CN202682564U - Full-time high-voltage steep pulse cancer therapeutic apparatus - Google Patents
Full-time high-voltage steep pulse cancer therapeutic apparatus Download PDFInfo
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- CN202682564U CN202682564U CN 201220246559 CN201220246559U CN202682564U CN 202682564 U CN202682564 U CN 202682564U CN 201220246559 CN201220246559 CN 201220246559 CN 201220246559 U CN201220246559 U CN 201220246559U CN 202682564 U CN202682564 U CN 202682564U
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Abstract
The utility model relates to a full-time high-voltage steep pulse cancer therapeutic apparatus which comprises a switch power source, a pulse generator, a tail cut switch, a load electrode with an endoscope, an oscilloscope, a cable, an optical fiber, a computer and relevant accessories. The load electrode comprises a titaniferous platinum electrode, the switch power source is composed of a switch and a driver, the switch of the switch power source is connected with an input end of the pulse generator, an output end of the pulse generator is connected with the load electrode through a wire, the optical fiber or the cable, and by means of the cable, the optical fiber or the cable, the output end of the pulse generator is sequentially connected with a switch device, the oscilloscope and the load electrode. The pulse generator comprises a high-voltage nanosecond square-wave pulse generator based on field programmable gate array (FPGA) control.
Description
Technical field
The present invention relates to a kind of medical therapy instrument, being used for the treatment of benign tumor and malignant tumor is the medical therapy instrument of cancer, also can be used for the auxiliary treatment of the treatment of other diseases.
Background technology
Malignant tumor has become the very high disease of mortality rate.Existing technology of cancer treatment method mainly is chemotherapy, gene therapy, Chinese traditional treatment and therapy of combining Chinese and Western medicine, gene therapy, ultrasonic therapy and Drug therapy, and take chemotherapy as main technique methods, chemotherapy is because of its high medical expense and huge side effect, allows most cancer patient's abandoning cure.And the HIB treatment cancer of Chinese Academy of Sciences's Contemporary Physics institute invention, technology maturation, respond well, effective for most middle and terminal cancer patient treatment, previous experiments show through after the treatment late period the patient of general headquarters without the recurrence symptom, but the investment of this equipment and auxiliary facility is up to more than 1,000,000,000 yuan, equipment is huge, manufacturing cycle is long, is unfavorable for promoting.These treatment technologies all can not or be difficult to the fundamentally diffusion of kill cancer cell and anticancer, and the side effect of chemotherapy is larger for patient's somatic damage, and medical expense is high.According to utilizing irreversible electric capacity hole steep-sided pulse technology treatment tumor, experiment shows that the treatment tumor effect is good, this but to plant the electronic and electrical equipment of key problem in technology device pulse generator complicated, complex manufacturing technology, the porch of the pulse that produces is precipitous not, and the top is uneven.
The pulse generator technology is ripe producing, uses comprehensively.Existing based on the high-voltage pulse therapeutic equipment, the device and method that comprises the irreversible electroporation oncotherapy of application number 20101054616.7 patents of University Of Chongqing, the pulse that produces under these technical conditions is the us microsecond pulse, present medical experiment shows that microsecond pulse is not remarkable to the effect of optimum and treating malignant tumor; And patent documentation application number to be 201110195350.4 the solid high-voltage based on FPGA control the receive disclosed technology of square-wave pulse generator, the nanosecond pulse ripple that produces still can also carry out the steepness in a step.Modern high-voltage pulse technology research and experiment show, the high-voltage pulse that produces by switch or switching device paired pulses generator carries out truncation or tail is cut, further steepness high-voltage pulse ripple tailing edge.
Summary of the invention
The present invention is directed to above-mentioned technological deficiency, carry out secondary or repeatedly truncation steepness by using switching device that high pressure microsecond, millimicrosecond pulse generator are produced pulse square wave, thereby produce high-voltage nanosecond, the picopulse square wave of the more steepness after tail is cut, utilize this high-voltage pulse ripple by the medical electrode load discharge, carry out the treatment that effective oncotherapy, particularly malignant tumor are cancer.
Technical solution of the present invention: cut the pass tail by pulse tail and cut microsecond, the pulse that millimicrosecond pulse generator produces and steeper nanosecond of forming, the psec high-voltage pulse, the kill tumor cell is malignant cell particularly, capacitor and tail by clamp-pulse generator cut the pass, amplitude that can paired pulses, pulsewidth, the parameters such as pulse back edge are adjusted, its Component units mainly comprises Switching Power Supply, pulse generator, tail cuts and closes, electrode with endoscope, oscillograph, cable, optical fiber, computer and related accessory, described load electrode comprises the titaniferous platinum electrode, and described Switching Power Supply is made of switch and driver; Civil power by the switch of cable or wire by described Switching Power Supply and pulse generator input be connected, the outfan of pulse generator is connected with load by wire, optical fiber or cable, the outfan of described pulse generator cable, optical fiber or cable, after switching device is connected, and after being connected, oscillograph is connected with load again.A kind of all the period of time high pressure steep-sided pulse cancer treating instrument, it is characterized in that: mainly comprise Switching Power Supply, pulse generator, tail cuts and closes, load electrode with endoscope, oscillograph, cable, optical fiber, computer and related accessory, described load electrode comprises the titaniferous platinum electrode, described Switching Power Supply is made of switch and driver, the switch of described Switching Power Supply and pulse generator input be connected, the outfan of pulse generator passes through wire, optical fiber or cable are connected with described load electrode, the outfan cable of described pulse generator, optical fiber or cable, after switching device is connected, and after being connected, oscillograph is connected with load electrode again.
DescribedPulse generator comprise high-voltage nanosecond squarer based on FPGA control, mainly comprise power-supply system, pulse shaping system, impulsive measurement system, FPGA control system, signal translating system, computer or with the computer interface and the unit unit chip based on the high-voltage nanosecond squarer of FPGA control.
Described high pressure based on FPGA control is received the principle of square-wave pulse generator generator and is based on Marx generator, by to one group or the charging of multistage a plurality of Parallel-connected Capacitor, then by a plurality of derailing switch devices the pulse of capacitances in series discharge generation is repeatedly obtained needed high-voltage nanosecond, psec square-wave pulse after the copped wave.Have several tails to cut between load and the Marx generator pulse output end and close device, each tail cuts to close on device driver, and under the control of driver, tail cuts that putting into works leads and disconnect, and cuts thereby the paired pulses ripple carries out tail.Operator are by computer program user interface or single-chip microcomputer panel, the paired pulses generator arranges the parameters such as output amplitude, pulse width, pulse frequency and pulse number, transmits control signal to pulse shaping system and HVDC module by the Signal permuting system behind the module arithmetic You of FPGA control system.Thereby pulse width, pulse frequency and pulse number that the HVDC module is set according to operator carry out width, frequency and the pulse number of switch motion control output pulse.The output processing that potentiometer in the impulsive measurement system measures or load place pulse voltage, by sending to the FPGA control system after the processing circuit processes, regulate in real time charging voltage, can make so high-voltage nanosecond, psec square-wave pulse that the constant default amplitude of output is set; Current sensor measurement sends to the FPGA control system to the pulsed current signal of output place or load place after by processing circuit processes; when surpassing the current signal of setting; carry out the delay judgement lock control signal by the FPGA control system; the work of the switching device work in the shutoff pulse shaping system and the truncation switching device of load front end; turn-off pulse forms circuit and load electrode discharge circuit; realize the protection of whole device, and protect user, patient's safety.Described switching device or truncation switching device comprise gas switch, solid-state switch and liquid switch, and preferred solid-state switch, switching device or tail cut that the quantity of closing device comprises or more than one.
Described power-supply system comprises power supply, switch and switch driver, isolating transformer (voltage, frequency change are 1:1), HVDC module, Switching Power Supply T1, Switching Power Supply T2, DC-DC module.The electric current of described power supply is the 220V civil power, but be connected with the former limit of isolating transformer by the switch of wire cable by tape drive, and the secondary of isolating transformer is connected by the input of wire with the HVDC module, is used to the HVDC module that alternating current power supply is provided; Switch one end of tape drive draws power supply, and an end connects isolating transformer, and the control of the driver of this switch is connected by the output of the light in wire or optical fiber and the described signal translating system/electric transducer K2.Described HVDC module comprises that output ceiling voltage amplitude 2000V, maximum current amplitude are the commercial module of direct current of 40mA, the outfan of HVDC module is connected with the input of the Marx circuit of pulse shaping system after by the charging isolation resistance series connection of wire and pulse shaping system again, is used to the energy-storage capacitor group in the Marx circuit of pulse shaping system that charge power supply is provided.The earth lead on the former limit of described isolating transformer directly is not connected with the earth lead of secondary, described power supply and described HVDC module are isolated, their different the earth are connected, greatly reduced the various interfering signals of coming arrogantly, improve Systems balanth.The commercial element of described Switching Power Supply T1() input is connected with the power supply of book by wire, after described power supply T1 is replaced into the DC current of 15V with the 220V alternating current, be connected by the input of wire with the DC-DC module of book, the input of this DC-DC module by the switch driver of the switch driver in the Marx circuit of wire and pulse shaping system is connected the driver of closing and is connected with tail, for above-mentioned driver provides power supply, horizontal high voltage, the low pressure light current isolation between pressing of going forward side by side is to ensure the safety of whole system.Described Switching Power Supply T2 is that its input of commercial element is connected with described power supply by wire, after described Switching Power Supply T2 is converted to the 5V unidirectional current with the 220V alternating current power supply, respectively by the FPGA module in wire and the FPGG control system, one-chip computer module (or single-chip microcomputer), two electric to optic converter J1 of alarm module and Signal permuting system, J2 and two light/electric transducer K1, the input of K2, be used to described FPGA module, one-chip computer module (or single-chip microcomputer), alarm module and above-mentioned several transducers provide power supply, power-supply system is the pulse shaping system by above-mentioned working method, FPGA control system and signal translating system provide the power supply of safety and stability, ensure its normal operation.
Described pulse shaping system comprises charging isolation resistance, Marx circuit and load.
One end of charging isolation resistance is connected with the outfan of above-mentioned HVDC module, be used for current limliting and Marx's high pressure and the buffer action between the charging DC Module power supply low pressure of performance charging, the other end of charging isolation resistance is connected by the positive pole of wire with the bypass diode of the first order voltage cell of Marx circuit.Described Marx circuit is comprised of the voltage cell with the bypass diode that 4～10 or (or as required several) are connected on the electroplax motherboard, and the quantity of voltage cell can be determined as required.Each voltage cell comprises terminal full solid-state switch, switch driver, energy-storage capacitor, bypass diode, diode; In each voltage cell, the negative pole of bypass diode is connected parallel connection point by wire or cable and terminal full solid-state switch and is connected with capacitor, and the grid of terminal full solid-state switch is connected with the outfan of switch driver by wire; Switch driver is connected the input that closes driver and is connected by the outfan of wire with the DC-DC module of described power-supply system with tail.The driver of the switch between power supply and the isolating transformer, the switch driver in the Marx circuit be connected with tail close the drivers such as driver control end, be connected by the second light in wire and the described signal translating system/electric transducer K2, under the effect of this second light/electric transducer K2, above-mentioned switch and tail cut to close and open-turn-off; The other end of energy-storage capacitor is with after the positive pole of diode is connected, and is in parallel with terminal full solid-state switch.When terminal full solid-state switch disconnects, bypass diode and diode admittance, the energy-storage capacitor group is carried out charged in parallel; When the terminal full solid-state switch admittance was opened, diode and bypass diode oppositely ended, and the energy-storage capacitor that has been filled to predeterminated voltage cuts to close by tail with series system load is discharged, and tail cuts to close discharge pulse is carried out back-end crop; Control capacitor is cut the pass to pulsewidth and the adjusting tail of load discharge, can obtain the high-voltage nanosecond or the psec square wave that need; When terminal full solid-state switch disconnects, fill again capacitor is charged, so repeatedly.When one or more terminal full solid-state switchs lost efficacy, then bypass diode and diode admittance and auto by pass this one or more voltage cell, all the other voltage cell still can work, thus total system still can discharge nanosecond, the psec square wave of needs.Described load is the noninductive resistance load, is connected in parallel on the outfan of Marx circuit by wire, and this outfan is connected with the impulsive measurement system by wire with the junction of load.
[0009] described impulsive measurement system comprises potentiometer, current sensor and treatment circuit.The input of described potentiometer is connected with the end that goes out of described pulse shaping system by wire, the outfan of described potentiometer is connected with the input for the treatment of circuit by wire, for the pulse voltage signal of the Marx circuit generation of monitoring the pulse shaping system of writing.The input of described current sensor is connected by the outfan of wire with described pulse shaping system, the outfan of described power sensor is connected with the input for the treatment of circuit, is used for the pulsed current signal of the Marx circuit generation of monitoring pulse shaping system.The outfan of described treatment circuit is connected by the input of wire with the FPGA module of the FPGA control system of book.Go out described Marx circuit to the discharge condition information of book load by FPGA control system computing post-processing detection, comprise that pulse voltage cut the information of end of line before and after cutting of putting into by tail.
Described FPGA control system comprises brilliant idea FPGA module and synchronous trigger module and one-chip computer module and alarm module.Described FPGA module receives the voltage and current signal of high-voltage pulse of Marx circuit output of the described pulse shaping system of the monitoring that comes from the treatment circuit transmission of described measuring system, comprise through tail and cut the pulse voltage current signal that closes after tail is cut, through after the calculation process, on the one hand, described FPGA module is carried out exchanges data by wire and described one-chip computer module; On the other hand, above-mentioned FPGA module is connected with the input of described synchronous trigger module by wire, the outfan of described synchronous trigger module passes through optical fiber, the second electric to optic converter J2 and the second light/electric transducer K2 through signal translating system, with according to the control end of the switch driver of the Marx circuit of the driver of the switch of isolating transformer, described pulse shaping system and each tail cut the driver of closing control end be connected, avoid being subject to the interference of the high pressure of described pulse shaping system, guarantee the stable and synchronicity of synchronous start pulse signal.Described alarm module is connected with described FPGA module by wire, pulse current when load output, when surpassing the electric current of setting, above-mentioned FPGA module is carried out behind the delay judgement sending the signal enabling driver by synchronous trigger module, electric light conversion J2 and optical-electrical converter K2 and is cut off switch between isolating transformer and the power supply, send simultaneously alarm signal, prompting staff or operator cut off the electricity supply, thereby guarantee this pulse generator and operator's safety.Described one-chip computer module passes through optical fiber, through the first electric to optic converter J1 of signal translating system be connected light/electricity conversion K1 and be connected with the control end of the HVDC module of the power-supply system of writing, the control signal to described HVDC module that described FPGA control system is sent converts optical signal to and transmits, the high pressure that fiber-optic transfer can be avoided being subject to the pulse shaping system disturbs, control described HVDC module and charge normal to described energy-storage capacitor group, guarantee that the square wave pulse voltage amplitude arrives setting value.The major function of described FPGA controller system is to realize man-machine communication by computer or unit, send HVDC module, Marx circuit control signal, receive the measuring-signal that described impulsive measurement system obtains, control the work of whole pulse generator and therapeutic instrument, and process burst accident.
Described computer is commercial computer, hard disk is more than 320G, more than the internal memory 2G, the Duo Processor i5-460M of Intel, the above operating system of WIINDOWS XP, this computer expert crosses serial cable and is connected with single-chip microcomputer or the one-chip computer module of described FPGA control system, and user interface or the single-chip microcomputer display floater parameters, program of operator by computer program sends to described FPGA control system, thereby realize man-machine mutual trust.
Described high-voltage nanosecond pulse generator based on FPGA control, the pulse amplitude of output is 0～10kV, pulse width is that 200～1000ns, pulse frequency are 1～1000Hz, trailing edge is 0.2ns ~ 40ns, pulse number is 1～1000, and design parameter can be determined beneficial effect of the present invention according to needs such as related neoplasms treatments: the 1st, use safe and convenient, the intelligent design of automatization is possessed effect and has been ensured the personal safety of user and the safety of equipment itself.
Compare with traditional ICA device, structural units for ease of maintenaince safeguards.
Fiber-optic signal transmission, effective isolation that can strong and weak electricity ensures that the signal transmission is not disturbed by the electric current high pressure, the stable signal transmission fidelity.
Compact equipment, the non-inductive resistance load, Effective Raise rushes steepness.
The parameter of needed coherent pulse can be set within the specific limits, and the scope of application of equipment is provided, and can improve electric pulse to the tumor therapeutic effect of malignant tumor particularly.
The present invention can be widely used in the particularly treatment of malignant tumor of tumor, and the application of the aspect such as other physics, biology, medical.
Description of drawings
One of Fig. 1 enforcement schematic diagram;
One of Fig. 2 enforcement Marx circuit topological diagram;
One of Fig. 3 enforcement pulse is the back-end crop oscillogram not;
Fig. 4 Pulse Cut tail circuit topological diagram;
Fig. 5 invention sketch map;
One of Fig. 6 enforcement has tail to cut the pass and anury is cut switching pulse comparison of wave shape figure.
Among the figure: 1 power-supply system, 2 pulse shaping systems, 3 impulsive measurement systems, 4 FPGA control system, 5 signal translating systems, 6 computers or portable computer, 7 mark's circuit, 8 circuit units, the Rc isolation resistance that charges, C1 ~ C8 capacitor, D1 ~ D16 diode, S1 ~ S8 and Sa ~ Sb switch or terminal full solid-state switch, G1 ~ G8 and Ga, Gb switch driver.In Fig. 5, the switch of S1 tape drive, I1 are the pulse generator input current, and I2 is pulse generator output pulse current.
The specific embodiment
Its Component units of the present invention mainly comprises power supply, Switching Power Supply, pulse generator, truncation switch, the electrode with endoscope, oscillograph, cable, optical fiber, computer and related accessory.Described load electrode comprises the titaniferous platinum electrode.Technical solution of the present invention: by nanosecond, psec high-voltage pulse that pulse generator produces, the kill tumor cell is malignant cell particularly.Its Component units comprises that mainly power supply, Switching Power Supply, pulse generator, tail cut pass, the electrode with endoscope, oscillograph, cable, optical fiber, computer and related accessory, and described load electrode comprises the titaniferous platinum electrode.Described Switching Power Supply is made of switch and driver.Power supply by the switch of cable or wire by described Switching Power Supply and pulse generator input be connected, the outfan of pulse generator is connected with load by wire, optical fiber or cable, the outfan of described pulse generator cable, optical fiber or cable, after switching device is connected, and after being connected, oscillograph is connected with load again.When being used for oncotherapy, tumor locus is through routine disinfection or after performing the operation, under the guiding of the imaging devices such as B ultrasonic, degree according to tumor, set the coherent pulse amplitude, the parameters such as pulsewidth, load electrode is placed on tumor surface or thrusts tumor locus, by the nanosecond of the present invention's generation, the psec high-voltage pulse, inducing tumor cell is transferred and is died and the kill tumor cell, dead tumor cell is discharged outside the body by urine through the human body metabolism, optimum or the pernicious thin tumor born of the same parents of apoptosis are then eaten by its healthy cell nearby, thereby reach the purpose of effective treatment tumor.
One of embodiment: describedPulse generator comprise high-voltage nanosecond squarer based on FPGA control, mainly comprise 1 power-supply system, 2 pulse shaping systems, impulsive measurement system, FPGA control system, signal translating system and computer or with the computer interface and the unit unit chip based on the high-voltage nanosecond squarer of FPGA control;
The principle of described high-voltage nanosecond squarer generator based on FPGA control is based on Marx generator, by to one group or the charging of multistage a plurality of Parallel-connected Capacitor, then by a plurality of derailing switch devices the pulse of capacitances in series discharge generation is repeatedly obtained needed high-voltage nanosecond, psec square-wave pulse after the copped wave.Have several tails to cut between load and the Marx generator pulse output end and close device, each tail cuts to close on device driver, and under the control of driver, tail cuts that putting into works leads and disconnect, and cuts thereby the paired pulses ripple carries out tail.Operator are by computer program user interface or single-chip microcomputer panel, the paired pulses generator arranges the parameters such as output amplitude, pulse width, pulse frequency and pulse number, transmits control signal to pulse shaping system and HVDC module by the Signal permuting system behind the module arithmetic You of FPGA control system.Thereby pulse width, pulse frequency and pulse number that the HVDC module is set according to operator carry out width, frequency and the pulse number of switch motion control output pulse.The output processing that potentiometer in the impulsive measurement system measures or load place pulse voltage, by sending to the FPGA control system after the processing circuit processes, regulate in real time charging voltage, can make so high-voltage nanosecond, psec square-wave pulse that the constant default amplitude of output is set; Current sensor measurement sends to the FPGA control system to the pulsed current signal of output place or load place after by processing circuit processes; when surpassing the current signal of setting; carry out the delay judgement lock control signal by the FPGA control system; the work of the switching device work in the shutoff pulse shaping system and the truncation switching device of load front end; turn-off pulse forms circuit and load electrode discharge circuit; realize the protection of whole device, and protect user, patient's safety.Described switching device or truncation switching device comprise gas switch, solid-state switch and liquid switch, and preferred solid-state switch, switching device or tail cut that the quantity of closing device comprises or more than one;
Described power-supply system comprises power supply, switch and switch driver, isolating transformer (voltage, frequency change are 1:1), HVDC module, Switching Power Supply T1, Switching Power Supply T2, DC-DC module.The electric current of described power supply is the 220V civil power, but be connected with the former limit of isolating transformer by the switch of wire cable by tape drive, and the secondary of isolating transformer is connected by the input of wire with the HVDC module, is used to the HVDC module that alternating current power supply is provided; Switch one end of tape drive draws power supply, and an end connects isolating transformer, and the control of the driver of this switch is connected by the output of the light in wire or optical fiber and the described signal translating system/electric transducer K2.Described HVDC module comprises that output ceiling voltage amplitude 2000V, maximum current amplitude are the commercial module of direct current of 40mA, the outfan of HVDC module is connected with the input of the Marx circuit of pulse shaping system after by the charging isolation resistance series connection of wire and pulse shaping system again, is used to the energy-storage capacitor group in the Marx circuit of pulse shaping system that charge power supply is provided.The earth lead on the former limit of described isolating transformer directly is not connected with the earth lead of secondary, described power supply and described HVDC module are isolated, their different the earth are connected, greatly reduced the various interfering signals of coming arrogantly, improve Systems balanth.The commercial element of described Switching Power Supply T1() input is connected with the power supply of book by wire, after described power supply T1 is replaced into the DC current of 15V with the 220V alternating current, be connected by the input of wire with the DC-DC module of book, the input of this DC-DC module by the switch driver of the switch driver in the Marx circuit of wire and pulse shaping system is connected the driver of closing and is connected with tail, for above-mentioned driver provides power supply, horizontal high voltage, the low pressure light current isolation between pressing of going forward side by side is to ensure the safety of whole system.Described Switching Power Supply T2 is that its input of commercial element is connected with described power supply by wire, after described Switching Power Supply T2 is converted to the 5V unidirectional current with the 220V alternating current power supply, respectively by the FPGA module in wire and the FPGG control system, one-chip computer module (or single-chip microcomputer), two electric to optic converter J1 of alarm module and Signal permuting system, J2 and two light/electric transducer K1, the input of K2, be used to described FPGA module, one-chip computer module (or single-chip microcomputer), alarm module and above-mentioned several transducers provide power supply, power-supply system is the pulse shaping system by above-mentioned working method, FPGA control system and signal translating system provide the power supply of safety and stability, ensure its normal operation;
Described pulse shaping system comprises charging isolation resistance, Marx circuit and load, one end of charging isolation resistance is connected with the outfan of above-mentioned HVDC module, be used for current limliting and Marx's high pressure and the buffer action between the charging DC Module power supply low pressure of performance charging, the other end of charging isolation resistance is connected by the positive pole of wire with the bypass diode of the first order voltage cell of Marx circuit.Described Marx circuit is comprised of the voltage cell with the bypass diode that 4～10 or (or as required several) are connected on the electroplax motherboard, and the quantity of voltage cell can be determined as required.Each voltage cell comprises terminal full solid-state switch, switch driver, energy-storage capacitor, bypass diode, diode; In each voltage cell, the negative pole of bypass diode is connected parallel connection point by wire or cable and terminal full solid-state switch and is connected with capacitor, and the grid of terminal full solid-state switch is connected with the outfan of switch driver by wire; Switch driver is connected the input that closes driver and is connected by the outfan of wire with the DC-DC module of described power-supply system with tail.The driver of the switch between power supply and the isolating transformer, the switch driver in the Marx circuit be connected with tail close the drivers such as driver control end, be connected by the second light in wire and the described signal translating system/electric transducer K2, under the effect of this second light/electric transducer K2, above-mentioned switch and tail cut to close and open-turn-off; The other end of energy-storage capacitor is with after the positive pole of diode is connected, and is in parallel with terminal full solid-state switch.When terminal full solid-state switch disconnects, bypass diode and diode admittance, the energy-storage capacitor group is carried out charged in parallel; When the terminal full solid-state switch admittance was opened, diode and bypass diode oppositely ended, and the energy-storage capacitor that has been filled to predeterminated voltage cuts to close by tail with series system load is discharged, and tail cuts to close discharge pulse is carried out back-end crop; Control capacitor is cut the pass to pulsewidth and the adjusting tail of load discharge, can obtain the high-voltage nanosecond or the psec square wave that need; When terminal full solid-state switch disconnects, fill again capacitor is charged, so repeatedly.When one or more terminal full solid-state switchs lost efficacy, then bypass diode and diode admittance and auto by pass this one or more voltage cell, all the other voltage cell still can work, thus total system still can discharge nanosecond, the psec square wave of needs.Described load is the noninductive resistance load, is connected in parallel on the outfan of Marx circuit by wire, and this outfan is connected with the impulsive measurement system by wire with the junction of load;
Described impulsive measurement system comprises potentiometer, current sensor and treatment circuit; The input of described potentiometer is connected with the end that goes out of described pulse shaping system by wire, the outfan of described potentiometer is connected with the input for the treatment of circuit by wire, for the pulse voltage signal of the Marx circuit generation of monitoring the pulse shaping system of writing.The input of described current sensor is connected by the outfan of wire with described pulse shaping system, the outfan of described power sensor is connected with the input for the treatment of circuit, is used for the pulsed current signal of the Marx circuit generation of monitoring pulse shaping system.The outfan of described treatment circuit is connected by the input of wire with the FPGA module of the FPGA control system of book.Go out described Marx circuit to the discharge condition information of book load by FPGA control system computing post-processing detection, comprise that pulse voltage cut the information of end of line before and after cutting of putting into by tail.
Described FPGA control system comprises brilliant idea FPGA module and synchronous trigger module and one-chip computer module and alarm module.Described FPGA module receives the voltage and current signal of high-voltage pulse of Marx circuit output of the described pulse shaping system of the monitoring that comes from the treatment circuit transmission of described measuring system, comprise through tail and cut the pulse voltage current signal that closes after tail is cut, through after the calculation process, on the one hand, described FPGA module is carried out exchanges data by wire and described one-chip computer module; On the other hand, above-mentioned FPGA module is connected with the input of described synchronous trigger module by wire, the outfan of described synchronous trigger module passes through optical fiber, the second electric to optic converter J2 and the second light/electric transducer K2 through signal translating system, with according to the control end of the switch driver of the Marx circuit of the driver of the switch of isolating transformer, described pulse shaping system and each tail cut the driver of closing control end be connected, avoid being subject to the interference of the high pressure of described pulse shaping system, guarantee the stable and synchronicity of synchronous start pulse signal.Described alarm module is connected with described FPGA module by wire, pulse current when load output, when surpassing the electric current of setting, above-mentioned FPGA module is carried out behind the delay judgement sending the signal enabling driver by synchronous trigger module, electric light conversion J2 and optical-electrical converter K2 and is cut off switch between isolating transformer and the power supply, send simultaneously alarm signal, prompting staff or operator cut off the electricity supply, thereby guarantee this pulse generator and operator's safety.Described one-chip computer module passes through optical fiber, through the first electric to optic converter J1 of signal translating system be connected light/electricity conversion K1 and be connected with the control end of the HVDC module of the power-supply system of writing, the control signal to described HVDC module that described FPGA control system is sent converts optical signal to and transmits, the high pressure that fiber-optic transfer can be avoided being subject to the pulse shaping system disturbs, control described HVDC module and charge normal to described energy-storage capacitor group, guarantee that the square wave pulse voltage amplitude arrives setting value.The major function of described FPGA controller system is to realize man-machine communication by computer or unit, send HVDC module, Marx circuit control signal, receive the measuring-signal that described impulsive measurement system obtains, control the work of whole pulse generator and therapeutic instrument, and process burst accident.
Described computer is common commercial computer, hard disk is more than 320G, more than the internal memory 2G, the Duo Processor i5-460M of Intel, the above operating system of WIINDOWS XP, this computer expert crosses serial cable and is connected with single-chip microcomputer or the one-chip computer module of described FPGA control system, and operator send to described FPGA control system by user interface or the single-chip microcomputer display floater parameters inverted order of computer program, thereby realize man-machine mutual trust.
Described high-voltage nanosecond pulse generator based on FPGA control, the pulse amplitude of output is 0～10kV, pulse width is that 200～1000ns, pulse frequency are 1～1000Hz, trailing edge is 0.2ns ~ 40ns, pulse number is 1～1000, and design parameter can be determined according to needs such as related neoplasms treatments.Described switch, tail cut to close and comprise solid-state switch, gas switch and liquid switch, and described liquid switch comprises taps.
Claims (1)
- One kind all the period of time high pressure steep-sided pulse cancer treating instrument, it is characterized in that: mainly comprise Switching Power Supply, pulse generator, tail cuts and closes, load electrode with endoscope, oscillograph, cable, optical fiber, computer and related accessory, described load electrode comprises the titaniferous platinum electrode, described Switching Power Supply is made of switch and driver, the switch of described Switching Power Supply and pulse generator input be connected, the outfan of pulse generator passes through wire, optical fiber or cable are connected with described load, the outfan cable of described pulse generator, optical fiber or cable, after switching device is connected, and after being connected, oscillograph is connected with load again;(1) DescribedPulse generator comprise high-voltage nanosecond squarer based on FPGA control, mainly comprise power-supply system, pulse shaping system, impulsive measurement system, FPGA control system, signal translating system, computer or with the computer interface and the unit unit chip based on the high-voltage nanosecond squarer of FPGA control;(2) described power-supply system comprises power supply, switch and switch driver, isolating transformer, HVDC module, Switching Power Supply T1, Switching Power Supply T2, DC-DC module; Described power supply is the 220V civil power, but be connected with the former limit of isolating transformer by the switch of wire cable by tape drive, and the secondary of isolating transformer is connected by the input of wire with the HVDC module, is used to the HVDC module that alternating current power supply is provided; Switch one end of tape drive connects power supply, and an end connects isolating transformer, and the control of the driver of this switch is connected by the output of the light in wire or optical fiber and the described signal translating system/electric transducer K2; Described HVDC module comprises that output ceiling voltage amplitude 2000V, maximum current amplitude are the commercial module of direct current of 40mA, the outfan of HVDC module is connected with the input of the Marx circuit of pulse shaping system after by the charging isolation resistance series connection of wire and pulse shaping system again, is used to the energy-storage capacitor group in the Marx circuit of pulse shaping system that charge power supply is provided; The earth lead on the former limit of described isolating transformer directly is not connected with the earth lead of secondary, described power supply and described HVDC module are isolated, their different the earth are connected, greatly reduced the various interfering signals of coming arrogantly, improve Systems balanth; The input of described Switching Power Supply T1 is connected with the power supply of book by wire, after described power supply T1 is replaced into the DC current of 15V with the 220V alternating current, be connected by the input of wire with the DC-DC module of book, the input of this DC-DC module by the switch driver of the switch driver in the Marx circuit of wire and pulse shaping system is connected the driver of closing and is connected with tail, for above-mentioned driver provides power supply, horizontal high voltage, the low pressure light current isolation between pressing of going forward side by side is to ensure the safety of whole system; Described Switching Power Supply T2 is that its input of commercial element is connected with described power supply by wire, after described Switching Power Supply T2 is converted to the 5V unidirectional current with the 220V alternating current power supply, respectively by the FPGA module in wire and the FPGG control system, one-chip computer module, two electric to optic converter J1 of alarm module and Signal permuting system, J2 and two light/electric transducer K1, the input of K2, be used to described FPGA module, one-chip computer module, alarm module and above-mentioned several transducers provide power supply, power-supply system is the pulse shaping system by above-mentioned working method, FPGA control system and signal translating system provide the power supply of safety and stability, ensure its normal operation;(3) described pulse shaping system comprises charging isolation resistance, Marx circuit and load; One end of charging isolation resistance is connected with the outfan of above-mentioned HVDC module, be used for current limliting and Marx's high pressure and the buffer action between the charging DC Module power supply low pressure of performance charging, the other end of charging isolation resistance is connected by the positive pole of wire with the bypass diode of the first order voltage cell of Marx circuit; Described Marx circuit is comprised of the voltage cell with the bypass diode that is connected on the electroplax motherboard more than 4～10 or 10, and the quantity of voltage cell can be determined as required; Each voltage cell comprises terminal full solid-state switch, switch driver, energy-storage capacitor, bypass diode, diode; In each voltage cell, the negative pole of bypass diode is connected parallel connection point by wire or cable and terminal full solid-state switch and is connected with capacitor, and the grid of terminal full solid-state switch is connected with the outfan of switch driver by wire; Switch driver is connected the input that closes driver and is connected by the outfan of wire with the DC-DC module of described power-supply system with tail; The driver of the switch between power supply and the isolating transformer, the switch driver in the Marx circuit be connected with tail close the drivers such as driver control end, be connected by the second light in wire and the described signal translating system/electric transducer K2, under the effect of this second light/electric transducer K2, above-mentioned switch and tail cut to close and open-turn-off; The other end of energy-storage capacitor is with after the positive pole of diode is connected, and is in parallel with terminal full solid-state switch; When terminal full solid-state switch disconnects, bypass diode and diode admittance, the energy-storage capacitor group is carried out charged in parallel; When the terminal full solid-state switch admittance was opened, diode and bypass diode oppositely ended, and the energy-storage capacitor that has been filled to predeterminated voltage cuts to close by tail with series system load is discharged, and tail cuts to close discharge pulse is carried out back-end crop; Control capacitor is to the pulsewidth of load discharge and regulate tail and cut and close, and can obtain the high-voltage nanosecond or the psec square wave that need, when terminal full solid-state switch disconnects, fills capacitor is charged, so repeatedly; When one or more terminal full solid-state switchs lost efficacy, then bypass diode and diode admittance and auto by pass this one or more voltage cell, all the other voltage cell still can work, thus total system still can discharge nanosecond, the psec square wave of needs; Described load is the noninductive resistance load, is connected in parallel on the outfan of Marx circuit by wire, and this outfan is connected with the impulsive measurement system by wire with the junction of load;(4) described impulsive measurement system comprises potentiometer, current sensor and treatment circuit; The input of described potentiometer is connected with the end that goes out of described pulse shaping system by wire, the outfan of described potentiometer is connected with the input for the treatment of circuit by wire, for the pulse voltage signal of the Marx circuit generation of monitoring the pulse shaping system of writing; The input of described current sensor is connected by the outfan of wire with described pulse shaping system, the outfan of described power sensor is connected with the input for the treatment of circuit, is used for the pulsed current signal of the Marx circuit generation of monitoring pulse shaping system; The outfan of described treatment circuit is connected by the input of wire with the FPGA module of the FPGA control system of book; Go out described Marx circuit to the discharge condition information of book load by FPGA control system computing post-processing detection, comprise that pulse voltage cut the information of end of line before and after cutting of putting into by tail;(5) described FPGA control system comprises brilliant idea FPGA module and synchronous trigger module and one-chip computer module and alarm module; Described FPGA module receives the voltage and current signal of high-voltage pulse of Marx circuit output of the described pulse shaping system of the monitoring that comes from the treatment circuit transmission of described measuring system, comprise through tail and cut the pulse voltage current signal that closes after tail is cut, through after the calculation process, on the one hand, described FPGA module is carried out exchanges data by wire and described one-chip computer module; On the other hand, above-mentioned FPGA module is connected with the input of described synchronous trigger module by wire, the outfan of described synchronous trigger module passes through optical fiber, the second electric to optic converter J2 and the second light/electric transducer K2 through signal translating system, with according to the control end of the switch driver of the Marx circuit of the driver of the switch of isolating transformer, described pulse shaping system and each tail cut the driver of closing control end be connected, avoid being subject to the interference of the high pressure of described pulse shaping system, guarantee the stable and synchronicity of synchronous start pulse signal; Described alarm module is connected with described FPGA module by wire, pulse current when load electrode output, when surpassing the electric current of setting, above-mentioned FPGA module is carried out behind the delay judgement sending the signal enabling driver by synchronous trigger module, electric light conversion J2 and optical-electrical converter K2 and is cut off switch between isolating transformer and the power supply, send simultaneously alarm signal, prompting staff or operator cut off the electricity supply, thereby guarantee this pulse generator and operator's safety; Described one-chip computer module passes through optical fiber, through the first electric to optic converter J1 of signal translating system be connected light/electricity conversion K1 and be connected with the control end of the HVDC module of the power-supply system of writing, the control signal to described HVDC module that described FPGA control system is sent converts optical signal to and transmits, the high pressure that fiber-optic transfer can be avoided being subject to the pulse shaping system disturbs, control described HVDC module and charge normal to described energy-storage capacitor group, guarantee that the square wave pulse voltage amplitude arrives setting value; The major function of described FPGA controller system is to realize man-machine communication by computer or unit, send HVDC module, Marx circuit control signal, receive the measuring-signal that described impulsive measurement system obtains, control the work of whole pulse generator and therapeutic instrument, and process burst accident;(6) described computer is commercial computer, hard disk is more than 320G, more than the internal memory 2G, the Duo Processor i5-460M of Intel, the above operating system of WIINDOWS XP, this computer expert crosses serial cable and is connected with single-chip microcomputer or the one-chip computer module of described FPGA control system, and user interface or the single-chip microcomputer display floater parameters, program of operator by computer program sends to described FPGA control system, thereby realize man-machine mutual trust;(7) described high-voltage nanosecond pulse generator based on FPGA control, the pulse amplitude of output is that 0～10kV is adjustable, pulse width is that 200～1000ns is adjustable, pulse frequency is that 1～1000Hz is adjustable, trailing edge is that 0.2ns ~ 40ns is adjustable, pulse number be 1～1000 adjustable, design parameter can be determined according to needs such as related neoplasms treatments;(8) described switch, tail cut to close and comprise solid-state switch, gas switch and liquid switch, and described liquid switch comprises taps.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220246559 CN202682564U (en) | 2012-05-30 | 2012-05-30 | Full-time high-voltage steep pulse cancer therapeutic apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220246559 CN202682564U (en) | 2012-05-30 | 2012-05-30 | Full-time high-voltage steep pulse cancer therapeutic apparatus |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446667A (en) * | 2012-05-30 | 2013-12-18 | 张涛 | Apparatus and method for cancer therapy by full-interval high-voltage steep-sided pulses |
| CN112336444A (en) * | 2019-08-06 | 2021-02-09 | 深圳钮迈科技有限公司 | Charge-discharge monitoring circuit and tumor therapeutic instrument |
| CN112674838A (en) * | 2021-01-06 | 2021-04-20 | 苏州中荟医疗科技有限公司 | High-pressure shock wave generation system for cardiovascular stenosis |
-
2012
- 2012-05-30 CN CN 201220246559 patent/CN202682564U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446667A (en) * | 2012-05-30 | 2013-12-18 | 张涛 | Apparatus and method for cancer therapy by full-interval high-voltage steep-sided pulses |
| CN112336444A (en) * | 2019-08-06 | 2021-02-09 | 深圳钮迈科技有限公司 | Charge-discharge monitoring circuit and tumor therapeutic instrument |
| CN112674838A (en) * | 2021-01-06 | 2021-04-20 | 苏州中荟医疗科技有限公司 | High-pressure shock wave generation system for cardiovascular stenosis |
| CN112674838B (en) * | 2021-01-06 | 2022-06-21 | 苏州中荟医疗科技有限公司 | High-pressure shock wave generation system for cardiovascular stenosis |
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