CN202440512U - Detection device for gene detection - Google Patents
Detection device for gene detection Download PDFInfo
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- CN202440512U CN202440512U CN 201120569193 CN201120569193U CN202440512U CN 202440512 U CN202440512 U CN 202440512U CN 201120569193 CN201120569193 CN 201120569193 CN 201120569193 U CN201120569193 U CN 201120569193U CN 202440512 U CN202440512 U CN 202440512U
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Abstract
The utility model provides a simple, convenient and rapid detection device for gene detection. The detection device for gene detection comprises a gene detector and a controller, wherein the controller is used for controlling a gene detection process implemented by the gene detector, acquiring and receiving scanned data of the gene detector and carrying out result analysis on the scanned data. According to the utility model, a high-precision instrument is used for controlling the detection process, so that the detection speed and efficiency are greatly improved, detection cost and manpower resource are effectively saved, and the purposes of efficiently, accurately and exactly detecting DNA are achieved.
Description
Technical field
The utility model relates to the technique of gene detection field, particularly relates to a kind of proofing unit that is used for gene test.
Background technology
1998 the end of the year AAAS classify the electrochemical gene sensor technology one of as big progress in 1998 annual natural science fields ten, it serves to show its meaning in the history of science.It with its can be simultaneously, analyze the ability of thousands of genomic informations quickly and accurately and demonstrated huge power.These are used and mainly comprise genetic expression detection, sudden change detection, genome polymorphism analysis and aspects such as gene library mapping and sequencing by hybridization.
The change of adopting electrochemical gene sensor to detect genetic expression can be saved lot of manpower and material resources and financial resources; Former, the change situation of a plurality of genes is observed in scientist's a large amount of experiment of repetition of having to, and almost is inconceivable if use conventional methods the change of thousands of genes in the research cell; Because must extraction at first extract the nucleic acid of cell; And want abundant to satisfy the needs of Northern hybridization, each probe of mark is hybridized detection more respectively then.Adopt electrochemical gene sensor that thousands of times of ground of workload are reduced; Utilize electrochemical gene sensor to detect the function of 6000 genes in the yeast simultaneously, 8600 expression of gene changes among the human fibroblasts have then detected to achievement in the Patrick Brown of Stanford University leader's scientific research group.
Electrochemical gene sensor also can be used for gene sequencing; The present U.S. Human Genome Project is being greatly developed this technology and is being striven for substituting present automatic sequencing; Compare with automatic sequencing with existing manual order-checking, the electrochemical gene sensor order-checking can be saved a large amount of reagent and instrument loss.People more successfully comprise that to multiple biology Arabidopis thaliana, yeast and people's genomic expression situation studies in the research that genetic expression detects.Facts have proved that the electrochemical gene sensor technology also can be used for the detection of nucleic acid mutation and the analysis of genome polymorphism; The sudden change that reaches 98% grade with conventional sequencing result consistence detects, to evaluation, mapping and the somatotype of human genome SNP, the research of human mitochondria gene group polymorphum etc.
Biosensor is combined with chip technology,, thereby the yeast genes group is mapped through the order of confirming overlapping clone through the verified single base mutation that can detect gene of strength of electric field in change probe array zone.
Sequencing by hybridization is another important application of electrochemical gene sensor technology.This sequencing technologies a kind of efficient feasible sequence measurement of can yet be regarded as in theory, but need can derive the sequence of purpose nucleic acid molecule through the hybridization of a large amount of overlap probes and molecules of interest, so need to make a large amount of probes.The electrochemical gene sensor technology can be synthesized and fixing a large amount of nucleic acid molecule with comparalive ease, so its appearance provides the possibility of practice undoubtedly for sequencing by hybridization.
Employing electrochemical gene sensor technology; Can accelerate the job schedule of the Human Genome Project greatly; For example be used for that gene sequencing, genetic expression detect and new genetic marker such as SNP location etc., this is significant to seeking new functional gene, seek new drug target and developing new genomic medicine.Adopt that electrochemical gene sensor can carry out that workload out of the former imagination detects different plant species, different tissues, differently sickly plants, the genetic expression under the different treatment condition changes, thereby know exploitation have different purposes diagnostic kit.New drug must be through the human safety experiment in the experimental phase; Just must observe the influence of medicine to human gene expression; Owing to and do not know that medicine works to that a kind of gene; Just must the genetic expression in known all or the certain limit all be detected, adopt electrochemical gene sensor can accomplish this task rapidly and exactly.
But existing carry out gene test through electrochemical sensor and need more step, and for the artificial operational requirement than higher, the complex steps time of detecting simultaneously is longer; Simultaneously the situation that a plurality of samples detect is needed lot of manpower and material resources for needs, has improved the detection cost, again and; Owing to receive the restriction of local and equipment, the very big restriction that obviously has for the processing of various article is particularly for places such as hospital and laboratories; Receive the spatial restriction, too much equipment can not be installed and hold too much operator, lowered detection efficiency greatly for sample; Than and for need sample being shifted or operate in the testing process; Because a plurality of step separating treatment make sample or data be affected easily, thereby have influenced detection accuracy greatly.
Summary of the invention
The purpose of the utility model be to provide a kind of easy, be used for the proofing unit of gene test fast.
A kind of proofing unit that is used for gene test, said device comprises:
Gene test device and unit, said unit are controlled the process that said gene test device carries out gene test, gather and receive the scan-data of gene test device, and carry out interpretation of result;
Preferably; Said gene test device comprises: electrochemical gene sensor, junctor, the second connection management device and chip heating unit; Molecule after said electrochemical gene sensor adopts electrochemical techniques to thing hybridization to be detected carries out mark, realizes gene test, and the said second connection management device is through the detection signal of alternating voltammetry scanning through mark; And according to the process of the instruction control gene test of said unit, and the temperature of controlling said chip heating unit; Said junctor is used for said electrochemical gene sensor and is connected with the chip heating unit with the second connection management device, and said chip heating unit is used for electrochemical gene sensor is heated.
Preferably; Said unit comprises: first management link block, first processing module and second processing module; The said first management link block is connected with said gene test device; Receive the scan-data of second connection management device output, and carry out data interaction with the said second connection management device; Said second processing module is carried out interpretation of result to the data of obtaining; Said first processing module is connected with the said first management link block, is used for said gene test device is controlled and managed, and the chip heating unit is controlled, and be used for external communication and connection management.
Preferably; Said first processing module comprises: data processing unit and temperature control unit; Said data processing unit is used for said gene test device is controlled and managed; And being used for external communication and connection management, said temperature control unit is used for the control chip heating unit, the temperature of real-time regulated electrochemical gene sensor.
Preferably, said proofing unit comprises one or more gene test devices, is used for one or more things to be detected are carried out gene test, and said chip heating unit comprises one or more chip fire ends, is connected with said one or more gene test devices.
Preferably; Said temperature control unit comprises: one or more temperature control components and one or more Temperature Feedback element; Said one or more temperature control component corresponds respectively to one or more gene test devices; Said one or more Temperature Feedback element corresponds respectively to one or more gene test devices; Be used to detect the temperature of gene test device, said one or more temperature control components are controlled the chip heating unit on one or more gene test devices respectively with according to the monitoring temperature of said one or more Temperature Feedback unit to the gene test device in real time.
Preferably, said one or more temperature control component comprises:
Comparing element is used for after the detected temperature simulation digital conversion in one or more Temperature Feedback unit, converts numerary signal into temperature and target temperature compares;
Controlling elements based on comparative result, according to parameter prediction temperature variations such as the amplitude of temperature variation, speed, is adjusted temperature control work output in real time;
Power element according to the output manipulated variable of controlling elements, is controlled the temperature of said chip heating unit.
Preferably, junctor comprises:
First coupling end that is connected with said electrochemical gene sensor;
Be connected with said chip heating unit, regulate the environment control end of the temperature of control electrochemical gene sensor;
Second electric signal transmission interfaces that is connected with the said second connection management device;
Said first coupling end comprises: electrochemical gene sensor fixed bit and first electric signal transmission interfaces that is connected with said electrochemical gene sensor; Said electrochemical gene sensor fixed bit is used for fixing electrochemical gene sensor, and said first electric signal transmission interfaces is used for carrying out data transmission with electrochemical gene sensor;
Said second electric signal transmission interfaces and said first electric signal transmission interfaces interconnect, and are used for transmission of electric signals between the second connection management device and the said electrochemical gene sensor.
Preferably, the second connection management device comprises: digital circuit, modular converter, low-voltage driving module and voltage acquisition reaction circuit;
The work output of the energizing voltage that said Digital Circuit Control low-voltage driving module produces; The voltage acquisition reaction circuit is gathered energizing voltage; And modular converter becomes numerary signal with analog signal conversion; The unit collection comprise voltage acquisition and through the numerary signal that analog signal conversion becomes, detect, control and interpretation of result.
Compared with prior art, the utlity model has following advantage:
The technical scheme of the utility model since intend to adopt each chip independently temperature be controlled to be DNA hybridization highly stable independently environment be provided; And adopt high precision instrument that checkout procedure is controlled; The speed and the efficient of check have been improved greatly; And effectively practiced thrift the cost and the manpower of check, reached at a high speed, accurately and accurately checked DNA.Be used for gene sequencing, compare with automatic sequencing, can save a large amount of reagent and instrument loss with existing manual order-checking.As long as whole detection hybridization and testing process be 30 minutes, and fast with easy, cheapness is compared with order-checking and to have been reduced cost greatly, realizes low-cost to the pulsating detection of specific gene.Can hybridize detection to 24 chips simultaneously, high-throughout examination and the detection of carrying out disease.Whole hybridization and testing process robotization have realized unmanned guard, have alleviated operator's burden, have improved efficient.
Description of drawings
Fig. 1 is the structural representation of proofing unit in the utility model;
Fig. 2 is the structural representation of first processing module in the utility model;
Fig. 3 is the syndeton of junctor in the utility model;
Fig. 4 is a temperature controlled synoptic diagram in the utility model.
Embodiment
Below in conjunction with accompanying drawing and embodiment the utility model is done further detailed explanation.Should be appreciated that specific embodiment described herein only is used to explain the utility model, and be not used in qualification the utility model.
Shown in Fig. 1～4, the utility model technical scheme provides a kind of proofing unit that is used for gene test, and said device comprises:
Gene test device and unit, said unit are controlled the process that said gene test device carries out gene test, gather and receive the scan-data of gene test device, and carry out interpretation of result;
Preferably; Said gene test device comprises: the molecule after electrochemical gene sensor, junctor, the second connection management device and chip heating unit, said electrochemical gene sensor adopt electrochemical techniques to thing hybridization to be detected carries out mark; Realize gene test; The said second connection management device is through the alternating voltammetry scanning detection signal through mark, and according to the process of the instruction control gene test of said unit, and the temperature of controlling said chip heating unit; Said junctor is used for said electrochemical gene sensor and is connected with the chip heating unit with the second connection management device.
Wherein, Described electrochemical gene sensor comprises: detection zone and electrical signal transmission ends; Said detection zone is used for the samples using electrochemical techniques before and after the thing hybridization to be detected; And, be transferred in the said second connection management device via the electrical signal transmission ends, and then make further analyzing and processing through the detection signal of alternating voltammetry scanning through mark; Said detection zone can be DNA electrochemical sensor or electronics electrochemical gene sensor or the like, can realize the gene detection tool of electrochemical measuring technique.
Said unit comprises: first management link block, first processing module and second processing module;
The said first management link block is connected with said gene test device, receives the scan-data of second connection management device output, and carries out data interaction with the said second connection management module, and said second processing module is carried out interpretation of result to the data of obtaining; Said first processing module is connected with the said first management link block, is used for said gene test device is controlled and managed, and the chip heating unit is controlled, and be used for external communication and connection management.
Preferably; Said first processing module comprises: data processing unit and temperature control unit; Said data processing unit is used for said gene test device is controlled and managed; And being used for external communication and connection management, said temperature control unit is used for the control chip heating unit, the temperature of real-time regulated electrochemical gene sensor.
Gene test device and unit exist lot of data exchange and numerous wires, and for reaching high performance hardware connection and being connected configuration flexibly, the first management link block and the two or two connection management device all adopt FPGA as linkage interface among both.FPGA (Field Programmable Gate Array) is a field programmable gate array, and it is the product that on the basis of programming devices such as PAL, GAL, EPLD, further develops.It occurs as a kind of semi-custom circuit in application specific integrated circuit (ASIC) field, has both solved the deficiency of custom circuit, has overcome the limited shortcoming of original programming device gating circuit number again.The use of FPGA is very flexible, can produce the different circuits function with a slice FPGA through the different programming data.FPGA provides the highest logic density, the abundantest characteristic and the highest performance.Detection module is intended the FPGA device that adopts 10-50 ten thousand gate leves, and the tower switchboard adopts the FPGA device of 1,000,000 gate leves.
The FPGA of gene test device connects the generation of this module of control energizing voltage, and energizing voltage comprises choppy sea and sine-wave superimposed, and waveform is produced through DAC by numerary signal; Chip electrode obtains digital quantity through switch arrays with after amplifying through ADC, and ADC is connected control with switch arrays by FPGA.Be connected with FPGA for transmitter provides the hybridization environment to get temperature controlling system, realize temperature control and flow rate control.With the manipulated variable of upper module FPGA and the upper processing terminal through the gene test device, the FPGA of unit connects, and realizes the instruction and data communication.
Unit can connect 8 gene test devices, requirement can be simultaneously to 8 transmitters scan, data gathering and analyzing and processing.There is a large amount of instruction and data exchanges between unit and gene test device,, adopts FPGA to carry out two kinds of module hardwares and connect for realizing the high speed data communication.The scan-data of each electrode of the essential analysis of unit simultaneously, the data of each electrode must be carried out data conversion and analysis, count task for processing fast and are accomplished by the second processing module DSP.DSP obtains data at a high speed through the first management link block (FPGA), and analytical results connects data processing unit (CPU) common data storage area through FPGA equally, and PC directly obtains analytical results from this zone by the CPU notice.
The transaction management of unit is accomplished by CPU (ARM9 treater), and CUP need carry out control and management to each module and DSP data analysis are initial.The hardware connection is carried out in being connected through the first management link block (FPGA) of CPU and gene test device, DSP, realizes that CPU carries out control and management to each controlled member, and the Status Flag of each controlled member also feeds back to CPU through FPGA.
The data upload PC of unit realizes through network.The embedded ICP/IP protocol stack of CPU software is connected with the network interface card unit on the hardware.System comprises 3 detection towers, and each detection tower is connected with inner route, and route is connected with embedded industry PC again, thereby realizes that the network that detects tower and PC is connected.Local area network through inside and ICP/IP protocol realize detecting the data exchange of tower and embedded industry PC.
Preferably, said proofing unit comprises one or more gene test devices, is used for one or more things to be detected are carried out gene test, and said chip heating unit comprises one or more chip fire ends, is connected with said one or more gene test devices.
Preferably; Said temperature control unit comprises: one or more temperature control components and one or more Temperature Feedback element; Said one or more temperature control component corresponds respectively to one or more gene test devices; Said one or more Temperature Feedback element corresponds respectively to one or more gene test devices; Be used to detect the temperature of gene test device, said one or more temperature control components are controlled the chip heating unit on one or more gene test devices respectively with according to the monitoring temperature of said one or more Temperature Feedback unit to the gene test device in real time.
Preferably, said one or more temperature control component comprises:
Comparing element is used for after the detected temperature simulation digital conversion in one or more Temperature Feedback unit, converts numerary signal into temperature and target temperature compares;
Controlling elements based on comparative result, according to parameter prediction temperature variations such as the amplitude of temperature variation, speed, is adjusted temperature control work output in real time;
Power element according to the output manipulated variable of controlling elements, is controlled the temperature of said chip heating unit.
Each transmitter of the utility model all requires with arriving with inspection; Therefore instrument must possess 24 independent detection modules; Each module can both be carried out separate temperature control; Hybridize the temperature requirements of detecting stages and different test items to satisfy difference, and the control of the temperature of each module must be stablized accurately.In order to reach this requirement; Each module all adopts independent closed loop thermal control unit; System comprises based on the comparing element of ARM9 treater, based on the controlling elements of PWM output control, based on the power element of heating power pipe, amplifies and the feedback element of ADC based on the heating target (being the chip heating unit) of high thermal conductivity copper base with based on high-precision sensing, and is as shown in Figure 4;
Test item based on each element of ARM9 Treatment Analysis; And obtain the target temperature of each current module through this project chip agreement and crossing phase; Obtain the copper base Current Temperatures through Temperature Feedback element (comprising temperature sensors of high precision, high precision amplification, accurate ADC) simultaneously, after relatively calculating, obtain temperature deviation and manipulated variable, power element control power outputs to heating tube; Copper base is carried out temperature control, make it obtain accurately stable temperature.Copper base fully contacts with the chip that inserts detection module, and temperature is transmitted on the chip, for chip hybridization provides suitable temperature environment.
Temperature control algorithm adopts ratio, integration, the differential control based on ARM9, is called for short PID control, claims that again PID regulates.The PID controller algorithm has good stability, reliable operation, advantage easy to adjust, is one of major technique of Industry Control, and the hybridization temperature control expection that is used for the utility model can reach good effect.The structure of controlled plant copper base, parameter and disturbance at random can not be on top of; Can not get precise math model; Other algorithm of control theory is difficult to adopt, so the temperature controlling system structure and parameter must rely on the debugging of experience and development to confirm, the thereof using PID control techniques is the most convenient; The PID unit is exactly the error according to system, and proportion of utilization, integration, difference gauge are calculated manipulated variable and controlled.Ratio (P) control is the simplest a kind of mode, the output of its unit and the proportional relation of error originated from input signal, and system exports and has steady-state error when proportional control only.The proportional relation that is integrated into of the output of integration (I) control and error originated from input signal is to the temperature controlling system of this instrument, if after the entering stable state, have the steady temperature error; This temperature controlling system has the steady temperature error, in order to eliminate steady-state error, in unit, introduces " integral "; Integral depends on the integration of time to error, and along with the increase of time, integral can increase; Even if error is very little like this; Integral also can strengthen along with the increase of time, and the output increase that it promotes unit further reduces the steady temperature error, up to equalling zero.Therefore, adopt proportional+integral (PI) controller algorithm, can make system's no steady temperature error after getting into stable state.The output of differential (D) control and the differential (being the error change rate) of error originated from input signal are proportional; Temperature controlling system vibration even unstability can occur in overcoming the regulate process of error; Its reason is owing to have big inertia assembly or lag module (lagging behind possibly appear in copper base heat conduction) is arranged; Have the effect that suppresses error, it changes the variation that always lags behind temperature error.For addressing this problem, make the variation " in advance " of the effect that suppresses error, make that in temperature error that suppresses error act as zero near zero the time, what need to increase is " differential term ", the trend that its can predicated error variation.Like this, have stability controller and the algorithm of PID, the control action kou that suppresses temperature error is equalled zero, even be negative value, thereby avoid the serious overshoot of controlled volume.
Preferably, said junctor comprises:
First coupling end is used to connect said electrochemical gene sensor;
The environment control end is connected with said chip heating unit, regulates the temperature of control electrochemical gene sensor;
Second electric signal transmission interfaces is connected with the said second connection management device;
Said first coupling end comprises: electrochemical gene sensor fixed bit and first electric signal transmission interfaces that is connected with said electrochemical gene sensor; Said electrochemical gene sensor fixed bit is used for fixing electrochemical gene sensor, and said first electric signal transmission interfaces is used for carrying out data transmission with electrochemical gene sensor;
Said second electric signal transmission interfaces and said first electric signal transmission interfaces interconnect, and are used for transmission of electric signals between the second connection management device and the said electrochemical gene sensor.
Preferably, the second connection management device comprises: digital circuit, modular converter, low-voltage driving module and voltage acquisition reaction circuit;
The work output of the energizing voltage that said Digital Circuit Control low-voltage driving module produces; The voltage acquisition reaction circuit is gathered energizing voltage; And modular converter becomes numerary signal with analog signal conversion; The unit collection comprise voltage acquisition and through the numerary signal that analog signal conversion becomes, detect, control and interpretation of result.
Claims (8)
1. a proofing unit that is used for gene test is characterized in that, said device comprises:
Gene test device and unit, said unit are controlled the process that said gene test device carries out gene test, gather and receive the scan-data of gene test device, and carry out interpretation of result;
Said gene test device comprises: electrochemical gene sensor, junctor, the second connection management device and chip heating unit; Molecule after said electrochemical gene sensor adopts electrochemical techniques to thing hybridization to be detected carries out mark; Realize gene test; The said second connection management device is through the alternating voltammetry scanning detection signal through mark, and according to the process of the instruction control gene test of said unit, and the output temperature of controlling said chip heating unit; Said junctor is used for said electrochemical gene sensor and is connected with the chip heating unit with the second connection management device respectively.
2. the proofing unit that is used for gene test according to claim 1 is characterized in that, said unit comprises: first management link block, first processing module and second processing module;
The said first management link block is connected with said gene test device, receives the scan-data of second connection management device output, and carries out data interaction with the said second connection management device, and said second processing module is carried out interpretation of result to the data of obtaining; Said first processing module is connected with the said first management link block, is used for said gene test device is controlled and managed, and the chip heating unit is controlled, and be used for external communication and connection management.
3. the proofing unit that is used for gene test according to claim 2; It is characterized in that; First processing module comprises: data processing unit and temperature control unit, said data processing unit are used for said gene test device is controlled and managed, and are used for external communication and connection management; Said temperature control unit is used for the control chip heating unit, the temperature of real-time regulated electrochemical gene sensor.
4. the proofing unit that is used for gene test according to claim 3; It is characterized in that; Said proofing unit comprises one or more gene test devices; Be used for one or more things to be detected are carried out gene test, said chip heating unit comprises one or more chip fire ends, is connected with said one or more gene test devices.
5. the proofing unit that is used for gene test according to claim 4; It is characterized in that; Said temperature control unit comprises: one or more temperature control components and one or more Temperature Feedback element; Said one or more temperature control component corresponds respectively to one or more gene test devices, and said one or more Temperature Feedback elements correspond respectively to one or more gene test devices, are used to detect the temperature of gene test device; Said one or more temperature control component is controlled the chip heating unit on one or more gene test devices respectively with according to the monitoring temperature of said one or more Temperature Feedback unit to the gene test device in real time.
6. the proofing unit that is used for gene test according to claim 5 is characterized in that, said one or more temperature control components comprise:
Comparing element is used for after the detected temperature simulation digital conversion in one or more Temperature Feedback unit, converts numerary signal into temperature and target temperature compares;
Controlling elements based on comparative result, according to parameter prediction temperature variations such as the amplitude of temperature variation, speed, is adjusted temperature control work output in real time;
Power element according to the output manipulated variable of controlling elements, is controlled the temperature of said chip heating unit.
7. the proofing unit that is used for gene test according to claim 6 is characterized in that, said junctor comprises:
First coupling end that is connected with said electrochemical gene sensor;
Be connected with said chip heating unit, regulate the environment control end of the temperature of control electrochemical gene sensor;
Second electric signal transmission interfaces that is connected with the said second connection management device;
Said first coupling end comprises: electrochemical gene sensor fixed bit and first electric signal transmission interfaces that is connected with said electrochemical gene sensor; Said electrochemical gene sensor fixed bit is used for fixing electrochemical gene sensor, and said first electric signal transmission interfaces is used for carrying out data transmission with electrochemical gene sensor;
Said second electric signal transmission interfaces and said first electric signal transmission interfaces interconnect, and are used for transmission of electric signals between the second connection management device and the said electrochemical gene sensor.
8. according to the arbitrary described proofing unit that is used for gene test of claim 1～7, it is characterized in that the second connection management device comprises: digital circuit, modular converter, low-voltage driving module and voltage acquisition reaction circuit;
The work output of the energizing voltage that said Digital Circuit Control low-voltage driving module produces; The voltage acquisition reaction circuit is gathered energizing voltage; And modular converter becomes numerary signal with analog signal conversion; The unit collection comprise voltage acquisition and through the numerary signal that analog signal conversion becomes, detect, control and interpretation of result.
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| CN 201120569193 CN202440512U (en) | 2011-12-31 | 2011-12-31 | Detection device for gene detection |
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| CN 201120569193 CN202440512U (en) | 2011-12-31 | 2011-12-31 | Detection device for gene detection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102559482A (en) * | 2011-12-31 | 2012-07-11 | 中山大学达安基因股份有限公司 | Gene detection device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102559482A (en) * | 2011-12-31 | 2012-07-11 | 中山大学达安基因股份有限公司 | Gene detection device |
| CN102559482B (en) * | 2011-12-31 | 2013-07-10 | 中山大学达安基因股份有限公司 | Gene detection device |
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