CN203408270U - Separation and extraction system for ganoderma lucidum triterpenoids - Google Patents
Separation and extraction system for ganoderma lucidum triterpenoids Download PDFInfo
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- CN203408270U CN203408270U CN201320386716.0U CN201320386716U CN203408270U CN 203408270 U CN203408270 U CN 203408270U CN 201320386716 U CN201320386716 U CN 201320386716U CN 203408270 U CN203408270 U CN 203408270U
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- 238000000926 separation method Methods 0.000 title claims abstract description 38
- 238000000605 extraction Methods 0.000 title claims abstract description 33
- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 17
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 17
- 150000003648 triterpenes Chemical class 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 23
- 239000012528 membrane Substances 0.000 claims abstract description 17
- 238000001914 filtration Methods 0.000 claims abstract description 14
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 14
- 238000000855 fermentation Methods 0.000 claims abstract description 13
- 230000004151 fermentation Effects 0.000 claims abstract description 13
- 241000222336 Ganoderma Species 0.000 claims description 23
- -1 triterpene compounds Chemical class 0.000 claims description 15
- 230000000844 anti-bacterial effect Effects 0.000 claims description 10
- 238000002386 leaching Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 230000029087 digestion Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 6
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- LWPLEHFGBRFRKI-NBCWKOIPSA-N Ganoderic acid B Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1C[C@H](O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)C[C@@H](C)C(O)=O)C)CC(=O)[C@]21C LWPLEHFGBRFRKI-NBCWKOIPSA-N 0.000 description 1
- LWPLEHFGBRFRKI-CQKTXKLZSA-N Ganoderic acid B Natural products C[C@H](CC(=O)C[C@H](C)C(=O)O)[C@H]1CC(=O)[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@H]4C[C@@H]3O LWPLEHFGBRFRKI-CQKTXKLZSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000222383 Polyporales Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A separation and extraction system for ganoderma lucidum triterpenoids comprises a ganoderma lucidum pulverizer, a fermentation tank, a digestion device, an ultrasonic extraction device, a solid-liquid storage tank, a membrane separation concentration and fine filtration device, a preparation tank, a feed liquid delivery pump, a sterilization device and an extraction and storage tank. The separation and extraction system is used in the separation and extraction process, reduces the use amount of all required solvents used in the extraction process, shortens the extraction time, improves the extraction rate of the ganoderma lucidum triterpenoids, and enables obtained products subjected to separation and extraction to be high in purity.
Description
Technical field
This utility model belongs to separation and Extraction and the processing technique field of natural product active ingredient, particularly a kind of separation and Extraction system of Ganoderma lucidum triterpenes components.
Background technology
Ganoderma is under the jurisdiction of Eumycota, Basidiomycotina, layer Basidiomycetes, Aphyllophorales, Ganoderma Cordycepps, Ganoderma fungus.In China, be distributed in the ground such as Hebei, river, Shanxi, Shandong, Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan, Hainan, Guangxi, Guizhou, Sichuan, Jilin and Yunnan.
Ganoderma has long history in China as medicine, the < < Sheng Nong's herbal classic > > of the Eastern Han Dynasty classifies Ganoderma as top grade medicine as, thinking that Ganoderma can prevent and treat various diseases, is the treasure of strengthening by means of tonics, strengthening the body resistance.Since nineteen fifties, due to the success of Ganoderma Lucidum sporophore, developed again subsequently the technology that Ganoderma mycelium and fermentation liquid are cultivated in submerged fermentation, the Application and Development of Ganoderma is increasingly extensive, the chemical composition of Ganoderma, pharmacological action and mechanism of action and clinical practice have been carried out to a large amount of research, and obtained great progress.
The people such as nineteen eighty-two KubotaT first from Ganoderma sporophore separation obtain three mushrooms compounds, Ganodenic acid A and ganoderic acid B, after this each state has all launched the research to Ganoderma three mushrooms compounds, wherein most study is Japan, next is China, in recent years, the state such as Korea S, Germany, France also possesses some special knowledge to three mushrooms materials in Ganoderma.Up to the present, successively from sporophore, mycelium and the spore powder of Ganoderma, assign to the three mushrooms compounds that kind more than 140 is new.
Ganoderma is a kind of medicinal fungi of preciousness, has multiple pharmacological function.Research in recent years discovery, triterpenoid is the material with pharmacologically active important in Ganoderma, has calmness, pain relieving, detoxifies, protects the liver, kills the effects such as tumor.Because Ganoderma triterpenoids is acid feature, at present, the extracting method of ganoderma lucidum triterpene compounds is mainly organic solvent extraction, is to utilize organic solvent lixiviate, alkali to carry acidify, chloroform extraction, and separation obtains relative triterpenoid compound.This method principle is simple, and equipment requirements is not high, but time consumption and energy consumption, solvent load are large, extraction efficiency is not high yet.
Utility model content
The purpose of this utility model is to provide a kind of separation and Extraction system of ganoderma lucidum triterpene compounds, it can reduce and extract required various solvent loads in separation and Extraction use procedure, short extraction time contracting, improve triterpenoid compound extraction ratio, and the product purity that separation and Extraction obtains is high.
The technical scheme that this utility model adopts: a kind of separation and Extraction system of ganoderma lucidum triterpene compounds, comprises Ganoderma pulverizer, fermentation tank, leaching device, ultrasonic extraction device, solid-liquid storage tank, membrane separation concentration fine filtering device, preparing tank, feed liquid delivery pump, bactericidal unit, extraction storage tank.
The separation and Extraction system of described ganoderma lucidum triterpene compounds, Ganoderma pulverizer is connected with one end of fermentation tank, the other end of fermentation tank is connected with one end of leaching device, the other end of leaching device is connected with one end of ultrasonic extraction device, the other end of ultrasonic extraction device is connected with one end of solid-liquid storage tank, the other end of solid-liquid storage tank is connected with one end of membrane separation concentration fine filtering device, the other end of membrane separation concentration fine filtering device is connected with one end of preparing tank, the other end of preparing tank is connected with one end of feed liquid delivery pump, the other end of liquid delivery pump is connected with one end of bactericidal unit, the other end of bactericidal unit is connected with the one end of extracting storage tank.
Described ultrasonic extraction device consists of tank body, stirring motor, axostylus axostyle, stirring paddle, discharge ball valve, ultrasonic transducer; Charge door and air vent are established in described tank body top.
Described membrane separation concentration fine filtering device consists of membrance separation groove, membrane module, absorption pump.
Compare with conventional organic solvents extraction element, the utlity model has following advantage: medicinal raw material treating capacity is large; Effective ingredient is easy to isolation of purified; Without high temperature, do not destroy triterpene compound structure; Energy consumption is low; Use procedure, without pressurization; Extraction efficiency is high; The equipment suitability is wide.
Accompanying drawing explanation
The separation and Extraction system structure schematic diagram of a kind of ganoderma lucidum triterpene compounds that Fig. 1 provides for this utility model.
In figure, 1, Ganoderma pulverizer; 2, fermentation tank; 3, leaching device; 4, ultrasonic extraction device; 5, solid-liquid storage tank; 6, membrane separation concentration fine filtering device; 7, preparing tank; 8, feed liquid delivery pump; 9, bactericidal unit; 10, extract storage tank.
The specific embodiment
Below in conjunction with most preferred embodiment and accompanying drawing, this utility model is further described.
Please refer to Fig. 1, the present embodiment is a kind of separation and Extraction system of ganoderma lucidum triterpene compounds, comprises Ganoderma pulverizer 1, fermentation tank 2, leaching device 3, ultrasonic extraction device 4, solid-liquid storage tank 5, membrane separation concentration fine filtering device 6, preparing tank 7, feed liquid delivery pump 8, bactericidal unit 9, extracts storage tank 10.
Please refer to Fig. 1, the separation and Extraction system of described ganoderma lucidum triterpene compounds, Ganoderma pulverizer 1 is connected with one end of fermentation tank 2, the other end of fermentation tank 2 is connected with one end of leaching device 3, the other end of leaching device 3 is connected with one end of ultrasonic extraction device 4, the other end of ultrasonic extraction device 4 is connected with one end of solid-liquid storage tank 5, the other end of solid-liquid storage tank 5 is connected with one end of membrane separation concentration fine filtering device 6, the other end of membrane separation concentration fine filtering device 6 is connected with one end of preparing tank 7, the other end of preparing tank 7 is connected with one end of feed liquid delivery pump 8, the other end of liquid delivery pump 8 is connected with one end of bactericidal unit 9, the other end of bactericidal unit 9 is connected with the one end of extracting storage tank 10.
Please refer to Fig. 1, described ultrasonic extraction device 4 consists of tank body, stirring motor, axostylus axostyle, stirring paddle, discharge ball valve, ultrasonic transducer; Charge door and air vent are established in described tank body top.
Please refer to Fig. 1, described membrane separation concentration fine filtering device 6 consists of membrance separation groove, membrane module, absorption pump.
Compare with conventional organic solvents extraction element, it is large that this specific embodiment has medicinal raw material treating capacity; Effective ingredient is easy to isolation of purified; Without high temperature, do not destroy triterpene compound structure; Energy consumption is low; Use procedure, without pressurization; Extraction efficiency is high; The advantage that the equipment suitability is wide.
By reference to the accompanying drawings this utility model has been carried out to exemplary description above; obvious realization of the present utility model is not subject to the restrictions described above; as long as the various improvement that adopted technical solutions of the utility model to carry out; or say that without improvement design of the present utility model and technical scheme are applied to other occasions, all in protection domain of the present utility model.
Claims (3)
1. the separation and Extraction system of a ganoderma lucidum triterpene compounds, it is characterized in that, comprise Ganoderma pulverizer, fermentation tank, leaching device, ultrasonic extraction device, solid-liquid storage tank, membrane separation concentration fine filtering device, preparing tank, feed liquid delivery pump, bactericidal unit, extraction storage tank, it is characterized in that, Ganoderma pulverizer is connected with one end of fermentation tank, the other end of fermentation tank is connected with one end of leaching device, the other end of leaching device is connected with one end of ultrasonic extraction device, the other end of ultrasonic extraction device is connected with one end of solid-liquid storage tank, the other end of solid-liquid storage tank is connected with one end of membrane separation concentration fine filtering device, the other end of membrane separation concentration fine filtering device is connected with one end of preparing tank, the other end of preparing tank is connected with one end of feed liquid delivery pump, the other end of liquid delivery pump is connected with one end of bactericidal unit, the other end of bactericidal unit is connected with the one end of extracting storage tank.
2. a kind of separation and Extraction system of ganoderma lucidum triterpene compounds according to claim 1, is characterized in that, described ultrasonic extraction device consists of tank body, stirring motor, axostylus axostyle, stirring paddle, discharge ball valve, ultrasonic transducer; Charge door and air vent are established in described tank body top.
3. a kind of separation and Extraction system of ganoderma lucidum triterpene compounds according to claim 1, is characterized in that, described membrane separation concentration fine filtering device consists of membrance separation groove, membrane module, absorption pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320386716.0U CN203408270U (en) | 2013-07-02 | 2013-07-02 | Separation and extraction system for ganoderma lucidum triterpenoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320386716.0U CN203408270U (en) | 2013-07-02 | 2013-07-02 | Separation and extraction system for ganoderma lucidum triterpenoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203408270U true CN203408270U (en) | 2014-01-29 |
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| CN201320386716.0U Expired - Fee Related CN203408270U (en) | 2013-07-02 | 2013-07-02 | Separation and extraction system for ganoderma lucidum triterpenoids |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203408270U (en) |
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2013
- 2013-07-02 CN CN201320386716.0U patent/CN203408270U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140129 Termination date: 20150702 |
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| EXPY | Termination of patent right or utility model |