CN203403096U - Biological reaction pot - Google Patents
Biological reaction pot Download PDFInfo
- Publication number
- CN203403096U CN203403096U CN201320374460.1U CN201320374460U CN203403096U CN 203403096 U CN203403096 U CN 203403096U CN 201320374460 U CN201320374460 U CN 201320374460U CN 203403096 U CN203403096 U CN 203403096U
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- tank body
- plate
- fixed plate
- round tube
- guide shell
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Abstract
The utility model discloses a biological reaction pot in the field of medical equipment. The biological reaction pot comprises a pot body and a guide cylinder, a porous round pipe, a multi-stage speed adjustment stirrer, an even number of guide pipes, an upper fixed plate and a lower fixed plate which are positioned in the pot body, wherein the bottom of the guide cylinder is concentrically connected with the top of the porous round pipe; the multi-stage speed adjustment stirrer extends into the porous round pipe through the bottom of the porous round pipe; the upper fixed plate is arranged around the top of the guide cylinder; the lower fixed plate is arranged around the bottom of the porous round pipe; the outer circumference of the lower fixed plate is fixed on the inner wall of the pot body; both the upper fixed plate and the lower fixed plate are porous plates; a cell culturing room is formed among the upper fixed plate, the lower fixed plate, the pot body, the guide pipes and the porous round pipe; the even number of guide pipes are uniformly distributed around the guide cylinder and the circumference of the porous round pipe and penetrate through the upper fixed plate and the lower fixed plate; first ventilating pipes are inserted into the even number of guide pipes in a manner of mutual spacing; the first ventilating pipes are communicated with a ventilating opening in the top of the pot body.
Description
Technical field
The utility model relates to a kind of biological reactor in medical equipment field.
Background technology
Carry out at present the biological reactor of cell cultures, be mainly divided into fluidized bed bio retort and fixed bed biological reactor.
Fixed bed biological reactor is to comprise tank body, and the upper mounted plate and the bottom plate that are positioned at tank body, between upper mounted plate and bottom plate, forms cell culture chamber.Cell culture fluid cycles through described cell culture chamber, and the negative pressure that cell culture fluid relies on agitator to produce in stirring is constantly indoor mobile in described cell cultures, to carry out the transmission of nutritive ingredient and oxygen.The indoor nutrient solution velocity of flow of cell cultures is large, and Growth of Cells density is high, and the consumption of the albumen in the time of can reducing serum-free culture is applicable to breed suspension cell.Simultaneously to cell cell cultures is indoor while carrying out cell cultures, can not be subject to the mechanical wounding of agitator, but, fixed bed biological reactor, oxygen is difficult to enter described cell culture chamber by deep ventilation, even if oxygen enters cell culture chamber, also with bubble form, enter, bubble is easily to producing infringement in the indoor cultured cells of carrying out of cell cultures, and cell is cell cultures is indoor while cultivating, and its meta-bolites and dead cell are difficult to discharge.It is inhomogeneous that simultaneously cell culture fluid causes channeling and nutrient distribution indoor inhomogeneous the flowing of described cell cultures, and Growth of Cells speed consistence is poor.
Utility model content
The purpose of this utility model is in order to overcome the deficiencies in the prior art, and a kind of biological reactor is provided, and it can, when the cell indoor to cell cultures carries out deep ventilation, not produce infringement to the indoor cell of cell cultures.
A kind of technical scheme that realizes above-mentioned purpose is: a kind of biological reactor, comprise tank body, and the guide shell, stephanoporate round tube, multistep speed regulation agitator, even number root thrust-augmenting nozzle, upper mounted plate and the bottom plate that are positioned at described tank body;
The bottom of described guide shell joins with the top of described stephanoporate round tube is concentric, and described multistep speed regulation agitator stretches into described stephanoporate round tube from the bottom of described stephanoporate round tube;
Fixed plate arranges around the top of described guide shell; Described bottom plate arranges around the bottom of described stephanoporate round tube; The excircle of described bottom plate and the inwall of described tank body are fixed; Fixed plate and described bottom plate are porous plate; Between fixed plate, described bottom plate, described tank body, described thrust-augmenting nozzle and described stephanoporate round tube, form cell culture chamber;
Described even number root thrust-augmenting nozzle is around described guide shell and described stephanoporate round tube circumference uniform distribution, and runs through fixed plate and described bottom plate; In described even number root thrust-augmenting nozzle, be plugged with spaced reciprocally the first ventpipe, the top of the first described ventpipe communicates with the ventage at described tank body top.
Further, on the tube wall of the thrust-augmenting nozzle described in every, along the circumference of described thrust-augmenting nozzle, be evenly equipped with even column the first radial direction through hole, and described first radial direction through hole of the arbitrary neighborhood two row layout that is all staggered.
Further, in described tank body, be also provided with overhead gage and lower baffle plate between fixed plate and described bottom plate, the inner periphery of described overhead gage and described lower baffle plate and described guide shell are fixed, the excircle of described overhead gage and described lower baffle plate is separated with the inwall of described tank body, and described overhead gage and described lower baffle plate are porous plate.
Further, be plugged with the second ventpipe of being close to described guide shell inwall in described guide shell and described stephanoporate round tube, the height of described the second ventpipe end face is lower than the height of described the first ventpipe end face.
Further, described the second ventpipe is fixed by being positioned at the filter screen at described guide shell top.
Further, the top of described stephanoporate round tube is up-small and down-big toroidal.
Further, the sidewall of described tank body is provided with bubble output hole, and the top of described tank body is provided with condenser mouth, and described bubble output hole is connected by wet cyclone with described condenser mouth.
Adopted the technical scheme of a kind of biological reactor of the present utility model, the thrust-augmenting nozzle in bioreactor and the first ventpipe of being plugged on described thrust-augmenting nozzle carry out deep ventilation to biological reactor, by multistep speed regulation agitator, smash the bubble that deep ventilation produces simultaneously, formation is dissolved in the dissolved oxygen in cell culture fluid, enters the technical scheme of the cell culture chamber of this biological reactor.Its technique effect is: it can, when the cell indoor to cell cultures carries out deep ventilation, not produce infringement to the indoor cell of cell cultures.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of biological reactor of the present utility model.
Embodiment
Refer to Fig. 1, contriver of the present utility model is in order to understand the technical solution of the utility model better, below by embodiment particularly, and is described in detail by reference to the accompanying drawings:
Refer to Fig. 1, a kind of biological reactor of the present utility model, comprises tank body 1, guide shell 21, stephanoporate round tube 22, the second ventpipe 23, filter screen 24, multistep speed regulation agitator 3, upper mounted plate 41, overhead gage 42, lower baffle plate 43, bottom plate 44 and thrust-augmenting nozzle 51 and the first ventpipe 52.
Wherein, the top of tank body 1 is provided with ventage 11, liquid supplementation pipe 12 and condenser mouth 13, and the bottom that the sidewall of tank body 1 is provided with bubble output hole 14, tank body 1 is provided with discharging valve port 15 and sampling valve port 16.On the inwall of tank body 1, be also provided with circumference filter screen (not shown).Liquid supplementation pipe 12 for adding cell culture fluid in biological reactor.
Wherein guide shell 21 and stephanoporate round tube 22 are all positioned at the central position of tank body 1, and the top of stephanoporate round tube 22 is fixed by welding and the bottom of guide shell 21.And guide shell 21 and stephanoporate round tube 22 are to arrange with one heart.On the tube wall of stephanoporate round tube 22, be evenly equipped with the second radial direction through hole (not shown).The top of stephanoporate round tube 22 is up-small and down-big toroidal, is beneficial to the circulation of cell culture fluid in biological reactor.Multistep speed regulation agitator 3 stretches into stephanoporate round tube 22 from the bottom of stephanoporate round tube 22.Meanwhile, the top of guide shell 21 is provided with filter screen 24.
The second ventpipe 23 is close to the inwall of guide shell 21, from the top of guide shell 21, stretches into guide shell 21, and through whole guide shell 21, then it is fixing by filter screen 24 to stretch into stephanoporate round tube 22, the second ventpipes 23.
Upper mounted plate 41, overhead gage 42, lower baffle plate 43, bottom plate 44 are all positioned at tank body 1, and set gradually from top to bottom along vertical direction.Wherein upper mounted plate 41 arranges around the top of guide shell 21, and overhead gage 42 arranges around the middle part of guide shell 21, and lower baffle plate 43 arranges around the bottom of guide shell 21.Upper mounted plate 41 is fixing by flange and guide shell 21.Bottom plate 44 arranges around the bottom of stephanoporate round tube 22, and bottom plate 44 is fixing by flange and stephanoporate round tube 22.Wherein, on the excircle of bottom plate 44, be also provided with flange, and be socketed in the packing ring of described flange excircle on week, for bottom plate 44 and the inwall of tank body 1 are fixed.Upper mounted plate 41 bottom surfaces are cell culture chamber end faces, the bottom surface that bottom plate 44 end faces are cell culture chamber.Between the inwall of retaining plate 41, bottom plate 44, guide shell 21, stephanoporate round tube 22 and tank body 1, formed the cell culture chamber of this biological reactor.Between the bottom surface of the bottom surface of bottom plate 44 and tank body 1, form a back cavity 17.On the excircle of overhead gage 42 and lower baffle plate 43, also overlap acting flange, between this flange and the inwall of tank body 1, leave gap.On the excircle of upper mounted plate 41, be also provided with flange and be socketed in the packing ring of described flange excircle on week, between this packing ring and the sidewall of tank body 1, leaving gap.Distance between upper mounted plate 41 bottom surfaces and bottom plate 44 end faces is h.Wherein, distance between overhead gage 42 end faces and upper mounted plate 41 bottom surfaces is less than h/3, distance between lower baffle plate 43 bottom surfaces and bottom plate 44 end faces is less than h/2, upper mounted plate 42 and bottom plate 43 are for when the indoor filling cell culture vector of cell cultures, control the amount of cell culture vector, the end face of cell culture vector higher than lower baffle plate 43 end faces lower than the bottom surface of overhead gage 42.
In the present embodiment, upper mounted plate 41, overhead gage 42, lower baffle plate 43, bottom plate 44 are all porous plates, select stainless steel or plastics to make.Upper mounted plate 41, overhead gage 43, lower baffle plate 43, the preferred material of bottom plate 44 are porous polyethylene plate, porous polypropylene plate and porous EFTE(polyethylene-polytetrafluoroethyl-ne alkene copolymer) plate.
The quantity of thrust-augmenting nozzle 51 is even number root, and this even number root thrust-augmenting nozzle 51 is the circumference uniform distributions around this stephanoporate round tube 22 and guide shell 21.This even number root thrust-augmenting nozzle 51 all runs through upper mounted plate 41, overhead gage 42, lower baffle plate 43 and bottom plate 44 successively.The top of this even number root thrust-augmenting nozzle 51 is upwards inserted and is run through upper mounted plate 41, and the bottom of this even number root thrust-augmenting nozzle 51 is run through bottom plate 44 downwards.The first ventpipe 52 inserts this even number root thrust-augmenting nozzle 51 spaced reciprocally, and the thrust-augmenting nozzle 51 that is inserted with the thrust-augmenting nozzle 51 of the first ventpipe 52 and is not inserted with the first ventpipe 52 is spaced apart.The top of the first ventpipe 52 communicates with the ventage 11 of tank body 1.Therefore, the height of the first ventpipe 52 end faces is higher than the height of the second ventpipe 23 end faces.
Simultaneously on the tube wall of thrust-augmenting nozzle 51, around thrust-augmenting nozzle 51, be evenly distributed in even column the first radial direction through hole (not shown), described first radial direction through hole of two row of the arbitrary neighborhood layout that is staggered.
The effect of stephanoporate round tube 22 is to prevent that in the indoor cell culture vector of described cell cultures cultured cells is subject to the injury of multistep speed regulation agitator 3 shearing forces.
In tank body 1, cell culture fluid flows to the bottom of tank body 1 from thrust-augmenting nozzle 51 and guide shell 21, the swirling flow that cell culture fluid flows downward in each thrust-augmenting nozzle 51, guide shell 21 and the interior formation of stephanoporate round tube 22, the back cavity 17 that enters tank body 1 bottom is gone out in this swirling flow flowing downward from the bottom of each thrust-augmenting nozzle 51 and stephanoporate round tube 22.From each thrust-augmenting nozzle 51 and the swirling flow flowing downward of going out from stephanoporate round tube 22 bottoms, under the effect of multistep speed regulation agitator 3, in back cavity 17 then formed the mobile swirling flow that makes progress.
Because upper mounted plate 41, overhead gage 42, lower baffle plate 43 and bottom plate 44 are all porous plate, this mobile swirling flow that makes progress enters described cell culture chamber from the bottom of bottom plate 44.For the indoor cell of cell cultures provides nutrition and dissolved oxygen.The continuation of this mobile swirling flow that makes progress is upwards flowed, flow through lower baffle plate 43 and overhead gage 42, then through upper mounted plate 41, be back to the top of tank body 1, complete the once circulation of cell culture fluid in tank body 1.Or around the gap of lower baffle plate 43, overhead gage 42 and upper mounted plate 41 excircles and tank body 1 inwall, be back to the top of tank body 1, complete the once circulation of cell culture fluid in tank body 1.
In the present embodiment, by changing the stirring velocity of multistep speed regulation agitator 3, can change the movement velocity that this mobile swirling flow that makes progress makes progress in described cell culture chamber.And cell cultures is indoor while having cell culture vector, the two-layer obstruct that is subject to overhead gage 42 and upper mounted plate 41 of described cell culture vector, and can not go out, guaranteed that the top of upper mounted plate 41 end faces is supernatant liquids.
In order to guarantee the speed governing of multistep speed regulation agitator 3, the blade that multistep speed regulation agitator 3 adopts is Ping Ye or propeller shape blade.
This biological reactor can be realized highdensity cell cultures, and cell density can reach 10
8individual/more than ml, and can carry out long-time continuous cultivation, this is to supply with cell culture fluid and dissolved oxygen by the bottom of continuously past tank body 1, the supernatant liquor of the top of tank body 1 output is simultaneously realized.The first radial direction through hole on thrust-augmenting nozzle 51 is constantly sent into cell culture fluid described cell culture chamber.The solid meta-bolites that cell in described cell culture chamber produces simultaneously, and dead cell constantly second radial direction through hole discharge from stephanoporate round tube 22 under the effect of multistep speed regulation agitator 3, and from bottom plate 44, do not flow out, then the solid meta-bolites that cell produces, and dead cell deposits to the bottom of tank body 1 and discharges, prevent that bottom plate 44 from being stopped up by solid meta-bolites and the dead cell of cell, affect the generation of the mobile swirling flow that makes progress.On thrust-augmenting nozzle 51, the effect of the first radial direction through hole is: in the vertical direction guarantees the homogeneity of described cell culture chamber inner cell nutrient solution.Described the first radial direction through hole layout that is staggered, further in the vertical direction guarantees the homogeneity of described cell culture chamber inner cell nutrient solution.
The oxygen of extraneous input is by the first ventpipe 52, be transported to the bottom of tank body 1, this biological reactor is carried out to deep ventilation, owing to being subject to the restriction in the aperture of the first radial direction through hole on thrust-augmenting nozzle 51, the bubble that the first ventpipe 52 produces in deep ventilation can't enter described cell culture chamber by the first described radial direction through hole.Described bubble breaks under the stirring of multistep speed regulation agitator 3, formation is dissolved in the dissolved oxygen of cell culture fluid, and enter described cell culture chamber by the bottom of bottom plate 44, to carrying out oxygen supply in the indoor cultured cells of cell cultures, to reduce described bubble to the damage in the indoor cultured cells of cell cultures.Therefore,, in a kind of biological reactor of the present utility model, the approach that the solid product that cell culture fluid enters described cell culture chamber and cellular metabolism is discharged described cell culture chamber is different.
The height of the end face of the second ventpipe 23 is lower than the height of the first ventpipe 52 end faces, and the height of supernatant liquid end face, in order to the dissolved oxygen with in supernatant liquid, this biological reactor is carried out to deep ventilation, further guarantee the supply of the oxygen that the indoor cell of cell cultures is required.
Because this biological reactor is at interior first ventpipe 52 that inserted of the first thrust-augmenting nozzle 51, when having solved the problem of deep ventilation, prevented the damage of bubble to cell in deep ventilation process.Therefore its amplification potential is good, can in this cell cultures bed, realize highdensity cell cultures, and cell density can reach 10
8individual/more than ml, to use the bio-reactor of this biological reactor, amplify potential high, its volume at least can be accomplished 500L.
Because this biological reactor has carried out highdensity cell cultures, therefore in cell cultivation process, due to the respiratory metabolism of cell, produced a large amount of viscous foams, described viscous foam is emerged from the excircle of upper mounted plate 41 end faces and upper mounted plate 41 and the gap between tank body 1 inwall.Due to the entrance of foam output tube 14 end face higher than upper mounted plate 41.Therefore bubble output hole 14 can be connected with the entrance of a wet cyclone (not shown), condenser mouth 13 is connected with the outlet of this wet cyclone.Like this, can be by wet cyclone by cell cultivation process, because the viscous foam producing respiration day of cell is removed.The effect of filter screen 24 is to prevent that viscous foam is back to the bottom of biological reactor.
Simultaneously, in the sampling valve port 16 of tank body 1 bottom, insert sampling valve (not shown), the valve rod of described sampling valve is through bottom plate 44, to carrying out sterile sampling in the indoor cell culture vector of described cell cultures, every sub-sampling only samples several cell culture vectors, sampling amount is few, and the cell culture vector of sampling can carry out cell counting, observation of cell growthhabit.The discharging valve port 15 of tank body 1 bottom is for the discharging after completing in cell cultures.
This biological reactor can be reused simultaneously, repeats to load cell culture vector and reaches more than 10 times, and this greatly reduces costs for scientific effort.
Those of ordinary skill in the art will be appreciated that, above embodiment is only for the utility model is described, and be not used as restriction of the present utility model, as long as within the scope of connotation of the present utility model, to the variation of the above embodiment, modification, all will drop within the scope of claims of the present utility model.
Claims (7)
1. a biological reactor, it is characterized in that: comprise tank body (1), and the guide shell (21), stephanoporate round tube (22), multistep speed regulation agitator (3), even number root thrust-augmenting nozzle (51), upper mounted plate (41) and the bottom plate (44) that are positioned at described tank body (1);
Concentric the joining of top of the bottom of described guide shell (21) and described stephanoporate round tube (22), described multistep speed regulation agitator (3) stretches into described stephanoporate round tube (22) from the bottom of described stephanoporate round tube (22);
Fixed plate (41) arranges around the top of described guide shell (21); Described bottom plate (44) arranges around the bottom of described stephanoporate round tube (22); The inwall of the excircle of described bottom plate (44) and described tank body (1) is fixed; Fixed plate (41) and described bottom plate (44) are porous plate; Between fixed plate (41), described bottom plate (44), described tank body (1), described thrust-augmenting nozzle (21) and described stephanoporate round tube (22), form cell culture chamber;
Described even number root thrust-augmenting nozzle (51) is around described guide shell (21) and described stephanoporate round tube (22) circumference uniform distribution, and runs through fixed plate (41) and described bottom plate (44); In described even number root thrust-augmenting nozzle (51), be plugged with spaced reciprocally the first ventpipe (52), the top of described the first ventpipe (52) communicates with the ventage (11) at described tank body (1) top.
2. a kind of biological reactor according to claim 1, it is characterized in that: on the tube wall of the thrust-augmenting nozzle described in every (51), along the circumference of described thrust-augmenting nozzle (51), be evenly equipped with even column the first radial direction through hole, and described first radial direction through hole of the arbitrary neighborhood two row layout that is all staggered.
3. a kind of biological reactor according to claim 1 and 2, it is characterized in that: in described tank body (1), be also provided with the overhead gage (42) and the lower baffle plate (43) that are positioned between fixed plate (41) and described bottom plate (44), the inner periphery of described overhead gage (42) and described lower baffle plate (43) and described guide shell (21) are fixing, the excircle of described overhead gage (42) and described lower baffle plate (43) is separated with the inwall of described tank body (1), and described overhead gage (42) and described lower baffle plate (43) are porous plate.
4. a kind of biological reactor according to claim 1 and 2, it is characterized in that: in described guide shell (21) and described stephanoporate round tube (22), be plugged with the second ventpipe (23) of being close to described guide shell (21) inwall, the height of described the second ventpipe (23) end face is lower than the height of described the first ventpipe (52) end face.
5. a kind of biological reactor according to claim 4, is characterized in that: described the second ventpipe (23) is fixing by being positioned at the filter screen (24) at described guide shell (21) top.
6. a kind of biological reactor according to claim 4, is characterized in that: the top of described stephanoporate round tube (22) is up-small and down-big toroidal.
7. according to a kind of biological reactor described in claim 1 or 2, it is characterized in that: the sidewall of described tank body (1) is provided with bubble output hole (14), the top of described tank body (1) is provided with condenser mouth (13), and described bubble output hole (14) is connected by wet cyclone with described condenser mouth (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320374460.1U CN203403096U (en) | 2013-06-27 | 2013-06-27 | Biological reaction pot |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320374460.1U CN203403096U (en) | 2013-06-27 | 2013-06-27 | Biological reaction pot |
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| Publication Number | Publication Date |
|---|---|
| CN203403096U true CN203403096U (en) | 2014-01-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320374460.1U Expired - Lifetime CN203403096U (en) | 2013-06-27 | 2013-06-27 | Biological reaction pot |
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| CN (1) | CN203403096U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108421106A (en) * | 2018-03-21 | 2018-08-21 | 中国人民解放军陆军军医大学第附属医院 | Bioartificial liver system based on people iHep cells and membrane type panel-shaped reactor |
-
2013
- 2013-06-27 CN CN201320374460.1U patent/CN203403096U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108421106A (en) * | 2018-03-21 | 2018-08-21 | 中国人民解放军陆军军医大学第附属医院 | Bioartificial liver system based on people iHep cells and membrane type panel-shaped reactor |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140122 |
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| CX01 | Expiry of patent term |