CN103394161A - Cerebral alpha wave feedback regulation acupoint magnetic stimulation system - Google Patents
Cerebral alpha wave feedback regulation acupoint magnetic stimulation system Download PDFInfo
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Abstract
The invention provides a cerebral alpha wave feedback regulation acupoint magnetic stimulation system. The system consists of a magnetic stimulation generating instrument, an electroencephalograph and a computer. According to the system, a trumpet-shaped stimulation coil of the magnetic stimulation generating instrument is fixed on an acupuncture point of a human body to magnetically stimulate, the electroencephalograph is used for acquiring electroencephalograms, and the electroencephalogram data processing computer analyzes the power spectrum of a cerebral alpha wave and computes the energy of the cerebral alpha wave, draws and displays a dynamic brain electrical activity mapping; and the stimulation intensity, stimulation frequency and stimulation waveform are respectively and automatically regulated in a feedback manner and manually regulated according to the energy of the electroencephalogram cerebral alpha wave and the dynamic brain electrical activity mapping so as to obtain an optimum acupoint stimulation effect. The system can promote the nervous system recovery of cerebral palsy patients and the autonomous rehabilitation training of acroparalysis patients.
Description
Technical field
The invention belongs to the rehabilitation medical instrument technical field, relate to the feedback regulation of a kind of brain α ripple through the cave magnetic stimulation system.
Background technology
At present, the Physical rehabilitation treatment means of cerebral palsy and paralyses patient mainly adopts the methods such as acupuncture, functional electrical stimulation.The functional electrical stimulation therapy adopts stimulating electrode to act on patient's specific part, recovers patient's componental movement function, fast track rehabilitation speed.But, no matter be functional electrical stimulation therapy or acupuncture and moxibustion treatment, all can produce pain and traumatic to the patient, all need the subjective feeling of dependent patient and doctor's experience, the qualitative stimulation input mode that applies, will certainly affect the effect of rehabilitation.
The magnetic stimulating technology is produced transient pulse by the magnetic coil of stimulation location and stimulates by being placed on, and the magnetic field perpendicular to coil plane occurs, utilizes this time-varying magnetic field Induced Electric Field produce faradic current in vivo, with this, stimulates excitable tissue.Through cave magnetic, stimulating is that the magnetic stimulating technology is combined with Traditional Chinese Medicine acupuncture point theory, utilizes magnetic coil to produce the faradize acupuncture point, activates the histiocyte that is connected with acupuncture point.Because nerve and blood vessel near acupuncture point are abundanter, stimulating acupoint can strengthen neural function, improve damaged position blood circulation and metabolism, makes damaged tissues and cell be able to quick recovery, thereby reaches the effect for the treatment of disease and rehabilitation.That the magnetic stimulating acupoint has is painless, without wound, directly do not contact, be easy to repetition and carry out the advantages such as deep stimulation.
The magnetic stimulating coil that adopts through the cave magnetic stimulation system both at home and abroad is not specially through the cave magnetic stimulating coil, the magnetic coil of some employing transcranial magnetic stimulation instruments, and some employing small magnets, this certainly will produce considerable influence to accuracy and the reliability that magnetic stimulates.
The shape of magnetic coil and structure directly affect the distribution of induction field, determine the focusing in magnetic field and stimulate the degree of depth.Therefore, coil design is the key problem of magnetic stimulation system.8 traditional fonts or two 8 font coils, and the Slinky coil all is being difficult to reach the requirement that stimulates through cave magnetic stimulating aspect the degree of depth and focusing, being only applicable to cortex magnetic stimulates.
In addition, existing rehabilitation stimulating apparatus is all to stimulate adjusting according to patient's subjective sensation and doctor's experience at present.Patient for losing with extraneous communication capability, easily cause excessive stimulation or stimulus intensity inadequate, can not reach effectively and optimal treatment, even causes extra wound.In addition, medical personnel are rule of thumb to carry out to the adjusting of stimulation mode, can not carry out quantification to the effect that the patient accepts to stimulate, and carry out the Real-time and Dynamic adjusting according to quantized result, are difficult to reach the expection therapeutic effect.How seeking best magnetic stimulus intensity, stimulus frequency and stimulus waveform for different patients, is the key issue that needs of rehabilitation field solve.
Summary of the invention
Brain α ripple is a kind of spontaneous brain wave rhythm, and frequency range is distributed in 8-13Hz, and the normal person is when being in the natural relaxation state, and brain there will be a large amount of alpha waves.Research finds that the α ripple is the state that is suitable for the activity of brain subconsciousness, and people can obtain bulk information well by subconsciousness, and brain α ripple is the optimum state of obtaining high efficient memory, can promote inspiration, accelerate collection of data, hypermnesis.
For overcoming the deficiencies in the prior art, the invention provides a kind of eegαwave energy that utilizes, feedback regulation is through cave magnetic stimulus parameter, optimize magnetic stimulate input through cave magnetic stimulation system and implementation method.This invention can promote cerebral palsy patient's nervous system to recover, and also is applicable to quadriplegia patient's autonomous rehabilitation training.
A kind of brain α ripple provided by the invention feedback regulation through the cave magnetic stimulation system, by magnetic, stimulate generator, electroencephalograph and computer to form; Magnetic stimulates generator to comprise single-chip microcomputer and stimulating coil; Described single-chip microcomputer comprises stimulus intensity adjustment module, stimulus frequency adjustment module and stimulus waveform adjustment module, and stimulating coil is for meeting magnetic focusing at 1cm
2The horn-like magnetic coil that scope is interior, the magnetic stimulation degree of depth reaches 1.5-2cm; Described electroencephalograph comprises electrode for encephalograms, eeg amplifier and A/D modular converter; Described computer comprises the eeg data processing module, and the eeg data processing module comprises EEG alpha power spectrum real-time analysis module and the real-time display module of Dynamic ElectroencephalogramSystem.
Described stimulus intensity adjustment module, the intensity adjustments instruction that sends for receiving the eeg data processing module, by increasing or reduce stimulus intensity, the successively forward and backward eegαwave energy of comparison stimulus intensity adjustments, stimulus intensity while obtaining α wave energy maximum, outputing to magnetic stimulates generator.
Described stimulus frequency adjustment module, the stimulus frequency regulating command that sends for receiving the eeg data processing module, by increasing or reduce stimulus frequency, the forward and backward eegαwave energy of comparison stimulus frequency adjustment successively, stimulus frequency while obtaining α wave energy maximum, outputing to magnetic stimulates generator.
Described stimulus waveform adjustment module, the stimulus waveform regulating command that sends for receiving the eeg data processing module, by switching different stimulated waveform, the eegαwave energy while relatively applying the different stimulated waveform, stimulus waveform while choosing α wave energy maximum, outputing to magnetic stimulates generator.
Described EEG alpha power spectrum real-time analysis module, for brain α wave power spectrum is carried out to real-time analysis, calculate the α wave energy, is provided for the digital command of feedback regulation stimulus intensity, stimulus frequency and stimulus waveform.
The real-time display module of described Dynamic ElectroencephalogramSystem, for showing in real time the topography of brain α wave energy, the foundation of regulating stimulus intensity, stimulus frequency and stimulus waveform as manual button.
The heavy caliber of described horn-like stimulating coil, small-bore, axial height and coil turn, meet Maxwell equation.The heavy caliber 0.5cm of preferred horn-like stimulating coil, small-bore 0.1cm, axial height 0.25cm, coil turn monolayer 25 circles, totally 5 layers, wire is the copper cash of wire diameter 1mm.
Its implementation, step comprises:
Stimulate the horn-like stimulating coil of generator to be fixed on human acupoint magnetic and carry out the magnetic stimulation, with electroencephalograph, gather EEG signals, the eeg data processing module is processed the EEG signals that gathers by AR model the Power Spectrum Estimation Method, obtain brain α wave power spectrum, calculate the α wave energy, and be translated into the digital command that stimulus intensity is regulated, stimulus frequency is regulated and stimulus waveform is regulated and feed back to single-chip microcomputer, single-chip microcomputer stimulates generator to regulate to magnetic.
The real-time display module of Dynamic ElectroencephalogramSystem of the present invention can be used as the foundation of manual adjustments stimulus intensity, stimulus frequency and stimulus waveform.The implementation method of manual adjustments, step comprises:
stimulate the horn-like magnetic coil of generator to be fixed on human acupoint magnetic and carry out the magnetic stimulation, electroencephalograph gathers EEG signals, the eeg data processing module is processed the EEG signals that gathers by the Power Spectrum Estimation Method based on the AR model, obtain brain α wave power spectrum, calculate the α wave energy, draw Dynamic ElectroencephalogramSystem, by the observation Dynamic ElectroencephalogramSystem, carry out manual button and regulate respectively the magnetic stimulus intensity, stimulus frequency and stimulus waveform, when Dynamic ElectroencephalogramSystem presents the red area maximum, magnetic stimulates generator output stimulus intensity, stimulus frequency and stimulus waveform.
Compared with prior art, of the present invention through the cave magnetic stimulation system, introduced real-time brain wave acquisition and eeg data processing module, to through cave magnetic effect of stimulation, quantizing, and directly perceived the demonstration; Its magnetic stimulus signal generation module can be composed and topography by EEG alpha power, and feedback regulation stimulus intensity, stimulus frequency and stimulus waveform are optimized through cave magnetic and stimulated input mode, improve effectiveness and reliability that magnetic stimulates; Described horn-like stimulating coil has good focusing and stimulates the degree of depth, has improved the accuracy that magnetic stimulates.This system is not only brand-new rehabilitation magnetic stimulating technology, and can promote the use of other related stimulus rehabilitation assistive device fields.
The accompanying drawing explanation
Fig. 1 is of the present invention through cave magnetic stimulation system work schematic diagram.
Fig. 2 is that magnetic of the present invention stimulates generator to form structured flowchart.
Fig. 3 is horn-like stimulating coil cutaway view of the present invention.
Fig. 4 is radially Distribution of Magnetic Field figure of stimulating coil of the present invention.
Fig. 5 is stimulating coil of the present invention Distribution of Magnetic Field figure vertically.
Fig. 6 is eeg signal acquisition of the present invention and processing system block diagram.
Fig. 7 is eeg signal acquisition electrode position scattergram of the present invention.
Fig. 8 is EEG Processing flow chart of the present invention.
Fig. 9 is magnetic stimulus intensity of the present invention/frequency window effect schematic diagram.
Figure 10 is of the present invention through cave magnetic stimulus intensity feedback regulation flow chart.
Figure 11 is of the present invention through cave magnetic stimulus intensity effect figure.
Figure 12 is of the present invention through cave magnetic stimulus frequency effect figure.
Figure 13 is brain α ripple brain electrical activity mapping of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples, the present invention is further described:
Embodiment 1
A kind of brain α ripple of the present invention feedback regulation through the cave magnetic stimulation system, mainly comprise three parts: magnetic stimulates generator, electroencephalograph and computer, and the system works schematic diagram is as shown in Figure 1.At first, apply certain magnetic stimulus signal and act on human acupoint, carry out human's collateral channels and acupoints magnetic stimulation (this moment, brain α ripple can change), electroencephalograph gathers EEG signals, through amplification, filtering and A/D conversion, EEG signals is sent into to computer, brain α ripple is carried out to power spectrumanalysis, calculate brain α wave energy, and draw and demonstration α fluctuation state brain electrical activity mapping.Simultaneously, according to brain α wave energy feedback regulation magnetic stimulus intensity, stimulus frequency and stimulus waveform, to reach best through cave magnetic effect of stimulation.
Magnetic of the present invention stimulates generator to form structured flowchart as shown in Figure 2, comprises single-chip microcomputer, key control circuit, external memory storage, liquid crystal display, power amplification circuit, power circuit and stimulating coil.Single Chip Microcomputer (SCM) system produces the sine of varying strength and frequency/pulse stimulation signal, by stimulating coil by the magnetic stimulation in human acupoint, cause that brain α wave energy changes.
(1) single-chip microcomputer: adopt system-level MCU chip C8051F021, it comprises 12 high-precision adcs, voltage reference circuit, and 5 16 bit timing devices, 5 passage PCA and 32 digital I/O mouths etc.Its major function is: while automatically regulating, intervalometer scanning serial ports, receive the control instruction that data handling machine sends, and to magnetic, stimulates stimulus intensity, stimulus frequency and the stimulus waveform of generator to carry out feedback regulation; During manual adjustments, intervalometer scanning button, regulate stimulus intensity, stimulus frequency and stimulus waveform.
(2) key control circuit: it is the man-machine interaction circuit of this device, for manual adjustments magnetic, stimulates stimulus intensity, stimulus frequency and the stimulus waveform of generator output, and it comprises four buttons: pattern, add, subtract, determine.
(3) liquid crystal display: be used to showing stimulus intensity, the isoparametric interface of frequency.In the present embodiment, adopt the LCD1602ZFA liquid crystal display, have 16 pins, the capacity of display is 16*2 character, running voltage 4.5-5.5V, operating current 2.0mA, character size 2.95*4.35mm.
(4) external memory storage: the design parameter to this device stimulus signal intensity, stimulus frequency and stimulus waveform is stored.The present embodiment peripheral memorizer adopts the AT24C02 chip.This chip is the 2K Bits Serial CMOS EEPROM that CATALYST company utilizes the CMOS technology to produce.AT24C02 has 16 byte page write buffers, and this device passes through I
2The C EBI operates, and a special writing protection function is arranged.After the intensity that changes each time stimulus signal, frequency and waveform, pass through I
2The C bus is stored stimulus parameter.
(5) power amplification circuit: comprise two parts, the one, voltage/current conversion circuit, the 2nd, current amplification circuit.
Voltage/current conversion circuit is carried out the voltage/current conversion to the voltage signal of single-chip microcomputer DAC end output.In the present embodiment, adopt high speed JFET double operational TL082 chip, in conjunction with simple peripheral circuit, can realize the voltage signal of single-chip microcomputer DAC end output is converted to current signal.
In the present embodiment, current amplification circuit is take integrated power amplification chip TDA2030 as core, in conjunction with simple peripheral circuit, form the dual power supply power amplification circuit, making the electric current that outputs to stimulating coil is the required size of current that reaches, thereby produces corresponding magnetic field intensity.
Through cave magnetic stimulation system stimulus intensity, regulating is by changing the resistance realization in current amplification circuit, shows as digital regulation resistance resistance in single chip machine controlling circuit and changes.The digital regulation resistance X9313Z that the digital regulation resistance that uses in the present embodiment is produced as U.S. Xicor company, the change in resistance scope is 0-1K Ω.Its inside comprises control circuit, 5 up/down binary counters, 32 and selects 1 decoder, 5 E2PROM and electric resistance array.Electric resistance array includes 31 resistance units, and the slip increment is 32.3 Ω.
(6) stimulating coil: Fig. 3 is horn-like stimulating coil cutaway view, and its bore, axial height and coil turn, meet Maxwell equation.In the present embodiment, by creating FEM (finite element) model, utilize the Ansys software emulation, preferred heavy caliber 0.5cm, small-bore 0.1cm, axial height 0.25cm, coil turn monolayer 25 circles, totally 5 layers, the copper cash of wire diameter 1mm, do skeleton with round table-like nylon rod, turns to horn-like stimulating coil.
Fig. 4 is radially Distribution of Magnetic Field figure of the stimulating coil of surveying in the present embodiment, and as can be seen from the figure, it is 1cm that magnetic field mainly focuses on area
2Border circular areas in, Distribution of Magnetic Field has focusing preferably.
Fig. 5 is the stimulating coil of surveying in the present embodiment Distribution of Magnetic Field figure vertically, and as can be seen from the figure, magnetic field is at the small-bore central shaft of the horn-like coil of distance to the 1cm place, and magnetic field intensity can reach the 3mT left and right.
Because human acupoint approximately is in 1.5cm left and right under epidermis, the acupuncture point area is about 1cm
2, the Distribution of Magnetic Field measurement result of above-mentioned magnetic coil meets the focusing of acupoint stimulation and stimulates the requirement of the degree of depth.
Fig. 6 is eeg signal acquisition and processing system block diagram.Brain electric data collecting and processing system comprise electroencephalograph and computer.Wherein, electroencephalograph is comprised of electrode for encephalograms, eeg amplifier and A/D converter.Electroencephalograph output digitized EEG signals is to computer, computer carries out power spectrumanalysis to brain α ripple, calculate brain α wave energy, draw Dynamic ElectroencephalogramSystem, and by the RS232 serial ports, the feedback regulation instruction is exported to magnetic stimulation generator, regulating magnetic stimulates stimulus intensity, stimulus frequency and the stimulus waveform of generator, optimal stimulus intensity, stimulus frequency and the stimulus waveform of the brain α ripple content that is improved.
The model that adopts BeiJing ZhongKe Xin Tuo company to produce in the present embodiment is that 16 of UE-BZ leads portable electroencephalograph, realizes eeg signal acquisition, and sample frequency is 1KHz, and resolution is 0.5 μ v, adopts USB interface directly to power.
The eeg signal acquisition electrode position distributes as shown in Figure 7, adopts international " 10-20 " electrode to lay standard, and eeg data is processed and chosen C3, C4, Cz, P3, the individual eeg data that leads of P4, Pz6.
Fig. 8 is the eeg data process chart.At first the brain wave acquisition signal is carried out to the 8-13Hz bandpass filtering, filtered signal is carried out to AR model power Spectral Estimation, obtain the electroencephalogram power spectrum density, and then calculating brain α wave energy, and draw brain α fluctuation state brain electrical activity mapping, according to brain α wave energy automatic feedback, regulate stimulus parameter and the waveform that magnetic stimulates generator.
Fig. 9 is magnetic stimulus intensity/frequency window effect schematic diagram.Existing research finds that the magnetic stimulation has window effect, is similar to parabola and changes.As seen from the figure, brain α wave energy can strengthen and increase gradually along with stimulus intensity/frequency, when stimulation reaches a certain value, brain α wave energy enters a stabilised platform phase, afterwards can be along with stimulus intensity/frequency strengthens and reduces gradually, after continuing to increase stimulus intensity/frequency, brain α wave energy can be less than spontaneous brain electricity α wave energy.
Figure 10 is through cave magnetic stimulus intensity feedback regulation flow chart.Concrete control method is: at first, calculate brain spontaneous brain electricity α wave energy E
0, put initial impulse intensity human acupoint is carried out to the magnetic stimulation, gather EEG signals and calculate above-mentioned 6 α wave energy meansigma methods E that lead
1If, E
1<E
0, reduce stimulus intensity, and calculate 6 α wave energy meansigma methodss of leading, until this energy value is more than or equal to E
0If E
1>=E
0, increase stimulus intensity, and calculate the 6 α wave energy meansigma methods E that lead
2.If E
2E
1, continue increasing stimulus intensity, and calculate the 6 α wave energy meansigma methodss of leading, the α wave energy meansigma methods that successively more forward and backward twice stimulus intensity is corresponding, until energy value no longer increases; If E
2<E
1, reducing stimulus intensity, and calculate the 6 α wave energy meansigma methodss of leading, the α wave energy meansigma methods that successively more forward and backward twice stimulus intensity is corresponding, until α wave energy value no longer increases.Export this stimulus intensity, carry out stimulating through cave magnetic.
Stimulus frequency control method and stimulus intensity control method are similar, do not repeat them here.
The stimulus waveform control method is: at first carrying out sine wave stimulates through cave magnetic, gather EEG signals and calculate the brain 6 α wave energy meansigma methods of leading, then be switched to impulse wave and carry out the magnetic stimulation, again gather EEG signals and calculate the brain 6 α wave energy meansigma methods of leading, twice α wave energy meansigma methods compared, select the larger magnetic stimulus waveform of corresponding α wave energy value, carry out stimulating through cave magnetic.
In the present embodiment, select brain α wave energy of calculating in every 5 seconds, when needing increase or reducing stimulus intensity, computer sends digital command " 11 " or " 00 " to single-chip microcomputer, and the Single-chip Controlling stimulus intensity changes, and in the present embodiment, shows as digital regulation resistance change in resistance 32.3 Ω; When needing increase or reducing stimulus frequency, computer sends digital command " 10 " or " 01 " to single-chip microcomputer, and the Single-chip Controlling stimulus frequency changes, and stimulus frequency is set in the present embodiment and changes 10Hz at every turn.
10 experimenters (men and women half and half, 25 years old mean age) have adopted and of the present inventionly through the cave magnetic stimulation system, have tested.Figure 11 is that wherein experimenter's varying strength magnetic stimulates corresponding brain α wave energy, as seen from the figure, when this experimenter's magnetic stimulus intensity reaches 2mT, eegαwave energy maximum.Figure 12 is for experimenter wherein under fixing 2mT stimulus intensity, and different frequency magnetic stimulates corresponding brain α wave energy, and as seen from the figure, this experimenter's magnetic stimulus frequency is in 200Hz place eegαwave energy maximum.10 experimenter's experimental results all show pulse stimulation, for improving brain α wave energy more remarkable effect.
Figure 13 is brain α ripple brain electrical activity mapping.Brain electrical activity mapping is the physiologic information of Graphics Application characterized by techniques brain, can utilize intuitively the neural activity of color plane reaction brain.Drawing Dynamic ElectroencephalogramSystem specific implementation process is:
(1) power Spectral Estimation: gather 16 and lead EEG signals, carry out AR model power Spectral Estimation, EEG power spectrum is divided into to five frequency ranges, represent respectively δ, θ, α, the beta, gamma rhythm and pace of moving things, calculate the α wave energy on the 8-13Hz frequency range of respectively leading;
(2) interpolation calculation: adopt the space interpolation mode, calculate the α wave energy of each interpolation point;
(3) color map: α wave energy value is divided into to several grades, is mapped as different colours, wherein blueness represents α wave energy minima, and redness represents α wave energy maximum;
(4) brain electrical activity mapping is drawn: utilize two buffer memory plotting modes, in buffer memory, all α wave energy value pointwises are composed to rgb value, then the disposable computer screen that copies to, show Dynamic ElectroencephalogramSystem.
Brain α ripple brain electrical activity mapping, as the foundation of manual adjustments magnetic stimulus parameter, can coordinate α ripple automatic feedback to regulate stimulus parameter and use.By manual adjustments stimulus intensity, stimulus frequency or stimulus waveform, make experimenter's brain α wave energy be in a higher scope, on topography, so that red area is maximum, represent.
Stimulate the horn-like coil of generator to be fixed on the experimenter acupuncture point magnetic and carry out the magnetic stimulation, electroencephalograph gathers EEG signals, the eeg data processing module is processed the EEG signals that gathers by AR model the Power Spectrum Estimation Method, obtain brain α wave power spectrum, calculate the α wave energy, draw Dynamic ElectroencephalogramSystem, according to topography, with manual button, regulate respectively stimulus intensity, stimulus frequency and stimulus waveform, when Dynamic ElectroencephalogramSystem presented the red area maximum, magnetic stimulated generator output stimulus intensity, stimulus frequency and stimulus waveform.
This manual adjustments pattern has overcome traditional electrical, magnetic stimulates the defect with doctors experience subjective judgment stimulating effect, has guaranteed effectiveness and reliability through cave magnetic stimulation treatment and rehabilitation training.
A kind of brain α ripple of the present invention feedback regulation through cave magnetic stimulation system safety, effectively, utilize the eegαwave energy to through cave magnetic effect of stimulation, having carried out quantification and feedback regulation, utilize Dynamic ElectroencephalogramSystem to through cave magnetic effect of stimulation, having carried out demonstration directly perceived, for through the stimulation of cave magnetic, improving the α wave energy that brain is useful, have remarkable effect.This network system realization is convenient, reliable, has two kinds of functions of automatic adjusting and manual adjustments, without medical personnel's operation, has saved a large amount of man power and materials.
The applicant has done detailed explanation with regard to design of the present invention and embodiment, still, for the professional and technical personnel, can also make and improving and conversion on the basis of the above description.But improvement and conversion are still within claim scope of the present invention.
Claims (6)
- Brain α ripple feedback regulation through the cave magnetic stimulation system, it is characterized in that, by magnetic, stimulate generator, electroencephalograph and computer to form; Magnetic stimulates generator to comprise single-chip microcomputer and stimulating coil; Described single-chip microcomputer comprises stimulus intensity adjustment module, stimulus frequency adjustment module and stimulus waveform adjustment module, and stimulating coil is for meeting magnetic focusing at 1cm 2The horn-like magnetic coil that scope is interior, the magnetic stimulation degree of depth reaches 1.5-2cm; Described electroencephalograph comprises electrode for encephalograms, eeg amplifier and A/D modular converter; Described computer comprises the eeg data processing module, and the eeg data processing module comprises EEG alpha power spectrum real-time analysis module;Described stimulus intensity adjustment module, the stimulus intensity regulating command that sends for receiving the eeg data processing module, by increasing or reduce stimulus intensity, the forward and backward eegαwave energy of comparison stimulus intensity adjustments successively, stimulus intensity while obtaining α wave energy maximum, outputing to magnetic stimulates generator;Described stimulus frequency adjustment module, the stimulus frequency regulating command that sends for receiving the eeg data processing module, by increasing or reduce stimulus frequency, the forward and backward eegαwave energy of comparison stimulus frequency adjustment successively, stimulus frequency while obtaining α wave energy maximum, outputing to magnetic stimulates generator;Described stimulus waveform adjustment module, the stimulus waveform regulating command that sends for receiving the eeg data processing module, by switching different stimulated waveform, the eegαwave energy while relatively applying the different stimulated waveform, stimulus waveform while choosing α wave energy maximum, outputing to magnetic stimulates generator;Described EEG alpha power spectrum real-time analysis module, for brain α wave power spectrum is carried out to real-time analysis, calculate the α wave energy, is provided for the digital command of feedback regulation stimulus intensity, stimulus frequency and stimulus waveform.
- A kind of brain α ripple as claimed in claim 1 feedback regulation through the cave magnetic stimulation system, it is characterized in that, described stimulating coil is horn-like stimulating coil, its heavy caliber, small-bore, axial height and coil turn, meet Maxwell equation.
- 3. a kind of brain α ripple as claimed in claim 2 feedback regulation through the cave magnetic stimulation system, it is characterized in that, the heavy caliber of described horn-like stimulating coil is that 0.5cm, the small-bore 0.1cm of being, axial height are 0.25cm, coil turn monolayer 25 circles, totally 5 layers, wire is the copper cash of wire diameter 1mm.
- 4. the implementation method through the cave magnetic stimulation system of a kind of brain α ripple as claimed in claim 1 feedback regulation, is characterized in that, step comprises:Stimulate the horn-like stimulating coil of generator to be fixed on human acupoint magnetic and carry out the magnetic stimulation, with electroencephalograph, gather EEG signals, the eeg data processing module is processed the EEG signals that gathers by AR model the Power Spectrum Estimation Method, obtain brain α wave power spectrum, calculate the α wave energy, and be translated into the digital command that stimulus intensity is regulated, stimulus frequency is regulated and stimulus waveform is regulated and feed back to single-chip microcomputer, single-chip microcomputer stimulates generator to regulate to magnetic.
- A kind of brain α ripple as claimed in claim 1 feedback regulation through the cave magnetic stimulation system, it is characterized in that, described eeg data processing module also comprises the real-time display module of Dynamic ElectroencephalogramSystem;The real-time display module of described Dynamic ElectroencephalogramSystem, for showing in real time the topography of brain α wave energy, the foundation of regulating stimulus intensity, stimulus frequency and stimulus waveform as manual button.
- 6. the implementation method through the cave magnetic stimulation system of a kind of brain α ripple as claimed in claim 5 feedback regulation, is characterized in that, step comprises:Stimulate the horn-like stimulating coil of generator to be fixed on human acupoint magnetic and carry out the magnetic stimulation, with electroencephalograph, gather EEG signals, the eeg data processing module is processed the EEG signals that gathers by AR model the Power Spectrum Estimation Method, obtain brain α wave power spectrum, calculate the α wave energy, draw Dynamic ElectroencephalogramSystem, according to topography, with manual button, regulate respectively stimulus intensity, stimulus frequency and stimulus waveform, when Dynamic ElectroencephalogramSystem presented the red area maximum, magnetic stimulated generator output stimulus intensity, stimulus frequency and stimulus waveform.
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