CN203120680U - Unloading weightlessness simulation device for hind legs of laboratory mice - Google Patents
Unloading weightlessness simulation device for hind legs of laboratory mice Download PDFInfo
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- CN203120680U CN203120680U CN 201320107972 CN201320107972U CN203120680U CN 203120680 U CN203120680 U CN 203120680U CN 201320107972 CN201320107972 CN 201320107972 CN 201320107972 U CN201320107972 U CN 201320107972U CN 203120680 U CN203120680 U CN 203120680U
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- 238000004088 simulation Methods 0.000 title claims abstract description 17
- 241000699670 Mus sp. Species 0.000 title abstract 4
- 239000000725 suspension Substances 0.000 claims abstract description 18
- 239000003651 drinking water Substances 0.000 claims description 31
- 235000020188 drinking water Nutrition 0.000 claims description 31
- 210000003141 lower extremity Anatomy 0.000 claims description 10
- 230000005484 gravity Effects 0.000 claims description 9
- 230000002146 bilateral effect Effects 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 230000000302 ischemic effect Effects 0.000 abstract description 3
- 230000017074 necrotic cell death Effects 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000012856 packing Methods 0.000 abstract 2
- 230000035622 drinking Effects 0.000 abstract 1
- 238000003032 molecular docking Methods 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005486 microgravity Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Abstract
An unloading weightlessness simulation device for hind legs of laboratory mice comprises a suspension cage and a suspension component. The suspension cage comprises a cage frame. A cage cover buckled with the cage frame is arranged on an upper frame opening of the cage frame. A packing tray is arranged on a lower frame opening of the cage frame, and a cage bottom plate and a feed box are arranged on the packing tray. Transparent side plates are arranged on front, the back, the left and the right frame openings of the cage frame. First and second upper slides are symmetrically arranged on two upper sides inside the cage frame, and first and second middle slides are symmetrically arranged on two middle sides inside the cage frame. A drinking bottle is arranged on the right transparent side plate. Round nuts are respectively connected to two ends of a suspension bar, a connecting shackle and a suspension clamp are respectively arranged at two ends of a suspension chain penetrating through a lower loop of a suspension loop, and the upper loop of the suspension loop is sleeved to the suspension bar. The suspension bar can be correspondingly assembled with the upper slide or the middle slide. By the arrangement, the problems that suspension failure and ischemic necrosis or even docking of tails of the laboratory mice caused by difficulty in control of suspension angles when a simulation weightlessness device is shared by the mice of different species and body lengths are solved, and the unloading weightlessness simulation device is suitable for medium and long-term weightlessness simulation researches.
Description
Technical field
The utility model belongs to medical experiment and uses the equipment field, and particularly the experimental rat hind leg removes the load simulation zero gravity facility, is applicable to physiology, the pharmacological experiment study of aerospace medicine field experimental rat ground simulation microgravity.
Background technology
In the space travel process, the spacefarer is subjected to various physical factors and Effect of Environmental, and for example weightless, overweight, vibration, noise, radiation, circadian rhythm change, pernicious gas etc. in narrow and small living environment and the cabin.These factors all can produce adverse influence to human body, can cause a series of pathology of human body, psychology, physiological change.Wherein weightlessness acts on human body for a long time, constantly, to having the greatest impact of human body.Therefore ground simulation weightlessness is the key that guarantees that the spacefarer is healthy and increase work efficiency to organism physiology effect and the research that prevents and treats the weightlessness reaction.
The weightless internationally recognized rat of ground simulation and mouse model are that afterbody suspention hind leg removes load model.Used drinking-water bottleneck is curved bottleneck in the device of existing this model of making, needs to make separately, and drinking-water bottle general in the laboratory can not be utilized effectively, and has caused waste.When suspention experimental mouse afterbody, how to keep suspending in midair angle by the different parts of regulating the suspention afterbody, during different height experimental mouse afterbodys suspention, the suspention angle is wayward, or often causes suspention failure, afterbody ischemic necrosis to fester serious even phenomenon such as come off.Suspend cage body top uncovered in midair or for slideway cage lid, easily cause escaping of laboratory animal.
The utility model content
The purpose of this utility model provides the experimental rat hind leg and removes the load simulation zero gravity facility, and this zero gravity facility is provided with the slideway of differing heights and the suspention chain of adjustable length, for the experimental rat that suspends different genera and height in midair provides better choice.
The technical scheme that adopts is:
The experimental rat hind leg removes the load simulation zero gravity facility, comprises suspention cage body and suspention assembly.
Its technical essential is:
Suspention cage body comprises cage body frame, and cage body frame is rectangular shape.
Cage body frame upper ledge mouth is hinged with cage lid by hinge, passes through the corresponding assembling of hasp between a cage lid side relative with hinge and the cage body frame upper ledge mouth.
Cage body frame lower frame mouth is equiped with the bedding and padding pallet.
There is the cage base plate bedding and padding pallet top.Be set with feed box on the cage base plate.
The preceding frame mouth of cage body frame, after-frame mouth, left frame mouth and right frame mouth fixedly have transparent lateral plate respectively.
Cage body frame internal upper part bilateral symmetry is provided with first sliding way and second sliding way.
The middle part bilateral symmetry is provided with first middle slideway and second middle slideway in the cage body frame.
Offer drinking-water bottle hole at transparent lateral plate, fixedly there is drinking-water bottle gripper shoe in the transparent lateral plate outside below drinking-water bottle hole, and drinking-water bottle gripper shoe is provided with the drinking-water bottle, and the drinking-water bottleneck is positioned at suspention cage body, and it is external that the drinking-water bottle is positioned at the suspention cage.
The suspention assembly comprises suspending rod, suspention chain and suspension ring.The two ends of suspending rod are connected with round nut respectively.
Suspention chain one end has cuff link, and the suspention chain other end has the suspention folder.
Suspension ring comprises that two mutual sheathed going up encircle and encircle down.The suspention chain passes down ring, and upper ring cap is located on the suspending rod.
Suspending rod and the corresponding assembling of described two sliding ways, perhaps suspending rod and the corresponding assembling of described two middle slideway.
Described transparent lateral plate is poly (methyl methacrylate) plate.Drinking-water bottle gripper shoe becomes miter angle with ground.The drinking-water bottle is straight mouthful of drinking-water bottle.
Its advantage is:
This device is provided with, in two pairs of slideways, the hind leg that not only can be used for rat remove the load simulation weightless test, also can be used for this type of experiment of mouse.Suspention chain one end of this device has cuff link, regulate the length of suspention chain when being convenient to suspend experimental mouse in midair, when having solved different height experimental mouse afterbodys suspention hind legs and going to load, body and ground angle are wayward, or be prone to suspention failure, the afterbody ischemic necrosis problem serious even that come off of festering, be suitable for medium-term and long-term simulated weightlessness research.There is hasp to fix between this device cage lid and the cage body frame upper ledge mouth, guaranteed that the suspention mouse can not escape.This device adopts whole transparent design, is conducive to the researcher to the direct observation of animal subject.
Description of drawings
Fig. 1 is the structural representation of an embodiment of the present utility model.
Fig. 2 is the structural representation of another embodiment of the present utility model.
Fig. 3 is the structural representation of suspention assembly.
Embodiment
The experimental rat hind leg removes the load simulation zero gravity facility, comprises suspention cage body and suspention assembly.
Suspention cage body comprises cage body frame 1, and cage body frame 1 is rectangular shape.
The cage body frame 1 of bedding and padding pallet 4 tops is provided with cage base plate 5.Be set with feed box 6 on the cage base plate 5, cage base plate 5 is for having the base plate of equidistant from distance bonding jumper.
The preceding frame mouth of cage body frame 1, after-frame mouth, left frame mouth and right frame mouth fixedly have transparent lateral plate by screw respectively, and the feather edge of described transparent lateral plate is mutually concordant with cage base plate 5.
Described transparent panel is followed successively by front side board, back side panel, left plate and right plate.
Front side board upper left-hand and back side panel upper left-hand are set with first sliding way 7 by screw between the symmetrical position.
Front side board upper right and back side panel upper right are set with second sliding way 8 by screw between the symmetrical position.First sliding way 7 and second sliding way 8 are symmetrical.
Front side board middle part left side and left side, back side panel middle part are set with first middle slideway 9 by screw between the symmetrical position.
Right side, front side board middle part and right side, back side panel middle part are set with second middle slideway 10 by screw between the symmetrical position.First middle slideway 9 and second middle slideway 10 are symmetrical.Two sliding ways are positioned at two middle slideway tops.
Offer drinking-water bottle hole 11 at left plate, fixedly there is drinking-water bottle gripper shoe 12 in the left plate outside below drinking-water bottle hole 11, and drinking-water bottle gripper shoe 12 is provided with drinking-water bottle 13, the straight mouthful of drinking-water bottle that this drinking-water bottle 13 uses for the laboratory, this is known technology, so repeated description not.The drinking-water bottleneck is positioned at suspention cage body, and it is external that the drinking-water bottle is positioned at the suspention cage.
The suspention assembly comprises suspending rod 14, suspention chain 15 and suspension ring 19.The two ends of suspending rod 14 are connected with round nut 16 respectively.
Suspending rod 14 and the corresponding assembling of described two sliding ways, two round nuts 16 are installed in described two sliding ways.
Described cage lid 2 is the lateral metal bar square.Drinking-water bottle gripper shoe 12 becomes miter angle with ground.
Described transparent lateral plate is poly (methyl methacrylate) plate.What use in the present embodiment is rat.
Each strain rat is individual than mouse to be big.General adult rat body length is not less than 18 ~ 20 centimetres.The male rat body weight can reach 300～400g during 10 ages in week, and female rats reaches 180～270g.
The small white mouse morphological feature is basic identical, and is slightly variant.Be example with the Kunming mouse, (during 12 ages in week) on the 90th Kunming kind small white mouse, long 9～11.0 centimetres of body, body weight 35～55g.
Claims (3)
1. the experimental rat hind leg removes the load simulation zero gravity facility, comprises suspention cage body and suspention assembly; It is characterized in that:
Suspention cage body comprises cage body frame (1), and cage body frame (1) is rectangular shape;
Cage body frame (1) upper ledge mouth is hinged with cage lid (2) by hinge, passes through the corresponding assembling of hasp (3) between cage lid (2) side relative with hinge and cage body frame (1) the upper ledge mouth;
Cage body frame (1) lower frame mouth is equiped with bedding and padding pallet (4);
There is cage base plate (5) bedding and padding pallet (4) top; Be set with feed box (6) on the cage base plate (5);
The preceding frame mouth of cage body frame (1), after-frame mouth, left frame mouth and right frame mouth fixedly have transparent lateral plate respectively;
Cage body frame (1) internal upper part bilateral symmetry is provided with first sliding way (7) and second sliding way (8);
The middle part bilateral symmetry is provided with first middle slideway (9) and second middle slideway (10) in the cage body frame (1);
Offer drinking-water bottle hole (11) at transparent lateral plate, in the transparent lateral plate outside of below, drinking-water bottle hole (11) drinking-water bottle gripper shoe (12) is arranged fixedly, drinking-water bottle gripper shoe (12) is provided with drinking-water bottle (13), and the drinking-water bottleneck is positioned at suspention cage body, and it is external that the drinking-water bottle is positioned at the suspention cage;
The suspention assembly comprises suspending rod (14), suspention chain (15) and suspension ring (19); The two ends of suspending rod (14) are connected with round nut (16) respectively;
Suspention chain (15) one ends have cuff link (17), and suspention chain (15) other end has suspention folder (18);
Suspension ring (19) comprises that two mutual sheathed going up encircle and encircle down; Suspention chain (15) passes down ring, and upper ring cap is located on the suspending rod (14);
Suspending rod (14) and the corresponding assembling of described two sliding ways, perhaps suspending rod (14) and the corresponding assembling of described two middle slideway.
2. experimental rat hind leg according to claim 1 removes the load simulation zero gravity facility, it is characterized in that: described transparent lateral plate is poly (methyl methacrylate) plate.
3. experimental rat hind leg according to claim 1 and 2 removes the load simulation zero gravity facility, it is characterized in that: drinking-water bottle gripper shoe (12) becomes miter angle with ground.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320107972 CN203120680U (en) | 2013-03-11 | 2013-03-11 | Unloading weightlessness simulation device for hind legs of laboratory mice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320107972 CN203120680U (en) | 2013-03-11 | 2013-03-11 | Unloading weightlessness simulation device for hind legs of laboratory mice |
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| Publication Number | Publication Date |
|---|---|
| CN203120680U true CN203120680U (en) | 2013-08-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201320107972 Expired - Fee Related CN203120680U (en) | 2013-03-11 | 2013-03-11 | Unloading weightlessness simulation device for hind legs of laboratory mice |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103999794A (en) * | 2014-05-28 | 2014-08-27 | 中国航天员科研训练中心 | Rat simulation weightless treadmill training method and rat simulation weightless treadmill |
| CN107897016A (en) * | 2017-12-20 | 2018-04-13 | 黑龙 | The device of reptile model is raised under a kind of erectility |
| CN110345901A (en) * | 2019-06-28 | 2019-10-18 | 西安医学院 | A kind of suspention angle measurement and control system of tail suspended rats |
| CN110352860A (en) * | 2019-07-29 | 2019-10-22 | 广东省第二中医院（广东省中医药工程技术研究院） | A kind of tail like chain mouse cage |
| CN112400718A (en) * | 2020-11-05 | 2021-02-26 | 天津大学 | Screw-nut type buckle structure and method for simulating weightless rat tail suspension |
-
2013
- 2013-03-11 CN CN 201320107972 patent/CN203120680U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103999794A (en) * | 2014-05-28 | 2014-08-27 | 中国航天员科研训练中心 | Rat simulation weightless treadmill training method and rat simulation weightless treadmill |
| CN103999794B (en) * | 2014-05-28 | 2016-08-24 | 中国航天员科研训练中心 | A kind of rat simulated weightlessness treadmill exercise method and rat simulated weightlessness treadmill |
| CN107897016A (en) * | 2017-12-20 | 2018-04-13 | 黑龙 | The device of reptile model is raised under a kind of erectility |
| CN107897016B (en) * | 2017-12-20 | 2023-05-19 | 黑龙 | Device for feeding reptiles in upright state |
| CN110345901A (en) * | 2019-06-28 | 2019-10-18 | 西安医学院 | A kind of suspention angle measurement and control system of tail suspended rats |
| CN110352860A (en) * | 2019-07-29 | 2019-10-22 | 广东省第二中医院（广东省中医药工程技术研究院） | A kind of tail like chain mouse cage |
| CN112400718A (en) * | 2020-11-05 | 2021-02-26 | 天津大学 | Screw-nut type buckle structure and method for simulating weightless rat tail suspension |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130814 Termination date: 20150311 |
|
| EXPY | Termination of patent right or utility model |