CN203055856U - Array ion trap mass spectrum system - Google Patents
Array ion trap mass spectrum system Download PDFInfo
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- CN203055856U CN203055856U CN 201320010206 CN201320010206U CN203055856U CN 203055856 U CN203055856 U CN 203055856U CN 201320010206 CN201320010206 CN 201320010206 CN 201320010206 U CN201320010206 U CN 201320010206U CN 203055856 U CN203055856 U CN 203055856U
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Abstract
The utility model belongs to the technical field of an analyzing device, and particularly to an array ion trap mass spectrum system. The array ion trap mass spectrum system provided by the utility model comprises the following components: an array ion source, an array ion guiding system, an array ion trap mass analyzer, an ion detector, a vacuum chamber and a vacuum pump. The ions which are generated by the array ion source enter the array ion guiding system in the vacuum chamber through an ion sample entering interface equipped on the vacuum chamber, and successively enter the array ion trap mass analyzer and the ion detector. The vacuum chamber is provided with an outlet which is connected with the vacuum pump. The array ion trap mass spectrum system can realize high-flux mass spectrometry of a plurality of kinds of samples.
Description
Technical field
The utility model belongs to technical field of analytical instruments, is specifically related to a kind of array ion trap mass spectrometry system that can carry out the synchronous analysis of several samples.
Background technology
Mass spectral analysis is the analytical method of a kind of measurement ion charge-mass ratio (charge-to-mass ratio), its basic principle is to make each component in the testing sample that ionization take place in ion source, generate the charged ion of different charge-mass ratios, effect through accelerating field or ion guides, form ion beam, enter mass analyzer.In mass analyzer, utilize electric field or magnetic field to finish the quality analysis process, obtain mass spectrogram, thereby determine its quality.
Mass spectral analysis is a kind of method that is widely used in the modern analysis method at present.The employed mass spectrometer of mass spectral analysis is a kind of for the various chemical compositions of amalyzing substances sample, the scientific instrument of content and molecular structure, it has very high sensitivity and the specificity on analyte is identified, therefore is widely used in every field such as scientific research, medical hygiene, environmental science, food security, biomedicine.Mass spectrometric structure has generally comprised vacuum system, sampling device and separator, ion source, ion-optic system, mass spectral analysis assembly, ion detection and data handling system.Mass spectrometer at present commonly used comprises a variety of, according to the difference of the mass analyzer that adopts, mainly contains magnetic mass spectrometer, quadrupole mass spectrometer, ion trap mass spectrometer, ion cyclotron resonance mass spectrometer (ICR), time-of-flight mass spectrometer, track trap mass spectrometer.In these instruments, ion strap mass analyzer has its special advantages: volume is little, simple in structure, work under can be the more higher air pressure and analyzer is finished the ability of collision induced dissociation and tandem mass spectrometry.In the evolution of the mass spectral analysis in modern times and mass spectrometer, the miniaturization of mass spectrometer and high-throughout mass spectrometric analysis method all have been subjected to research widely.Ion trap mass spectrometer the earliest is called as the three-dimensional trap of Paul, be the 1950's people such as Paul invent in Univ Bonn Germany.This device is made up of 3 electrodes, comprises 2 endcap electrodes and 1 ring electrode, and the working face of electrode all is hyperboloid.The constraint mode of this three-dimensional ion trap is the effect of the rf electric field on the three-dimensional, make ion be bound in the ion cluster that becomes about 1mm in the trap, these interionic interactions can cause very big space charge effect to exist, this shortcoming of thereupon bringing is that the ion storage amount is little, storage efficiency is low, and space charge effect also can cause the decline of mass resolution; And 3 electrodes of three-dimensional trap all are hyperboloids, all have difficulty on machining and assembly precision, so also there is difficulty in miniaturization.The R. Graham Cooks working group of the Purdue University of the U.S. has proposed a kind of new three-dimensional trap and has been called cylinder trap (Cylindrical Ion Trap) subsequently, has used cylinder to replace the hyperbolic ring electrode, and the hyperbolic endcap electrode is also replaced by plate electrode.Ion storage amount and the storage efficiency of this cylinder trap are improved, and the research of the miniaturization of cylinder trap and high throughput analysis has all obtained good development subsequently, but the problem that still has the space charge effect of three-dimensional trap, ion storage amount and storage efficiency improve limited.Linear ion hydrazine has also obtained good development and research subsequently, linear ion hydrazine is a kind of two-dimensional ion trap, apply radio-frequency voltage on the radial electrode of trap, realize two dimension radio frequency constraint radially, apply direct voltage on axially, form direct current constraint potential well, the mode of this axial linear constraint, make ion point arrangement from the center in trap become axial line arrangement, improved ion storage amount and storage efficiency significantly, reduced space charge effect greatly.In the time of 2004, R. Graham Cooks working group has proposed a kind of two-dimensional linear ion trap rectilinear ion trap (Rectilinear Ion Trap) again, this trap is to be surrounded by 6 rectangular flat electrodes, simple in structure, easy to process, be fit to very much miniaturization and high throughput analysis, very fast rectilinear ion trap just is applied to the mass spectrometric research of miniaturization, make portable mass spectrometer Mini10 and Mini11, and successful Application is in the mass spectral analysis of multichannel array rectilinear ion trap high flux.
Summary of the invention
The purpose of this utility model is to propose a kind of high flux mass spectrometry system, and it can realize that a cover mass spectrometry system realizes that several samples analyzes synchronously, improves the efficient of mass spectral analysis greatly with this.
A kind of array ion trap mass spectrometry system that the utility model provides comprises array ion source, array ion guides system, array ion strap mass analyzer, ion detector, vacuum chamber and vacuum pump;
The ion that described array ion source produces enters array ion guides system in the vacuum chamber by the ion sample introduction interface that arranges on the vacuum chamber, enter array ion strap mass analyzer and ion detector more successively, on the described vacuum chamber outlet is set, its exit is connected with vacuum pump;
Described array ion source is made up of the ion source of a plurality of identical or different kinds; There are a plurality of ion guides passages in described array ion guides system, and the form of ion guides can be the array guide bar, also can be ion lens, also can be two kinds complex form or the form of multistage guide bar; Described array ion strap mass analyzer is to be made up of a plurality of parallel quality analysis passages, its side arranges two endcap electrodes, a plurality of sample holes are set above the described endcap electrode, the number of described quality analysis passage is identical with the number of described sample holes, two electrodes up and down are set respectively on each quality analysis passage, an ion lead-out groove is set, the two ends that are positioned at the quality analysis passage of the mass of ion analyzer both sides ground electrode that also respectively be arranged in parallel on each electrode.
The high flux mass spectrometry system that proposes in the utility model has adopted the array ion source, is used for producing the ion signal of the several samples for the treatment of quality analysis; Array ion guides system focuses on and guides the ion signal that ion source produces; Focus on signal ion afterwards through guiding and enter in the array ion trap, eject in trap by the ion trap storage and after further finishing quality analysis, received and detect by ion detector.A whole set of high flux mass spectrometry system needs vacuum cavity to settle as carrier, and need provide the vacuum pump of keeping vacuum condition for vacuum cavity.
Ionogenic quantity in the array ion source described in the utility model can be two, also can be three, also can be four, even can be more; The ion guides number of channels of array ion guides system can be two, also can be three, also can be four, even can be more; The number of channels of same array ion trap also can be two, three, four, even can be more.
Array ion source described in the utility model is not subjected to the influence of ion source kind, can be various types of ion sources, as the electron spray ionisation source, the electron impact ionization source, chemical ionization source, matrix desorption ionization source etc. also can use the different kinds of ions source as required simultaneously.
Array ion guides system described in the utility model can be the form of guide bar array, also can be ion lens, or both complex forms, the perhaps form of multistage guide bar.In the guide bar array, be not subjected to the restriction of the shape of guide bar, can be hyperboloid bar, cylindrical bar, square bar or other shapes as long as can guarantee to finish the guiding of ion, are not subjected to the restriction of size length and material category yet.
In the utility model, described vacuum chamber is different shapes such as cube, cylinder.
In the utility model, the sample holes on the endcap electrode of described array mass of ion analyzer is circular, and the electrode of described array ion trap is not subjected to the restriction of shape, size and manufactured materials kind, as long as can guarantee quality storage and the quality analysis of ion; The upper/lower electrode of described quality analysis passage setting is plate electrode, hyperboloid electrode or face of cylinder electrode etc.Manufactured materials can be various conducting metals, semiconductor, but and the material of surface metal-coated membrane such as printed substrate, pottery, macromolecular material.
The beneficial effects of the utility model are: can realize that a cover mass spectrometry system realizes that several samples analyzes synchronously, thereby improve the efficient of mass spectral analysis greatly.
Description of drawings
Fig. 1 is the structural representation of array ion trap mass spectrometry of the present utility model system.
Fig. 2 is the three-dimensional structure schematic diagram of the cylindrical electrode array ion guides system in the utility model.
Fig. 3 is the three-dimensional structure schematic diagram of the hyperboloid electrod-array ion guides system in the utility model.
Fig. 4 is the three-dimensional structure schematic diagram of the square-shaped electrode array ion guides system in the utility model.
Fig. 5 is the three-dimensional structure schematic diagram of array ion strap mass analyzer in the utility model.
The single electrode that Fig. 6 independently processes for the array ion strap mass analyzer in the utility model and the entire electrode structural representation that is assembled.
Fig. 7 is the electrode structure schematic diagram of whole processing in the array ion strap mass analyzer in the utility model.
Fig. 8 is the schematic cross-section of array ion strap mass analyzer avaivable electrode in the array ion trap mass spectrometry of the present utility model system.
Fig. 9 is the direct voltage distribution schematic diagram of array ion strap mass analyzer of the present utility model.
Figure 10 is the radio-frequency voltage distribution schematic diagram of array ion strap mass analyzer of the present utility model.
Figure 11 analyzes different sample mass spectrograms for two passages by array ion trap mass spectrometry system experimentation gained, and wherein a figure is leucine, glutamine and histidine biased sample, and b figure is valine, asparagine and methionine biased sample.
Number in the figure: 101-array ion source; 102-ion sample introduction interface; 103-array ion guides system; 104-array ion strap mass analyzer; The 105-ion detector; The 106-vacuum chamber; The 107-vacuum pump; 201,202,203,204,205,206,207,208,209,210-round bar; The 301-sample holes; 302-quality analysis passage; 303-ion lead-out groove; 304,305-termination electrode; The 306-ground electrode.
Embodiment
Below in conjunction with drawings and Examples the utility model is further specified.
Fig. 1 represents is the schematic diagram of a whole set of array ion trap mass spectrometry system.It comprises array ion source 101, array ion guides system 103, array ion strap mass analyzer 104, ion detector 105, vacuum chamber 106 and vacuum pump 107.In the utility model, produce the sample ions that needs analysis through array ion source 101, enter into array ion guides system 103 through ion sample introduction interface 102, these ions are under the constraint and guide function of array ion guides system 103, become motion and enter into array ion strap mass analyzer 104 than the ion beam of rule, ion storage and quality analysis through array ion strap mass analyzer 104 are ejected from the ion lead-out groove afterwards, are detected by ion detector 105 and obtain signal.
Figure 2 shows that cylindrical electrode array ion guides system configuration schematic diagram, also is 103 among Fig. 1.In this system, comprise a plurality of bars compositions, be illustrated as round bar wherein four round bars 201,205,206,210 on next door belong to two passages on next door, and other all round bars 202,203,204,207,208,209 are all shared by two adjacent passages.As shown in Figure 2, wherein the round bar 201,203,205,207,209 of odd positions connects together and draws connection radiofrequency signal Φ
1(t) 211, the round bar 202,204,206,208,210 of even number position connects together to draw and connects radiofrequency signal Φ
2(t) 212, Φ
1(t) and Φ
2(t) polarity is opposite, is shown below:
Φ
1(t)=+(U+Vcosωt)
Φ
2(t)=-(U+Vcosωt)
In the formula, U represents direct voltage, and V represents alternating voltage, and ω=2 π f represent the angular frequency of radio-frequency power supply, and f is the frequency of radio-frequency power supply.
Figure 3 shows that hyperboloid electrod-array ion guides system configuration schematic diagram.Fig. 4 is square-shaped electrode array ion guides system configuration schematic diagram.
Figure 5 shows that array ion strap mass analyzer structural representation, also is 104 among Fig. 1.Include a plurality of in order to ion storage and quality analysis passage in this mass analyzer.
Array ion strap mass analyzer 104 is rectangle, and its side arranges two endcap electrodes 304,305, and as the ion gate of ion sample introduction, structure is identical, is used for applying the direct current potential well that direct voltage forms the constraint ion.Array ion strap mass analyzer 104 the insides arrange a plurality of parallel quality analysis passages 302, quality analysis passage 302, and structure is identical and have a plurality ofly, mainly is responsible for ion storage and quality analysis; A plurality of circular sample holes 301 are set above the endcap electrode 304, two electrodes up and down are set respectively on each quality analysis passage 302, each electrode next door arranges an ion lead-out groove 303, with to eject trap outer and received by electronic detectors so that finish the ion of quality analysis, the two ends that are positioned at the quality analysis passage 302 of the array ion strap mass analyzer 104 both sides ground electrode 306 that also respectively be arranged in parallel.
Fig. 6, Figure 7 shows that the structural representation of the electrode part of array ion strap mass analyzer.Wherein, the overall electrode figure that Fig. 6 is assembled for independent machined electrode and the schematic diagram of single electrode are that 6 single electrodes are combined into an overall electrode shown in the figure, and single electrode need pass through the surface treatment plated film, form conductive layer in order to apply voltage.Identical and the conducting of conductive layer surfaces externally and internally coating, a plurality of electrodes form overall electrode through assembling.The electrode structure of the as a whole processing of Fig. 7, the as a whole structure of entire electrode, the surface treatment plated film forms the zone that works alone of not conducting mutually, adventitia mutual conduction in each zone.
Figure 8 shows that the schematic cross-section of the electrode part of the array ion strap mass analyzer that other are available.The electrode of this array ion strap mass analyzer can be different shape, and what provide among the figure is the hyperboloid electrode structure.
Fig. 9, Figure 10 shows that the voltage distribution schematic diagram that applies on the array ion strap mass analyzer.Wherein, Fig. 9 is the direct voltage distribution schematic diagram, two endcap electrodes 304,305 in the array ion trap apply higher DC potential, add lower DC potential at two electrodes up and down, like this can be in the direct current constraint of the potential difference that axially forms a direct current in order to ion in for trap, just axial DC potential well.Figure 10 is radio-frequency voltage (RF) distribution schematic diagram, is applied with all identical radio-frequency voltages of big or small polarity for two electrodes up and down of each passage, and what apply at the electrode of two adjacent passages then is that size is identical, opposite polarity radio-frequency voltage.An AC field voltage (AC) is applied on the trap electrode by the mode with the coupling of radio-frequency voltage (RF) signal simultaneously.Two semaphore request sizes of radio-frequency voltage (RF) and AC field voltage (AC) signal output are identical, and polarity is opposite, and the applying and do not require the appointment electrode of its positive negative sense is as long as satisfy above-mentioned condition.
Figure 11 analyzes different sample mass spectrograms for two passages that use the array ion trap mass spectrometry system experimentation gained that the utility model proposes.Two groups of samples wherein are respectively leucine, glutamine and histidine biased sample and valine, asparagine and methionine biased sample.Sample solution uses methyl alcohol: the solvent of the volume ratio=50:50 of water is prepared, and has added the acetic acid of mass percent concentration 0.05%, and sample concentration is every kind of material 2 ╳ 10
-5M.What use in the experiment is the RF power supply that the Sciex formula is produced, and model 009701, frequency are 768KHz.What use is the array ESI source of 2 passages, produces leucine, glutamine and histidine biased sample signal and valine, asparagine and methionine biased sample respectively; The array guidance system is 4 channel designs, the long 200mm of bar; The array ion strap mass analyzer is 6 channel designs, and the quality analysis passage that uses is third and fourth passage as two passages of centre.A figure is leucine, glutamine and histidine biased sample signal mass spectrogram, and b figure is valine, asparagine and methionine biased sample signal mass spectrogram.
Claims (6)
1. an array ion trap mass spectrometry system is characterized in that: comprise array ion source, array ion guides system, array ion strap mass analyzer, ion detector, vacuum chamber and vacuum pump; The ion that described array ion source produces enters array ion guides system in the vacuum chamber by the ion sample introduction interface that arranges on the vacuum chamber, enter array ion strap mass analyzer and ion detector more successively, on the described vacuum chamber outlet is set, its exit is connected with vacuum pump;
There are a plurality of ion guides passages in described array ion guides system, and the form of ion guides is array guide bar, ion lens or two kinds complex form or the form of multistage guide bar; Described array ion strap mass analyzer is made up of a plurality of parallel quality analysis passages, its side arranges two endcap electrodes, a plurality of sample holes are set above the described endcap electrode, the number of described quality analysis passage is identical with the number of described sample holes, two electrodes up and down are set respectively on the described quality analysis passage, an ion lead-out groove is set, the two ends that are positioned at the quality analysis passage of the described array ion strap mass analyzer both sides ground electrode that also respectively be arranged in parallel on each electrode.
2. array ion trap mass spectrometry according to claim 1 system, it is characterized in that: described array ion source is selected from the electron spray ionisation source, electron impact ionization source, chemical ionization source, one or more in the matrix desorption ionization source; Ion source number in the described array ion source is two or more.
3. array ion trap mass spectrometry according to claim 1 system, it is characterized in that: described vacuum chamber is cube or cylinder.
4. array ion trap mass spectrometry according to claim 1 system, it is characterized in that: described ion guides passage is more than two.
5. array ion trap mass spectrometry according to claim 1 system, it is characterized in that: the sample holes on the described endcap electrode is for circular.
6. array ion trap mass spectrometry according to claim 1 system, it is characterized in that: described quality analysis passage is more than two; The upper/lower electrode of described quality analysis passage setting is plate electrode, hyperboloid electrode or face of cylinder electrode.
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| CN 201320010206 CN203055856U (en) | 2013-01-09 | 2013-01-09 | Array ion trap mass spectrum system |
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| CN 201320010206 CN203055856U (en) | 2013-01-09 | 2013-01-09 | Array ion trap mass spectrum system |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103811268A (en) * | 2014-02-27 | 2014-05-21 | 中国科学院大连化学物理研究所 | Multichannel triple quadrupole mass spectrum array system |
| CN103824750A (en) * | 2014-02-17 | 2014-05-28 | 同济大学 | Array triple-quadrupole mass spectrum system |
| CN104792856A (en) * | 2015-04-21 | 2015-07-22 | 苏州大学 | Ion sample introduction method and multi-channel array ion trap mass spectrum system |
| WO2016177164A1 (en) * | 2015-05-05 | 2016-11-10 | 中国计量科学研究院 | Networked mass analysis method and device |
| CN110706998A (en) * | 2018-07-24 | 2020-01-17 | 宁波海歌电器有限公司 | Double-ion-source double-channel mass spectrometer |
| CN111684274A (en) * | 2018-02-09 | 2020-09-18 | 浜松光子学株式会社 | Sample support, ionization method, and mass analysis method |
| CN114171368A (en) * | 2022-02-10 | 2022-03-11 | 国开启科量子技术(北京)有限公司 | Ion trap driving system and control method thereof |
-
2013
- 2013-01-09 CN CN 201320010206 patent/CN203055856U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103824750A (en) * | 2014-02-17 | 2014-05-28 | 同济大学 | Array triple-quadrupole mass spectrum system |
| CN103811268A (en) * | 2014-02-27 | 2014-05-21 | 中国科学院大连化学物理研究所 | Multichannel triple quadrupole mass spectrum array system |
| CN104792856A (en) * | 2015-04-21 | 2015-07-22 | 苏州大学 | Ion sample introduction method and multi-channel array ion trap mass spectrum system |
| WO2016177164A1 (en) * | 2015-05-05 | 2016-11-10 | 中国计量科学研究院 | Networked mass analysis method and device |
| CN111684274A (en) * | 2018-02-09 | 2020-09-18 | 浜松光子学株式会社 | Sample support, ionization method, and mass analysis method |
| CN111684274B (en) * | 2018-02-09 | 2023-09-05 | 浜松光子学株式会社 | Sample support, ionization method, and mass analysis method |
| CN110706998A (en) * | 2018-07-24 | 2020-01-17 | 宁波海歌电器有限公司 | Double-ion-source double-channel mass spectrometer |
| CN114171368A (en) * | 2022-02-10 | 2022-03-11 | 国开启科量子技术(北京)有限公司 | Ion trap driving system and control method thereof |
| CN114171368B (en) * | 2022-02-10 | 2022-05-10 | 国开启科量子技术(北京)有限公司 | Ion trap driving system and control method thereof |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130710 Termination date: 20160109 |