CN203220682U - Active particles for tumor treatment - Google Patents
Active particles for tumor treatment Download PDFInfo
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- CN203220682U CN203220682U CN 201220101318 CN201220101318U CN203220682U CN 203220682 U CN203220682 U CN 203220682U CN 201220101318 CN201220101318 CN 201220101318 CN 201220101318 U CN201220101318 U CN 201220101318U CN 203220682 U CN203220682 U CN 203220682U
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- radioactive particle
- flexible element
- rigid
- tumor
- radiosiotope
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Abstract
The utility model relates to active particles for tumor treatment, comprising rigid units and an elastic unit. The rigid unit contains radio isotope capable of tumor treatment, and the elastic unit is an elastic body which can be deformed under the effect of outside force and can be recovered from deformation after the outside force is removed. The elastic unit is placed between two rigid units, and is respectively connected to the rigid units at two ends. As the elastic unit is placed between two rigid units and can be bended and deformed, the active particles have good flexibility and can be released through a complicated bent pipeline. Accordingly, the demand of implanting conformal active particles in clinic tumor treatment can be met.
Description
Technical field
This utility model relates to a kind of radioactive particle, especially for the embedded type radioactive particle for the treatment of tumor.
Background technology
By implanting
125I, namely I (iodine) 125 radioactive particles are treated tumor, have become one of a kind of effective ways for the treatment of of solid tumors at present.Prior art
125The typical structure of I radioactive particle is as follows: will
125I is adsorbed on the silver metal rod of diameter 0.5mm, length 3.5mm, has adsorbed this then
125It is that 0.8mm, length are in the titanium light-wall pipe of 4.5mm that the silver-colored rod of I is encapsulated in external diameter.Because prior art is this
125The I radioactive particle is the cylinder of rigidity, thereby can only put by staight needle type implantation device, needs repeatedly tumor section to be punctured, and could form effective increased radioactivity and covering.There is following shortcoming in this prior art:
1) a radion implant needle can only relate to a direction, a position.But in tumor therapeutic procedure, often need radion is distributed in multi-direction implantation a plurality of positions of tumor, so just needing to implement multichannel puncture particle implants, namely need a plurality of percutaneous puncture points and a plurality of puncture needle tubing and a plurality of puncture nook closing member, the apparatus that uses is more, cloth source and inconvenient operation, the damage that the patient is caused is big, and the medical expense height.
2) tumor, intracranial tumor behind the rib that stops if any skeleton for the tumor of privileged sites or behind the breastbone, and the tumor at the many position of peripheral vessels and intestinal tube such as pancreas tumor etc., the radion implant needle of prior art is difficult to reach desired location, thereby can't implement and operate.
3) can not select and change direction and the position of implantation, so be difficult to be fit to the tumor form, can't realize that suitable shape is implanted.
For this reason, the inventor discloses a kind of single channel multidirectional tumor conformal shape radioactive particle implanting device in the patent application of CN101829393A, by being arranged on the looper of head, can realize the implantation of multi-direction multi-section position by single channel, reduce the use of apparatus, reduced patient's damage.But this new particle implanting device head is looper, i.e. arc pin, this rigid cylindrical build of prior art
125The I radioactive particle is can not be by the bending section of looper, thereby need the radioactive particle of prior art be improved, and provides a kind of new
125The I radioactive particle.
Summary of the invention
The shape of the solid tumor of patients with solid tumor, normally irregular.What the radioactive particle treatment technology of prior art solid tumor was used is bar-shaped rigid cylindrical body radioactive particle, and this rigid rod radioactive particle can only be placed by staight needle.Staight needle will carry out percutaneous puncture at different parts repeatedly, places radioactive particle; Like this, the risk of existing increase tumor planting can not adapt to the complicated shape of solid tumor again, carries out the efficient emission covering.For this reason, need a kind of resilient radioactive particle of exploitation, can implant resilient radioactive particle by looper; Both reduce the position of percutaneous puncture, reduced the risk of tumor planting; Can adapt to the complicated shape of solid tumor by the implantation of looper again, reach the purpose of effective covering solid tumor.
Provided by the inventionly a kind ofly can carry out strain, and the radioactive particle of the treatment tumor that can implant by looper is achieved like this:
The radioactive particle for the treatment of tumor, described radioactive particle contains rigid element 1 and Flexible element 2; Rigid element 1 contains the radiosiotope 13 that can treat tumor; Flexible element 2 is the elastomers that can deform under external force and can recover to be out of shape behind the external force removal; Described radioactive particle contains a Flexible element 2 at least, and Flexible element 2 places between two rigid elements 1, is connected with the rigid element 1 at two ends respectively.
Further, described rigid element 1 contains seal casinghousing 12, metallic particles 11 and radiosiotope 13; Radiosiotope 13 is adsorbed on the metallic particles 11; The metallic particles 11 of absorption radiosiotope 13 is placed in the seal casinghousing 12, and sealed housing 12 coats sealing.Sphere or ellipsoidal particle that metallic particles 11 adopts argent to make usually, sphere or the ellipsoidal particle that can also adopt medical titanium and titanium alloy to make.The center laser boring of these metallic particles 11, the centre bore of formation are used for the helical spring tinsel of riveted and fixed as Flexible element 2.
Described seal casinghousing 12 has housing 121 and seals 122, and housing 121 is to hold metallic particles 11 hollow bodies that adsorbed radiosiotope 13, seal 122 be can seal casinghousing 121 opening seal the limit.
Described Flexible element 2 is can be at spring wire or the helical spring of the medium-term and long-term medical elastic material manufacture of implanting of human body.Described medical elastic metal is selected from: Ti-Ni marmem, titanium zirconium niobium elastic alloy, titanium-based amorphous attitude elastic alloy, Zirconium based amorphous elastic alloy, medical elastic rustless steel.
Described metallic particles 11 riveted and fixed are on the tinsel of Flexible element 2, and sealed housing 12 coats sealing.
Described housing 121 is short titanium light-wall pipes, and seal the smooth titanium of formation with smooth titanium and seals 122 at the both ends open place of the housing 121 that constitutes at the titanium light-wall pipe; The tinsel of making Flexible element 2 is fixed on titanium and seals on 122; Form rounding off between rigid element 1 and the Flexible element 2.
The length L 1 of described rigid element 1 is usually between 0.5mm～2mm; The diameter D1 of rigid element 1 is usually between 0.5mm～2mm; The ratio of the length L 1 of rigid element 1 and the diameter D1 of rigid element 1 is less than 3.
The helical spring length L 2 of described Flexible element 2 is usually between 0.5mm～5mm; The diameter D2 of Flexible element 2 is usually between 0.3mm～1mm.
Described radiosiotope 13 is selected from: I (iodine) 125, Pd (palladium) 103, Ir (iridium) 192, Cs (caesium) 131, Yb (ytterbium) 169; The most frequently used is
125I, i.e. I (iodine) 125.
The utility model discloses the radioactive particle for the treatment of tumor, contain rigid element and Flexible element; Rigid element contains the radiosiotope that can treat tumor, and Flexible element places between two rigid elements, is connected with the rigid element at two ends respectively.
Owing between two rigid elements, be provided with Flexible element, so this radioactive particle has good compliance, can discharge by the crooked pipeline of complexity, satisfy the requirement that tumor conformal shape radioactive particle is implanted.
Description of drawings
Fig. 1 is the structural representation of radioactive particle of the spring connecting-type of this utility model.
Fig. 2 is the structural representation that 2 rigid elements and 1 Flexible element are formed 2 radioactive source types.
Fig. 3 is the structural representation that 4 rigid elements and 3 Flexible elements are formed 4 radioactive source types.
Fig. 4 is the structural representation that 5 rigid elements and 4 Flexible elements are formed 5 radioactive source types.
Fig. 5 is the structural representation of radioactive particle of the silk connecting-type of this utility model.
Fig. 6 is that the radioactive particle of this utility model is by the fundamental diagram of the arc-shaped bend section of particle implantation device.
Among the above-mentioned figure: 1 is rigid element, and 2 is Flexible element, and 3 is radiosiotope, and 4 is the radioactive particle of this utility model, and 5 is the crooked interior pin of implantation device, and 6 is the outer pin of implantation device, and 7 is the inner core push rod of implantation device; 11 is metallic particles, and 12 is seal casinghousing, and 121 is housing, and 122 for sealing.
L1 is the length of rigid element, and D1 is the diameter of rigid element.
L2 is the length of Flexible element, and D2 is the diameter of Flexible element.
The specific embodiment
Embodiment 1: the radioactive particle of the spring connecting-type of this utility model
With reference to figure 1, in the present embodiment, a kind of radioactive particle of spring connecting-type of this utility model is disclosed, described radioactive particle contains rigid element 1 and Flexible element 2.Rigid element 1 contains seal casinghousing 12, metallic particles 11 and radiosiotope 13.Radiosiotope is selected for use
125I.
The metallic particles 11 of rigid element 1 is that diameter is the ping-pong ball of 0.5mm, and it is the through hole of 0.25mm that there is diameter at the center of ping-pong ball.The effect of this through hole is that convenient helical spring tinsel as Flexible element 2 inserts, and riveted and fixed.Sphere or ellipsoidal particle that metallic particles 11 adopts argent to make usually, sphere or the ellipsoidal particle that can also adopt medical titanium and titanium alloy to make.The center laser boring of these metallic particles 11, the centre bore of formation are used for the helical spring tinsel of riveted and fixed as Flexible element 2.
Then, with radiosiotope
125I is adsorbed on the metallic particles 11.
Riveted and fixed will be inserted as a helical spring end tinsel head of Flexible element 2 in the central through hole of metallic particles 11.Then, helical spring another terminal filament head is inserted in the central through hole of another metallic particles 11, riveted and fixed has namely formed helical spring two ends respectively with the structure of a ping-pong ball.So analogize, the 3rd ping-pong ball, the 4th ping-pong ball etc. are installed.
Be that 0.7mm, external diameter are that 0.8mm, length are that the housing 121 of the titanium light-wall pipe of 1.2mm is enclosed within on each metallic particles 11 with internal diameter, then with the two ends fusing of laser with the housing 121 of titanium light-wall pipe, the titanium drop will seal the two ends of titanium light-wall pipe, what form titanium seals 122, sealed at both ends with housing 121; To fix as the helical spring tinsel head of Flexible element 2 simultaneously, the formation titanium seals 122 rounding off.Like this, just form and contain a Flexible element 2 at least, Flexible element 2 places between two rigid elements 1, and the structure that is connected with the rigid element 1 at two ends has respectively namely obtained the radioactive particle of the spring connecting-type of this utility model.
The radioactive particle of the spring connecting-type of this utility model can have different size, to satisfy different clinical demands.As:
2 rigid elements and 1 Flexible element are formed 2 radioactive source types, with reference to figure 2;
3 rigid elements and 2 Flexible elements are formed 3 radioactive source types, with reference to figure 1;
4 rigid elements and 3 Flexible elements are formed 4 radioactive source types, with reference to figure 3;
5 rigid elements and 4 Flexible elements are formed 5 radioactive source types, with reference to figure 4; So analogize.
The length L 1 of rigid element 1 is usually between 0.5mm～2mm; The diameter D1 of rigid element 1 is usually between 0.5mm～2mm; The ratio of the length L 1 of rigid element 1 and the diameter D1 of rigid element 1 makes things convenient for rigid element 1 by crooked arc section less than 3.
The helical spring length L 1 of Flexible element 2 is usually between 0.5mm～5mm; The diameter D1 of Flexible element 2 is usually between 0.3mm～1mm; Flexible element 2 can deform under external force and can recover distortion behind the external force removal, makes things convenient for Flexible element 2 by crooked arc section.Like this, even the radioactive particle of the spring connecting-type of this utility model of 5 radioactive source types or 95 radioactive source types, also can be conveniently the crooked arc section of complexity by the particle implantation device, carry out particle and implant.In addition, the Flexible element 2 of spiral spring type has the transmission type of good power, makes things convenient for release, the release of particle, with reference to figure 6.
Embodiment 2: the radioactive particle of the silk connecting-type of this utility model
In the present embodiment, substantially the same manner as Example 1, its difference is: Flexible element 2 has directly adopted elastic metallic yarn, as, adopting diameter is the Ti-Ni marmem silk of 0.3mm, and each rigid element 1 is linked together, and this structure manufacturing cost is lower, also can satisfy clinical requirement, with reference to figure 5.
Embodiment 3: the method for implantation of the radioactive particle of this utility model
The radioactive particle of this utility model is put into special particle implantation device, and when particle passed through the crooked segmental arc of implantation device, the Flexible element 2 of particle deformed, the needle tubing 5 that adapts to the implantation device bending, the radioactive particle of invention can be submissive pass through crooked segmental arc, discharge, with reference to figure 6.
Should be noted that herein openly can replace with the identical structure of other effect with the structure of explanation that the embodiment that while this utility model is introduced realizes unique structure of the present utility model.Though preferential embodiment of the present utility model is introduced in this article and is illustrated; but those skilled in the art know and know that these embodiment illustrate; those skilled in the art can make countless variations, improvement and replacement; and can not break away from this utility model; therefore, should define protection domain of the present utility model according to what the spirit and scope of this utility model appending claims were come.
Claims (9)
1. treat the radioactive particle of tumor, it is characterized in that: described radioactive particle contains rigid element (1) and Flexible element (2); Rigid element (1) contains the radiosiotope (13) that can treat tumor; Flexible element (2) is the elastomer that can deform under external force and can recover to be out of shape behind the external force removal; Described radioactive particle contains a Flexible element (2) at least, and Flexible element (2) places between two rigid elements (1), is connected with the rigid element (1) at two ends respectively.
2. according to the radioactive particle of the described treatment tumor of claim 1, it is characterized in that: described rigid element (1) contains seal casinghousing (12), metallic particles (11) and radiosiotope (13); Radiosiotope (13) is adsorbed on the metallic particles (11); The metallic particles (11) of absorption radiosiotope (13) is placed in the seal casinghousing (12), and sealed housing (12) coats sealing.
3. according to the radioactive particle of the described treatment tumor of claim 2, it is characterized in that: described seal casinghousing (12) has housing (121) and seals (122), housing (121) is to hold metallic particles (11) hollow body that has adsorbed radiosiotope (13), seal (122) be can seal casinghousing (121) opening seal the limit.
4. according to the radioactive particle of the described treatment tumor of claim 1, it is characterized in that: described Flexible element (2) is can be at spring wire or the helical spring of the medium-term and long-term medical elastic material manufacture of implanting of human body.
5. according to the radioactive particle of the described treatment tumor of claim 2, it is characterized in that: described metallic particles (11) riveted and fixed is on the tinsel of Flexible element (2), and sealed housing (12) coats sealing.
6. according to the radioactive particle of the described treatment tumor of claim 3, it is characterized in that: described housing (121) is short titanium light-wall pipe, and seal the smooth titanium of formation with smooth titanium and seals (122) at the both ends open place of the housing (121) that constitutes at the titanium light-wall pipe; The tinsel of making Flexible element (2) is fixed on titanium and seals on (122); Form rounding off between rigid element (1) and the Flexible element (2).
7. according to the radioactive particle of the described treatment tumor of claim 1, it is characterized in that: the length L 1 of described rigid element (1) is usually between 0.5mm～2mm; The diameter D1 of rigid element (1) is usually between 0.5mm～2mm; The ratio of the length L 1 of rigid element (1) and the diameter D1 of rigid element (1) is less than 3.
8. according to the radioactive particle of the described treatment tumor of claim 1, it is characterized in that: the helical spring length L 2 of described Flexible element (2) is usually between 0.5mm～5mm; The diameter D2 of Flexible element (2) is usually between 0.3mm～1mm.
9. according to the radioactive particle of the described treatment tumor of claim 1, it is characterized in that: described radiosiotope (13) is selected from:
125I or
103Pd or
192Ir or
131Cs or
169Yb.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220101318 CN203220682U (en) | 2012-03-16 | 2012-03-16 | Active particles for tumor treatment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220101318 CN203220682U (en) | 2012-03-16 | 2012-03-16 | Active particles for tumor treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203220682U true CN203220682U (en) | 2013-10-02 |
Family
ID=49247700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220101318 Expired - Fee Related CN203220682U (en) | 2012-03-16 | 2012-03-16 | Active particles for tumor treatment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203220682U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301560A (en) * | 2012-03-16 | 2013-09-18 | 吴沛宏 | Radioactive particles for treating tumor and implantation method |
| CN105727432A (en) * | 2016-04-19 | 2016-07-06 | 牛洪欣 | Recyclable conformal radioactive particle cabin |
-
2012
- 2012-03-16 CN CN 201220101318 patent/CN203220682U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301560A (en) * | 2012-03-16 | 2013-09-18 | 吴沛宏 | Radioactive particles for treating tumor and implantation method |
| CN105727432A (en) * | 2016-04-19 | 2016-07-06 | 牛洪欣 | Recyclable conformal radioactive particle cabin |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131002 Termination date: 20210316 |