CN203169185U - Combination blood sample collection tube for Gamma interferon release test - Google Patents
Combination blood sample collection tube for Gamma interferon release test Download PDFInfo
- Publication number
- CN203169185U CN203169185U CN 201220533572 CN201220533572U CN203169185U CN 203169185 U CN203169185 U CN 203169185U CN 201220533572 CN201220533572 CN 201220533572 CN 201220533572 U CN201220533572 U CN 201220533572U CN 203169185 U CN203169185 U CN 203169185U
- Authority
- CN
- China
- Prior art keywords
- tube
- antigen
- pipe
- blood sample
- release test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008280 blood Substances 0.000 title claims abstract description 36
- 210000004369 blood Anatomy 0.000 title claims abstract description 36
- 238000012360 testing method Methods 0.000 title claims abstract description 32
- 102000008070 Interferon-gamma Human genes 0.000 title abstract 3
- 108010074328 Interferon-gamma Proteins 0.000 title abstract 3
- 229940044627 gamma-interferon Drugs 0.000 title abstract 3
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 21
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 21
- 102000036639 antigens Human genes 0.000 claims abstract description 16
- 108091007433 antigens Proteins 0.000 claims abstract description 16
- 239000013641 positive control Substances 0.000 claims description 13
- 239000013642 negative control Substances 0.000 claims description 12
- 230000000890 antigenic effect Effects 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 230000001681 protective effect Effects 0.000 claims description 4
- 229920005549 butyl rubber Polymers 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000000427 antigen Substances 0.000 abstract description 6
- 238000001514 detection method Methods 0.000 abstract description 5
- 229920001184 polypeptide Polymers 0.000 abstract description 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 4
- 102000004169 proteins and genes Human genes 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 230000035945 sensitivity Effects 0.000 abstract description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract description 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract description 2
- 239000000706 filtrate Substances 0.000 abstract description 2
- 239000003226 mitogen Substances 0.000 abstract description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract 3
- 238000004555 blood preservation Methods 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 3
- 238000011998 interferon-gamma release assay Methods 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Images
Abstract
The utility model provides a blood collection tube, and especially provides a combination blood sample collection tube for a Gamma interferon release test, comprising a negative contrast tube, a positive contrast tube and a test sample tube, which are respectively formed by an original tube and a rubber plug. The rubber plug is sealed to a mouth of the original tube. The negative contrast tube is filled with anti-coagulants. The positive contrast tube is filled with anti-coagulants and antigen stimulants, and the test sample tube is filled with anti-coagulants and antigen proteins. The anti-coagulants contain heparin salt, EDTA salt, sodium citrate salt, buffer solution, blood preservation liquid or other anticoagulant substances. The antigen stimulant is T cell mitogen substance. The antigen protein comprises a singularity antigen target protein polypeptide, a filtrate protein substance or a singularity antigen mixing polypeptide. The combination blood sample collection tube for a Gamma interferon release test is advantageous in that detection sensitivity and reliability can be improved; clinic detection efficiency can be improved; pollution and trouble brought by blood division can be prevented.
Description
Technical field
This utility model is a kind of blood taking tube, particularly a kind of combination blood sample blood taking tube for the IFN-release test.
Background technology
Tuberculosis is a global serious public health problem, at present to diagnosis lungy mainly according to clinical symptoms, chest x-ray sheet and bacteriology checking, these traditional diagnostic methods are time-consuming and verification and measurement ratio is low, incured loss through delay the best opportunity of early discovery and early stage treatment.
Along with the continuous understanding of IFN-being regulated the effect of tuberculosis infection cell immune response, people recognize that progressively (inter feron gamma release assay s IGRAs) can be used for the diagnosis of tuberculosis infection to the IFN-release test.
The IFN-release test is used for the diagnosis of tuberculosis infection, has fast and convenient good effect, but experiment showed, that its testing result still has false-positive problem with interferon release test diagnosis tuberculosis infection.In order to solve the false positive problem, often set feminine gender and positive control in the test, blood drawing divide blood again but need earlier during operation, and its step is loaded down with trivial details, and detection sensitivity, reliability and conventional efficient all can be affected.
Summary of the invention
The purpose of this utility model is to have the low defective of the loaded down with trivial details sensitivity of step in order to overcome existing IFN-release test for the tuberculosis infection diagnosis, invents a kind of can directly the blood drawing and carries out the combination blood sample blood taking tube that is used for the IFN-release test of tuberculosis infection diagnosis.
The purpose of this utility model realizes as follows: described combination blood sample blood taking tube for the IFN-release test, comprise negative control pipe, positive control pipe and test specimens QC, negative control pipe, positive control pipe and test specimens QC are formed by former pipe and plug, plug connects airtight on the mouth of pipe of former pipe, the negative control pipe is built-in with anticoagulant, the positive control pipe is built-in with anticoagulant and antigenic stimulus agent, and the test specimens QC is built-in with anticoagulant and antigen protein class material.
Described former pipe plastic or glass material are made; Plug is made of butyl rubber.
The outside of described plug is provided with protective cap.
Described anticoagulant, antigenic stimulus agent and antigen protein class material can be used as solution and directly add in the former pipe, also can be sprayed on the tube wall of former pipe, or the combination of the two.
Good effect of the present utility model is as follows: 1) can improve detection sensitivity and reliability; 2) improve Clinical detection efficient; 3) pollution and the trouble of avoiding branch blood to bring.
Description of drawings
Fig. 1 is this utility model first example structure figure
Fig. 2 is this utility model second example structure figure
Among the figure: 1 negative control pipe, 2 positive control pipes, 3 test specimens QCs
4 plugs, 5 former pipe 6 anticoagulant
7 antigenic stimulus agent, 8 antigen proteins, 9 protective caps
The specific embodiment
As shown in Figure 1, described combination blood sample blood taking tube for the IFN-release test, comprise negative control pipe 1, positive control pipe 2 and test specimens QC 3, the position of negative control pipe 1, positive control pipe 2 and test specimens QC 3 can be arranged arbitrarily, negative control pipe 1, positive control pipe 2 and test specimens QC 3 are formed by former pipe 5 and plug 4, plug 4 connects airtight on the mouth of pipe of former pipe 5, negative control pipe 1 is built-in with anticoagulant 6, positive control pipe 2 is built-in with anticoagulant 6 and antigenic stimulus agent 7, and test specimens QC 3 is built-in with anticoagulant 6 and antigen protein 8.
Described former pipe 4 usefulness plastics or glass material are made; Plug is made of butyl rubber.
As shown in Figure 2, the outside of described plug 4 can be provided with protective cap 9.
Described anticoagulant 6, antigenic stimulus agent 7 and antigen protein 8 can be used as solution and directly add in the former pipe 5, also can be sprayed on the tube wall of former pipe, or the combination of the two.
In concrete enforcement, described anticoagulant can be selected heparinate, edta salt, sodium citrate salt, anticoagulant buffer, anticoagulant for storage of whole blood for use; Described antigenic stimulus agent can be selected the former class material of T cell mitogen for use; Described antigen protein can be selected the mixed polypeptide analog of specific antigen target protein polypeptide, filtrate protein matter or specific antigen for use.
This utility model is made up of 3 blood taking tubes, and 3 blood taking tubes can (putting order arbitrarily) packaging together, also can pack respectively.Wherein a blood taking tube is as negative control, and another blood taking tube is as positive control, and the 3rd blood taking tube is as specimen.
Claims (4)
1. combination blood sample blood taking tube that is used for the IFN-release test, it is characterized in that: described combination blood sample blood taking tube for the IFN-release test, comprise negative control pipe, positive control pipe and test specimens QC, negative control pipe, positive control pipe and test specimens QC are formed by former pipe and plug, plug connects airtight on the mouth of pipe of former pipe, the negative control pipe is built-in with anticoagulant, the positive control pipe is built-in with anticoagulant and antigenic stimulus agent, and the test specimens QC is built-in with anticoagulant and antigen protein class material.
2. the combination blood sample blood taking tube for the IFN-release test according to claim 1 is characterized in that: described former pipe plastic or glass material making; Plug is made of butyl rubber.
3. the combination blood sample blood taking tube for the IFN-release test according to claim 1, it is characterized in that: the outside of described plug is provided with protective cap.
4. the combination blood sample blood taking tube for the IFN-release test according to claim 1, it is characterized in that: described anticoagulant, antigenic stimulus agent and antigen protein class material, can be used as solution and directly add in the former pipe, also can be sprayed on the tube wall of former pipe, or the combination of the two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220533572 CN203169185U (en) | 2012-10-18 | 2012-10-18 | Combination blood sample collection tube for Gamma interferon release test |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220533572 CN203169185U (en) | 2012-10-18 | 2012-10-18 | Combination blood sample collection tube for Gamma interferon release test |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203169185U true CN203169185U (en) | 2013-09-04 |
Family
ID=49065945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220533572 Expired - Lifetime CN203169185U (en) | 2012-10-18 | 2012-10-18 | Combination blood sample collection tube for Gamma interferon release test |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203169185U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109813884A (en) * | 2019-03-25 | 2019-05-28 | 中国动物卫生与流行病学中心 | A kind of perlsucht gamma interferon quickly detects product |
-
2012
- 2012-10-18 CN CN 201220533572 patent/CN203169185U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109813884A (en) * | 2019-03-25 | 2019-05-28 | 中国动物卫生与流行病学中心 | A kind of perlsucht gamma interferon quickly detects product |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130904 |
|
| CX01 | Expiry of patent term | ||
| DD01 | Delivery of document by public notice |
Addressee: Fu Shiming Document name: Notice of Expiration and Termination of Patent Right |
|
| DD01 | Delivery of document by public notice |