CN202693582U - Detection device - Google Patents

Detection device Download PDF

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Publication number
CN202693582U
CN202693582U CN 201220201240 CN201220201240U CN202693582U CN 202693582 U CN202693582 U CN 202693582U CN 201220201240 CN201220201240 CN 201220201240 CN 201220201240 U CN201220201240 U CN 201220201240U CN 202693582 U CN202693582 U CN 202693582U
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CN
China
Prior art keywords
pick
test paper
loam cake
overlayer
detection
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Ceased
Application number
CN 201220201240
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Chinese (zh)
Inventor
商涛
王春明
刘胜强
唐林勇
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Acon Biotech Hangzhou Co Ltd
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Acon Biotech Hangzhou Co Ltd
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Abstract

The utility model provides a detection device which comprises an upper cover, a base plate combined with the upper cover, and detection test paper located between the upper cover and the base plate. The detection device is characterized in that the detection test paper comprises at least two detection areas and a covering layer connected with the at least two detecting areas, the upper cover comprises an upper surface, a lower surface and a sample feeding hole penetrating through the upper surface and the lower surface, the lower surface of the upper cover is opposite to the covering layer of the detection test paper, a diversion structure is arranged on the lower surface of the upper cover, and a liquid transmission path is formed between the sample feeding hole of the upper cover, the diversion structure, the covering layer and the at least two detection areas of the detection test paper. The detection device can effectively and evenly distribute a fed liquid sample so that detection is more accurate. The detection device is applied to the detection of a series of physiological and biochemical criteria such as glucose, cholesterol, high density fatty acid, low density fatty acid, triglycerides, uric, bilirubin, total protein, hemoglobin, and ketone bodies.

Description

Pick-up unit
Technical field
The utility model relates to for pick-up unit, the especially pick-up unit of Fast Measurement biochemical indicator of measuring the clinical physiological index.
Background technology
At present, the drying chemical reagent paper detection method often is used to measure whether have certain composition or this component content in the liquid sample, for example measures glucose in the blood sample, cholesterol, triglyceride equal size.
Drying chemical reagent paper is different according to disposable measurable sample size and testing index kind, is divided into the test paper of measuring single analyte and the test paper of measuring a plurality of analytes.For example US Patent No. 7087397 disclosed single analyte test papers are used for measuring blood middle-high density fatty acid.Also comprise the device that loads test paper in this piece United States Patent (USP), described device has the upper plate of well and has the lower plate of view window, is pressing the test paper of measuring high density fat acid between upper plate and lower plate.If measure biochemical indicators different in the same sample, when for example measuring simultaneously high density fat acid, low density fat acid, content of triglyceride, then must measure with three described pick-up units of US7087397.When need are measured a plurality of biochemical indicator simultaneously, use this class single analyte test paper can affect detection efficiency.In US Patent No. 7625721 embodiment illustrated in fig. 8, different single analyte test papers is incorporated in the device the corresponding well of each test item.The pick-up unit of this structure can reduce the consumption of pick-up unit, avoids using the mistake that does not match pick-up unit.But the operator still will add sample one time to each test item respectively.For example detect three projects, will drip sample three times.Therefore the workload that adds sample is still very large.
US6524864 and US7494818 all disclose the pick-up unit that application of sample just can be finished a plurality of test events.The US6524864 patent comprises a well and a plurality of test block, and increases a Distribution Layer between well and a plurality of test block, and this Distribution Layer can be assigned to the sample that drips on a plurality of reagent pieces equably.Such structure has realized only adding a sample and has finished a plurality of detection purpose functions.In the US7494818 patent, disclosed too the pick-up unit of realizing above-mentioned functions, realize that by Distribution Layer sample distributes on a plurality of test modules.This design that increases Distribution Layer at well and reagent interblock can make many procedures in the production run of assembling detection device, not only affects the production cycle, also may increase in process of production the contaminated probability of reagent piece.
There is not the liquid Distribution Layer in Figure 34 of US Patent No. 5962215 in well and a plurality of reagent piece to embodiment shown in Figure 36, but realize that by the groove in the upper plate liquid of liquid between a plurality of test modules distributes.When the fluid sample that adds transmitted in groove, the gas that originally was present in the groove was discharged at the opening at upper plate two ends by groove, thereby the air resistance that reduces in the groove is realized the transmission of liquid in groove smoothly.If the sample size that adds in the described mode of this patent is excessive, the sample that the reagent piece has little time to absorb will flow out from the opening part of upper plate two ends groove, has not only polluted surrounding environment, also may be infected with operator's cause danger.
Another weak point is, and is different for the employed chemical reagent of different test items, therefore as its degree of expansion of carrier material of reagent piece also can be because of the difference of processing chemical reagent thereon difference.To shown in Figure 36, when having arranged a plurality of reagent piece on the test paper, may cause the upper surface of different reagent pieces not on the same level face such as US5962215 patent Figure 34.If the distance between the height heterogeneity of test block, test block upper surface and loam cake groove is just not identical.At the large position of upper surface and groove distance, the speed of fluid transport is slow.At the little position of upper surface and groove distance, the speed of fluid transport is just slow.The difference of fluid transport speed just can not be controlled so that each reagent piece receives the time of sample, causes the time of obtaining test result uncontrollable, causes puzzlement for result's the time of reading, and has affected the accuracy of test result.
Do not have in the prior art the reagent occluding device between the different detection zones, when liquid when test paper transmits, the reagent in the different detection zones will enter on other the detection zone along with the transmission of liquid, has polluted other detection zone.
In addition, in existing product and disclosed document, for example in the described patented claim of US20080112848A1, the parts of the periphery of pick-up unit and detector shown in Figure 20 all are that hard and incompressible material are made.If make pick-up unit successfully put into detector and again can be from easily landing of detector, this just requires that the very high goodness of fit is arranged between pick-up unit and the detector.In the process of producing, if its size of a certain batch pick-up unit during greater than the value of in advance design, this batch pick-up unit just can not insert in the detector smoothly, can only do and scrap processing.If the size of a certain batch pick-up unit during less than the value of in advance design, although can be inserted into smoothly in the detector, because size is little, is easy to landing from detector.Same, if detector is processed to such an extent that be not very accurate, can occur also that above-mentioned detection device can not be inserted or the easy phenomenon of landing from detector of pick-up unit.Therefore for pick-up unit of the prior art and detector, the error range that allows in the production run is very little, and this just proposes very high requirement to production technology, increased production cost, otherwise the scrappage of product can be higher, has increased the cost of material.
The utility model content
One of the purpose of this utility model is to provide a kind of pick-up unit, can the effective communication fluid sample.Described pick-up unit comprises: loam cake, the base plate that combines with loam cake and the test paper between loam cake and base plate, it is characterized in that: test paper comprises at least two detection zones and the overlayer that is connected with these at least two detection zones, loam cake comprises upper surface and lower surface and runs through, the well of lower surface, the lower surface of loam cake is relative with the overlayer of test paper, loam cake is provided with flow-guiding structure at the lower surface place, at the well of loam cake, described flow-guiding structure, form fluid transfer between the overlayer of test paper and described at least two detection zones.
Further the described flow-guiding structure of this pick-up unit comprises the groove that is arranged on surface under the loam cake, forms roughly uniform liquid transfer chamber of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.
Further described flow-guiding structure comprises the enclosing wall that is arranged on surface under the loam cake, is provided with groove in the enclosing wall, forms roughly uniform liquid transfer chamber of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.
Preferably, described recess width is the 0.1-2 millimeter, and the degree of depth is the 0.01-0.5 millimeter.Preferred, the width of described groove is 1 millimeter, and the degree of depth is 0.3 millimeter.
At least two detection zones on the test paper include respectively the reagent piece on the other hand, and described overlayer is positioned at the top of reagent piece.
Preferably separate with spacer block 103 between each detection zone on the test paper, overlayer sticks on detection zone and the spacer block.
Further flow-guiding structure is across at least two detection zones on described test paper, and described overlayer and flow-guiding structure form the uniform liquid transfer of a cavity chamber.
On the one hand, also comprise exhausr port on the described base plate again.
Preferably, flow-guiding structure surface described in the utility model or overlayer or above-mentioned both with including hydroaropic substance.
Two of the utility model purpose is to provide a kind of pick-up unit with arrangement for adjusting height, this pick-up unit comprises: loam cake, the base plate that combines with loam cake and the test paper between loam cake and base plate, it is characterized in that, also comprise the arrangement for adjusting height adaptive with detector, at least one face of described arrangement for adjusting height is the lofty perch that contacts with detector of pick-up unit or to low spot.
Preferably, arrangement for adjusting height described in the utility model is an elastomeric element.
Preferred, described arrangement for adjusting height is a kind of arch-shaped or semicircle is spherical or the semicircular spherical structure.
On the other hand, have flank in the both sides of loam cake or base plate, this flank cooperates the guiding pick-up unit to enter detecting instrument with detecting instrument.
On the other hand, described arrangement for adjusting height is assemblied on loam cake, base plate or the flank.
Preferably, pick-up unit has discontinuous flank, and arch bridge type arrangement for adjusting height is across between two flanks of pick-up unit homonymy.
Again on the one hand, the analyte that analysis module is measured is selected from: glucose, cholesterol, high density fat acid, low density fat are sour, triglyceride, uric acid, cholerythrin, total protein, haemoglobin, ketoboidies.
Three of the utility model purpose has been to provide a kind of test paper to have the pick-up unit of spacer block, this pick-up unit comprises: loam cake, the base plate that combines with loam cake and the test paper between loam cake and base plate, test paper comprises at least two detection zones and the overlayer that is connected with these at least two detection zones, it is characterized in that, separate with spacer block between each detection zone on the test paper, overlayer sticks on detection zone and the spacer block.
Further, there is spacer block the both sides of described each reagent piece, and tectal two ends are overlapped on outmost two spacer blocks, on the spacer block in the middle of the overlayer center section sticks to.
Further also comprise the test paper storage tank on the base plate.
Preferably, each detection zone and spacing block with the reagent piece stick on the base material, and described base material is packed in the test paper storage tank.
Preferred, described spacer block is non-hydrophilic material.
The beneficial effects of the utility model are: 1) form fluid transfer between the overlayer of the flow-guiding structure of pick-up unit, test paper and described at least two detection zones, sample can be assigned on the test module uniformly, and reduce production process.2) design of the fence around the flow-guiding structure can prevent effectively that liquid from flowing out from flow-guiding structure.3) arrangement for adjusting height on the pick-up unit base plate can make pick-up unit cooperate well detecting instrument, and machining precision is not accurate enough in process of production to prevent detector or pick-up unit, and can't successfully be placed in the detector.Because the existence of arrangement for adjusting height has reduced the accuracy requirement to production technology, has reduced production cost, reduce product rejection rate.4) separate with spacer block between each detection zone on the test paper, so just prevented the cross pollution between the reagent piece in the different detection zones.
Description of drawings
Fig. 1 is the utility model pick-up unit unitized construction synoptic diagram.
Fig. 2 is the utility model pick-up unit exploded view.
Fig. 3 is the utility model pick-up unit loam cake.
Fig. 4 is another embodiment of the utility model pick-up unit loam cake.
Fig. 5 is the utility model pick-up unit lower plate.
Fig. 6 is the structural representation of the utility model Fig. 1 embodiment A-A direction.
Fig. 7 is the structural representation of the utility model Fig. 1 Embodiment B-B direction.
Fig. 8 is the enlarged diagram of regional C among the utility model Fig. 7.
Fig. 9 is an embodiment of the utility model arrangement for adjusting height.
Figure 10 is another embodiment of the utility model arrangement for adjusting height.
Figure 11 is detector draw-in groove size when suitable, the synoptic diagram that cooperates with the utility model pick-up unit.
Figure 12 is detector draw-in groove size when less than normal, the synoptic diagram that cooperates with the utility model pick-up unit.
Figure 13 is when detector draw-in groove size is suitable in the prior art, the synoptic diagram that cooperates with pick-up unit.
Figure 14 is when detector draw-in groove size is less than normal in the prior art, the synoptic diagram that cooperates with pick-up unit.
Embodiment
Below in conjunction with concrete accompanying drawing the utility model is described in detail.These specific embodiments only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
Shown in Fig. 1 to 8, pick-up unit 1 comprises loam cake 2, the base plate 3 that combines with loam cake and the test paper between loam cake and base plate 100.Described loam cake comprises upper surface 4 and lower surface 5 and the well 6 that runs through upper and lower surface.Loam cake is provided with flow-guiding structure 7 at the lower surface place.Described test paper 100 comprises at least two detection zones 101, comprises that also an overlayer 102 covers on the above-mentioned detection zone 101.The lower surface of loam cake is relative with the overlayer of test paper.Between the overlayer of the well of loam cake, flow-guiding structure, test paper, form liquid transfer passage 8.After fluid sample adds from well, fluid sample will be passed along the liquid transfer passage.
Flow-guiding structure comprises the groove 9 that is arranged on loam cake lower surface 5, forms roughly uniform liquid transfer chamber 8 of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.Among the embodiment as shown in Figure 4, flow-guiding structure can be arranged on the enclosing wall 10 of loam cake lower surface, be provided with groove in the enclosing wall, form roughly uniform liquid transfer chamber 8 of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.The wide of groove is the 0.1-2 millimeter, and the degree of depth is the 0.01-0.5 millimeter, and preferred version is that the wide of groove is 1 millimeter, and the degree of depth is 0.3 millimeter.Flow-guiding structure is across at least two detection zones on test paper, and described overlayer and flow-guiding structure form the uniform liquid transfer of a cavity chamber.
Loam cake 2 two ends can also comprise beading 11, include rivet 12 around the loam cake.When test paper was installed between upper plate and the base plate, beading 11 can press the two ends of test paper, prevented that the two ends perk of test paper is to keep the smooth of test paper.
Among the embodiment as shown in Figure 4, has test paper storage tank 13 on the base plate 3 of pick-up unit.Mode by direct placement or stickup is placed on test paper in the storage tank 13.Have test result view window 14 on the base plate, each detection zone is corresponding to a view window in the test paper.
Among the embodiment as shown in Figure 4, the pick-up unit Handheld Division 15 that the person that also can comprise the handled easily on the base plate is affectedly bashful.Lockhole 16 on the base plate closely is assembled together loam cake and base plate with rivet 12 interference fit of loam cake.Loam cake does not have rivet in another embodiment, and base plate does not have lockhole, passes through the mode close fit of ultra-sonic welded between loam cake and the base plate together.In one embodiment, be assembled together by ultrasonic mode between the loam cake of pick-up unit and the base plate, then also comprise exhausr port on the base plate.
Such as Fig. 6 to 8, have at least two detection zones 101 and one deck overlayer 102 to cover on the test paper on the test paper 100.A view window 14 is arranged under the detection zone on the described test paper 100.Test paper can directly be placed on the corresponding view window, also can be to reinstall in the test paper storage tank 13 of base plate after in advance each detection zone with the reagent piece being sticked on the liner of the materials such as plastics.Separate with spacer block 103 between each detection zone on the test paper, overlayer sticks on detection zone and the spacer block.Described spacer block is non-hydrophilic material, has so just prevented the cross pollution between the reagent piece in the different detection zones.In one embodiment, there is spacer block the both sides of each reagent piece, and described spacer block is non-hydrophilic viscosity material, and the two ends of overlayer 102 are overlapped on outmost two spacer blocks 103, on the spacer block in the middle of the overlayer center section sticks to.
Can effectively press effect to the detection zone generation at one deck overlayer 102 that test paper adheres to, so that the upper surface of all detection zones remains on the identical surface level.When test paper was clamped between loam cake and the base plate, overlayer 102 had formed a uniform liquid transfer passage 8 of cavity with flow-guiding structure 7, also be the different parts of test paper with distance between the flow-guiding structure was identical.As shown in Figure 8, after sample drop is added in well, at the both sides Transmit evenly of liquid transfer passage 8 interior liquid to pick-up unit, and arrive on each detection zone by overlayer.After sample arrives detection zone, thereby finish test reaction with vertical spread mode transmit fluid sample again.Because sample is at the uniform velocity transmitted, so the time of reading of test result is just controlled.
In one embodiment, the mesh material of processing this overlayer or selecting specific dimensions with specific chemical reagent is as overlayer, and overlayer can also play the effect of filtered sample impurity.
For better transmit fluid sample, flow-guiding structure surface or overlayer or above-mentioned both process with hydroaropic substance in advance.
Among the embodiment shown in Fig. 1, Fig. 5 and Fig. 9 to 12, on pick-up unit, also comprise the arrangement for adjusting height that pick-up unit and detector are adaptive.At least one face of described arrangement for adjusting height is the lofty perch of pick-up unit and detector or to low spot.Insert in the detector process at pick-up unit, the height of arrangement for adjusting height can shorten, and has reduced pick-up unit and has inserted the height at position, successfully enters in the detector in detector size situation less than normal guaranteeing.Arrangement for adjusting height can be the elastomeric element of making of resilient material, also can be the retractable member that combines by physical construction.Arrangement for adjusting height as shown in Figure 5 is an arch-shaped elastomeric element 20.Arrangement for adjusting height shown in Fig. 9 to 10 is the elastomeric element 21 of a spheroidal.Arrangement for adjusting height can be assemblied in the positions such as the loam cake, base plate of pick-up unit.
Among the embodiment, flank 30 is extended in the outer peripheral both sides of base plate as shown in Figure 5, and flank is inserted into pick-up unit in the detector along detector draw-in groove 210, until pick-up unit arrives locating of detector.In this embodiment, flank is discontinuous, and arch-shaped elastomeric element 20 is across between the flank of two homonymies.At least one face of described arch bridge type elastomeric element 20 is the lofty perch that contacts with detector of pick-up unit or to low spot.Insert in the detecting instrument process at pick-up unit, described elastomeric element can be extruded, and reduces the height that pick-up unit inserts the position, to guarantee successfully to enter detecting instrument and fastening being placed in the detecting instrument in detector size situation less than normal.
Such as Figure 11 and shown in Figure 13, size on the detector after draw-in groove 210 processing of receiving detection device is measure-alike with in advance design, namely in not compressed situation, the top of pick-up unit arch bridge type elastomeric element 20 is just in time identical with the height H of detector draw-in groove to the height of base plate bottom surface.Detector draw-in groove height H refers to the distance between detector two clamping groove plates 211 opposite faces.Therefore pick-up unit does not need just can enter smoothly in the draw-in groove 210 of detector by the distortion of arch-shaped elastomeric element 20.The size of the draw-in groove 210 of receiving detection device is less than the size of in advance design on the detector shown in Figure 12 and 14, and namely the distance h between the detector draw-in groove two card behaviour plates was than accurate distance H hour of Figure 11.The described pick-up unit of this Figure 12 utility model can be subjected to the crimp of card behaviour plate by elastomeric element, thereby reduces the elastomeric element top to the height of base plate bottom surface, so that pick-up unit can successfully enter in the size detector draw-in groove 210 less than normal.And the pick-up unit of prior art shown in Figure 14 just can not enter the detector draw-in groove.Otherwise, larger than the size of in advance design if the processing technology of pick-up unit is not accurate, then can pick-up unit 1 successfully be inserted in the detector by the method for elasticity of compression parts too.
The detection of a series of physiological and biochemical indexs such as pick-up unit described in the utility model can be used for glucose, cholesterol, high density fat is sour, low density fat is sour, triglyceride, uric acid, cholerythrin, total protein, haemoglobin, ketoboidies.

Claims (10)

1. pick-up unit, comprise: loam cake, the base plate that combines with loam cake and the test paper between loam cake and base plate, it is characterized in that: test paper comprises at least two detection zones and the overlayer that is connected with these at least two detection zones, loam cake comprises upper surface and lower surface and runs through, the well of lower surface, the lower surface of loam cake is relative with the overlayer of test paper, loam cake is provided with flow-guiding structure at the lower surface place, at the well of loam cake, described flow-guiding structure, form fluid transfer between the overlayer of test paper and described at least two detection zones.
2. pick-up unit according to claim 1, it is characterized in that: described flow-guiding structure comprises the groove that is arranged on surface under the loam cake, forms roughly uniform liquid transfer chamber of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.
3. pick-up unit according to claim 1, it is characterized in that: described flow-guiding structure comprises the enclosing wall that is arranged on surface under the loam cake, be provided with groove in the enclosing wall, form roughly uniform liquid transfer chamber of a cross sectional dimensions between the contoured surface of described groove and the overlayer of test paper.
4. according to claim 2 or 3 described pick-up units, it is characterized in that: groove wide is the 0.1-2 millimeter, and the degree of depth is the 0.01-0.5 millimeter.
5. pick-up unit according to claim 4, it is characterized in that: the width of groove is 1 millimeter, the degree of depth is 0.3 millimeter.
6. pick-up unit according to claim 1, it is characterized in that: at least two detection zones on the test paper include respectively the reagent piece, and described overlayer is positioned at the top of reagent piece.
7. pick-up unit according to claim 1, it is characterized in that: separate with spacer block between each detection zone on the test paper, overlayer sticks on detection zone and the spacer block.
8. pick-up unit according to claim 1 is characterized in that: flow-guiding structure is across at least two detection zones on test paper, and described overlayer and flow-guiding structure form the uniform liquid transfer of a cavity chamber.
9. pick-up unit according to claim 1 is characterized in that: also comprise exhausr port on the base plate.
10. pick-up unit according to claim 1 is characterized in that: flow-guiding structure surface or overlayer or above-mentioned both with including hydroaropic substance.
CN 201220201240 2012-05-08 2012-05-08 Detection device Ceased CN202693582U (en)

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Application Number Priority Date Filing Date Title
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102680672A (en) * 2012-05-08 2012-09-19 艾康生物技术(杭州)有限公司 Detection device
CN107219170A (en) * 2017-07-24 2017-09-29 苏州鼎实医疗科技有限公司 Analoids
CN109512398A (en) * 2018-12-26 2019-03-26 长春市亿健科技有限公司 Test paper
CN109917142A (en) * 2019-04-01 2019-06-21 北京怡成生物电子技术股份有限公司 A kind of blood sample multi objective translocation cartridge

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102680672A (en) * 2012-05-08 2012-09-19 艾康生物技术(杭州)有限公司 Detection device
CN102680672B (en) * 2012-05-08 2015-02-11 艾康生物技术(杭州)有限公司 Detection device
CN107219170A (en) * 2017-07-24 2017-09-29 苏州鼎实医疗科技有限公司 Analoids
CN107219170B (en) * 2017-07-24 2023-09-19 苏州鼎实医疗科技有限公司 Reagent tablet
CN109512398A (en) * 2018-12-26 2019-03-26 长春市亿健科技有限公司 Test paper
CN109917142A (en) * 2019-04-01 2019-06-21 北京怡成生物电子技术股份有限公司 A kind of blood sample multi objective translocation cartridge

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