CN202638414U

CN202638414U - Chemical reactor

Info

Publication number: CN202638414U
Application number: CN2012202840791U
Authority: CN
Inventors: 何际婵; 董志超; 陈长潭
Original assignee: Tropical Crops Genetic Resources Institute CATAS
Current assignee: Tropical Crops Genetic Resources Institute CATAS
Priority date: 2012-06-16
Filing date: 2012-06-16
Publication date: 2013-01-02
Anticipated expiration: 2022-06-16

Abstract

The utility model discloses a chemical reactor, which comprises a reaction container, an ultrasonic transducer, an ultrasonic generator, a temperature control device and a heating plate, wherein the ultrasonic transducer is fixed on the inner wall of the reactor container, the bottom of the reaction container is provided with the heating plate, or the inner layer of the reaction container is lined with a backflow clamping sleeve, and the ultrasonic generator and the ultrasonic transducer are electrically connected. The chemical reactor is simple in structure and low in construction cost, dead angle is avoided by ultrasonic treatment, the reaction time is greatly shortened, the crystallization time can be obviously shortened, the grain size is smaller, size distribution is more uniform, and the chemical reactor can be adapted to simple medicinal chemistry reaction mostly performed on conditions of normal pressure, normal temperature or heating, and is easy to use.

Description

A kind of chemical reactor

Technical field

The utility model relates to the pharmaceutical chemistry processing unit (plant), especially a kind of small drug chemical reactor.

Background technology

Mini-reactor generally adopts water-bath or oil bath temperature control, agitator to stir and evenly mix to carry out chemical reaction traditionally.It is longer to be not suitable for being applied to some reaction time consumption, or product needs the chemical reaction of long-time crystallization.

Ultrasonic technology is in the applied chemistry reaction in recent years.Ultrasonic transducer drive circuit, convert civil power to the high-frequency and high-voltage electric energy, this energy is in liquid and produce powerful pressure wave, and this pressure wave can form millions upon millions of microcosmic bubbles, along with dither, bubble will increase rapidly, then closed suddenly, when bubble is closed, because mutual collision produces powerful shock wave between liquid, produce around it thousands of atmospheric pressure (being ultrasonic cavitation) and moment high temperature, thereby Reaction time shorten greatly.

In reaction crystallization process later, hyperacoustic effect also has: 1. regulate crystal size, the fineness ratio conventional method is less; 2. improve size distribution, be more evenly distributed; 3. nucleation time is shorter, shortens crystallization time.

Existing ultrasonic response equipment also Shortcomings when having above-mentioned advantage.Be that 200520035923.7 utility model patent " tubular circulating ultrasonic chemical reactor " complex structure, equipment manufacturing cost are high such as application number, the large-scale production that suitable technique is comparatively complicated, and be not suitable for using in, produced in smaller volumes relatively simple in technique or the test.

The utility model content

The purpose of this utility model be to provide a kind of simple in structure, cost is low, reaction time consumption is short, can adapt to the chemical reactor of most simple pharmaceutical chemistry reactions of carrying out under normal pressure, normal temperature or heating condition.

To achieve these goals, the technical solution of the utility model is: a kind of chemical reactor is provided, wherein, comprises reaction vessel, ultrasonic transducer, supersonic generator, temperature controller and heating plate; Described ultrasonic transducer is fixed on the inwall of reaction vessel, and the internal layer that the bottom of reaction vessel is provided with heating plate or reaction vessel is lined with the backflow chuck, and supersonic generator is electrically connected with ultrasonic transducer.

The inwall skin of described reaction vessel is provided with heat-insulation layer.

The quantity of described ultrasonic transducer is at least one.

Described supersonic generator sends the ultrasonic wave of at least one wavelength.

The utility model is simple in structure, cost is low, ultrasonic wave is processed does not have the dead angle, Reaction time shorten and can significantly shorten crystallization time greatly, grain size number is less, size distribution is more even, can adapt to most simple pharmaceutical chemistry reactions of under normal pressure, normal temperature or heating condition, carrying out, be easy to use.

Description of drawings

Fig. 1 is the main TV structure schematic diagram of the utility model chemical reactor;

Fig. 2 is the plan structure schematic diagram of the utility model chemical reactor;

Among the figure: 1, reaction vessel; 2, ultrasonic transducer; 3, supersonic generator; 4, temperature controller; 5, heating plate; 6, heat-insulation layer; 7, shell; 8, fixed mount; 9, back flow reaction bottle.

The specific embodiment

For the technology contents that describes the utility model chemical reactor in detail, structural feature, below in conjunction with embodiment and cooperate accompanying drawing to be described further.

As shown in Figure 1, 2, the utility model chemical reactor comprises reaction vessel 1, ultrasonic transducer 2, supersonic generator 3, temperature controller 4 and heating plate 5; Described ultrasonic transducer 2 is fixed on the inwall of reaction vessel 1, is symmetrical and places.Reaction vessel can be stainless steel or other any material, its cross section can be circle, square or arbitrary shape, the internal layer that the bottom of reaction vessel 1 is provided with heating plate 5 or reaction vessel is lined with the backflow chuck to realize temperature control, and supersonic generator 3 is electrically connected with ultrasonic transducer 2.The inwall skin of described reaction vessel 1 is provided with heat-insulation layer 6.The quantity of described ultrasonic transducer 2 is 8, is symmetrical fixed placement in the inner wall outside of reaction vessel 1.Described supersonic generator 3 occurrence frequencies are 40KHz, and power is 1000W, are electrically connected with ultrasonic transducer 2.Supersonic generator 3 and temperature controller are located on the shell 7.

Salt-forming reaction with catharanthine illustrates concrete use of the present utility model: first distilled water being added in the reaction vessel 1, regulate temperature controller 4, is 50 ℃ with Temperature Setting; To add through the catharanthus roseus mixed biologic alkali that impurity and purification are processed in the back flow reaction bottle 9 of 3000ml, add an amount of anhydrous alcohol solution, add again 20% tartaric acid ethanol solution, be placed in the reaction vessel 1 fixing with fixed mount 8 after mixing, install reflux at back flow reaction bottle 9, begin heating, open simultaneously supersonic generator 3.Begin to occur the crystallization of tartaric acid catharanthine after 30 minutes, post crystallization was finished in 1 hour.

Above disclosed only is preferred embodiment of the present utility model, certainly can not limit with this interest field of the utility model, and the equivalent variations of therefore doing according to the utility model claim still belongs to the scope that the utility model is contained.

Claims

1. a chemical reactor is characterized in that: comprise reaction vessel, ultrasonic transducer, supersonic generator, temperature controller and heating plate; Described ultrasonic transducer is fixed on the inwall of reaction vessel, and the internal layer that the bottom of reaction vessel is provided with heating plate or reaction vessel is lined with the backflow chuck, and supersonic generator is electrically connected with ultrasonic transducer.

2. chemical reactor as claimed in claim 1, it is characterized in that: the inwall skin of described reaction vessel is provided with heat-insulation layer.

3. chemical reactor as claimed in claim 1, it is characterized in that: the quantity of described ultrasonic transducer is at least one.

4. chemical reactor as claimed in claim 1, it is characterized in that: described supersonic generator sends the ultrasonic wave of at least one wavelength.