CN202254653U - Freeze dryer - Google Patents
Freeze dryer Download PDFInfo
- Publication number
- CN202254653U CN202254653U CN2011203654856U CN201120365485U CN202254653U CN 202254653 U CN202254653 U CN 202254653U CN 2011203654856 U CN2011203654856 U CN 2011203654856U CN 201120365485 U CN201120365485 U CN 201120365485U CN 202254653 U CN202254653 U CN 202254653U
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- freeze
- drying box
- condenser
- freeze drying
- freeze dryer
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Abstract
The utility model provides a freeze dryer, which comprises a freeze drying box, a condenser and a vacuum pump. The condenser is respectively communicated with the freeze drying box and the vacuum pump via valves, a freeze dryer body is respectively connected onto the condenser and the freeze drying box, and the freeze drying box is connected with a heater by a circulation pump. By the aid of the freeze dryer, a sterile operation procedure is simplified, and original characteristics of a preparation can be kept.
Description
Technical field
The utility model relates to a kind of drying equipment, especially a kind of freeze dryer through vacuum freezedrying.
Background technology
Dry method has a lot, such as dry, boil dry, oven dry, spray-drying and vacuum drying, but these methods all are to carry out more than 0 ℃ or under the higher temperature, the product of drying generally is a volume-diminished, or the quality hardening; Oxidation also can take place in some material, and some volatile compositions also can lose.Sex change when dry at a certain temperature, can take place like vitamin, protein etc. in the material of some thermal sensitivitys; Microorganism can lose biologos, or dried matter is difficult for being dissolved in the water.Vacuum freezedrying is drug product a kind of drying means commonly used, is called for short freeze-drying.Freeze drying is to keep one of unlikely putrid and deteriorated method of material.
Freeze drying is carried out in the temperature below 0 ℃ basically, for further reducing the remaining moisture content of product, just lets the temperature of product be elevated to more than 0 ℃, but is no more than 40 ℃ usually.Therefore the dried constancy of volume of preparation, loose porous.Ice will absorb heat when distillation, thereby causes the decline of freezing the medicine preparation self-temperature, causes slowing down of rate of sublimation; In order to increase the speed of distillation; Shorten drying time, must carry out suitable heating to medicine, but whole drying is under lower temperature, to carry out.
Lyophilization has been simplified the process of sterile procedures, to the material particularly suitable of many thermal sensitivitys, simultaneously, in the preparation loss of some volatile components very little, can keep original proterties, improved the stability of dry powder; Dried matter is loose porous, is spongy, adds that dissolving almost recovers original proterties rapidly and fully immediately behind the water.
Therefore freeze-drying is very useful and necessary technology for fields such as bio-pharmaceuticals.
Summary of the invention
To the demand; The utility model proposes a kind of freeze dryer; Said freeze dryer comprises freeze drying box, condenser, vavuum pump, and said condenser is communicated with said freeze drying box and vavuum pump respectively through valve, and is connected with refrigerator respectively on said condenser and the freeze drying box; Said freeze drying box is connected with heater through a circulating pump.
Be connected with heat abstractor on the said refrigerator respectively; Be connected with a vacuum measurement head on the said vavuum pump; Be connected with vent valve and defrost valve on the said condenser; Be connected with vent valve and vacuum measurement head on the said freeze drying box.
Before the freeze-drying, be divided in the product that needs freeze-drying in the suitable containers, make evaporating surface as far as possible big and thickness is thin as far as possible; Put into then and carry out freezing with said freeze drying box.Also can be earlier said freeze drying box be carried out the empty van cooling, and then product put into carry out pre-freeze, freezing again.In the refrigerating process, when the temperature in the said condenser is lower than the temperature of setting, adopt said vavuum pump that said condenser is vacuumized.After treating that vacuum reaches certain numerical value, continue to vacuumize 1～2h; Again the product in the said freeze drying box is heated.After being heated to maximum temperature, after maintenance 2h is above, can finish freeze-drying.
About about 12～24h of the time of primary drying, with the loading amount of product in container, the inventory in the drying box, the shape of container, specification, the kind of product, the performances of freeze-drying curve and machine etc. are relevant.
The freeze dryer of the utility model is simple for structure, and is convenient and practical.
Description of drawings
Accompanying drawing 1 is the structural representation of the freeze dryer of the utility model preferred embodiment.
The specific embodiment
Preferred embodiment below in conjunction with accompanying drawing 1 further specifies the utility model.
The freeze dryer of the utility model preferred embodiment comprises freeze drying box 1, condenser 2, vavuum pump 3, and said condenser 2 is communicated with vavuum pump 3 with said freeze drying box 1 respectively through valve, and is connected with refrigerator 4 respectively on said condenser 2 and the freeze drying box 1; Said freeze drying box 1 is connected with heater 6 through a circulating pump 5.
Be connected with heat abstractor 7 on the said refrigerator respectively; Be connected with a vacuum measurement 8 on the said vavuum pump 3; Be connected with vent valve 9 and defrost valve 10 on the said condenser 2; Be connected with vent valve 9 and vacuum measurement 8 on the said freeze drying box 1.
Freeze drying box 1 is one and can freezes to about-40 ℃.Can be heated to again+about 50 ℃ high-low temperature chamber, also be one can evacuated closed container.It is the major part of freeze dryer, needs the product of freeze-drying can be placed on the sheet-metal layers of layering in the case, product is carried out freezing, and under vacuum, heats, and makes moisture content distillation in the pharmaceutical products and dry.
Freeze drying box 1, condenser 2, vavuum pump 3, and the vacuum system of vacuum pipe and valve formation freeze dryer.Vacuum system requires not gas leakage.Refrigerator 4 and freeze drying box 1, condenser 2, and pipeline etc. is formed refrigeration system.Refrigerator 4 can be separate several covers, also can share a cover.4 pairs of freeze drying box of refrigerator 1 are freezed with condenser 2, needed low temperature when producing and keeping their work.
The effect of heater 6 is that the product in the freeze drying box 1 is heated, so that the moisture content in the product constantly distils, and reaches the remaining moisture content requirement of regulation.Directly electrical heating or utilize intermediate medium heating can constantly circulate intermediate medium by one or several circulating pumps 5.
Before the freeze-drying, be divided in the product that needs freeze-drying in the suitable containers, make evaporating surface as far as possible big and thickness is thin as far as possible; Put into then and carry out freezing with said freeze drying box 1.Also can be earlier said freeze drying box 1 be carried out the empty van cooling, and then product put into carry out pre-freeze, freezing again.In the refrigerating process, when the temperature in the said condenser 2 is lower than the temperature of setting, adopt 3 pairs of said condensers 2 of said vavuum pump to vacuumize.After treating that vacuum reaches certain numerical value, continue to vacuumize 1～2h; Again the product in the said freeze drying box 1 is heated.After being heated to maximum temperature, after maintenance 2h is above, can finish freeze-drying.
The freeze dryer of the utility model has the following advantages:
Therefore (1) liquid preparation is easy to process, has simplified the process of sterile procedures, and freeze-drying process is to carry out at low temperatures, to the material particularly suitable of many thermal sensitivitys.
(2) in the low temperature drying process, in the drug product loss of some volatile components very little, the effect of microbial growth and organized enzyme can't be carried out, so keeps original proterties, has improved the stability of dry powder.
(4) volume of preparation changes hardly, has kept original structure, concentration phenomena can not take place.
(5) dried matter is loose porous, is spongy, adds that dissolving almost recovers original proterties, good water solubility rapidly and fully immediately behind the water.
(6) freeze drying is under vacuum, to carry out, and oxygen is few, so the material of some easy oxidations has obtained protection in the medicine preparation.
(7) freeze drying can be got rid of the above moisture content of 95%-96% in the medicine preparation, can make the dried preparation dry powder can long preservation and never degenerate.
Last institute should be noted that; Above embodiment is only in order to the technical scheme of explanation the utility model but not to the restriction of the utility model protection domain; Although the utility model has been done detailed description with reference to preferred embodiment; Those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement the technical scheme of the utility model, and do not break away from the essence and the scope of the utility model technical scheme.
Claims (5)
1. freeze dryer, it is characterized in that: said freeze dryer comprises freeze drying box, condenser, vavuum pump, said condenser is communicated with said freeze drying box and vavuum pump respectively through valve, and is connected with refrigerator respectively on said condenser and the freeze drying box; Said freeze drying box is connected with heater through a circulating pump.
2. freeze dryer as claimed in claim 1 is characterized in that: be connected with heat abstractor on the said refrigerator respectively.
3. freeze dryer as claimed in claim 1 is characterized in that: be connected with a vacuum measurement head on the said vavuum pump.
4. freeze dryer as claimed in claim 1 is characterized in that: be connected with vent valve and defrost valve on the said condenser.
5. freeze dryer as claimed in claim 1 is characterized in that: be connected with vent valve and vacuum measurement head on the said freeze drying box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203654856U CN202254653U (en) | 2011-09-28 | 2011-09-28 | Freeze dryer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203654856U CN202254653U (en) | 2011-09-28 | 2011-09-28 | Freeze dryer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202254653U true CN202254653U (en) | 2012-05-30 |
Family
ID=46115885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011203654856U Expired - Fee Related CN202254653U (en) | 2011-09-28 | 2011-09-28 | Freeze dryer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202254653U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105509422A (en) * | 2015-12-24 | 2016-04-20 | 甘肃银光化学工业集团有限公司 | Vacuum freeze drying system and method for vacuum freeze drying of energetic material by using system |
-
2011
- 2011-09-28 CN CN2011203654856U patent/CN202254653U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105509422A (en) * | 2015-12-24 | 2016-04-20 | 甘肃银光化学工业集团有限公司 | Vacuum freeze drying system and method for vacuum freeze drying of energetic material by using system |
| CN105509422B (en) * | 2015-12-24 | 2018-09-25 | 甘肃银光化学工业集团有限公司 | A kind of vacuum freeze-drying system and using the system to the method for energetic material vacuum freeze drying |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120530 Termination date: 20200928 |