CN200939129Y - Mini electrode for recording vision electrical physiological reaction of experimental animal - Google Patents
Mini electrode for recording vision electrical physiological reaction of experimental animal Download PDFInfo
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- CN200939129Y CN200939129Y CN 200620045228 CN200620045228U CN200939129Y CN 200939129 Y CN200939129 Y CN 200939129Y CN 200620045228 CN200620045228 CN 200620045228 CN 200620045228 U CN200620045228 U CN 200620045228U CN 200939129 Y CN200939129 Y CN 200939129Y
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- electrode
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- visual
- microelectrode
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Abstract
The utility model relates to a micro-electrode used to record the visual physiological reaction of the laboratory animals belonging to the physiological test instrument field. The micro-electrode comprises a record electrode and/or a reference electrode; the micro-electrode is characterized in that the record electrode comprises a conductive electrode rod bolt with the exteriorized insulation layer and the electrode positioned on one end of the rod bolt conductor; the electrode is a metal ring corneal contact electrode; or, the record electrode and/or the reference electrode comprises the conductive electrode rod bolt with the exteriorized insulation layer and the electrode positioned on one end of the rod bolt conductor; the electrode is a metal needle electrode. The technical proposal has precise and convenient position which is applicable to different test objects, stable signal extraction, high signal-noise ratio and good repeatability of the measure results; which is widely applicable in the test field of visual physiological reaction for a plurality of animals (especially small rodents).
Description
Technical field
This utility model belongs to the physiological test instrument field, relates in particular to a kind of device that is used to measure the animal organism signal of telecommunication.
Background technology
Visual System Electrophysiology Technique is a unique objective visual function detection method commonly used on the clinical ophthalmology, and since clinical practice over half a century, its generation all be unable to do without this basis of zoopery with development.
The non-invasive of Visual System Electrophysiology Technique, objectivity, can be deep into cellular and molecular level under the specific condition, and to retina, look the layering location and the accuracy of road lesion detection, make this technology clinical ophthalmology in addition with the relevant crossing research of neural section office in extremely important and irreplaceable effect is arranged.
Visual System Electrophysiology Technique is advanced by leaps and bounds over nearly 10 years, has produced a lot of new techniques, and as the multifocal visual electrophysiology technology, different stimulated figure, spatio-temporal frequency, color etc. can be brought how valuable information to clinical diagnosis and treatment; Developing rapidly of ophthalmology scientific research also impels this technology to be able to continuous expansion, thereby more urgent to the needs of the research of zoopery; Clinical with the scientific research propelling, must be in conjunction with zooperal research, the detection of animal visual electrophysiology is the considerable ingredient in the ophthalmology scientific research.
Along with the foundation of laboratory animal disease model, people also more and more pay attention to the record and the application of animal visual electrophysiology.
Recording electrode, reference electrode and ground electrode are separately positioned on the eye of laboratory animal, near the eye socket and pillow (tail) portion, use suitable recording parameters, can record the corresponding visual electrophysiology response waveform of laboratory animal.
The electrophysiological record of laboratory animal visual needs three essential conditions: unified equipment, unified detected parameters and unified electrode.Now, the former two can and provide by corresponding electric physiological apparatus manufacturing firm's production, aims at the test electrode that animal is used but lack always.
The eighties in last century, wire electrodes such as beginning applied metal silk or carbon fibre serve as recording electrode in the external experiment.Because wire electrode settles in animal eye, fixing inconvenient, drift easily, disturbance records makes the waveform that records repeated relatively poor and amplitude is little, thereby directly has influence on the electrophysiological extensive use of laboratory animal visual.
Simultaneously, since cornea size, the radian difference of animal eye, the eyelid difference, and the shape of recording electrode and the difference of processing technology all can have influence on the record result to a great extent.
In addition, the dedicated reference electrode product that never is fit to the test of animal visual electrophysiology now, normally adopt the human reference electrode to substitute in the actual experiment temporarily, because the human reference electrode is a kind of sucked type electrode, for the small-sized laboratory rodent (as testing) that body surface length has more hair with mouse or rabbit etc., its fixing difficulty, and because it can not closely contact with the skin of animal, can bring such as fixing inconvenient, contact bad, problems such as the big and measurement result deviation of contact resistance is big, the waveform repeatability that has also caused recording is relatively poor and amplitude is little, equally directly has influence on the electrophysiological extensive use of laboratory animal visual.
The utility model content
Technical problem to be solved in the utility model provides a kind of microelectrode that is used for the recording laboratory animal visual electrophysiologic response, and its location is convenient, accurate, and is easily fixing, and wave recording is stable, the signal to noise ratio height, and repeatability is well, and is cheap for manufacturing cost.
The technical solution of the utility model is: a kind of microelectrode that is used for the recording laboratory animal visual electrophysiologic response is provided, comprise recording electrode and/or reference electrode, it is characterized in that: its recording electrode is made of with the electrode that is arranged on one of body of rod conductor end the conductive electrode body of rod of external insulating barrier; Its described electrode is a metal ring cornea contact electrode.
Above-mentioned ring-type cornea contact electrode is the individual pen contact electrode, and the eye's cornea size of individual pen contact electrode and measurand is complementary.
Perhaps, the two circle contact electrodes of above-mentioned ring-type cornea contact electrode for constituting by outer ring electrode and inner ring electrode, its inside and outside circle electrode is connected with the electrode body of rod after linking to each other, the eyelid size of circle electrode and measurand is complementary outside two circle contact electrodes, and the eye's cornea size of its inner ring electrode and measurand is complementary.
Further, the outer ring electrode of its pair circle contact electrode and inner ring electrode are arranged in the same plane or are arranged in two planes that are parallel to each other.
Above-mentioned single, double circle contact electrode is circle, ellipse, sub-circular or approximate ellipsoidal.
Above-mentioned single, double circle contact electrode surface is provided with gold-plated or silver coating.
This utility model also provides another to be used for the microelectrode of recording laboratory animal visual electrophysiologic response, comprise recording electrode and/or reference electrode, it is characterized in that: its recording electrode and/or reference electrode are made of with the electrode that is arranged on one of body of rod conductor end the conductive electrode body of rod of external insulating barrier; Its described electrode is the metal needle electrode.
Compared with the prior art, the utility model has the advantages that:
1. recording electrode adopts circulus, and the location is convenient, accurate, can adapt to different tested objects;
2. adopt gold-plated or the silver coating structure, draw signal stabilization, the signal to noise ratio height, cheap for manufacturing cost;
3. adopt two coil structures, guaranteed that contact is good, make and draw signal stabilization, the signal to noise ratio height, repeating of measurement result is functional;
4. recording electrode and/or reference electrode adopt the metal needle electrode, and its location is convenient, accurate, and is easily fixing, guarantee contact well, and wave recording is stable, the signal to noise ratio height, and the waveform that records repeatability is good;
5. be specially adapted to the detection and the record of the visual electrophysiology response waveform of small-sized rodent.
Description of drawings
Fig. 1 is the structural representation of this utility model annular contact electrode;
Fig. 2 is the structural representation of this utility model annular contact electrode embodiment;
Fig. 3 is the structural representation of this utility model needle electrode.
1 is electrode stem among the figure, and 2 is the ring-type contact electrode, and 3 is the outer ring electrode, and 4 is the inner ring electrode, and 5 is needle electrode.
The specific embodiment
Among Fig. 1, the technical program is provided with ring-type cornea contact electrode 2 at an end of the body of rod 1 conductor.
Wherein, ring-type cornea contact electrode is the individual pen contact electrode, and the eye's cornea size of individual pen contact electrode and measurand is complementary.
Individual pen contact electrode surface is provided with gold-plated or silver coating.
The individual pen contact electrode is circular or oval.
Among Fig. 2, the two circle contact electrodes of ring-type cornea contact electrode for constituting by outer ring electrode 3 and inner ring electrode 4, its inside and outside circle electrode is connected with the electrode body of rod 1 after linking to each other, the eyelid size of circle electrode and measurand is complementary outside two circle contact electrodes, and the eye's cornea size of its inner ring electrode and measurand is complementary.
The outer ring electrode of above-mentioned two circle contact electrodes and inner ring electrode are arranged in the same plane or are arranged in two planes that are parallel to each other.
All the other same Fig. 1.
Because of the eyeball of the animal of variety classes varies in size, leading electrode adopts the version of ring electrode, both can adapt to different experimental animal kinds by the diameter of regulating ring electrode, can guarantee again that the location of electrode is convenient, accurately; Because adopt gold-plated or silver coating structure, electrode impedance is less, draws signal stabilization, the signal to noise ratio height, the while has also been reduced the manufacturing cost of electrode; In addition, adopt two coil structures, put into animal eyeball easily and fix, its outer ring had both increased contact area, can play fixation again, and inner ring can play the measurement effect, the contact that has guaranteed test electrode is good, makes to draw signal stabilization, and repeating of measurement result is functional.
Among Fig. 3, recording electrode and/or reference electrode are made of the electrode body of rod 1 and the electrode that is arranged on one of body of rod conductor end; Its electrode is a metal needle electrode 5.
Adopt the metal needle electrode, can directly it be thrust the subcutaneous of laboratory animal, its location is convenient, accurate, and is easily fixing, guaranteed that the contact of test electrode is good, makes wave recording stable, the signal to noise ratio height, and the waveform that records repeatability is well.
Adopt above-mentioned leading electrode, cooperate with U.S. LKC UTAS-2000 type electrophysiology instrument, the electric physiological conditions of eye to rat, rabbit, Cavia porcellus, mice is tested, all can record ERG (Electroretinogram very easily, electroretinogram) and VEP (Visual Evoked Potential, visual evoked potential), the waveform stabilization that is recorded, repeating of measurement result is functional.
How burnt electroretinogram record to laboratory animal has also carried out preliminary observation, and conclusion is to measure and to record the visual electrophysiology waveform of laboratory animal with above-mentioned electrode, and it is relatively good that the wave mode that same animal records repeats performance.
As seen, development of this electrode and exploitation are the research and the scientific research of animal visual electrophysiology reaction, have established good detection basis.
This utility model can be widely used in the field tests of the visual electrophysiology reaction of multiple animal (especially small-sized rodent).
Claims (9)
1. a microelectrode that is used for the recording laboratory animal visual electrophysiologic response comprises recording electrode and/or reference electrode, it is characterized in that:
Its recording electrode is made of with the electrode that is arranged on one of body of rod conductor end the conductive electrode body of rod of external insulating barrier;
Its described electrode is a metal ring cornea contact electrode.
2. according to the described microelectrode that is used for the recording laboratory animal visual electrophysiologic response of claim 1, it is characterized in that described ring-type cornea contact electrode is the individual pen contact electrode.
3. according to the described microelectrode that is used for the recording laboratory animal visual electrophysiologic response of claim 2, it is characterized in that the eye's cornea size of described individual pen contact electrode and measurand is complementary.
4. according to the described microelectrode that is used for the recording laboratory animal visual electrophysiologic response of claim 1, it is characterized in that the two circle contact electrodes of described ring-type cornea contact electrode for being made of outer ring electrode and inner ring electrode, its inside and outside circle electrode is connected with the electrode body of rod after linking to each other.
5. according to the described microelectrode that is used for the recording laboratory animal visual electrophysiologic response of claim 4, it is characterized in that the eyelid size of enclosing electrode and measurand outside described two circle contact electrode is complementary, the eye's cornea size of its inner ring electrode and measurand is complementary.
6. according to the described microelectrode that is used for the recording laboratory animal visual electrophysiologic response of claim 4, it is characterized in that the outer ring electrode of described two circle contact electrodes and inner ring electrode are arranged in the same plane or are arranged in two planes that are parallel to each other.
7. according to claim 2,3,4,5 or 6 described microelectrodes that are used for the recording laboratory animal visual electrophysiologic response, it is characterized in that described single, double circle contact electrode is circular, oval, sub-circular or approximate ellipsoidal.
8. according to claim 2,3,4,5 or 6 described microelectrodes that are used for the recording laboratory animal visual electrophysiologic response, it is characterized in that described single, double circle contact electrode surface is provided with gold-plated or silver coating.
9. a microelectrode that is used for the recording laboratory animal visual electrophysiologic response comprises recording electrode and/or reference electrode, it is characterized in that:
Its recording electrode and/or reference electrode are made of with the electrode that is arranged on one of body of rod conductor end the conductive electrode body of rod of external insulating barrier;
Its described electrode is the metal needle electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620045228 CN200939129Y (en) | 2006-08-29 | 2006-08-29 | Mini electrode for recording vision electrical physiological reaction of experimental animal |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620045228 CN200939129Y (en) | 2006-08-29 | 2006-08-29 | Mini electrode for recording vision electrical physiological reaction of experimental animal |
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| CN200939129Y true CN200939129Y (en) | 2007-08-29 |
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| CN 200620045228 Expired - Lifetime CN200939129Y (en) | 2006-08-29 | 2006-08-29 | Mini electrode for recording vision electrical physiological reaction of experimental animal |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110487996A (en) * | 2019-08-05 | 2019-11-22 | 汕头大学医学院 | The mono- biphasic action potential of nerve cord while Record analysis experimental method |
-
2006
- 2006-08-29 CN CN 200620045228 patent/CN200939129Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110487996A (en) * | 2019-08-05 | 2019-11-22 | 汕头大学医学院 | The mono- biphasic action potential of nerve cord while Record analysis experimental method |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070829 |
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| EXPY | Termination of patent right or utility model |