CN202676710U - Noninvasive intelligent cholesterol monitoring system based on biological chip - Google Patents
Noninvasive intelligent cholesterol monitoring system based on biological chip Download PDFInfo
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- CN202676710U CN202676710U CN 201220355689 CN201220355689U CN202676710U CN 202676710 U CN202676710 U CN 202676710U CN 201220355689 CN201220355689 CN 201220355689 CN 201220355689 U CN201220355689 U CN 201220355689U CN 202676710 U CN202676710 U CN 202676710U
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Abstract
The utility model discloses a noninvasive intelligent cholesterol monitoring system based on a biological chip, which comprises a skin sample acquisition device, a biological chip and an intelligent monitoring system, wherein a skin mucosa, a convex-edged small knife or other devices capable of acquiring skin samples can be selected as the skin sample acquisition device; the biological chip comprises a substrate carrier, a reaction region on the carrier and a biochemical sensor; and the intelligent monitoring system comprises a singlechip as a main control core, an additional display unit, an alarm unit, a remote monitoring unit and a functional switch. The noninvasive intelligent cholesterol monitoring system based on a biological chip has the characteristics of quickness and accuracy in testing and high reliability, not only is the problem that the cholesterol content of personnel to be noninvasively detected solved, but also various humanized arrangements such as intelligent detection are provided, and the noninvasive intelligent cholesterol monitoring system has extensive application prospects.
Description
Technical field
The utility model belongs to the cholesterol detection field, relates in particular to the method for utilizing biochip and carries out without the intelligent monitor system of creating cholesterol.
Background technology
Studies show that for many years, atherosclerosis disease and complication thereof, angiocardiopathies such as coronary heart disease, apoplexy is the whole world population deadly main cause that disables.Take China as example, " the China Health career development situation statistical communique " of ministry of Health of China statistical information center issue in 2006 shows, China's angiocardiopathy mortality ratio and PMI continue to rank first from nineteen ninety, at least, account at present 40% of the total death toll in the whole nation, and these data also can increase whenever to be close on speed necessarily, and therefore visible atherosclerosis disease and complication thereof are very large to the threat of human health.And multinomial studies show that, high cholesterol count in the human body is to cause one of atherosclerotic main reason, the control of cholesterol-lowering drug and diet all is the basis for the treatment of relevant disease, and these measures all be unable to do without correctly obtaining related personnel's cholesterol level.
At present, the method of the most traditional widely cholesterol detection content all has wound, namely by extracting the content of blood measuring plasma total cholesterol levels or high/low density lipoprotein, these methods all need fasting a period of time before detection, not only take time and effort, cost is high, also can bring certain painful and risk of infecting to the tested personnel.Even the user adopts the mode of the self check of being in, also need expensive reagent and test paper etc., and may produce blood sampling and pollute and the bacterium infection problems, therefore utilize the content of noninvasive mode cholesterol detection, can help people to avoid the relevant issues of above existence as far as possible.
Existing nothing wound cholesterol determination technology mainly contains:
(1) Chinese invention patent prospectus " method and apparatus that is used for non-invasive measurement of skin tissue cholesterol " (application number: 200680006258.6, open day on June 4th, 2008), this patent disclosure a kind of chemical reagent that directly utilizes read final measurement result at skin tissue surface generation chemical reaction and by instruments such as colour comparator or photometers.The method is directly measured on skin, and a whole set of testing process of tested personnel needs special personnel to operate and control the dropping etc. of amount of reagent, can limit on a large scale like this and detect.
(2) Chinese invention patent prospectus " Direct Analysis is by the skin cholesterol in the skin samples of tape stripping acquisition " (application number: 200580013893.2, open day on May 9th, 2007), this patent disclosure a kind of sample that utilizes adhesive tape to peel off to obtain the skin exocuticle, recycling can with the cholesterol level of a series of chemical reagent quantitative measurement samples of cholesterol specific binding.Although the method has overcome the detection limit on a large scale of a upper technology, whole testing process still needs substep to carry out a plurality of experiments, not only waste of manpower but also holding time.
The cholesterol detection of in the market combined with intelligent detection almost is blank, and human nature service is more and more by the requirement of modern society, so exploitation has the system of Intelligent Measurement cholesterol level information, is a kind of inevitable trend.
Summary of the invention
The purpose of this utility model is to overcome the shortcoming in the above background description, and a kind of nothing wound cholesterol intelligent monitor system based on biochip is provided, and can measure quicker, extensive, accurately the content of cholesterol.
The technical solution that realizes the utility model purpose is: a kind of nothing wound cholesterol intelligent monitor system based on biochip, comprise the skin samples deriving means, and biochip and intelligent monitor system, wherein:
The skin samples deriving means is used for getting the skin cholesterol sample without new discovery; Biochip is used for realizing sample process, detection and transforms detection signal; Intelligent monitor system is used for measuring and calculating, output detections result, control information transmission.Further, in order to make things convenient for sampling operation, the skin samples deriving means can be designed as and has independently structure on physical construction, can separate use with biochip and intelligent monitor system.
Skin samples deriving means mentioned above is selected from following technical scheme: adopt directly sticking getting or the scraping scurf of mucocutaneous, protruding sword pocket knife, or other can obtain the device of skin samples;
Further, in order to control more accurately sampling quantity, mucocutaneous, protruding sword pocket knife can also be separately fixed on the automaton, use device automatically controlled is to realize equal time, equal pressure and to take uniformly the sample at selected skin place.
Further, the mucocutaneous pressure-sensitive that has mentioned above, its material can be selected from the elastic body that acrylic tackifier, synthetic rubber elastomer precursor gum stick, siloxy group adhesive, styrene-isoprene-phenylethene or s-B-S block polymer form.
Biochip mentioned above is made of the reaction zone on substrate carrier, the carrier and biochemical sensor, wherein:
Described substrate carrier can be made of materials such as glass sheet, silicon chip, nylon membranes; Reaction zone on the described carrier refers to the reaction zone for the detection of sample cholesterol level; Described biochemical sensor is used for collecting the physics and chemistry signal of the reaction zone on the carrier, and transforms detection signal (electric signal).
Biochip mentioned above can be connected with intelligent monitor system by data line, and the detection signal of biochip is transferred to intelligent checking system;
Described intelligent monitor system is by take single-chip microcomputer as the major control core, additional display unit, alarm unit, remote monitoring unit and functional switch consist of, that is: described intelligent monitor system is take single-chip microcomputer as the major control core, described these unit need to be by Single-chip Controlling or interactive instruction control operation; Wherein,
1. described single-chip microcomputer can receive the detection signal of biochip transmission, and finishes the measuring and calculating of cholesterol level and the calculation process of data;
2. described single-chip microcomputer can prestore, inputs and/or export the database of cholesterol level secure threshold;
3. the cholesterol level information of different samples can be stored, inputs and/or be exported to described single-chip microcomputer;
4. described display unit can be exported the operation result of single-chip microcomputer, and its display mode can comprise: with reference to the demonstration of secure threshold Direct Digital content, and/or contain discharge curve with reference to the stage of secure threshold and show; Further, described display unit also can be controlled function by integrated touch, to realize the control to other operations.
5. described alarm unit refers to, single-chip microcomputer can be reported to the police to the results suggest that has exceeded the secure threshold scope; The mode of reporting to the police comprises: the screen at display unit arranges information, perhaps audio alert, perhaps remote alarms.
6. described remote monitoring unit can send tested personnel's cholesterol level information to related personnel or website, perhaps the secure threshold database that prestores in the single-chip microcomputer is upgraded by the remote monitoring unit; Further, its remote mode can be internet, mobile communications network (such as GPRS network), blue-tooth intelligence terminal etc.;
7. intelligent checking system is provided with corresponding functional switch, to realize the selecting output to functional requirement to control; Further, functional switch can be unit independently, can be compound, also can finish the selection of functional switch by utilizing the touch control display screen.
The utility model compared with prior art, its remarkable advantage is:
1, detects without wound, alleviated significantly tested personnel's misery, avoided blood drawing to detect the various infection risks that bring;
2, quick, accurate based on the test of biochip, reliability is high;
3, data accumulating memory function can be remembered multidigit tested personnel's cholesterol level and the interim cholesterol level curve that demonstrates the tested personnel as required simultaneously;
4, system's hommization arranges, and takes full advantage of the wireless communication functions of present information, makes the cholesterol level situation that related personnel or website can the Real Time Monitoring tested personnel.
Description of drawings
Fig. 1 is based on the nothing wound cholesterol intelligent monitor system structural drawing of biochip;
Fig. 2 is the structural drawing of intelligent monitor system;
Wherein, 1. skin samples deriving means; 2. biochip; 3. intelligent monitor system; 21. substrate carrier; 22. the reaction zone on the substrate carrier; 23. biochemical sensor; 31. single-chip microcomputer; 32. functional switch; 33. display unit; 34. alarm unit; 35. remote monitoring unit.
Embodiment
Below in conjunction with attached Fig. 1 and 2 and embodiment, the utility model is further elaborated.
The sampling position:
At first clean the skin surface of the required sampling of tested personnel, the skin of general preferred palm part in order to get rid of the impact of other disturbing factors (for example sebaceous glands), thereby collects the skin samples source of high-quality.
Sample obtains:
Recycling skin samples deriving means 1 carries out the skin sampling.Utilize directly sticking getting or the scraping skin samples of mucocutaneous or protruding sword pocket knife; If mucocutaneous or protruding sword pocket knife is fixed on the automaton, then can utilize the power of mechanical part and the design of inertia control, with automatic control sampled pressure, time and homogeneity; Also can take above-mentioned mechanical part in conjunction with simple single-chip microcomputer control program, with automatic control sampled pressure, time and homogeneity, so that control assembly can be guaranteed the relatively accurate of sampling quantity, not be subjected to sample collector's difference and difference to some extent.
Biochip 2 is processed:
The skin samples that obtains directly is positioned over the reaction zone 22 of the substrate carrier on the substrate carrier 21 corresponding on the biochip 2, again by carrying out sample preparation with the effect of the chemical reagent of cholesterol specific reaction or combination, and with the physics and chemistry signal that produces in sample preparation process biochemical sensor 23 perception receptions, the converting sensed signals (electric signal) by biochip 2, and send to intelligent monitor system 3.
Data management:
Accompanying drawing 2 is the structural drawing of intelligent monitor system 3; Wherein, after intelligent monitor system 3 receives the detection signal (electric signal) of biochip 2, can send to intelligent monitor system 3, carry out the calculation process of data by single-chip microcomputer 31, and the cholesterol level testing result of correspondence is exported in certain mode of needs by display unit 33.
Display unit 33 can binding function switch 32 selection, show the content results of the direct digital content information result of output or interim curve;
Alarm unit 34 can binding function switch 32 selection whether need to report to the police with control, whether need remote alarms, with which type of mode warning etc., the mode of warning can have three kinds, comprises audio alert, display alarm, long-distance monitoring and alarming; The reference information that whether sends warning in the alarm unit 34 derives from the secure threshold database of storage in the single-chip microcomputer 31.
Remote monitoring unit 35 can binding function switch 32 the selection implementing monitoring, the mode of remote monitoring comprises: internet, mobile communications network (such as GPRS network), blue-tooth intelligence terminal.
Functional switch 32 can adopt independence or combination switch key, also can use the directly actuated mode of display screen.
Single-chip microcomputer 31 has been stored the database of cholesterol secure threshold, and this database can be finished Data Update by remote monitoring unit 35.Selection that also can binding function switch 32 whether to control opening network, is carried out database update.
Single-chip microcomputer 31 dispose memory function, simultaneously stage storage multidigit tested personnel's cholesterol level information, can remember simultaneously multidigit tested personnel's cholesterol level and the interim cholesterol level curve that demonstrates the tested personnel as required, to meet individual requirements.
Claims (8)
1. the nothing wound cholesterol intelligent monitor system based on biochip comprises skin samples deriving means (1), biochip (2) and intelligent monitor system (3), wherein:
Described skin samples deriving means (1) is selected from mucocutaneous, protruding sword pocket knife or other can obtain the device of skin samples;
Described biochip (2) is made of the reaction zone (22) on substrate carrier (21), the carrier and biochemical sensor (23), and wherein: described substrate carrier (21) is made of glass sheet, silicon chip or nylon membrane material; Reaction zone on the described carrier (22) is used for the reaction zone that the sample cholesterol level detects; Described biochemical sensor (23) is used for the detection signal of the reaction zone (22) on collection and the conversion carrier;
Described biochip (2) is connected with intelligent monitor system (3) by data line, and the detection signal of biochip (2) is transferred to intelligent checking system (3);
Described intelligent monitor system (3) is made of the single-chip microcomputer (31) of integrated display unit (33), alarm unit (34), remote monitoring unit (35) and functional switch (32); Wherein,
1. described single-chip microcomputer (31) can receive the detection signal of biochip (2) transmission, and finishes the measuring and calculating of cholesterol level and the calculation process of data;
2. described single-chip microcomputer (31) can prestore, inputs and/or export the database of cholesterol level secure threshold;
3. the cholesterol level information of different samples can be stored, inputs and/or be exported to described single-chip microcomputer (31);
4. described display unit (33) can be exported the operation result of single-chip microcomputer (31);
5. described alarm unit (34) is that the results suggest that has exceeded the secure threshold scope is reported to the police;
6. described remote monitoring unit (35) can send tested personnel's cholesterol level information to related personnel or website, perhaps the secure threshold database that prestores in the single-chip microcomputer (31) is upgraded by remote monitoring unit (35);
7. intelligent checking system (3) is provided with functional switch (32).
2. a kind of nothing based on biochip as claimed in claim 1 is created the cholesterol intelligent monitor system, and it is characterized in that: described skin samples deriving means (1) has independently physical construction.
3. a kind of nothing based on biochip as claimed in claim 2 is created the cholesterol intelligent monitor system, and it is characterized in that: described mucocutaneous, protruding sword pocket knife is separately fixed on the automaton.
4. a kind of nothing based on biochip as claimed in claim 3 is created the cholesterol intelligent monitor system, it is characterized in that: the described mucocutaneous pressure-sensitive that has, its material are selected from the elastic body that acrylic tackifier, synthetic rubber elastomer precursor gum stick, siloxy group adhesive, styrene-isoprene-phenylethene or s-B-S block polymer form.
5. such as claim 1 or 4 described a kind of nothing wound cholesterol intelligent monitor systems based on biochip, it is characterized in that: the display mode of described display unit (33) comprising: the digital content with reference to secure threshold shows, and/or contains the discharge curve demonstration with reference to the stage of secure threshold.
6. a kind of nothing wound cholesterol intelligent monitor system based on biochip as claimed in claim 5 is characterized in that: described display unit (33) integrated touch control function.
7. such as claim 1 or 6 described a kind of nothing wound cholesterol intelligent monitor systems based on biochip, it is characterized in that: the mode of described warning comprises: at display unit (33) information, audio alert or remote alarms are set.
8. a kind of nothing based on biochip as claimed in claim 7 is created the cholesterol intelligent monitor system, and it is characterized in that: described remote mode is internet, mobile communications network or blue-tooth intelligence terminal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220355689 CN202676710U (en) | 2012-07-20 | 2012-07-20 | Noninvasive intelligent cholesterol monitoring system based on biological chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220355689 CN202676710U (en) | 2012-07-20 | 2012-07-20 | Noninvasive intelligent cholesterol monitoring system based on biological chip |
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| Publication Number | Publication Date |
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| CN202676710U true CN202676710U (en) | 2013-01-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220355689 Withdrawn - After Issue CN202676710U (en) | 2012-07-20 | 2012-07-20 | Noninvasive intelligent cholesterol monitoring system based on biological chip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102749462A (en) * | 2012-07-20 | 2012-10-24 | 常熟柏宇医疗电子有限公司 | Noninvasive cholesterol intelligent monitoring system based on biological chip |
-
2012
- 2012-07-20 CN CN 201220355689 patent/CN202676710U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102749462A (en) * | 2012-07-20 | 2012-10-24 | 常熟柏宇医疗电子有限公司 | Noninvasive cholesterol intelligent monitoring system based on biological chip |
| CN102749462B (en) * | 2012-07-20 | 2014-08-06 | 常熟柏宇医疗电子有限公司 | Noninvasive cholesterol intelligent monitoring system based on biological chip |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20130116 Effective date of abandoning: 20140806 |
|
| RGAV | Abandon patent right to avoid regrant |