CN201799009U - Transcranial magnetic stimulation device - Google Patents
Transcranial magnetic stimulation device Download PDFInfo
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- CN201799009U CN201799009U CN2010202701268U CN201020270126U CN201799009U CN 201799009 U CN201799009 U CN 201799009U CN 2010202701268 U CN2010202701268 U CN 2010202701268U CN 201020270126 U CN201020270126 U CN 201020270126U CN 201799009 U CN201799009 U CN 201799009U
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Abstract
The utility model provides a transcranial magnetic stimulation device, which mainly comprises a high voltage pulse power supply, a myoelectricity acquisition device and a temperature measuring device, wherein, the high voltage pulse power supply, the myoelectricity acquisition device and the temperature measuring device are respectively connected with a data acquisition card; the data acquisition card is connected with LabVIEW (Laboratory Virtual Instrument Engineering Workbench) control software of a microcomputer; and the high voltage pulse power supply is connected with a stimulation coil. The transcranial magnetic stimulation device controls the high voltage pulse power supply to act on the coil through the LabVIEW software, can achieve various simulations such as magnetic stimulation single pulse, repetitive pulse, random pulse and train pulse; the temperature measuring device is combined with the LabVIEW software, so that the coil temperature can be acquired and alarming control can be carried out; the LabVIEW software is combined with the myoelectricity acquisition device, so that myoelectricity signals can be acquired; in addition, the transcranial magnetic stimulation device also achieves multiple functions such as database management, report printing, remote control, data communication and the like, and can be widely used for diagnosis and treatment in the department of psychiatry, the department of neurology and a laboratory.
Description
Technical field
This utility model relates to a kind of transcranial magnetic stimulation system, particularly only based on the transcranial magnetic stimulation system of Labview development platform.
Background technology
Transcranial magnetic stimulation (Transcranial Magnetic Stimulation TMS) is that Barker equals a kind of cortical stimulation method of at first founding in 1985, has painless, not damaged, advantage such as easy and simple to handle, safe and reliable, obtains clinical practice very soon.So-called " through cranium " is that the explanation magnetic signal can see through skull undampedly and stimulates to cerebral cortex, is not limited to the stimulation of brains in the practical application, and peripheral nervous muscle can stimulate equally, so it is also passable simply to be called " magnetic stimulation ".
It is a kind of physical stimulation form that magnetic stimulates, it is that time-dependent current flows into coil when utilizing, become pulsed magnetic field when producing high strength, in time, become pulsed magnetic field produce induction field and induced current in tissue, and faradic current makes some excitable tissue produce a kind of stimulating method of excitement.The method that magnetic at present commonly used stimulates is by the capacitor stores electric energy, again by coil discharge, forms strong pulsed magnetic field when pulse high current passes through coil, and then produces induced electric field, thereby reach the purpose of stimulation.
Present known transcranial magnetic stimulation instrument, its control section is Embedded substantially, be characterized in not needing to use special computer, volume is little, and cost is low, the performance height, but its software development difficulty, used technical difficulty height, and all very high to programming people's software and hardware basis requirement, be unfavorable for that so very the user is according to self-defined use.
The utility model content
The purpose of this utility model is to provide a kind of transcranial magnetic stimulation device based on Labview, its advantage is: easy to operate, stable performance can be revised or upgrade-system at any time as required, can realize simultaneously between printed report, database communication, software multinomial additional functions such as interaction.
For achieving the above object, the transcranial magnetic stimulation device that provides of this utility model mainly comprises:
One high-voltage pulse power source, a myoelectricity harvester and a temperature measuring equipment are connected to a data collecting card respectively;
This data collecting card is connected to a microcomputer;
Described high-voltage pulse power source is connected with stimulating coil.
Described transcranial magnetic stimulation device, wherein high-voltage pulse power source, myoelectricity harvester and temperature measuring equipment are connected to data collecting card by a rosette respectively, or directly with between the data collecting card are connected with data wire.
Described transcranial magnetic stimulation device, wherein stimulating coil is by the copper cash coiling, coiling be shaped as circular coil, 8 font coils, butterfly shaped coils or array coil.
Described transcranial magnetic stimulation device, wherein the myoelectricity harvester is the anti-interference electromyographic signal collection module of the dual pathways.
Described transcranial magnetic stimulation device, wherein rosette is a protected type I/O rosette.
Described transcranial magnetic stimulation device, wherein data collecting card is the pci data capture card.
Described transcranial magnetic stimulation device, wherein temperature measuring equipment is made up of temperature sensor, holding circuit and gain amplifying circuit; Temperature sensor is the platinum temperature sensor, and the gain amplifier section adopts the dual operational amplifier of internal frequency compensation.
Described transcranial magnetic stimulation device, wherein high-voltage pulse power source includes charge power supply, control circuit and discharge switch three parts.
The utility model has the advantages that:
1) complete function: coil is discharged and recharged by Labview software programming and parameter-definition control high-voltage pulse power source, realized the various modes such as single stimulation, repetitive stimulation, random stimulus, sequence of stimuli of transcranial magnetic stimulation, have the electromyographic signal collection function simultaneously, the temperature alarming function, sequence countdown function, and the patient information data base administration, patient report editor and printing, multinomial additional functions such as Long-distance Control and data communication;
2) having given full play to computer's role has powerful data processing function, has guaranteed the instrument speed of service and quality;
3) because system programmes based on Labview, under the situation that does not change hardware, only, can realize new function according to the new needs of user by changing software, very convenient flexibly, be that to be equivalent to software be hardware.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
Fig. 2 is a transcranial magnetic stimulation device mesohigh pulse power structural representation of the present utility model.
Fig. 3 is a transcranial magnetic stimulation device mesohigh pulse power electrical schematic diagram of the present utility model.
Fig. 4 is the circuit theory diagrams of transcranial magnetic stimulation device mesohigh pulse power EMI filtering of the present utility model and rectification.
Fig. 5 is a transcranial magnetic stimulation device mesohigh pulse power full-bridge inverting modular circuit schematic diagram of the present utility model.
Fig. 6 is transcranial magnetic stimulation device mesohigh pulse power source control circuit theory diagrams of the present utility model.
Fig. 7 is the structure chart of myoelectricity harvester in the transcranial magnetic stimulation device of the present utility model.
Fig. 8 is the functional block diagram that signal amplifying part is divided among Fig. 7.
Fig. 9 is the electrical schematic diagram of myoelectricity harvester in the transcranial magnetic stimulation device of the present utility model.
Figure 10 is the software operation interface of transcranial magnetic stimulation device of the present utility model based on the Labview programming platform.
Figure 11 is a transcranial magnetic stimulation device software operational flowchart of the present utility model.
Figure 12 is a temperature measuring equipment structure chart in the transcranial magnetic stimulation device of the present utility model.
Figure 13 is a temperature measuring equipment electrical schematic diagram in the transcranial magnetic stimulation device of the present utility model.
The specific embodiment
See also Fig. 1, basic structure of the present utility model is:
High-voltage pulse power source 1 links to each other with coil 2 by 14 control lines, high-voltage pulse power source 1, myoelectricity harvester 3 and temperature measuring equipment 8 join by data wire and rosette 4 respectively, rosette 4 links to each other with pci data capture card 6 in the host computer by cable 5 again, the realization digital-to-analogue conversion that intercoms mutually of pci data capture card 6 and Labview software 7.
High-voltage pulse power source 1 of the present utility model mainly is made up of charge power supply, control circuit and discharge switch three parts.Its structure as shown in Figures 2 and 3, wherein Fig. 2 is the transcranial magnetic stimulation device mesohigh pulse power structural representation of present embodiment, Fig. 3 is the transcranial magnetic stimulation device mesohigh pulse power electrical schematic diagram of present embodiment.
In the charge power supply, filtering is connected the input of a full-bridge inverting module with rectification module; The outfan of this full-bridge inverting module connects the filter rectification module by a high frequency transformer boost module, and the outfan of this rectification module connects storage capacitor.The outfan of charge power supply is connected to the output of discharge switch and goes into end; Charge power supply links to each other with control circuit by 11 holding wires such as starting-up signal, main electric ok signals; Control circuit is connected to discharge switch by a discharge clock line.
Wherein charge power supply mainly is made of EMI (low pass) filtering and rectification module (the physical circuit principle sees also as shown in Figure 4), full-bridge inverting module (the physical circuit schematic diagram is shown in Fig. 5 a), high frequency transformer boost module (model can adopt YD-PQ26/25, YD-G02), filter rectification module (with the rectification module of Fig. 4) and five parts of storage capacitor (can adopt the storage capacitor of 2kv/1uF).Full-bridge inverting module wherein mainly is made of four IGBT power models, and four IGBT divide two groups of (VT wherein
1, VT
2Be one group, VT
3, VT
4Be one group) the conducting closure, thus the conducting closure of control high frequency transformer.Work process is: form alternative square-wave signal after the alternating current process EMI filtering of 220V and rectification module and the full-bridge inverting module, square-wave signal boost through high frequency transformer and filter rectification after just formed highly compressed voltage signal, at last the high pressure that obtains is charged to storage capacitor.
Discharge switch mainly contains two modules and constitutes: MDD95-16 diode (led) module and SKKT250/16E silicon controlled rectifier module.Wherein silicon controlled module is as controllable point of discharge switch, and diode (led) module is as the holding circuit of discharge switch.2 pins of diode connect the input of silicon controlled module, and 3 pins connect the outfan of silicon controlled module, and 1 foot links to each other with the control end of trigger board.
Control circuit mainly is made up of interface board and trigger board, interface board mainly is that the signal that the external control signal that enters and charge power supply module are returned is isolated by the TPL521 optical coupling isolator, output is afterwards controlled charge power supply and discharge switch and is fed back signal to control end, to prevent that high-voltage pulse from causing interference to control signal, consequently damage control circuit.Interface board mainly is made up of terminating device and optocoupler, and signal is defeated by the optocoupler input through input, exports to outfan behind optocoupler.Trigger board mainly is made of terminating device, plays signal overseas Chinese federation.The control signal of interface board is exported from CZ3, and inserts the input (as shown in Figure 6) of trigger board.
The concrete parameter of high-voltage pulse power source of the present utility model is as follows:
Maximum output voltage: 1.5KV;
Output voltage is variable: 0-1.5KV (by external 0-10V Control of Voltage);
Output voltage pulse width: 280-400 microsecond (width is by external TTL signal controlling);
Output voltage pulse frequency: 100Hz when output voltage is 0.6KV, 15Hz when output voltage is 1.5KV (frequency is by external TTL signal controlling);
Maximum output pulse string number: 500;
The shortest interval between two trains of pulse: 3 seconds.
Fig. 7 has provided each member connection structure figure of this utility model myoelectricity harvester.
The myoelectricity harvester mainly is made up of electrode, signal amplifying part branch (gain amplifying circuit, gain control circuit, optical coupling isolator, wave trap) and signal acquiring system.This harvester is the dual pathways, and each passage has 3 electrodes, is respectively float electrode, reference electrode and ground, and the electromyographic signal that is used to gather human body, using method are known technology.Electrode links to each other with the signal amplifying part parallel circuit by data wire.The electromyographic signal that electrode collects is after the signal amplifying part branch amplifies, gather by signal acquiring system again, acquisition mode can be common known signal acquisition method/technology, the signal amplifying part of this enforcement divide with signal acquiring system between have 4 data wires to link to each other, article 2, be dual pathways holding wire separately, article 1, be ground wire, article 1, be power line, article 4, data wire is received on the rosette that NI company provides, rosette links to each other with the computer PCI card by the protected type cable again, pci card and upper strata Labview software communication are gathered electromyographic signal.
Fig. 8 is the sketch map that signal amplifying part is divided among Fig. 7.
Fig. 9 is the electrical schematic diagram of myoelectricity harvester in the transcranial magnetic stimulation device of present embodiment.
Because the myoelectricity device need directly contact with human body, so the requirement to power supply is relatively stricter, power supply in the novel circuit before optical coupling isolator TLP521 of this reality adopts float power Vf, circuit after the optocoupler adopts power supply Vs on the spot, so just can block the interference of external interference signals, improve the Electro Magnetic Compatibility of entire circuit faint electromyographic signal.In circuit, adopted simultaneously the TLP521 optical coupling isolator, the electromyographic signal amplifying circuit of front end and the signal acquisition circuit of rear end are carried out light-coupled isolation fully, avoid the high-voltage signal of rear end that front-end circuit is impacted, improve the high pressure isolation and the anti-high pressure ability of device.
See also Fig. 8 and shown in Figure 9, in the high gain signal amplifying circuit of present embodiment, adopted four-operational amplifier LF444 and two low noise high precision operating amplifier OP07 of two low-power consumption field effect inputs.Wherein first LF444 constitutes the differential amplifier circuit that first order difference is imported the high input impedance of single-ended output, and difference discrepancy circuit can provide very high common mode rejection ratio, helps improving signal quality.
The main gain control circuit in the second level that two amplifiers among second LF444 have constituted this circuit, input in each amplifier has increased toggle switch, by toggle switch promptly can regulating circuit gain, the time parameter that also can regulating circuit and the free transmission range of circuit.The maximum adjustable gain of this circuit is 60dB, and adjustable free transmission range is 0-2KHz.
Through behind the main gain control circuit, isolate adapter and the buffer of being with null adjustment by the light that OP07 constitutes, pass through optical coupling isolator TLP521 afterwards again.
The signal that optical coupling isolator comes out through one by 3 1uF electric capacity, 2 536K and 1 50Hz wave trap that 267K resistance constitutes.This wave trap can prevent the power frequency interference of 50HZ, also has the effect of low pass filter simultaneously.
The signal that is come out by wave trap amplifies through the OP07 operational amplifier more at last, and exports to collecting device.
Operational amplifier LF444 and OP07 that this utility model adopts, and optical coupling isolator TLP521 is known module.
This utility model rosette 4 can adopt that American National instrument (NI) company releases with the supporting rosette of PCI 6221 cards, its model is NI SCB-68.NI SCB-68 is a protected type I/O rosette, the I/O signal can be connected toward being furnished with plug-in type data acquisition (DAQ) equipment (PCI 6221) of 68 pin connectivity ports.During in conjunction with the protected type cable, SCB-68 can provide Signal Terminal firm and that noise is extremely low.
PCI 6221 data collecting cards that pci data capture card 6 of the present utility model provides for America NI company, its relevant parameter is: 2 tunnel 16 simulation outputs (frequency range 833kS/s), up to 24 way word I/O; 32 digit counters; Numeral triggers, and 16 tunnel single-ended inputs (sample rate is 250KS/s, maximum voltage range ± 10V), related DIO (8 clock lines, 1MHz), NIST calibration certificates of recognition and more than 70 signal condition option.
Figure 10,11 has showed transcranial magnetic stimulation instrument Labview software operation interface and operational flowchart in this utility model.
The operation principle of transcranial magnetic stimulation device of the present utility model, be that Labview is as the charging of control end control high-voltage pulse power source, discharge, by setting various parameters, to determine amplitude, pulsewidth and the frequency of high-voltage pulse power source output pulse at the Labview software interface; High-voltage pulse power source discharge generation high-voltage pulse or high-voltage pulse string obtain high-intensity magnetic field thereby high-voltage pulse produces the high power pulse electric current by stimulating coil, and then produce induction field in tissues, reach the stimulation purpose; Temperature measuring equipment magnetic test coil temperature feeds back to Labview control software with temperature value, to realize real-time monitoring and the control to coil temperature.
Workflow of the present utility model is: PC is provided with the parameter of charge power supply by control circuit, the control power supply is converted to unidirectional current with alternating current, and storage capacitor charged, charge power supply is returned corresponding state by control circuit and is given PC simultaneously, when the charge power supply charging is finished, it returns to the ready signal of PC charging, and PC just can be controlled discharge switch by control circuit the electric energy in the storage capacitor was discharged in the coil this moment.In this process, PC is also monitored the state of coil constantly by control circuit.
Transcranial magnetic stimulation device of the present utility model comprises following function:
Have on the stimulation mode: 4 of single stimulations, repetitive stimulation, random stimulus, sequence pattern, wherein parameter comprises: six of stimulus intensity, frequency, persistent period, pulse number, train of pulse number, waiting time etc.;
Status display function has: the coil connection status shows that the high-voltage pulse power source charged state shows, the too high alarm of coil temperature, repetitive stimulation and random stimulus stimulate residue countdown demonstration etc.;
Additional function has: patient information is registered and is read (containing data base administration), and patient and diagnosis report are printed (it is multinomial to contain electromyogram, treatment parameter, therapeutic effect analysis etc.), and Long-distance Control and data communication etc.Wherein patient and diagnosis report are the word documents that system generates automatically in conjunction with the various information of patient, and the operator can edit according to own needs, and be convenient easy-to-use.
Single stimulation, repetitive stimulation, random stimulus and sequence pattern design principle communicate, and all are by interface setting parameter separately, and control NI PCI-6221 integrated circuit board output digital pulse signal comprises the frequency and the amplitude of pulse signal.Utilize the output of the Counter 0 passage control discharge pulse signal of NI PCI-6221 integrated circuit board.
The single stimulation to once triggering a pulse signal, repetitive stimulation, random stimulus and sequence pattern are for once triggering a plurality of pulse signals, the repetitive stimulation fixed-frequency, the every single of random stimulus triggers the frequency of pulse train signal for producing at random in the frequency range of user's setting, sequence pattern then is the sequence form of repetitive stimulation, the i.e. set of a plurality of repetitive stimulations.
Single stimulation, repetitive stimulation, random stimulus and sequence pattern are by setting the strength of discharge parameter, and control NI PCI-6221 integrated circuit board output reference voltage analogue signal is utilized the AO 0 passage control reference voltage signal output of PCI-6221 integrated circuit board.
Temperature measuring equipment of the present utility model its each parts annexation figure such as Figure 12, Figure 13 is the electrical schematic diagram of present embodiment.
Wherein PT100 places coil inside, is used for the temperature of induction coil, and the signal that induction is returned is given signal acquiring system collection again after gain amplifying circuit is sent out signal greatly.If adopt 8 font coils, then PT100 is placed two loop transfer places of 8 font coils, with coil by the embedding of insulating heat-conductive silicone rubber (data wire is exposed to the outside of the coil module of embedding).PT100 links to each other with gain amplifying circuit by common connecting line, and gain amplifying circuit links to each other with signal acquiring system by common connecting line again.This signal acquiring system can be common known signal acquisition mode/technology, the gain amplifying circuit of present embodiment links to each other with the rosette of Labview by data wire, rosette links to each other pci card and upper strata Labview software communication, collecting temperature by the protected type cable again with the computer PCI card.Electromyographic signal is amplified by signal behind the LF444 difference amplification module, enters gain control module again, by the time parameter of toggle switch regulating circuit and the free transmission range of circuit, to the signal control that gains; Block the interference of external interference signals by optical coupling isolator again, and avoid the high-voltage signal of rear end that front-end circuit is impacted faint electromyographic signal; Finally amplify signal is exported to collecting device by filtering and computing.
Transcranial magnetic stimulation system temperature measuring device operation principle based on Labview of the present utility model as seen from Figure 13, that is: temperature is when the 0-100 degree changes, when temperature rises, it is big that the resistance of PT100 becomes, it is big that the differential signal of input difference circuit becomes, the corresponding rising of output voltage AV of amplifying circuit.PT100, R2, R3 and R4 form the sensor measurement electric bridge, the output differential signal, and in order to guarantee the stability of bridge output voltage, the input voltage of electric bridge passes through TL431 surely to 2.5V.After amplifying, the differential signal process LM358 double operational two-stage of electric bridge output imports data collecting card.Wherein regulator potentiometer R3 can adjust the size of differential input signal, is generally used for zeroing.D1, D2, D3 and D4 are the lightning protection circuit that is connected in parallel on the PT100, and they are made up of 4 high pressure Transient Suppression Diode SMBJ18A, and they can improve the impact resistance of circuit effectively.
Claims (8)
1. a transcranial magnetic stimulation device is characterized in that, mainly comprises:
One high-voltage pulse power source, a myoelectricity harvester and a temperature measuring equipment are connected to a data collecting card respectively;
This data collecting card is connected to a microcomputer;
Described high-voltage pulse power source is connected with stimulating coil.
2. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that, high-voltage pulse power source, myoelectricity harvester and temperature measuring equipment are connected to data collecting card by a rosette respectively, or directly with between the data collecting card is connected with data wire.
3. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that, stimulating coil is by the copper cash coiling, coiling be shaped as circular coil, 8 font coils, butterfly shaped coils or array coil.
4. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that, the myoelectricity harvester is the anti-interference electromyographic signal collection module of the dual pathways.
5. transcranial magnetic stimulation device as claimed in claim 2 is characterized in that, rosette is a protected type I/O rosette.
6. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that, data collecting card is the pci data capture card.
7. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that temperature measuring equipment is made up of temperature sensor, holding circuit and gain amplifying circuit; Temperature sensor is the platinum temperature sensor, and the gain amplifier section adopts the dual operational amplifier of internal frequency compensation.
8. transcranial magnetic stimulation device as claimed in claim 1 is characterized in that, high-voltage pulse power source includes charge power supply, control circuit and discharge switch three parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202701268U CN201799009U (en) | 2010-07-26 | 2010-07-26 | Transcranial magnetic stimulation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202701268U CN201799009U (en) | 2010-07-26 | 2010-07-26 | Transcranial magnetic stimulation device |
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| CN201799009U true CN201799009U (en) | 2011-04-20 |
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| CN2010202701268U Expired - Lifetime CN201799009U (en) | 2010-07-26 | 2010-07-26 | Transcranial magnetic stimulation device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587605A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | Electromyographic signal controlled peripheral magnetic stimulation system and method |
| CN104587606A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | TMS (transcranial magnetic stimulation) system and method controlled by electroencephalogram signals |
-
2010
- 2010-07-26 CN CN2010202701268U patent/CN201799009U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587605A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | Electromyographic signal controlled peripheral magnetic stimulation system and method |
| CN104587606A (en) * | 2015-01-11 | 2015-05-06 | 北京工业大学 | TMS (transcranial magnetic stimulation) system and method controlled by electroencephalogram signals |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: MINDTOUCH HIGH TECHNOLOGY CO., LTD. Assignor: Mind Touch High Technology Co., Ltd., Hong Kong Contract record no.: 2011990000962 Date of cancellation: 20130401 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: MINDTOUCH HIGH TECHNOLOGY CO., LTD. Assignor: Mind Touch High Technology Co., Ltd., Hong Kong Contract record no.: 2013990000152 Denomination of utility model: Transcranial magnetic stimulation device Granted publication date: 20110420 License type: Exclusive License Record date: 20130415 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Transcranial magnetic stimulation device Effective date of registration: 20161107 Granted publication date: 20110420 Pledgee: Zhongguancun development group Limited by Share Ltd Pledgor: Mind Touch High Technology Co., Ltd., Hong Kong Registration number: 2016990000952 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| CX01 | Expiry of patent term |
Granted publication date: 20110420 |
|
| CX01 | Expiry of patent term |