CN201320668491U CN203569103U CN 203569103 U CN203569103 U CN 203569103U CN 201320668491 U CN201320668491 U CN 201320668491U CN 203569103 U CN203569103 U CN 203569103U
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CN
China
Prior art keywords
temperature control
control type
type cell
shower nozzle
injector
Prior art date
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Expired - Lifetime
Application number
CN201320668491.8U
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Chinese (zh)
Inventor
刘长勇
弥胜利
刘多静
孙伟
林峰
张磊
张婷
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Shenzhen International Graduate School of Tsinghua University
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Shenzhen Graduate School Tsinghua University
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Priority to CN201320668491.8U priority Critical patent/CN203569103U/en
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Publication of CN203569103U publication Critical patent/CN203569103U/en
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Abstract

The utility model provides a temperature control type cell printing nozzle. The temperature control type cell printing nozzle comprises supports, heating devices with temperature sensors, ejector driving devices and ejectors, wherein the heating devices and the ejector driving devices are arranged on the supports; the ejectors are arranged in the heating devices; each ejector driving device comprises a motor, a propulsion plate and a screw rod-screw nut transmission mechanism arranged between the propulsion plate and the motor; the propulsion plates are matched with the ends of piston rods of the ejectors; the piston rods are pushed to move by being driven by the motors; each heating device comprises a fixed part, a movable part and a locking mechanism used for locking the movable part and the fixed part together; after the movable parts are separated from the fixed parts, columnar containing cavities used for containing the ejectors in the heating devices are divided into two grooves by axes along the columnar containing cavities. The nozzle not only is beneficial for miniaturization of the whole equipment but also is very convenient in change of the ejectors.

Description

Temperature control type cell printing shower nozzle
Technical field
The utility model design Biotechnology field more particularly, is a kind of temperature control type cell printing shower nozzle.
Background technology
Three-dimensional cell printing technique is the Yi Ge branch of three-dimensional printing technology, and it adopts cell to carry out three-dimensional assembling as material, and current technology mainly comprises laser biology printing, spray ink Printing and the controlled assembling of cell three-dimensional etc.The cost that laser biology is printed is higher, and needs laser apparatus; Spray ink Printing is used the lower cell solution of commercial printing of inkjet printer viscosity of improvement; The controlled assembling of cell three-dimensional utilizes shower nozzle that cell and epimatrix are expressed in the substrate under low temperature environment simultaneously, then piles up layer by layer the three-dimensional structure that formation needs, and utilizes the method for physical crosslinking or chemically crosslinked to be cured.
Application number is that 201210042990.6 Chinese patent application discloses a kind of three-dimensional cell assemble method based on distribution gelation principle, it has adopted the method for distribution gelation, physics and chemical gelation distribution are carried out, aqueous solution by one or more cells respectively at the temperature sensitive Biodegradable material of sterilizing, is placed in pregelatinized under aseptic 4 ℃ of-10 ℃ of environment; Under the direct driving of cad model, the blend of preparation, by different shower nozzle extruding/injections, is formed to cell-material miniflow/droplet unit, under temperature control moulding environment, be piled into the histoorgan blank with a fixed structure.Wherein do not mention and how to carry out the extruding/injection of cell.Cell, as special material, need to carry out accurate control to keep cell to have suitable viscosity to temperature, reduce the shearing force that cell bears in print procedure, and the viscosity of material has important impact as far as possible.
Application number is to disclose temperature control type cell printing shower nozzle in 200910093785.0 Chinese patent application, it comprises support 44, be arranged at heating unit (heating tube 5) and the injector drive unit of the band temperature sensor (thermopair 65) on support 44, and be arranged at the injector 61 in heating unit 5, described injector drive unit comprises motor 41, pushing plate (briquetting 43) and be arranged on the leading screw-screw transmission rig between this pushing plate and motor, described pushing plate coordinates with the piston rod end of injector, under the driving of motor, promote piston rod movement.This cell printing shower nozzle is provided with heating unit and temperature sensor in injector periphery, can carry out accurately controlling and making the celliferous shaped material in it have suitable viscosity to the temperature in injector.But the volume of this temperature control type cell printing shower nozzle is larger, is unfavorable for the miniaturization of whole equipment.In addition, the injector of this shower nozzle is changed complicated operation, is unsuitable for quick-replaceable injector.
Utility model content
The purpose of this utility model is to provide a kind of temperature control type cell printing shower nozzle, this temperature control type cell printing shower nozzle not only can make the shaped material in injector have suitable viscosity in application process, and small volume, be conducive to the miniaturization of whole equipment, the replacing of injector is simple to operation.
The technical solution adopted in the utility model is as follows:
A kind of temperature control type cell printing shower nozzle, comprise: support, be arranged at the heating unit with temperature sensor and injector drive unit on support, and be arranged at the injector in heating unit, described injector drive unit comprises motor, pushing plate and be arranged on the leading screw-screw transmission rig between this pushing plate and motor, described pushing plate coordinates with the piston rod end of injector, under the driving of motor, promote piston rod movement, described heating unit is by fixed part, movable part and forming for the locking mechanism that movable part and fixed part are locked in together, movable part from fixed part from, in heating unit, for holding the cylindricality container cavity of injector, by the axis along this cylindricality container cavity, be divided into two grooves.
In above-mentioned temperature control type cell printing shower nozzle, preferably, from inside to outside, the fixed part of described heating unit and movable part form by heating jacket, muff and overcoat, and heating rod open holes and temperature sensor open holes are set on heating jacket.
In above-mentioned temperature control type cell printing shower nozzle, preferably, an edge of movable part is by gemel connection fixed part.
In above-mentioned temperature control type cell printing shower nozzle, preferably, described leading screw-screw transmission rig is arranged on the side of piston rod of described injector and the two is parallel to each other.
In above-mentioned temperature control type cell printing shower nozzle, preferably, described motor is arranged on the lower end of leading screw.
In above-mentioned temperature control type cell printing shower nozzle, preferably, described printing head also comprises liner, this liner comprises by slide block to be combined and orthogonal the first guide rail and the second guide rail, the first guide rail is arranged on described support along described leading screw, and the second guide rail is fixed on described pushing plate.
In above-mentioned temperature control type cell printing shower nozzle, preferably, described locking mechanism comprises rotating bolt pedestal, rotating bolt sliding seat, rotating bolt and set nut, rotating bolt pedestal is fixed on described fixed part, rotating bolt sliding seat is fixed on described movable part, during locking, rotating bolt penetrates in the circular hole of rotating bolt pedestal and rotating bolt sliding seat, with set nut, screws in rotating bolt.
The utlity model has following advantage:
Injector periphery is provided with the heating unit with temperature sensor, can accurately control the temperature of material while injecting, thereby can guarantee viscosity and the performance of injection material.Adopt Combined type heating device, reduced the size of sprinkler height direction, reduced the space that shower nozzle takies, thereby be conducive to the miniaturization of whole equipment; Also make to change injector very convenient simultaneously.
By the underlying of leading screw-screw transmission rig, be arranged side by side with the piston rod of injector, and/or by after provided with motor at lower, further reduced the size of sprinkler height direction, thereby be conducive to the miniaturization of whole equipment, simultaneously due to decentralization, make that operation is more stable, precision is higher.
Accompanying drawing explanation
Fig. 1 is the structural representation of an embodiment temperature control type cell printing shower nozzle.
Embodiment
Below in conjunction with drawings and Examples, utility model is described further.
Fig. 1 shows the structure of the present embodiment temperature control type cell printing shower nozzle, there is shown two temperature control type cell printing shower nozzle A and B, and two temperature control type cell printing shower nozzle A and B combine by web plate C.For showing internal structure, in opened condition, the heating unit 2 of the temperature control type cell printing shower nozzle B on right side is closure state to the heating unit of the temperature control type cell printing shower nozzle A in left side.
As shown in Figure 1, temperature control type cell printing shower nozzle A and the B in the present embodiment comprises: support 1, be arranged at the heating unit 2 with temperature sensor and the injector drive unit 3 on support 1 and be arranged at the injector 4 in heating unit 2.
Heating unit 2 is by fixed part 22, movable part 21 and forming for the locking mechanism 24 that movable part 21 and fixed part 22 are locked in together, an edge of movable part 21 is connected and fixed portion 22 by hinge 23, another edge arranges locking mechanism 24, after movable part 21 and fixed part 22 closures, heating unit 2 is inner forms one for holding the cylindricality container cavity of injector 4, movable part 21 wraps page 23 and rotates from fixed part 22 separation, in heating unit 2, for holding the cylindricality container cavity of injector 4, by the axis along this cylindricality container cavity, be divided into two grooves (cross section semicircular in shape), at this moment can take out easily the replacing that injector 4 is realized injector.Review in 200910093785.0 Chinese patent application, when changing injector, need first manual rotary screw to make briquetting increase, for installing, vacate enough spaces, after replacing, need rotary screw rod that briquetting is moved down with piston rod end and contacted, the replacing that can find out its injector is upwards extracted/is inserted injector out and realizes from heating tube; This structure makes the length of screw mandrel longer, and the twice that is about injector plunger pole length could realize the replacing of injector, is unfavorable for the miniaturization of whole equipment, and can affect the stability of shower nozzle operation.Than the structure in 200910093785.0 Chinese patent application, the heating unit 2 of the application's integrated structure, to take out from the side injector 4, shorter (approximately one times of injector plunger pole length) that the length of leading screw 32 arranges can realize the replacing of injector, thereby is conducive to realize the miniaturization of whole equipment and is conducive to improve the stability of shower nozzle operation.
In order to guarantee better viscosity and the performance of injection material.Heating unit 2 has adopted following design: from inside to outside, the fixed part 22 of heating unit 2 consists of heating jacket 221, muff 222 and overcoat 223, and movable part 21 consists of heating jacket 211, muff 212 and overcoat 213.Heating jacket preferably adopts copper material to make, and two holes is set on it and to put into heating rod and temperature sensor, adds in real time thermal control.Overcoat preferably adopts aluminium alloy to make.Muff adopts well-insulated material to make.Heating jacket, muff and overcoat can be connected and fixed with tackiness agent, and heating unit 2 should be tried one's best airtight to reach better heat insulating effect.
Locking mechanism 24 comprises rotating bolt pedestal 241, rotating bolt sliding seat 242, rotating bolt 243 and set nut 244, rotating bolt pedestal 241 is fixed on fixed part 22, rotating bolt sliding seat 242 is fixed on movable part 21, rotating bolt 243 is penetrated in the circular hole of rotating bolt pedestal 241 and rotating bolt sliding seat 242, with set nut 244, screw in rotating bolt 243 and reach fixedly movable part 21 and the fixed part 22 of heating unit 2.In certain embodiments, locking mechanism 24 also can adopt hasp etc.
Injector drive unit 3 comprises stepper-motor 31, pushing plate 33 and is arranged on the leading screw-screw transmission rig between this pushing plate 33 and motor 31, leading screw-screw transmission rig comprises leading screw 32 and screw 34, leading screw 32 upper ends are arranged on support 1 by back up pad 35, and lower end connects with the axle of motor 31.Pushing plate 33 coordinates with piston rod 41 ends of injector 4, promotes piston rod 41 motions under the driving of motor 31.For the stability that further reduced volume and raising shower nozzle move, leading screw-screw transmission rig is arranged on to the side of the piston rod 41 of injector 4, the two (that is, leading screw-screw transmission rig and piston rod 41) is parallel to each other.Can further reduce the height of temperature control type cell printing shower nozzle like this, to realize miniaturization, can also make decentralization improve the stability of shower nozzle operation.Further, in the present embodiment, also motor 31 is arranged on to the lower end of leading screw 32, has further reduced center of gravity, improved the stability of shower nozzle operation.In addition, between motor 31 and injector 4, by screw thread transmission, can realize the accurate control to flow of material.
The present embodiment temperature control type cell printing shower nozzle also comprises liner 5, this liner 5 comprises by slide block 52 to be combined and orthogonal the first guide rail 51 and the second guide rail 52, the first guide rail 51 is arranged on described support 1 along described leading screw 52, and the second guide rail 52 is fixed on described pushing plate 33.By the effect of liner 5, pushing plate 33 can move downward vertically under motor 31 drives, and can further improve the stability of shower nozzle operation.
Above content is in conjunction with concrete preferred implementation further detailed description of the utility model, can not assert that concrete enforcement of the present utility model is confined to these explanations.For the utility model person of ordinary skill in the field; without departing from the concept of the premise utility; can also make some being equal to substitutes or obvious modification, and performance or purposes identical, all should be considered as belonging to protection domain of the present utility model.

Claims (7)

1. a temperature control type cell printing shower nozzle, comprise: support (1), be arranged at the heating unit with temperature sensor (2) and injector drive unit (3) on support, and be arranged at the injector (4) in heating unit, described injector drive unit comprises motor (31), pushing plate (33) and be arranged on the leading screw-screw transmission rig (32 between this pushing plate and motor, 34), described pushing plate coordinates with piston rod (41) end of injector, under the driving of motor, promote piston rod movement, it is characterized in that: described heating unit (2) is by fixed part (22), movable part (21) and forming for the locking mechanism (24) that movable part and fixed part are locked in together, movable part from fixed part from, in heating unit, for holding the cylindricality container cavity of injector, by the axis along this cylindricality container cavity, be divided into two grooves.
2. temperature control type cell printing shower nozzle according to claim 1, it is characterized in that: from inside to outside, the fixed part of described heating unit and movable part form by heating jacket (213,223), muff (212,222) and overcoat (211,221), and heating rod open holes and temperature sensor open holes are set on heating jacket.
3. temperature control type cell printing shower nozzle according to claim 1, is characterized in that: an edge of movable part (21) is connected and fixed portion (22) by hinge (23).
4. temperature control type cell printing shower nozzle according to claim 1, is characterized in that: described leading screw-screw transmission rig is arranged on the side of piston rod (41) of described injector and the two is parallel to each other.
5. temperature control type cell printing shower nozzle according to claim 4, is characterized in that: described motor (31) is arranged on the lower end of leading screw (32).
6. temperature control type cell printing shower nozzle according to claim 1, it is characterized in that: described printing head also comprises liner (5), this liner comprises by slide block (52) to be combined and orthogonal the first guide rail (51) and the second guide rail (53), it is upper that the first guide rail is arranged on described support (1) along described leading screw, and the second guide rail is fixed on described pushing plate (33).
7. temperature control type cell printing shower nozzle according to claim 1, it is characterized in that: described locking mechanism (24) comprises rotating bolt pedestal (241), rotating bolt sliding seat (242), rotating bolt (243) and set nut (244), rotating bolt pedestal (241) is fixed on described fixed part (22), rotating bolt sliding seat (242) is fixed on described movable part (21), during locking, rotating bolt penetrates in the circular hole of rotating bolt pedestal and rotating bolt sliding seat, with set nut, screws in rotating bolt.
CN201320668491.8U 2013-10-28 2013-10-28 Temperature control type cell printing nozzle Expired - Lifetime CN203569103U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201320668491.8U CN203569103U (en) 2013-10-28 2013-10-28 Temperature control type cell printing nozzle

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Application Number Priority Date Filing Date Title
CN201320668491.8U CN203569103U (en) 2013-10-28 2013-10-28 Temperature control type cell printing nozzle

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104985814A (en) * 2015-06-25 2015-10-21 浙江大学 High temperature and low temperature combined biological 3D printing spray head
CN105925479A (en) * 2016-04-25 2016-09-07 清华大学深圳研究生院 Gradient 3D printing head and 3D printer
CN108891026A (en) * 2018-08-03 2018-11-27 广州迈普再生医学科技股份有限公司 A kind of piston extruded type spray head of 3D printer
WO2019205832A1 (en) * 2018-04-23 2019-10-31 广州迈普再生医学科技股份有限公司 Piston extrusion nozzle of 3d printer, 3d printer and blank detection method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104985814A (en) * 2015-06-25 2015-10-21 浙江大学 High temperature and low temperature combined biological 3D printing spray head
CN105925479A (en) * 2016-04-25 2016-09-07 清华大学深圳研究生院 Gradient 3D printing head and 3D printer
CN105925479B (en) * 2016-04-25 2018-08-24 清华大学深圳研究生院 A kind of gradient 3D printing nozzle and 3D printer
WO2019205832A1 (en) * 2018-04-23 2019-10-31 广州迈普再生医学科技股份有限公司 Piston extrusion nozzle of 3d printer, 3d printer and blank detection method
CN108891026A (en) * 2018-08-03 2018-11-27 广州迈普再生医学科技股份有限公司 A kind of piston extruded type spray head of 3D printer

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CP01 Change in the name or title of a patent holder
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Address after: 518055 Guangdong city of Shenzhen province Nanshan District Xili of Tsinghua

Patentee after: Shenzhen International Graduate School of Tsinghua University

Address before: 518055 Guangdong city of Shenzhen province Nanshan District Xili of Tsinghua

Patentee before: GRADUATE SCHOOL AT SHENZHEN, TSINGHUA University