CN202740872U - Novel combined laminar flow transfer window installed with sterilizing filter - Google Patents
Novel combined laminar flow transfer window installed with sterilizing filter Download PDFInfo
- Publication number
- CN202740872U CN202740872U CN201220489524.8U CN201220489524U CN202740872U CN 202740872 U CN202740872 U CN 202740872U CN 201220489524 U CN201220489524 U CN 201220489524U CN 202740872 U CN202740872 U CN 202740872U
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- sterilizing filter
- clean area
- filter
- laminar flow
- box
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Abstract
The utility model discloses a novel combined laminar flow transfer window installed with a sterilizing filter. The novel combined laminar flow transfer window comprises a box body, two end doors of which cannot be opened simultaneously, wherein the box body is provided with an inner door and an outer door; and the sterilizing filter is arranged inside the box body. The novel combined laminar flow transfer window installed with the sterilizing filter is arranged at a clean area junction of a relative high-level clean area and a relative low-level clean area. The sterilizing filter enters the box body from the relative high-level clean area so as to be installed after being sterilized, so that environment pollution caused by installation in the relative low-level clean area is avoided. After the production is completed, the sterilizing filter is dismounted in the relative low-level clean area, so that the problem that residual fluid in the filter core pollutes the relative high-level clean area is avoided. The novel combined laminar flow transfer window installed with the sterilizing filter can effectively avoid the pollution problem caused by dismounting the filter in the processes of sterilizing and filtering.
Description
Technical field
The utility model belongs to the pharmaceutical equipment field, particularly a kind of novel combination layer stream pass-through box that sterilizing filter is installed.
Background technology
At present, the factory building of producing for medical industry needs higher air purity, the design of clean area must meet corresponding cleanliness factor requirement, for different production technology operations different clean other clean areas of level must be set, article transmission at different clean areas then needs to transmit by common pass-through box or the laminar flow pass-through box of mechanical chain, the pass-through box of mechanical chain is installed on the dividing wall of different clean areas, the pass-through box door of both sides is undertaken chain by mechanical device, the transmission window of both sides can not be opened simultaneously, to guarantee the not mutually circulation of both sides other air of different clean area level.
At present, for the aseptic medicine production technology, " GMP (revision in 2010) " appendix 1 aseptic medicine regulation should take measures to reduce the risk of filtration sterilization.Again filtering liquid medicine of second sterilized sterilizing filter should be installed, final sterilizing filter should be as far as possible near the can point, therefore, the aseptic filtration technique of pharmaceutical producing enterprise is the cascade filtration pattern at present, under the cascade filtration pattern, first sterilizing filter two kinds of situations are installed: 1. be installed in the relatively low-level clean area of clean rank; 2. be installed in the relatively high level clean area of clean rank.The former, the filter core of filter is installed at relatively low-level clean area through after the sterilization treatment, and the non-sterile zone at this assembling process place can produce microbial contamination to the filter core after the sterilization treatment and sterilized pipeline.The latter, sterilizing filter needs dismounting after producing end, and residual " the liquid concentrate " of sterilizing filter middle and upper reaches gathers the microorganism that is trapped in a large number, causes the microbial contamination risk to aseptic area.All there is the microbial contamination risk to product quality in two kinds of mounting means.
The utility model content
The purpose of this utility model is to provide the novel combination layer stream pass-through box that brings the installation sterilizing filter of secondary pollution in a kind of process that can avoid changing sterilizing filter.
For achieving the above object, the technical scheme that the utility model adopts is: a kind of novel combination layer stream pass-through box that sterilizing filter is installed, comprise the casing that two ends communicate, described casing is equipped with the inside door of the higher side of clean rank and the external door of the low side of clean rank, in the described casing sterilizing filter is installed.Pass-through box with aseptic filtration function is installed in relatively high level clean area and relatively low-level clean area intersection, the pipeline of described sterilizing filter adopts online sterilization method, rear being entered in the described casing by relatively high level clean area of filter core sterilization installed, the risk of environmental pollution that brings in the time of can not installing with relatively low other clean area of level of cause; Described sterilizing filter is dismantled by relatively rudimentary clean area after production is finished, and filter core upstream Liquid Residue can not occur and pollute relatively high level this problem of clean area.
Described pass-through box two side doors are connected by mechanical interlocking device, can only open separately.In described filter core installation and removal process, cut off the circulation of air between relatively high level clean area and the relatively low-level clean area, avoid relatively low-level clean area to pollute relatively high level clean area.
Described casing has hundred grades of laminar flow apparatus.In the inside door of opening the pass-through box with sterilizing filter or external door process, hundred grades of clean gas of the high efficiency particulate air filter of laminar flow apparatus avoid the air of box house to the pollution of its open area by flowing out in the casing.
Described inside door outside arranges the protection air outlet of holding court from behind a screen, and the air-out of described air outlet A level cleanliness factor guarantees that further described sterilizing filter is subject to secondary pollution in installation process.
Described sterilizing filter two sides are provided with Pressure gauge, and the pressure reduction of two sides that can monitor filter is avoided entering next process because Filter Core Failure makes the liquid without aseptic filtration.
The microbiological pollution that the utility model can effectively avoid the installation and removal of aseptic filtration technical process middle filtrator to bring.
Description of drawings
Fig. 1 is a kind of structural representation that the novel combination layer stream pass-through box of sterilizing filter is installed of the utility model.
The specific embodiment
Below in conjunction with Figure of description the utility model is made concrete elaboration.
As shown in Figure 1, a kind of novel combination layer stream pass-through box that sterilizing filter is installed is installed in relatively high level clean area and relatively low-level clean area intersection, comprise: the casing 1 that two sides can not be opened simultaneously, the two ends of phase body 1 are equipped with inside door 2 and external door 3, two ends that can seal case 1, inside door 2 is installed in a side of relatively high level clean area, external door 3 is installed in a side of relatively low-level clean area, casing 1 is equipped with sterilizing filter 4, the pipeline connection at sterilizing filter 4 and casing 1 two ends, the sidewall of casing 1 is provided with mechanical interlocking device 5, this mechanical interlocking device 5 is related with inside door 2 and external door 3, so that inside door 2 and external door 3 can only have a fan to be in open mode, casing 1 has laminar flow apparatus 6, the outside of the inside door 2 of casing 1 is provided with an A level air outlet 7, and the sterilizing filter 4 in the casing 1 is equipped with Pressure gauge 8.
During use, the laminar flow pass-through box that sterilizing filter is installed is positioned at relatively high level clean area and relatively low-level clean area intersection, enter described casing 1 by relatively higher clean area after described sterilizing filter 4 sterilizations and install, the installation environment that brings in the time of can not installing with relatively low other clean area of level of cause pollutes; Described sterilizing filter 4 is dismantled by relatively low-level clean area after production is finished, and relatively high level this problem of clean area of Liquid Residue pollution in the filter core can not occur.Described inside door 2 is connected by mechanical interlocking device 5 with external door 3, can only open individually inside door 2 or external door 3, can in described filter core installation and removal process, cut off circulation of air between relatively high level clean area and the relatively low-level clean area, avoid relatively low-level clean area to pollute relatively high level clean area.
Described casing 1 has laminar flow apparatus, can avoid casing 1 inner residual air to the pollution in its open zone by casing 1 interior outflow by A level cleanliness factor gas in the inside door 2 of opening pass-through box or external door 3 processes.
Air outlet 7 of described inside door arranged outside, described air outlet 7 is the air-out of A level cleanliness factor, guarantees that further described sterilizing filter is polluted in installation process.
Described sterilizing filter is provided with Pressure gauge 8.State that can monitor filter is avoided entering next process because Filter Core Failure causes the liquid of not aseptic filtration.
Claims (5)
1. the novel combination layer stream pass-through box that sterilizing filter is installed is characterized in that comprise the casing that two side doors can not be opened simultaneously, described casing is equipped with inside door and external door, in the described casing sterilizing filter is installed.
2. a kind of novel combination layer stream pass-through box that sterilizing filter is installed as claimed in claim 1 is characterized in that, is undertaken chain by mechanical interlocking device between described inside door and the external door.
3. a kind of novel combination layer stream pass-through box that sterilizing filter is installed as claimed in claim 1 is characterized in that described casing has laminar flow apparatus.
4. a kind of novel combination layer stream pass-through box that sterilizing filter is installed as claimed in claim 1 is characterized in that described inside door outside arranges an A level cleanliness factor air outlet.
5. such as the arbitrary described a kind of novel combination layer stream pass-through box that sterilizing filter is installed of claim 1-4, it is characterized in that described sterilizing filter two sides are provided with Pressure gauge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220489524.8U CN202740872U (en) | 2012-09-20 | 2012-09-20 | Novel combined laminar flow transfer window installed with sterilizing filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220489524.8U CN202740872U (en) | 2012-09-20 | 2012-09-20 | Novel combined laminar flow transfer window installed with sterilizing filter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202740872U true CN202740872U (en) | 2013-02-20 |
Family
ID=47700325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201220489524.8U Expired - Lifetime CN202740872U (en) | 2012-09-20 | 2012-09-20 | Novel combined laminar flow transfer window installed with sterilizing filter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202740872U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109914987A (en) * | 2019-02-22 | 2019-06-21 | 荣昌生物制药（烟台）有限公司 | A kind of transmitting window assembly |
-
2012
- 2012-09-20 CN CN201220489524.8U patent/CN202740872U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109914987A (en) * | 2019-02-22 | 2019-06-21 | 荣昌生物制药（烟台）有限公司 | A kind of transmitting window assembly |
| CN109914987B (en) * | 2019-02-22 | 2023-06-13 | 荣昌生物制药(烟台)股份有限公司 | Pass-through box subassembly |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 310018 No.1 street, Hangzhou Economic and Technological Development Zone, Zhejiang Province Patentee after: Hangzhou AoYa Biotechnology Co.,Ltd. Address before: 310012 No.1 street, Hangzhou Economic and Technological Development Zone, Hangzhou City, Zhejiang Province Patentee before: HANGZHOU AUSIA BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
| CP03 | Change of name, title or address | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130220 |
|
| CX01 | Expiry of patent term |