CN110706998A - Double-ion-source double-channel mass spectrometer - Google Patents
Double-ion-source double-channel mass spectrometer Download PDFInfo
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- CN110706998A CN110706998A CN201810821364.4A CN201810821364A CN110706998A CN 110706998 A CN110706998 A CN 110706998A CN 201810821364 A CN201810821364 A CN 201810821364A CN 110706998 A CN110706998 A CN 110706998A
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/107—Arrangements for using several ion sources
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Abstract
The invention discloses a dual-ion source dual-channel mass spectrometer, which comprises a bilateral ion source, a dual-channel transmission system, a dual-channel time-of-flight mass analyzer and a vacuum isolation cavity, wherein the two-channel transmission system is connected with the dual-channel transmission system; this mass spectrometer possesses the ability of acquireing the mass spectrum data of two kinds of ion sources simultaneously, and the ion parallel distribution of two passageways does not interfere with each other, need not to switch or change the ion source, has shortened the time of different grade type sample analysis, has practiced thrift the cost, and two sets of data that acquire moreover can be very convenient compare the analysis, have improved the quick accurate analytical ability of instrument.
Description
Technical Field
The invention belongs to the technical field of mass spectrometry instruments, and particularly relates to a dual-ion source dual-channel mass spectrometer.
Background
The mass spectrometer mainly comprises a sample introduction system, an ion source, a transmission system, a mass analyzer, a detector and a data processing system, and the working principle is as follows: under a certain vacuum environment, sample molecules to be detected are ionized by an ion source to form ions, the ions enter a mass analyzer through focusing transmission, and then the ions are separated according to different mass-to-charge ratios and sequentially enter an ion detector, so that the components of the sample to be detected are analyzed. For the same mass spectrometer, a reasonable ion source interface design can generally allow a plurality of ion sources to be configured for switching use, so as to satisfy the component analysis of different types of samples. In addition, there are also reports on the technology and patents in which the same instrument is provided with multiple ion sources, i.e., the compound ion source is adopted to simultaneously satisfy the analysis of different components of the same sample, thereby expanding the analysis range of the components of the sample.
Because the mass spectrum of the single ion source is difficult to meet the test requirement of a complex sample, more and more switchable ion sources and instruments of a compound ion source appear in the market; however, the conventional switchable ion source apparatus can only complete the analysis of sample components under one ion source at a time, and cannot simultaneously perform the synchronous analysis under two ion sources on a single sample through one-time sample loading.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a dual-ion-source dual-channel mass spectrometer which has the capability of simultaneously acquiring mass spectrum data of two ion sources, ions of the two channels are distributed in parallel without interference, the ion sources do not need to be switched or replaced, the time for analyzing different types of samples is shortened, the cost is saved, two sets of acquired data can be compared and analyzed very conveniently, and the capability of rapid and accurate analysis of an instrument is improved. Thus, the simultaneous parallel combination of mass spectrum, gas chromatography and liquid chromatography is possible. The same sample object only needs one sample introduction, and different forms of data such as single ion source data, two groups of ion source data, data subjected to superposition processing and the like can be selected automatically.
The invention is realized by the following technical scheme:
a dual-ion source dual-channel mass spectrometer comprises a dual-side ion source, a dual-channel transmission system, a dual-channel time-of-flight mass analyzer and a vacuum isolation cavity; the bilateral ion source comprises an atmospheric pressure ion source and a non-atmospheric pressure ion source which are arranged independently; the two-channel transmission system comprises an atmospheric pressure ion source transmission system in butt joint with an atmospheric pressure ion source and a non-atmospheric pressure ion source transmission system in butt joint with a non-atmospheric pressure ion source, and the two transmission systems are arranged side by side and are isolated from each other; the dual-channel time-of-flight mass analyzer comprises a dual-channel accelerator, a field-free flight zone, a dual-channel reflector and 2 detectors; the ion channel is for setting up side by side, the transmission system of bilateral ion source, two passageways is kept apart to the vacuum isolation cavity to reach the vacuum system of binary channels time of flight mass analyzer, be connected with the vacuum pump on the vacuum isolation cavity.
In the above technical solution, the atmospheric pressure ion source includes, but is not limited to, an electrospray ionization source, an atmospheric pressure chemical ion source, and an atmospheric pressure photoionization source.
In the above technical solution, the non-atmospheric pressure ion source includes, but is not limited to, an electron bombardment ionization source, and a chemical ionization source.
In the above technical scheme, the atmospheric pressure ion source transmission system comprises a first sample introduction capillary, a molecular ion reactor, a first radio frequency quadrupole, a first electrostatic quadrupole and a first electrostatic lens, which are connected in sequence; the molecular ion reactor, the first radio frequency quadrupole, the first electrostatic quadrupole and the first electrostatic lens are positioned on the same straight line.
In the above technical scheme, the non-atmospheric pressure ion source transmission system comprises a second sample introduction capillary, a second radio frequency quadrupole, a second electrostatic quadrupole and a second electrostatic lens which are connected in sequence, wherein the second radio frequency quadrupole, the second electrostatic quadrupole and the second electrostatic lens are connected in sequence.
In the above technical solution, the central axes of the two ion channels of the two-channel time-of-flight mass analyzer are all on the same plane.
In the above technical scheme, the electrode plates of the two-channel accelerator with two groups of ion channels distributed in parallel all adopt a double-hole parallel structure or two single-hole electrode plates distributed independently and in parallel.
In the technical scheme, the electrode plates of the two-channel reflectors with the two groups of ion channels distributed in parallel are of a double-hole parallel structure or two single-hole electrode plates independently distributed in parallel.
In the technical scheme, the field-free flight area is formed by separating two flight channels by a partition plate arranged in the middle of the two flight channels.
In the above technical scheme, the pole pieces of the detector are all of a single-hole structure and are independently distributed side by side.
The invention has the advantages and beneficial effects that:
the invention has the capability of simultaneously acquiring mass spectrum data of two ion sources, ions of two channels are distributed in parallel without mutual interference, ion sources do not need to be switched or replaced, particularly, for samples with different ionization modes, the functions of the two instruments can be completed by only one instrument, the time for analyzing different types of samples is greatly shortened, the cost is saved, and the acquired two groups of data can be compared and analyzed very conveniently, so that the capability of the instrument for quickly and accurately analyzing is improved.
Drawings
Fig. 1 is a general schematic diagram of a structure of a dual ion source dual channel mass spectrometer.
Fig. 2 is a schematic diagram of the overall structure of an atmospheric pressure ion source channel instrument.
FIG. 3 is a schematic diagram of the overall structure of a non-atmospheric pressure ion source channel apparatus.
Wherein: 1 is an atmospheric pressure ion source, 2 is a first sample introduction capillary, 3 is a molecular ion reactor, 4 is a first radio frequency quadrupole rod, 5 is a first electrostatic quadrupole rod, 6 is a first electrostatic lens, 7 is a non-atmospheric pressure ion source, 8 is a second sample introduction capillary, 9 is a second radio frequency quadrupole rod, 10 is a second electrostatic quadrupole rod, and 11 is a second electrostatic lens;
m is an atmospheric pressure ion source transmission system, N is a non-atmospheric pressure ion source transmission system, T is a time-of-flight mass analyzer, T1 is a first channel, T2 is a second channel, an A dual-channel accelerator, a B dual-channel reflector, a C field-free flight area, D1 is a first detector, D2 is a second detector, Q1 is a first vacuum cavity, Q2 is a second vacuum cavity, Q3 is a third vacuum cavity, Q4 is a fourth vacuum cavity, P1 is a first vacuum pump, P2 is a second vacuum pump, P3 is a third vacuum pump, and P4 is a fourth vacuum pump.
For a person skilled in the art, other relevant figures can be obtained from the above figures without inventive effort.
Detailed Description
In order to make the technical solution of the present invention better understood, the technical solution of the present invention is further described below with reference to specific examples.
Example 1
A dual-ion source dual-channel mass spectrometer comprises an atmospheric pressure ion source mass spectrum and a non-atmospheric pressure ion source which operate independently, and the dual-ion source dual-channel mass spectrometer consists of a bilateral ion source, a dual-channel transmission system, a dual-channel flight time mass analyzer and a vacuum isolation cavity; the bilateral ion source comprises an atmospheric pressure ion source 1 and a non-atmospheric pressure ion source 2 which are independently arranged at two sides; the two-channel transmission system comprises an atmospheric pressure ion source transmission system M and a non-atmospheric pressure ion source transmission system N, the two transmission systems are arranged in parallel, and the vacuum systems are isolated; two groups of ion channels of the dual-channel flight time mass analyzer T are distributed in parallel and comprise a dual-channel accelerator A, a field-free flight area C, a dual-channel reflector B and a dual detector D; the vacuum isolation chamber isolates the bilateral ion source, the two-channel transmission system, and the vacuum system of the two-channel time-of-flight mass analyzer. The transmission system M of the atmospheric pressure ion source comprises a first sample introduction capillary 2, a molecular ion reactor 3, a first radio frequency quadrupole 4, a first electrostatic quadrupole 5 and a first electrostatic lens 6; the non-atmospheric pressure ion source transmission system N comprises a second sample capillary 8, a second radio frequency quadrupole 9, a second electrostatic quadrupole 10, and a second electrostatic lens 11.
The central axes of the two groups of ion channels of the two-channel time-of-flight mass analyzer T are on the same plane. The electrode plates of the two-channel accelerator with two groups of ion channels distributed in parallel all adopt a double-hole parallel structure; the electrode plates of the two-channel reflectors distributed in parallel in the two groups of ion channels are all in a double-hole parallel structure.
The first sample introduction capillary 2, the molecular ion reactor 3, the first radio frequency quadrupole 4, the first electrostatic quadrupole 5 and the first electrostatic lens 6 of the transmission system M of the atmospheric pressure ion source are arranged on the same axis with the first channel T1 of the time-of-flight mass analyzer T, and the atmospheric pressure ion source 1 and the transmission system M are arranged on the same axis. A second radio frequency quadrupole 9, a second electrostatic quadrupole 10 and a second electrostatic lens 11 of the non-atmospheric pressure ion source transmission system N are all on the same axis as a second channel T2 of the non-atmospheric pressure ion source 7 and the time-of-flight mass analyzer T, and a second sample introduction capillary 8 is vertically arranged with the axis of the transmission system N; the field-free flight area C is shared by two flight channels, and the pole pieces of the double detectors are both in a single-hole structure and are respectively independently distributed in parallel.
As shown in the figure, the vacuum isolation chamber is divided into a first vacuum chamber, a second vacuum chamber, a third vacuum chamber and a fourth vacuum chamber (Q1, Q2, Q3 and Q4), and a first vacuum pump, a second vacuum pump, a third vacuum pump and a fourth vacuum pump (P1, P2, P3 and P4) are respectively adopted for vacuum pumping; vacuum is isolated between the chambers Q1 and Q2, between Q2 and Q4, and between Q3 and Q4 by adopting a vacuum differential hole structure to form differential vacuum gradient. The vacuum between the Q2 and Q3 cavities was completely isolated.
The dual-side ion source of this embodiment employs Electrospray Ionization (ESI) and Electron bombardment Ionization (EI), respectively.
Ions generated by ionization of a liquid sample through an ESI ion source 1 are introduced into a first-stage vacuum chamber Q1 through a first sample injection capillary 2, for transmission of the ions to a flying mass analyzer with higher efficiency, a micro round hole is adopted between the first-stage vacuum chamber Q1 and a second-stage vacuum chamber Q2 for vacuum difference, and a rectangular narrow slit structure is adopted between a second-stage vacuum chamber Q2 and a third-stage vacuum chamber Q3 for vacuum difference. The ions entering the first-stage vacuum chamber Q1 pass through the molecular ion reactor 3, reach the second-stage vacuum chamber Q2 through a differential hole, then sequentially pass through the radio frequency quadrupole 4, the electrostatic quadrupole 5 and the electrostatic lens 6, enter the first channel T1 of the dual accelerator a, are accelerated to enter the field-free flight zone C, are reflected by the first channel T1 of the dual reflector to pass through the field-free flight zone C again, and then reach the first detector D1 of the dual detector.
And in the mass spectrum system of the channel on the other side, a gaseous sample vertically enters the EI ion source system through the second sample injection capillary 8, then sequentially enters the second radio frequency quadrupole 9, the second electrostatic quadrupole 10 and the second electrostatic lens 11 for transmission focusing, and then enters the second channel T2 of the double accelerator. Similarly, the third stage vacuum chamber Q3 and the fourth stage vacuum chamber Q4 are vacuum differentiated by a rectangular narrow slit structure. The ions are accelerated into the field-free flight zone C, and then reflected by the second channel T2 of the dual reflector to re-traverse the field-free flight zone C before reaching the second detector D2 of the dual detector.
The first-stage vacuum chamber Q1 is evacuated by mechanical pump, and the second, third and fourth-stage vacuum chambers Q2, Q3 and Q4 are evacuated by molecular pumps P2, P3 and P4 respectively. In the method, a sample passes through two different ion sources, passes through two groups of parallel transmission systems, then sequentially enters two channels of a flight time mass analyzer respectively, and is finally detected by respective independent detectors, so that ion spectrogram information of the two samples is obtained simultaneously.
Example 2
On the basis of the embodiment 1, the atmospheric pressure ion source is replaced by an atmospheric pressure chemical ion source, an atmospheric pressure photoionization source or a matrix-assisted laser desorption ionization source; the non-atmospheric pressure ion source is replaced by a chemical ionization source by an electron bombardment ionization source.
Example 3
On the basis of the embodiment 1, the electrode plates of the two-channel accelerator with two groups of ion channels distributed in parallel are changed into two single-hole electrode plates independently distributed in parallel; the electrode plates of the two-channel reflectors with the two groups of ion channels distributed in parallel are changed into two single-hole electrode plates which are independently distributed in parallel.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings). In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
The invention has been described in an illustrative manner, and it is to be understood that any simple variations, modifications or other equivalent changes which can be made by one skilled in the art without departing from the spirit of the invention fall within the scope of the invention.
Claims (10)
1. A dual ion source dual channel mass spectrometer, characterized by: the device comprises a bilateral ion source, a double-channel transmission system, a double-channel flight time mass analyzer and a vacuum isolation cavity; the bilateral ion source comprises an atmospheric pressure ion source and a non-atmospheric pressure ion source which are arranged independently; the two-channel transmission system comprises an atmospheric pressure ion source transmission system in butt joint with an atmospheric pressure ion source and a non-atmospheric pressure ion source transmission system in butt joint with a non-atmospheric pressure ion source, and the two transmission systems are arranged side by side and are isolated from each other; the dual-channel time-of-flight mass analyzer comprises a dual-channel accelerator, a field-free flight zone, a dual-channel reflector and 2 detectors; the ion channel is for setting up side by side, the transmission system of bilateral ion source, two passageways is kept apart to the vacuum isolation cavity to reach the vacuum system of binary channels time of flight mass analyzer, be connected with the vacuum pump on the vacuum isolation cavity.
2. The dual ion source dual channel mass spectrometer of claim 1, wherein: including but not limited to electrospray ionization sources, atmospheric pressure chemical ion sources, and atmospheric pressure photoionization sources.
3. The dual ion source dual channel mass spectrometer of claim 1, wherein: the non-atmospheric pressure ion source includes but is not limited to electron bombardment ionization sources, chemical ionization sources.
4. The dual ion source dual channel mass spectrometer of claim 1, wherein: the atmospheric pressure ion source transmission system comprises a first sample introduction capillary, a molecular ion reactor, a first radio frequency quadrupole rod, a first electrostatic quadrupole rod and a first electrostatic lens which are sequentially connected; the molecular ion reactor, the first radio frequency quadrupole, the first electrostatic quadrupole and the first electrostatic lens are positioned on the same straight line.
5. The dual ion source dual channel mass spectrometer of claim 1, wherein: the non-atmospheric pressure ion source transmission system comprises a second sample introduction capillary, a second radio frequency quadrupole, a second electrostatic quadrupole and a second electrostatic lens which are sequentially connected, wherein the second radio frequency quadrupole, the second electrostatic quadrupole and the second electrostatic lens are sequentially connected.
6. The dual ion source dual channel mass spectrometer of claim 1, wherein: the central axes of the two groups of ion channels of the two-channel time-of-flight mass analyzer are on the same plane.
7. The dual ion source dual channel mass spectrometer of claim 1, wherein: the electrode plates of the two-channel accelerator with the two groups of ion channels distributed in parallel are of a double-hole parallel structure or two single-hole electrode plates independently distributed in parallel.
8. The dual ion source dual channel mass spectrometer of claim 1, wherein: the electrode plates of the two-channel reflectors with the two groups of ion channels distributed in parallel are of a double-hole parallel structure or two single-hole electrode plates independently distributed in parallel.
9. The dual ion source dual channel mass spectrometer of claim 1, wherein: the field-free flight area is formed by arranging a partition board in the middle of two flight channels to separate the two flight channels.
10. The dual ion source dual channel mass spectrometer of claim 1, wherein: the pole piece position of the detector is of a single-hole structure and is independently distributed side by side.
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| CN201810821364.4A CN110706998A (en) | 2018-07-24 | 2018-07-24 | Double-ion-source double-channel mass spectrometer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111739785A (en) * | 2020-06-30 | 2020-10-02 | 中国科学院上海应用物理研究所 | Dual ion source slow electron speed imaging device |
| CN117147673A (en) * | 2023-10-24 | 2023-12-01 | 广州源古纪科技有限公司 | Method, system and equipment for detecting breath mass spectrum |
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