CN203506713U - Digitalized multi-channel electric stimulus artifact eliminating device - Google Patents
Digitalized multi-channel electric stimulus artifact eliminating device Download PDFInfo
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- CN203506713U CN203506713U CN201320593357.6U CN201320593357U CN203506713U CN 203506713 U CN203506713 U CN 203506713U CN 201320593357 U CN201320593357 U CN 201320593357U CN 203506713 U CN203506713 U CN 203506713U
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Abstract
The utility model discloses a digitalized multi-channel electric stimulus artifact eliminating device and belongs to the intracerebral single nerve cell electric signal processing technology. A digital circuit is composed of a high-precision AD circuit and a multi-DSP-chip parallel execution type DSP automatic template matching and denoising circuit, wherein the output end of the high-precision AD circuit is connected with the input end of the DSP automatic template matching and denoising circuit, a plurality of microelectrodes used for acquiring electrophysiological signals are connected with the input end of a voltage follower, the output end of the voltage follower is connected with the input end of a signal amplifying and sorting artificial circuit, the output end of the artificial circuit is connected with the input end of the high-precision AD circuit in the digital circuit, the output end of the digital circuit is connected with the input end of a microcomputer through a PXI data communication bus, and the microcomputer is used for secondary denoising and data storage and display. The digitalized multi-channel electric stimulus artifact eliminating device can work stably even when a stimulus artifact is larger than a nerve cell by hundreds of times, acquisition and storage can be conducted together with artifact elimination, an experimental result can be displayed in real time, precision is high, efficiency is high, and operation is convenient.
Description
Technical field
This utility model belongs to the signal processing technology of single electrical signal of nerve cell in brain, particularly a kind of for eliminating the device of the electricity irritation artefact of single neurocyte discharge signal.
Background technology
In electrophysiologic study, by stimulator, to the electric pulse of one group of certain frequency of motor control core group input in animal brain, imitate the signal of telecommunication, observe function that animal studies this core group to the behavior reaction of this electricity irritation and be a kind of brain investigative technique of very important and extensive use.For the function of minor loop in more effective research brain, also usually need to, in brain structure of electricity irritation, record the electrical activity of neurons of another related brain structure.But when the structure of our electricity irritation upstream, the electric pulse that stimulating electrode discharges, by downstream neuron recording electrode being produced to huge electromagnetic interference (being called electricity irritation artefact), makes to observe its electrical activity impossible simultaneously.
Existing electricity irritation artefact is eliminated and mainly by compensation of resistance and capacitance circuit, is realized, but it is narrow by compensation of resistance and capacitance circuit, to eliminate electricity irritation artefact range of application.First, require two electrodes of record more similar; Secondly, each record all needs manual setting electric capacity and resistance to reach compensation effect, not only bothers, and degree of accuracy is poor, also can in the process of manually adjusting, can miss the record of electric discharge, thereby cause data to run off.In addition, existing compensation of resistance and capacitance circuit is the highest can only process the stimulus artifact that is not more than 40 times of signals, to eliminating completely higher than 40 times of above stimulus artifacts of signal.And in actual applications, very common higher than 40 times of above stimulus artifacts, thus in electrophysiologic study in the urgent need to can automatically eliminating the significantly recording equipment of electricity irritation artefact.
Utility model content
The purpose of this utility model is to overcome the above defect of the prior art, provides a kind of and eliminates recording equipment for eliminating the significantly digital multi-channel electricity irritation artefact of electricity irritation artefact.
The structure of this utility model device:
One digital circuit is comprised of the DSP automatic moulding plate coupling core circuit of a high-precision A/D circuit, more than one dsp chip executed in parallel, and wherein the outfan of high-precision A/D circuit is connected with the input of DSP automatic moulding plate coupling core circuit;
The many microelectrodes that gather electricity physiological signal are connected with the input of a voltage follower, the outfan of voltage follower amplifies with the analog circuit input arranging and is connected with a signal, signal amplifies with the analog circuit outfan arranging and is connected with the input of high-precision A/D circuit in said digital circuit, and the outfan of this digital circuit is connected by PXI data communication bus with the microcomputer input of storing demonstration for secondary noise reduction process, data.The quantity of above-mentioned microelectrode is preferably 16.
The analog circuit that the DSP automatic moulding plate coupling core circuit of said high-precision A/D circuit, a plurality of dsp chip executed in parallel, the microelectrode that gathers electricity physiological signal, voltage follower, signal amplify and arrange, the microcomputer showing for secondary noise reduction process, data storage etc. is prior art, by those skilled in the art is known.
The operation principle of this utility model device: comprise that some for gathering the microelectrode of electricity physiological signal, wherein a conduct is with reference to electrode; The electricity physiological signal that described microelectrode collects is through after a voltage follower, input to the signal acquiring system of being controlled by DSP and carry out signals collecting and storage, in primary signal storage, DSP rapidly Dui Ge road signal carries out computing and stencil matching, after drawing each road noise, subdue respectively, by friendly man machine interface, demonstrate in real time except the electricity physiological signal after making an uproar storage.This utility model device adopts digitizer, and the analogue signal collecting is converted to digital signal fast, then with DSP, carries out quick calculation process; Can adopt automatic gain closed control circuit automatically to adjust the amplification of electrode signal; Get one as with reference to electrode, utilize signal processing method, multiple tracks signal is compared and stencil matching automatically, then stimulus artifact is reduced from primary signal.The collection of device all can complete automatically with elimination artefact process.Due to by electrical stimulation technology and multi-channel nerve record, and digitized automatic technology organically combines, utilize multichannel collecting technology, by analog circuit and digital circuit, combine, and the integral body of using signal processing method to improve system eliminates artefact energy, be therefore a kind ofly can automatically eliminate the significantly multiple recording device of electricity irritation artefact.
The advantage of this utility model device: this device degree of accuracy is high, the situation that is greater than neuron hundreds of times at stimulus artifact also can steady operation, has almost met the requirement of all experiment conditions, in brain research, can be widely used.Owing to having adopted a plurality of dsp chip executed in parallel, gather storage and eliminate artefact process and can carry out simultaneously, on display interface, can show in real time experimental result, efficiency is high, simple to operation; Can adopt PXI bussing technique, expand to easily hundreds of roads and gather simultaneously.
Accompanying drawing explanation
Fig. 1 is circuit block diagram of the present utility model.
Fig. 2 is that voltage follower in embodiment, signal amplify the electrical schematic diagram being connected with the analog circuit arranging and this two parts.
Fig. 3 is the effect contrast figure that embodiment eliminates stimulus artifact.
The specific embodiment
Embodiment: see Fig. 1～Fig. 3.
Fig. 1 is circuit block diagram.Digital circuit 4 is comprised of the DSP automatic moulding plate coupling core circuit 6 of high-precision A/D circuit 5, a plurality of dsp chip executed in parallel, and wherein the outfan of high-precision A/D circuit 5 is connected with the input of DSP automatic moulding plate coupling core circuit 6.16 microelectrodes 1 that gather electricity physiological signal are connected with the input of voltage follower 2, the outfan of voltage follower 2 amplifies with the input of the analog circuit 3 arranging and is connected with signal, signal amplifies with the outfan of the analog circuit 3 arranging and is connected with the input of high-precision A/D circuit 5 in digital circuit 4, and the outfan of digital circuit 4 is connected by PXI data communication bus with microcomputer 7 inputs of storing demonstration for secondary noise reduction process, data.The display of microcomputer 7 has friendly man machine interface, shows except making an uproar result.High-precision A/D circuit 5 is 24 high accuracy low noise boards.
Embodiment comprises that nearly 16 for gathering the microelectrode of electricity physiological signal, the in the situation that of electricity irritation, gets a wherein conduct with reference to electrode.The electricity physiological signal that microelectrode collects is through after a voltage follower, the acquisition system that is input to DSP control gathers and stores, in primary signal storage, DSP rapidly Dui Ge road signal carries out computing and stencil matching, after drawing each road noise, subdue respectively, demonstrate in real time except the electricity physiological signal after making an uproar storage.
Fig. 2 is that voltage follower 2 in embodiment, signal amplify the electrical schematic diagram being connected with the analog circuit 3 arranging and this two parts.
The primary signal of twice for coming in by electrode collection before in Fig. 3, wherein first is the signal that reference electrode gathers; The signal of San road for directly subtracting each other, uses as a comparison; The result of last one signal for processing after the acquisition system algorithm by us.Result is to be about 2.5mV in electricity irritation, and electricity physiological signal is approximately in the situation of 25 μ V, and noise and signal ratio are 100 times, and noise still can be eliminated very totally, and electricity physiological signal has obtained perfect reproduction.The transverse axis of Fig. 3 is the time, and the longitudinal axis is electrical stimulation signal intensity.
A concrete example below:
The pyramidal cell of rat hippocampal CA 3 links by the pyramidal cell in Scaffer side shoot YuCA1 district, in order to study the impact of the excited DuiCA1 district cell electric discharge of Scaffer side shoot, we are placed on stimulating electrode on Scaffer side shoot, recording electrode is placed on CA1 pyramidal layer, if give the electric pulse stimulation of certain parameter on stimulating electrode, on recording electrode, just can be recorded to variation and the stimulating current artefact of the electric discharge of CA1 pyramidal cell, and the impact that the excited DuiCA1 district cell that will observe Scaffer side shoot discharges, it is particularly important that the elimination of electric current artefact seems.In experiment, use and by 3 road electrodes, record CA1 pyramidal cell and discharge, 1 road electrode as a reference, in electricity irritation amplitude, be 1.5mv, and electric physiology amplitude is in the situation of 100 μ V left and right, except the electric physiology discharge data on visible each road signal after making an uproar, can clearly reduce, not be subject to the artifacts of electricity irritation at all.
Technique effect parameter is as follows:
(1) static noise: 1 μ V
(2) normal working hours under room temperature: >10000 hour;
(3) noise compacting ability: signal/noise ratio=34.0dB;
(4) Compensation Regulation: automatically;
(5) road number: 16;
(6) amplifier input impedance: 10
13ohm;
(7) power supply mode: direct current;
(8) signal processing software: carry.
This digitized multi-channel intelligent electricity irritation artefact eliminate recording system not only can be in the situation that electricity irritation artefact be greater than neuron hundreds of times efficient operation, and due to whole system digitized automatization, easy to operate, control precise and stable.
Claims (2)
1. a digital multi-channel electricity irritation artefact is eliminated recording equipment, it is characterized in that: a digital circuit is comprised of the DSP automatic moulding plate coupling core circuit of a high-precision A/D circuit, more than one dsp chip executed in parallel, wherein the outfan of high-precision A/D circuit is connected with the input of DSP automatic moulding plate coupling core circuit;
The many microelectrodes that gather electricity physiological signal are connected with the input of a voltage follower, the outfan of voltage follower amplifies with the analog circuit input arranging and is connected with a signal, signal amplifies with the analog circuit outfan arranging and is connected with the input of high-precision A/D circuit in said digital circuit, and the outfan of this digital circuit is connected by PXI data communication bus with the microcomputer input of storing demonstration for secondary noise reduction process, data.
2. digital multi-channel electricity irritation artefact is eliminated recording equipment as claimed in claim 1, it is characterized in that: the quantity of said microelectrode is 16.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320593357.6U CN203506713U (en) | 2013-09-25 | 2013-09-25 | Digitalized multi-channel electric stimulus artifact eliminating device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320593357.6U CN203506713U (en) | 2013-09-25 | 2013-09-25 | Digitalized multi-channel electric stimulus artifact eliminating device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105725985A (en) * | 2016-04-19 | 2016-07-06 | 华中科技大学 | Pulse diagnosis instrument with self-power pulse sensors |
| CN108143414A (en) * | 2018-01-11 | 2018-06-12 | 福州大学 | It is a kind of it is adaptive filter out surface electromyogram signal electro photoluminescence artefact in line method |
-
2013
- 2013-09-25 CN CN201320593357.6U patent/CN203506713U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105725985A (en) * | 2016-04-19 | 2016-07-06 | 华中科技大学 | Pulse diagnosis instrument with self-power pulse sensors |
| CN108143414A (en) * | 2018-01-11 | 2018-06-12 | 福州大学 | It is a kind of it is adaptive filter out surface electromyogram signal electro photoluminescence artefact in line method |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140402 Termination date: 20140925 |
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| EXPY | Termination of patent right or utility model |