CN202942109U - Two-in-one isolated perfused heart His bundle electrogram recording electrode - Google Patents
Two-in-one isolated perfused heart His bundle electrogram recording electrode Download PDFInfo
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- CN202942109U CN202942109U CN 201120571610 CN201120571610U CN202942109U CN 202942109 U CN202942109 U CN 202942109U CN 201120571610 CN201120571610 CN 201120571610 CN 201120571610 U CN201120571610 U CN 201120571610U CN 202942109 U CN202942109 U CN 202942109U
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Abstract
The utility model belongs to the field of a heart electrophysiological study, and aims to design a two-in-one cannula electrode which integrates a Langendorff cardiac cannula and a His bundle electrogram recording electrode. The His bundle electrogram recording electrode comprises a aortic cannula, silver electrodes and a sleeve head for connecting with a Langendorff perfusing device, and is characterized in that the His bundle electrogram recording electrode is integrated on the cardiac cannula of the Langendorff perfusing device, such that the cannula has double functions. The isolated perfused heart His bundle electrogram recording electrode provided by the utility model has the advantages as follows: (1) the cardiac surface does not need to be cut in recording so that the integrity of a cardiac structure is not damaged; (2) a recording position is located at a root part of an aorta and is closer to a His bundle, so that a signal is clear; and (3) when the electrode is inserted into the aorta, the electrode is limited by a narrow space of the aorta so that the electrode is difficult to displace even if the heart beats violently and a recorded waveform is stable. Furthermore, the His bundle electrogram recording electrode has the advantages of simple manufacturing method, uncomplicated manufacturing process and low manufacturing cost.
Description
Technical field
This utility model relates to a kind of two-in-one isolated perfused heart His bundle electrogram recording electrode, and this electrode can be used for the detection of toy isolated heart his' bundle potential, belongs to cardiac electrophysiology stud method field.
Background technology
Recording His bundle electrogram is the important method of research heart atrioventricular conduction system physiological property.His' bundle potential is divided into atrioventricular nodal conduction time and Xi Shi bundle-Pu Shi fiber conduction time with the heart atrioventricular conduction time, for measuring the atrioventricular node effective refractory period, and analyzes some arrhythmia important information is provided.Recording His bundle electrogram on the animal isolated perfused heart, can get rid of the impact of regulating at body animal nerve body fluid, is the normal a kind of method that adopts in life science.
His' bundle potential is very faint, is often covered by other electrocardiosignal.When recording, electrode must contact near the Xi Shi bundle and just can clearly detect.The His bundle electrogram record of animal isolated perfused heart generally has three kinds of methods: 1. stainless steel electrode is placed in epicardial surface atrioventricular valves (A V valves) position record; 2. cut off right atrium, electrode is placed in record near Koch triangle summit endocardium; 3. close on right atrium at right ventricle and cut off an osculum, electrode is stretched into record on the endocardium that is placed in the atrioventricular node zone.The common shortcoming of these three kinds of methods is because heart is acutely beated, and electrode is difficult for fixing, and record also is difficult to stablize.And first method is at the epicardial surface record, and away from the Xi Shi bundle, current potential is very little, records unintelligible; Then two kinds of methods have been destroyed the integrity of cardiac structure, are subject to certain limitation in application.
The utility model content
The purpose of this utility model is to design the two-in-one plug pipe electrode of a kind of Langendorff of collection heart cathetrization and His bundle electrogram recording electrode, improves the defective of recording method in the past.
A kind of two-in-one isolated perfused heart His bundle electrogram recording electrode comprises that aortic cannulation, silver wire electrode and connection Langendorff perfusion device be connected pullover.It is characterized in that, on the heart cathetrization of Langendorff perfusion device, His bundle electrogram recording electrode in integration, a pipe dual-purpose.
Described His bundle electrogram recording electrode is incorporated on heart cathetrization.
Silver wire electrode one end sintering balling-up used as the contact of electrode, may be stuck in simultaneously on the intubate aperture and plays fixation.
This utility model one pipe dual-purpose is the heart cathetrization of Langendorff perfusion device, has integrated again His bundle electrogram recording electrode.Its advantage has: when 1. recording, need not cut off heart surface, destroy the integrity of cardiac structure; 2. record position is at aortic root, from the Xi Shi bundle close to, signal is clear; 3. electrode injects in aorta, is limited by the aorta small space, even heart is acutely beated, electrode also is not easy displacement, and wave recording is stable.In addition, this electrode manufacturing method is simple, and processing technology is uncomplicated, and is cheap for manufacturing cost.
Description of drawings
Fig. 1. the two-in-one plug pipe electrode that records His bundle electrogram is made and structural representation.
Fig. 2. this utility model application implementation mode: the intubate electrode is inserted to the isolated heart aortic root, makes ping-pong ball press close to be close to the aortic right coronary wall of right atrium.Adjoin the Xi Shi bundle because of the right atrium side of aortic root, be suitable for recording his' bundle potential.Both can give the cardiac perfusion nutritional solution by the intubate electrode, keep the activity of heart, can stably record His bundle electrogram again.
Fig. 3. use the visceral pericardium electrocardiogram (electrocardiogram, ECG) that the His bundle electrogram (His Bundle electrogram, HBE) of this utility model record and contrast are simultaneously recorded.Record result and show, the record of continuous long time journey, waveform is highly stable (upper figure) all.From the figure that launches, atrial depolarization A ripple and ventricular depolarization V have a gem-pure H ripple between ripple, and the equipotential line that the moment and ECG P-R interval occurs is corresponding, and susceptible of proof is his' bundle potential; Show intubate electrode of the present utility model to stablize and clearly be recorded to his' bundle potential.A: atrial depolarization ripple; H: Xi Shi restraints depolarization wave; V: ventricular depolarization ripple; P: P wave of electrocardiogram; QRS: QRS waves in ECG; T: ECG T wave.
Fig. 4. use the visceral pericardium electrocardiogram (ECG) that the His bundle electrogram (HBE) of this utility model record and contrast are simultaneously recorded.Study owing to often need to giving in addition the electricity irritation heart in experiment, this might affect and disturb the record of his' bundle potential.And our result that records shows, even give electricity irritation midway, and still can be clear and stably be recorded to his' bundle potential H ripple.Show that intubate electrode of the present utility model also has stronger capacity of resisting disturbance.S: auricular pacemaking electricity irritation ripple.
The specific embodiment
1. the concrete production method of intubate electrode selects 1 of plastic conduit as aortic cannulation as shown in Figure 1, and intercepting is about 3.0 centimetres.Pipe diameter size is different according to the laboratory animal cardiac size, for rat, and approximately 1.8 millimeters of approximately 2.0 millimeters of external diameters, internal diameter; For Cavia porcellus, approximately 2.5 millimeters of external diameters, approximately 2.2 millimeters of internal diameters; 2. intubate one end is cut into wedge shape as proximal part, on the tip and 2 apertures of gang drill, and 1.5 millimeters of pitch-rows; 3. get 2 and be about 15 centimetres, the filamentary silver that diameter is 0.15 millimeter is coated with polyester-imide insullac outward; One end of every filamentary silver burns till spherical.2 filamentary silver other ends are passed respectively 2 apertures outside managing, stretch out from the other end along inside pipe wall, tension is stuck on aperture ping-pong ball, and as 2 contacts of electrode, the filamentary silver other end is used for connecting the signal amplifier input; 4. get a large syringe syringe needle, approximately 1.5 millimeters of shank external diameters are truncated to 1.0 centimetres; Be coated with all-purpose adhesive outward, insert from the intubate distal end, cement and seal; The syringe needle other end can connect the Langendorff perfusion device.
Embodiment 1: the intubate electrode of making is connected the Langendorff perfusion device, and 2 filamentary silvers connect respectively signal amplifier input the two poles of the earth.After rat anesthesia, open breast and core dirty; The aorta broken ends of fractured bone that will be connected with heart is inserted in the intubate electrode, makes the intubate electrode extend aortic root; Whip around the aorta outer wall with silk thread, fixedly heart is on intubate; Open perfusion device, carry out the cardiac perfusion nutritional solution, keep the heart activity.Rotate the intubate direction, make the ping-pong ball of intubate electrode be affixed to the aortic right coronary wall.Can show by the computer that is connected with signal amplifier the waveform that is recorded to.
Embodiment 2: on embodiment 1 basis, separately with 2 filamentary silvers, one is placed on the aorta outer wall, and one is placed in apex; The filamentary silver other end connects signal amplifier the 2nd passage input the two poles of the earth.Can record simultaneously isolated heart His bundle electrogram and visceral pericardium electrocardiogram.
Embodiment 3: on embodiment 2 bases, and with 2 filamentary silvers, the contact nearly sinuatrial node of a right atrium place outer wall, a contact right ventricle wall; Filamentary silver other end connection stimulator outfan the two poles of the earth.In the time of can recording at the same time isolated heart His bundle electrogram and visceral pericardium electrocardiogram, give procedural stimulation and carry out complex experiment.
Claims (2)
1. two-in-one isolated perfused heart His bundle electrogram recording electrode, comprise that aortic cannulation, silver wire electrode and connection Langendorff perfusion device be connected pulloverly, it is characterized in that, on the heart cathetrization of Langendorff perfusion device, His bundle electrogram recording electrode in integration, a pipe dual-purpose.
2. two-in-one isolated perfused heart His bundle electrogram recording electrode according to claim 1, is characterized in that silver wire electrode one end sintering balling-up used, as the contact of electrode, may be stuck in simultaneously on the intubate aperture and play fixation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120571610 CN202942109U (en) | 2011-12-31 | 2011-12-31 | Two-in-one isolated perfused heart His bundle electrogram recording electrode |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120571610 CN202942109U (en) | 2011-12-31 | 2011-12-31 | Two-in-one isolated perfused heart His bundle electrogram recording electrode |
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| Publication Number | Publication Date |
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| CN202942109U true CN202942109U (en) | 2013-05-22 |
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| CN 201120571610 Expired - Fee Related CN202942109U (en) | 2011-12-31 | 2011-12-31 | Two-in-one isolated perfused heart His bundle electrogram recording electrode |
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2011
- 2011-12-31 CN CN 201120571610 patent/CN202942109U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130522 Termination date: 20131231 |