CN202372514U - Platelet gathering instrument - Google Patents
Platelet gathering instrument Download PDFInfo
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- CN202372514U CN202372514U CN2011205383914U CN201120538391U CN202372514U CN 202372514 U CN202372514 U CN 202372514U CN 2011205383914 U CN2011205383914 U CN 2011205383914U CN 201120538391 U CN201120538391 U CN 201120538391U CN 202372514 U CN202372514 U CN 202372514U
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Abstract
The utility model relates to a platelet gathering instrument, which comprises a test movement device, a sample disk device, a reagent bottle device, a cleaning disk device, a horizontal centrifugal device, a sample injection needle device and a cleaning needle device, wherein a magnetic stirring device is arranged in the test movement device; a sample injection needle in the sample injection needle device is connected with an automatic sample injection pipe and an automatic cleaning pipeline of the sample injection needle; and a cleaning needle in the cleaning needle device is connected with an automatic cleaning pipeline of the cleaning needle. According to the platelet gathering instrument, complete procedures of preparing platelet-poor plasma, preparing platelet-rich plasma, automatically injecting samples, automatically detecting the samples, automatically cleaning the samples and discharging waste liquid are integrated to the same instrument, so that the test speed of clinical examination is greatly increased, a phenomenon that an operator is contacted with a blood sample is avoided, and the accuracy of a detection result is improved.
Description
Technical field
The utility model relates to a kind of platelet aggregation instrument; This platelet aggregation instrument comprises test machine core apparatus, sample disc device, reagent bottle device, cleaning disc device, horizontal centrifugal device, sample needle device and needle cleaning device; Sample needle is connected with automatic application of sample pipeline, and cleaning needle is connected with automatic detergent line.
Background technology
Chinese patent 90207370.2 discloses intelligent platelet aggregation instrument, comprises that complete machine is made up of power supply, temperature-adjusting circuit, photoelectric switching circuit, amplifying circuit, programmable amplifying circuit, analog to digital conversion circuit, data converting circuit, imput output circuit, display, keyboard, printer, stirring motor and basic calculating system.Make central processing unit by 8-bit microprocessor, the control each several part has functions such as the automatic zero set (AZS) of test blood plasma, stirring, reporting printing and demonstration time.Adopt the micro computer special circuit that various corresponding control programs are solidificated in the integrated circuit, solve automatic zero set (AZS), different specimen blood plasma is carried out automatic zero set (AZS); Automatically drive stirring motor, and gathering curve and the laboratory report that can will test are printed automatically, are duplicated and show the time at that time automatically.But this patent once only can be measured a blood sample; The category that belongs to hand dipping not only can cause the prolongation of test period, also can be because of the negligence of operation of manual work; Influence precision of test result, operating personnel are because of directly contacting contaminated with patient's blood sample.Therefore, need to propose a kind of new platelet aggregation instrument.
Summary of the invention
The purpose of the utility model is to provide a kind of platelet aggregation instrument; This platelet aggregation instrument comprises test machine core apparatus, sample disc device, reagent bottle device, cleaning disc device, horizontal centrifugal device, sample needle device and needle cleaning device; Sample needle is connected with automatic application of sample pipeline, and cleaning needle is connected with automatic detergent line.The full-automatic detection mode of the utility model; Operating personnel have been avoided because of directly contacting contaminated with patient's blood sample; Protected greatly that the operator's is healthy; All application of sample program, test procedure, cleaning procedure are accomplished by instrument automatically, have improved the test speed and the accuracy of clinical examination greatly.
The purpose of the utility model is realized by following technical proposals: a kind of platelet aggregation instrument; A support is arranged; Said support is provided with automatic control circuit, and test machine core apparatus, sample disc device, reagent bottle device, cleaning disc device, horizontal centrifugal device are set on the testing stand of said support; Be provided with a plurality of magnetic stirring apparatuses in the said test machine core apparatus, the detection light path system be set, comprise the lighting transistor circuit and the photoelectric switching circuit of complete configuration in this detection light path system around this magnetic stirring apparatus; On the said sample disc device a plurality of sample cups are set; Said reagent bottle device bottom is provided with semiconductor cooling device; Comprise cleaning fluid bottle and waste collection bottle in the said cleaning disc device; Said horizontal centrifugal device comprises a base, and a vertical rotation axis is installed on the said base, and said vertical rotation axis upper end fixed cross shape rotary bracket is installed test tube basket on the boom of said cruciform rotary bracket; Said vertical rotation axis bottom is provided with the location code-disc, the supporting optocoupler that is provided with on the said base; Said vertical rotation axis is connected with motor power; The testing stand of said support top is provided with sample needle device and needle cleaning device, and this sample needle device and needle cleaning device are installed on the running gear, and this running gear comprises vertical travel mechanism, horizontal travel mechanism, vertically to travel mechanism; Sample needle in the said sample needle device is connected with the automatic detergent line of an automatic application of sample pipeline and a sample needle, and the cleaning needle in the said needle cleaning device is connected with the automatic detergent line of a cleaning needle.
The utility model compared with prior art has following advantage:
L, the utility model with platelet poor plasma preparation, platelet rich plasma preparation, automatically application of sample, detect automatically, clean automatically, on a complete set of integration procedure to an instrument of removal waste fluid; Improve the test speed of clinical examination greatly, shortened the time of waiting for testing result.
When 2, adopting the utility model to detect the platelet aggregation data; Platelet poor plasma can be deposited in the test tube in the test tube basket of horizontal centrifugal device and directly take; Make the position, sample cup hole in the sample disc device reduce half the; And can reduce the operation of once shifting blood sample, improved detection speed greatly.
3, the utility model can be realized the automatic preparation of platelet poor plasma and platelet rich plasma and automatic application of sample, has avoided contacting of operating personnel and blood sample, has improved the accuracy of testing result.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the utility model is described further.
Fig. 1 is the structural representation of the utility model;
Fig. 2 is the structural representation of testing stand;
Fig. 3 is the structural representation of vertical travel mechanism;
Fig. 4 is vertical structural representation to travel mechanism;
Fig. 5 is the structural representation of horizontal centrifugal device;
Fig. 6 is the pipeline synoptic diagram of the utility model;
Fig. 7 is the structural representation of magnetic stirring apparatus;
Fig. 8 is the structural representation of cup base in the magnetic stirring apparatus;
Fig. 9 is the scheme of installation that entad drives rotor in the magnetic stirring apparatus;
Figure 10 is the synoptic diagram of cup base upper surface in the magnetic stirring apparatus;
Figure 11 is the synoptic diagram of motor frame in the magnetic stirring apparatus;
Figure 12 is the synoptic diagram of pedestal in the magnetic stirring apparatus;
Figure 13 is the synoptic diagram of drive motor in the magnetic stirring apparatus;
Figure 14 is the synoptic diagram of angle entad in the magnetic stirring apparatus.
Embodiment
Embodiment one:
Referring to Fig. 1, Fig. 2, Fig. 5, Fig. 6; (Fig. 1 is the situation of taking off the front panel of the utility model), (Fig. 2 is the vertical view of the utility model; The layout situation that shows testing stand); The platelet aggregation instrument of the utility model; A support is arranged, and said support is provided with photoelectric turbidimetry test circuit, automatic control circuit, is installed in matcher, microcomputer (single chip circuit) in the automatic control circuit, and test machine core apparatus 2, sample disc device 3, reagent bottle device 4, cleaning disc device 5, horizontal centrifugal device 6 are set on the testing stand 1 of said support; Be provided with four magnetic stirring apparatuses 7 in the said test machine core apparatus, the detection light path system be set, comprise the lighting transistor circuit and the photoelectric switching circuit of complete configuration in this detection light path system around this magnetic stirring apparatus; A plurality of sample cups (being used to place blood plasma to be tested) are set on the said sample disc device; Said reagent bottle device bottom is provided with semiconductor cooling device; Comprise cleaning fluid bottle 31 and waste collection bottle 32 in the said cleaning disc device; Said horizontal centrifugal device comprises a base 8, and a vertical rotation axis 9 is installed on the said base, and said vertical rotation axis upper end fixed cross shape rotary bracket 10 is installed test tube basket 11 on the boom of said cruciform rotary bracket; Said vertical rotation axis bottom is provided with location code-disc 12, the supporting optocoupler 13 that is provided with on the said base; Said vertical rotation axis is connected with motor power; The testing stand of said support top is provided with sample needle device and needle cleaning device, and this sample needle device and needle cleaning device are installed on the running gear 16, and this running gear comprises vertical travel mechanism, horizontal travel mechanism, vertically to travel mechanism; Sample needle 14 in the said sample needle device is connected with the automatic detergent line of an automatic application of sample pipeline and a sample needle, and the cleaning needle 15 in the said needle cleaning device is connected with the automatic detergent line of a cleaning needle.
In the present embodiment, the photoelectric turbidimetry test circuit adopts prior art, is not described in detail.Computer Control Technology is adopted in the control of the utility model, and its automatic control circuit belongs to the routine techniques means, is not described in detail.
In the present embodiment, described magnetic stirring apparatus is provided with a test cup, disk is set below the test cup; In the test cup, add a little bar magnet; Magnetic agitation motor-driven disk rotates, and little bar magnet rotates thereupon, realizes the blood plasma to be measured in the test cup is stirred.This magnetic stirring apparatus belongs to prior art, is not described in detail.In the present embodiment, can also adopt disclosed magnetic stirring apparatus among the Chinese patent ZL 02265972.2 to the stirring of blood plasma to be measured.
Referring to Fig. 2; In the present embodiment, position, 16 sample cup holes 51 is set on the sample disc device 3, position, sample cup hole is by the lineament layout; Plug-in mounting has the sample cup of PRP (being platelet rich plasma) in the sample cup hole, and sample needle can be drawn to detect from sample cup and use plasma sample.After detecting end, sample cup is discarded.
In the present embodiment, reagent bottle device 4 tops are provided with reagent bottle hole 52, and plug-in mounting reagent bottle in it is preserved the platelet aggregation derivant in reagent bottle.In order to satisfy the temperature requirement of platelet aggregation derivant, said reagent bottle device bottom is provided with semiconductor cooling device; This refrigerating plant is made up of refrigeration circuit, heat radiator and fan, and refrigeration circuit belongs to prior art, is not described in detail.
In the present embodiment, cleaning disc device 5 is provided with service sink, and service sink is used for the cleaning of sample needle and cleaning needle.Two pin hole shapes of service sink set inside rinse bath 53 and waste collection mouth 54, the bottom is provided with the waste collection bottle, and the waste collection mouth is communicated with the waste collection bottle.Cleaning waste liquid that sample needle device, needle cleaning device and test cup produce and discarded blood plasma can be discharged in the waste collection bottle, the unified collection.
Referring to Fig. 5 (Fig. 5 is the A-A cut-open view of horizontal centrifugal device among Fig. 2), in the present embodiment, said horizontal centrifugal device comprises a base 8, and said center is provided with the rotation axis mounting hole, and vertically rotation axis 9 rotates through bearing and base and installs.Said vertical rotation axis upper end fixed cross shape rotary bracket 10; On four booms of said cruciform rotary bracket a test tube basket 11 is installed respectively; Test tube basket rotates installation through the shoulder axle of both sides and the boom of cruciform rotary bracket, and each test tube basket is provided with position, four test tube holes.Said vertical rotation axis bottom is provided with location code-disc 12, the supporting optocoupler 13 that is provided with on the said base; Said vertical rotation axis is fixedly connected with the output shaft of a motor.After each centrifugal EOP (end of program),, start the braking mechanism braking, automatically four test tube baskets are stopped the position (automatic control technology of horizontal centrifugal device belongs to prior art) to program setting then through the mark on the optocoupler detection and location code-disc.
Referring to Fig. 1, Fig. 2, Fig. 3, Fig. 4 (Fig. 3 is the situation of taking off the Left-Hand Panel of the utility model, the B-B cut-open view that Fig. 4 is Fig. 3); In the present embodiment; Sample needle device and needle cleaning device are installed on the running gear 16, this running gear comprise vertical travel mechanism 55, laterally travel mechanism 56, vertically to travel mechanism 57; Vertically (Y direction) travel mechanism comprises longitudinal rail, stepper motor, synchronous cog belt, the vertical carriage 58 of walking, carriage and the synchronous cog belt fixed installation of vertically walking; Laterally (X-direction) travel mechanism comprises cross slide way, stepper motor, synchronous cog belt, the horizontal carriage 59 of walking, carriage and the synchronous cog belt fixed installation of laterally walking; Vertically comprise two stepper motors, two synchronous cog belts, four synchronous pulleys to (Z-direction) travel mechanism, sample needle 14, cleaning needle 15 fixedly mount with a synchronous cog belt respectively; Vertically travel mechanism is installed on the horizontal walking carriage; Vertically be installed on vertical walking carriage to travel mechanism; Sample needle, cleaning needle are installed on vertical walking carriage.The sample needle device comprises sample needle, flexible pipe, solenoid valve, suction pumps, measuring element; Needle cleaning device comprises cleaning needle, flexible pipe, solenoid valve, suction pumps, measuring element; This device belongs to the prior art category, is not described in detail.
Referring to Fig. 6, the pipeline of present embodiment comprises the automatic detergent line of automatic application of sample pipeline, sample needle, the automatic detergent line and the liquid back pipe road of cleaning needle.Sample needle 14 in the sample needle device is connected with automatic application of sample pipeline, and this pipeline comprises solenoid valve, glass tube syringe pump 60, is used for drawing quantitative blood plasma from sample cup, injects the test cup.The automatic detergent line of sample needle comprises cleaning fluid bottle 31, T-valve 61, glass tube syringe pump; Deposit has clear water in the cleaning fluid bottle; (the cleaning fluid bottle is the special-purpose cleaning fluid of deposit usually to be used for cleaning sample needle; So that effectively clean protein matter, also can put clear water, but can reduce the effect of cleaning).Cleaning needle 15 in the needle cleaning device is connected with the automatic detergent line of cleaning needle, and the automatic detergent line of cleaning needle comprises cleaning fluid bottle, scavenging pump 62, T-valve 61; Be used for cleaning the test cup.Liquid back pipe connects mouth 28 and is connected with the liquid back pipe road, and the liquid back pipe road comprises waste collection bottle 32, negative pressure pump 63, six-way valve 64, liquid level detection device, is used for the raffinate of test cup, discarded blood plasma, cleaning waste collection.
Embodiment two:
Platelet aggregation instrument in the present embodiment is the improvement on embodiment one basis, and disclosed technology contents is not repeated in this description among the embodiment one, and embodiment one disclosed content also belongs to the disclosed content of present embodiment.
Referring to Fig. 7, Fig. 8, Fig. 9 (Fig. 7, Fig. 8, Fig. 9 are cut-open views); In the present embodiment, a pedestal 17 is arranged in the described magnetic stirring apparatus, the center of said pedestal is provided with a test cup mounting hole 18; The transparent test cup 19 of plug-in mounting pipe shape in the said test cup mounting hole; The top suit pressure cap 20 of said test cup, said pressure cap is connected with said test cup mounting hole screw top, is provided with in the said test cup to stir bar magnet 21; The bottom of said test cup mounting hole is symmetrical set two optic test passages 22; Said base bottom is fixed a cup base 23, boss 24 at the bottom of said cup base is provided with glass, and said cup end boss is connected with the lower port plug-in mounting of said test cup, between said test cup and the said cup base elastic sealing gasket 25 is set; Said cup end boss is provided with outage 26, and said cup base inside is provided with discharge opeing cavity 27, and said discharge opeing cavity one end is communicated with said outage, and the said discharge opeing cavity other end connects mouth 28 with liquid back pipe and is communicated with; The below of said cup base is provided with and entad drives rotor 29; The said rotor that entad drives has an entad magnetic patch carriage 30; Be symmetrically fixed with two entad magnetic patch 33 on the said entad magnetic patch carriage, said entad magnetic patch carriage is fixed on the output shaft 35 of a drive motor 34; The bottom of said cup base is provided with auxiliary bearing hole 36, and install in the output shaft termination of said drive motor and said auxiliary bearing hole.
Referring to Fig. 7, Figure 12; In the present embodiment, said pedestal 17 is to be processed by the duralumin one, and the center of pedestal is provided with test cup mounting hole; The top of test cup mounting hole is provided with pressure cap threaded hole 37 is installed, and said pressure cap is installed threaded hole and is communicated with said test cup mounting hole 18; The bottom of said pressure cap 20 is provided with external thread, and pressure cap is installed threaded hole with pressure cap and is threaded.Referring to Figure 10 (Figure 10 shows the upper surface of cup base), in the present embodiment, said cup base adopts the polyformaldehyde material one to process.Boss 24 at the bottom of the upper surface of said cup base is provided with glass; Said cup end boss is the cylinder bodily form; The diameter of tubular cup end boss adapts with the internal diameter size of test cup; The test cup 19 of said pipe shape is inserted in the said test cup mounting hole, and the lower port of test cup is connected with cup end boss plug-in mounting.Said cup end boss and said test cup are formed the test cup of splendid attire blood plasma to be measured.Said cup base is provided with the threaded hole contraposition on 38, four mounting holes of four mounting holes and the said base bottom face, installs through screw retention.When the cup base is installed, after the lower port contraposition with cup end boss on the cup base and test cup, again screw threads is fastened earlier.The interior edge of pressure cap is pressed on the port of test cup, will test cup and fix.Elastic sealing gasket 25 between test cup and the cup base can play the effect of sealing, damping.Cup end boss passes the circular hole at elastic sealing gasket center, elastic sealing gasket is played the effect of location.Test cup and cup base in the magnetic stirring apparatus can take off from pedestal efficiently, conveniently test cup and cup base are regularly cleaned or change, and guarantee that blood plasma to be measured is not contaminated.The bottom of said test cup mounting hole is arranged with two optic test passages 22; Two optic test passages are positioned on same the axis; This optic test passage and the perpendicular perforation of test cup mounting hole; Be respectively applied for lighting transistor circuit and the photoelectric switching circuit that detects in the light path system is set, detect light path system and mounting means thereof and belong to the prior art category, do not describe in detail here.
Referring to Fig. 7; In order to prevent that testing the slit that exists between cup mounting hole and the test cup gets into dust or foreign material; Influence the test result of detection optical system, on said test cup mounting hole top an O-ring seals 39 is set, said O-ring seals is positioned at the lower end of said pressure cap.
Referring to Fig. 8; In the present embodiment; Said cup boss 24 centers, the end are provided with outage 26, and said cup base inside is provided with discharge opeing cavity 27, and said discharge opeing cavity one end is communicated with said outage; The said discharge opeing cavity other end connects mouth 28 with liquid back pipe and is communicated with, and this liquid back pipe connects mouth and is connected with the liquid back pipe road.Adopt outage and liquid back pipe to connect mouth structure in the present embodiment; Can through control system realize cup inner externally by with the conversion of emissions status; Make the platelet aggregation tester have the function of automatic cleaning; Can after having accomplished the blood sample test, raffinate be discharged in the waste collection bottle 32 automatically, need not artificial cup is extracted and clean.
Referring to Fig. 7, Fig. 8, Figure 13, Figure 14, in the present embodiment, the bottom of said cup base 23 is provided with auxiliary bearing hole 36, and insert in the said auxiliary bearing hole output shaft termination of said drive motor.The auxiliary bearing hole has good self-lubricating and anti-wear performance.Fixing entad magnetic patch carriage 30 on the output shaft of said drive motor, entad the magnetic patch carriage is processed by polyformaldehyde material, and entad the center of magnetic patch carriage is provided with axis hole, and entad the output shaft of the axis hole of magnetic patch and drive motor is a wringing fit.The output shaft of drive motor is provided with a rib 40, through this rib magnetic patch carriage is entad carried out axial location.Be provided with two entad holes 41 on the said entad magnetic patch carriage axisymmetricly, each is one of hole internal fixation magnetic patch 33 entad entad.Entad magnetic patch is provided with upper surface magnetic pole 42 and 43, two entad upper surface magnetic pole opposite pole settings each other of magnetic patch of lower surface magnetic pole; When the upper surface magnetic pole of the entad magnetic patch in left side is the N utmost point, the upper surface magnetic pole of the entad magnetic patch on right side be the S utmost point just, perhaps setting on the contrary.
In the present embodiment, two in the described magnetic stirring apparatus entad the angle theta of normal 44 and the center line 45 of said test cup of magnetic patch be 15 degree.Said two entad the normal of magnetic patch intersect on the center line of said test cup.In the present embodiment, entad the normal of magnetic patch entad was meant the center of magnetic patch upper surface and the line vertical with this end face.Magnetic conduction gap between the upper surface magnetic pole of the entad magnetic patch in the described magnetic stirring apparatus and the said stirring bar magnet is 10～20 millimeters.Magnetic conduction gap between the upper surface magnetic pole of said entad magnetic patch and the said stirring bar magnet can be selected between 10～20 millimeters with the thickness of cup base and the power of drive motor; In the present embodiment, entad the magnetic conduction gap between the upper surface magnetic pole of magnetic patch and the said stirring bar magnet is 12 millimeters.
Referring to Fig. 7, Figure 11, Figure 13, drive motor 34 can directly be fixedly mounted on the frame of platelet aggregation tester.In the present embodiment; Said drive motor 34 is fixed on the motor frame 46; The motor frame is through two supports 47 and said pedestal 17 fixed installations (support that only shows the right side among Fig. 7); Said support upper end is threaded with the threaded hole of said base bottom, and the support lower end is threaded with the mounting hole 48 in the motor frame outside.The motor frame is by the ABS resin injection mo(u)lding, and the motor frame is provided with two drive motor mounting holes 49, and the drive motor mounting hole is a threaded hole, and drive motor is provided with flange 50, and drive motor is fixedly installed togather through bolt and motor frame.
Drive motor in the present embodiment drives and entad drives the rotor rotation; Stirring bar magnet rotates with entad driving rotor synchronously; Mixed liquor to blood plasma and platelet aggregation derivant in the test cup produces eddy current under the stirring of stirring bar magnet; Make the platelet aggregation of generation sink to the test bottom of cup, improved the precision of test.The rotating speed of output shaft that can be through changing drive motor is adjusted the rotating speed that stirs bar magnet, makes the demands of different that the stirring of blood plasma is reached the platelet aggregation test; In the present embodiment, the rotating speed of the output shaft of drive motor is that per minute 1000 changes.Entad driving rotor in the magnetic stirring apparatus is equipped with entad magnetic patch; Making and stirring bar magnet center line with the test cup in stirring the course of work is steadily rotation of axle; Avoid and test the cup inwall bumping; Make blood plasma and blood aggregation inducing agent mixing in the test cup more even, accelerate platelet aggregation and form speed, shortened the test duration.
The course of work of the utility model is following:
A, collection blood samples of patients sample (pressing the collection of examination criteria consumption, normally 5ml) carry out anti-freezing to this blood sample and handle, and generate anticoagulated whole blood; In the present embodiment, the blood samples of patients sample carries out anti-freezing with blood anticoagulant 3.8% (concentration) sodium citrate, and the ratio of anti-coagulants and blood is 1:9; This job step is accomplished by blood sampling department.
B, with the anticoagulated whole blood centrifugal treating, the preparation platelet rich plasma; The test tube that anticoagulated whole blood is housed is packed in the position, corresponding test tube hole in the test tube basket, and the coordinate of position, test tube hole has been preset in the program in the automatic control circuit.Operate the setting that microcomputer is accomplished the test tube sample number by operating personnel, said sample number can be an electronic marker, makes each sample number corresponding one by one with each position, test tube hole in the test tube basket.Carry out centrifugal treating by the horizontal centrifugal device, earlier, separate and prepare PRP (being platelet rich plasma) with low-speed centrifugal (500～800 rev/mins, centrifugal 5 minutes, the about 300g of centrifugal force); The order sample needle is drawn a certain amount of platelet rich plasma from the test tube of said test tube basket, be injected in the sample cup in the sample disc device, and sample number is set, and makes the sample number of each sample cup corresponding one by one with each position, test tube hole in the test tube basket.Automatically clean sample needle then; Said automatic cleaning sample needle; Be according to pre-set program, use the clear water in the washer bottle to clean sample needle, sample needle is after each absorption sample is accomplished an application of sample action; The clear water that all can introduce in the washer bottle cleans automatically, cleans the waste liquid that produces and is injected in the waste collection bottle of cleaning disc device by sample needle.
C, horizontal centrifugal device separate preparation PPP (being platelet poor plasma) again with high speed centrifugation (3000 rev/mins, centrifugal 10 minutes, centrifugal force was greater than 1000g).
D, the platelet aggregation derivant for preparing is put into the reagent bottle device of assembling appearance, cryopreservation is subsequent use; ADP more (adenosine diphosphate (ADP)) is generally used in the preparation of platelet aggregation derivant, and ADP generally is made into 3000 μ mol/l (concentration) with physiological saline, and in packing in a small amount below-20 ℃, low temperature is frozen.Face with preceding and redissolve at room temperature, and be diluted to 300 μ mol/l with physiological saline, put into the reagent bottle device of assembling appearance then, it is subsequent use to give stored refrigerated, refrigerated storage temperature 5-20 ℃; Derivant also can use a kind of among ADR (adrenal gland), COL (collagen), ARA (arachidonic acid), the RIS (ristomycin).
E, order sample needle are pressed the examination criteria consumption and are drawn platelet poor plasma from the test tube of said test tube basket; Inject the test cup of magnetic stirring apparatus; Starting magnetic stirring apparatus stirs platelet poor plasma; The detection light path system reads platelet poor plasma sample transmission data automatically and stores in the microcomputer, automatically platelet poor plasma is discharged from test cup bottom then, cleans sample needle and test cup automatically; In the present embodiment; The platelet poor plasma consumption is 300 μ l, and said automatic cleaning sample needle and test cup are according to pre-set program; Use the clear water in the washer bottle to clean sample needle and test cup; Sample needle is after each absorption sample is accomplished an application of sample action, and the clear water that all can introduce in the washer bottle cleans automatically, cleans in the waste collection bottle of waste liquid by sample needle injection cleaning disc device that produces.After test procedure was accomplished, cleaning needle injected test glass cleaning with the clear water in the washer bottle, and the discarded blood plasma in the test cup is discharged in the waste collection bottle with the vent valves of cleaning waste liquid bottom it.
F, order sample needle are pressed the examination criteria consumption and are drawn platelet rich plasma from said sample disc device; Inject the test cup of magnetic stirring apparatus; Start magnetic stirring apparatus platelet rich plasma is stirred, the detection light path system reads platelet rich plasma sample transmission data automatically and stores in the microcomputer; Automatically clean sample needle; In the present embodiment; The platelet rich plasma consumption is 300 μ l, and said automatic cleaning sample needle is according to pre-set program; Use the clear water in the washer bottle to clean sample needle; Sample needle is after each absorption sample is accomplished an application of sample action, and the clear water that all can introduce in the washer bottle cleans automatically, cleans in the waste collection bottle of waste liquid by sample needle injection cleaning disc device that produces.
G, order sample needle are pressed the examination criteria consumption and are drawn the platelet aggregation derivant from the reagent bottle device; Inject the test cup of magnetic stirring apparatus; Starting magnetic stirring apparatus mixes platelet rich plasma and platelet aggregation derivant; Detect light path system and read the platelet rich plasma sample transmission data in the platelet aggregation forming process in the stipulated time automatically; Describe aggregation curve and storage, automatically the platelet rich plasma sample is discharged from test cup bottom then, next clean sample needle and test cup automatically; In the present embodiment; Platelet aggregation derivant consumption is 5 μ l, and said automatic cleaning sample needle and test cup are according to pre-set program; Cleaning fluid in the sample needle cleaning liquid suction bottle cleans automatically; Sample needle all can cleaning liquid suction clean after each absorption sample is accomplished an application of sample action automatically, cleans in the waste collection bottle of waste liquid by sample needle injection cleaning disc device that produces; After test procedure was accomplished, cleaning needle injected the test cup with the cleaning fluid in the cleaning liquid suction bottle and cleans, and the waste liquid in the test cup is discharged in the waste collection bottle through the vent valves of its bottom.
H, calculate the platelet aggregation rate of tested blood sample, the mensuration result of platelet aggregation property is generated test report according to the patient information of being imported.
In the present embodiment, the data of being measured are handled all belong to the proven technique content, be not described in detail at this.
In actual application, the quantity of the magnetic stirring apparatus in the test machine core apparatus of the utility model, the sample cup in the sample disc device and the position, test tube hole on each test tube basket can be set as required, is not limited to disclosed quantity among the embodiment.
Claims (4)
1. a platelet aggregation instrument has a support, and said support is provided with automatic control circuit, it is characterized in that: test machine core apparatus, sample disc device, reagent bottle device, cleaning disc device, horizontal centrifugal device are set on the testing stand of said support; Be provided with a plurality of magnetic stirring apparatuses in the said test machine core apparatus, the detection light path system be set, comprise the lighting transistor circuit and the photoelectric switching circuit of complete configuration in this detection light path system around this magnetic stirring apparatus; On the said sample disc device a plurality of sample cups are set; Said reagent bottle device bottom is provided with semiconductor cooling device; Comprise cleaning fluid bottle and waste collection bottle in the said cleaning disc device; Said horizontal centrifugal device comprises a base, and a vertical rotation axis is installed on the said base, and said vertical rotation axis upper end fixed cross shape rotary bracket is installed test tube basket on the boom of said cruciform rotary bracket; Said vertical rotation axis bottom is provided with the location code-disc, the supporting optocoupler that is provided with on the said base; Said vertical rotation axis is connected with motor power; The testing stand of said support top is provided with sample needle device and needle cleaning device, and this sample needle device and needle cleaning device are installed on the running gear, and this running gear comprises vertical travel mechanism, horizontal travel mechanism, vertically to travel mechanism; Sample needle in the said sample needle device is connected with the automatic detergent line of an automatic application of sample pipeline and a sample needle, and the cleaning needle in the said needle cleaning device is connected with the automatic detergent line of a cleaning needle.
2. platelet aggregation instrument according to claim 1; It is characterized in that: a pedestal is arranged in the described magnetic stirring apparatus; The center of said pedestal is provided with a test cup mounting hole, the transparent test cup of plug-in mounting pipe shape in the said test cup mounting hole, the top suit pressure cap of said test cup; Said pressure cap is connected with said test cup mounting hole screw top, is provided with the stirring bar magnet in the said test cup; The bottom of said test cup mounting hole is symmetrical set two optic test passages; Said base bottom is fixed a cup base, boss at the bottom of said cup base is provided with glass, and said cup end boss is connected with the lower port plug-in mounting of said test cup, between said test cup and the said cup base elastic sealing gasket is set; Said cup end boss is provided with outage, and said cup base inside is provided with the discharge opeing cavity, and said discharge opeing cavity one end is communicated with said outage, and the said discharge opeing cavity other end connects mouth with liquid back pipe and is communicated with; The below of said cup base is provided with and entad drives rotor, and the said rotor that entad drives has an entad magnetic patch carriage, is symmetrically fixed with two entad magnetic patch on the said entad magnetic patch carriage, and said entad magnetic patch carriage is fixed on the output shaft of a drive motor; The bottom of said cup base is provided with the auxiliary bearing hole, and install in the output shaft termination of said drive motor and said auxiliary bearing hole.
3. platelet aggregation instrument according to claim 2 is characterized in that: in the described magnetic stirring apparatus two entad the angle of the center line of normal and the said test cup of magnetic patch be 15 degree.
4. platelet aggregation instrument according to claim 3 is characterized in that: the magnetic conduction gap between the upper surface magnetic pole of the entad magnetic patch in the described magnetic stirring apparatus and the said stirring bar magnet is 10～20 millimeters.
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| CN2011205383914U CN202372514U (en) | 2011-12-21 | 2011-12-21 | Platelet gathering instrument |
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| CN2011205383914U CN202372514U (en) | 2011-12-21 | 2011-12-21 | Platelet gathering instrument |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104931460A (en) * | 2014-03-18 | 2015-09-23 | 北京泰利康信科技有限公司 | Method for improving stability of platelet aggregation index |
| CN105938096A (en) * | 2015-03-02 | 2016-09-14 | 山东泰利信医疗科技有限公司 | Method for determination of platelet aggregation rate |
| CN109297863A (en) * | 2018-09-11 | 2019-02-01 | 卢新 | A kind of automatic flushing double slit gap sensor structure |
| CN109791159A (en) * | 2016-10-05 | 2019-05-21 | 索尼公司 | Platelet aggregation capability analysis method, platelet aggregation capability analytical equipment, program and platelet aggregation capability analysis system for analyzing platelet aggregation capability |
| CN113574392A (en) * | 2019-01-11 | 2021-10-29 | 迈恩医疗解决方案有限公司 | Pipetting device and method for liquid transfer |
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2011
- 2011-12-21 CN CN2011205383914U patent/CN202372514U/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104931460A (en) * | 2014-03-18 | 2015-09-23 | 北京泰利康信科技有限公司 | Method for improving stability of platelet aggregation index |
| CN105938096A (en) * | 2015-03-02 | 2016-09-14 | 山东泰利信医疗科技有限公司 | Method for determination of platelet aggregation rate |
| CN109791159A (en) * | 2016-10-05 | 2019-05-21 | 索尼公司 | Platelet aggregation capability analysis method, platelet aggregation capability analytical equipment, program and platelet aggregation capability analysis system for analyzing platelet aggregation capability |
| US20190346352A1 (en) * | 2016-10-05 | 2019-11-14 | Sony Corporation | Platelet aggregation analysis method, platelet aggregation analysis device, program for analyzing platelet aggregation, and platelet aggregation analysis system |
| US11802825B2 (en) | 2016-10-05 | 2023-10-31 | Sony Corporation | Platelet aggregation analysis method, platelet aggregation analysis device, program for analyzing platelet aggregation, and platelet aggregation analysis system |
| CN109297863A (en) * | 2018-09-11 | 2019-02-01 | 卢新 | A kind of automatic flushing double slit gap sensor structure |
| CN109297863B (en) * | 2018-09-11 | 2021-02-19 | 卢新 | Automatic washing type double-gap sensor structure |
| CN113574392A (en) * | 2019-01-11 | 2021-10-29 | 迈恩医疗解决方案有限公司 | Pipetting device and method for liquid transfer |
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Effective date of registration: 20191218 Address after: Room b0407-0411, innovation base, no.213-3, Torch Road, Weihai high district, Shandong Province Patentee after: Shandong Talentine Medical Technology Co Ltd Address before: 100085, No. 2, No. 401, building 1, AVON garden, West West, Beijing, Haidian District Patentee before: Chen Sheng |
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