CN101476815B - In-place cleaning method for freeze drying machine - Google Patents
In-place cleaning method for freeze drying machine Download PDFInfo
- Publication number
- CN101476815B CN101476815B CN 200810207292 CN200810207292A CN101476815B CN 101476815 B CN101476815 B CN 101476815B CN 200810207292 CN200810207292 CN 200810207292 CN 200810207292 A CN200810207292 A CN 200810207292A CN 101476815 B CN101476815 B CN 101476815B
- Authority
- CN
- China
- Prior art keywords
- shelf
- freeze drying
- drying box
- valve
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Drying Of Solid Materials (AREA)
Abstract
The invention relates to a method for cleaning a freeze dryer in place, which is characterized in that the method comprises the following steps: a tee valve is arranged between the lower part of a jacket of a freeze drying box and a circulating pipeline of the freeze dryer, a jacket valve is arranged between the upper part of the jacket of the freeze drying box and a balancing barrel, and the topof the freeze drying box is provided with a master steam valve communicated with steam; when the freeze drying box and a shelf need to be cleaned in place, a compressor is started to refrigerate heattransfer oil in a circulating system, and the tee valve and the jacket valve are opened to ensure that the refrigerated heat transfer oil is led into the jacket; the tee valve is closed to ensure that the circulating system refrigerates the shelf; and when the temperature of the shelf reaches between 8 and 10 DEG C, the master steam valve is opened, and pure steam with high temperature and high pressure immediately produces a large amount of condensed water when touching the shelf and cold surfaces of four walls of the freeze drying box, so the shelf and the box walls is cleaned. The method has the advantages that the cleaning coverage rate can reach 100 percent, and water for injection for the cleaning can be greatly saved.
Description
Technical field
The present invention relates to the method for a kind of freeze dryer cleaning on the throne, can be widely used in pharmaceuticals industry, biological products, biological tissue, animals and plants, food industry, chemical industry, health care products and Chinese herbal medicine etc., belong to the vacuum freeze drier technical field.
Background technology
Vacuum freeze drying (abbreviation freeze dryer) but be exactly that the hydrous matter of freeze-drying or solution are freezed in advance at low temperatures, under vacuum environment, make the material dehydration obtain dry article then.
This drying means with common dry, dry, boil dry, spray-drying is compared with vacuum drying that many outstanding advantages are arranged:
(1) do not make protein, microorganism and so on produce sex change or lose biologos;
(2) loss of the nutritional labeling of volatile ingredient in the material and heated denaturalization is little;
(3) effect of microbial growth and enzyme almost can't be carried out, and can keep the original proterties of material best;
(4) drying back form is constant substantially, is spongy open structure; Rehydration is easy, can promptly be reduced into original proterties;
(5) dry under vacuum, oxygen is few, makes the material of easy oxidation obtain protection;
(6) can remove in the material 95%～99% moisture, the goods long shelf-life;
So freeze dryer is widely used in: pharmaceuticals industry, biological products; Biological tissue, microbiology class; Animals and plants; Food industry; Chemical industry; Health care products and Chinese herbal medicine etc.
Freeze dryer mainly comprises refrigeration system, vacuum system, the circulatory system, hydropneumatic system, CIP/SIP system, control system etc., a good freeze dryer is the perfect adaptation of freeze drying technology and asptic technique, and the conscientious consideration of asptic technique seems particularly important for the pharmaceutical factory that utilizes freeze dryer to make medicine.Because freeze-drying prods self characteristics, end article is Powdered, area has the freeze-drying prods dust on freeze dryer shelf and freeze dryer tank wall easily, how to clean the most completely is the problem that each freeze dryer manufacturer and pharmaceutical factory face jointly always, the cleaning method of freeze dryer employing at present is to be provided with various nozzles around freeze dryer casing top and freeze dryer in general, utilize the deionized water or the water for injection of high pressure to come the shelf and the tank wall of freeze dryer are carried out cleaning on the throne, because nozzle is provided with the difference of position, add the unstability of rinse water pressure and flow, often the effect of Qing Xiing is not near as people's will, can't guarantee surperficial 100% covering to be cleaned; Or say that each effect of cleaning is inconsistent, repeatability is not strong; And the huge size of casing makes the consumption of cleansing medium (water for injection) very many, increases cost.
The shelf refrigeration dependence compressor of conventional freeze dryer is delivered to plate type heat exchanger inside to cold-producing medium freon and is evaporated, simultaneously the conduction oil of circulatory system inside is freezed, cooled conduction oil circulates by the inside that acts on shelf of circulating pump, thereby reach the purpose of refrigeration, the effect of balance bucket is that conduction oil to circulatory system inside carries out balance in the system.The freeze dryer casing of conventional belt steam sterilizing finishes the quick cooling of back freeze dryer tank wall owing to require to adopt steam sterilizing for feasible the sterilization, is provided with cooling jacket around the freeze dryer tank wall, and generally employing is water cooling mode.
Summary of the invention
The purpose of this invention is to provide a kind of method that can guarantee the freeze dryer cleaning on the throne of surperficial 100% covering to be cleaned.
For realizing above purpose, technical scheme of the present invention provides the method for a kind of freeze dryer cleaning on the throne, and this is characterised in that its method is:
The first step is installed triple valve between the chuck bottom of freeze drying box and freeze dryer circulation line, between the chuck top of freeze drying box and balance bucket the chuck valve is installed, and the steam main valve that communicates with steam is installed at the freeze drying box top;
Second step when freeze drying box and the cleaning on the throne of shelf needs, started compressor the conduction oil in the circulatory system is freezed, and opened triple valve and chuck valve and made cooled conduction oil be directed in the chuck, 8 ℃-10 ℃ of the temperature of conduction oil;
In the 3rd step, when the temperature of conduction oil reaches 8 ℃-10 ℃, close triple valve and make the circulatory system freeze shelf;
When the temperature of shelf reaches 8 ℃-10 ℃, open the steam main valve, steam pressure is 0.15MPa-0.20MPa, temperature is that 128 ℃-134 ℃ pure steam is directed in the freeze drying box, the pure steam of HTHP is run into 8 ℃-10 ℃ the shelf and the cold surface of freeze drying box wall, produce a large amount of condensed waters, condensed water produces a large amount of motive forces at shelf and tank wall surface, thereby shelf and tank wall are produced cleaning at once.
The present invention adopts steam to be cooled to condensed water shelf and tank wall is produced cleaning, reaches the purpose of cleaning.
Advantage of the present invention is to clean coverage rate can reach 100%, can save greatly to clean and use water for injection.
Description of drawings
Fig. 1 is the method schematic diagram of a kind of freeze dryer cleaning on the throne.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Embodiment
As shown in Figure 1, be the method schematic diagram of a kind of freeze dryer cleaning on the throne, the method for described a kind of freeze dryer cleaning on the throne is:
The first step is installed triple valve 5 between chuck 8 bottoms of freeze drying box 7 and freeze dryer circulation line, between chuck 8 tops of freeze drying box 7 and balance bucket 4 chuck valve 6 is installed, the steam main valve 10 that communicates with steam in the installation of freeze drying box 7 tops;
In second step, when freeze drying box 7 and the cleaning on the throne of shelf 9 needs, the conduction oil that starts in 1 pair of circulatory system of compressor freezes, and opens triple valve 5 and chuck valve 6 and makes cooled conduction oil be directed in the chuck 8,8 ℃-10 ℃ of the temperature of conduction oil;
In the 3rd step, when the temperature of conduction oil reaches 8 ℃-10 ℃, close triple valve 5 and make the circulatory system freeze shelf 9;
The 4th step, when the temperature of shelf 9 reaches 8 ℃-10 ℃, open steam main valve 10, steam pressure is 0.15MPa, temperature is that 128 ° pure steam is directed in the freeze drying box 7, and the pure steam of HTHP is run into 8 ℃-10 ℃ the shelf 9 and the cold surface of freeze drying box wall, produces a large amount of condensed waters at once, condensed water produces a large amount of motive forces at shelf and tank wall surface, thereby shelf and tank wall are produced cleaning.
Claims (1)
1. the method for a freeze dryer cleaning on the throne is characterized in that, this method is:
The first step is installed triple valve (5) between chuck (8) bottom of freeze drying box (7) and freeze dryer circulation line, between chuck (8) top of freeze drying box (7) and balance bucket (4) chuck valve (6) is installed,
The steam main valve (10) that communicates with steam is installed at freeze drying box (7) top;
Second step, when freeze drying box (7) and the cleaning on the throne of shelf (9) needs, start compressor (1) conduction oil in the circulatory system is freezed, open triple valve (5) and chuck valve (6) and make cooled conduction oil be directed in the chuck (8), 8 ℃-10 ℃ of the temperature of conduction oil;
In the 3rd step, when the temperature of conduction oil reaches 8 ℃-10 ℃, close triple valve (5) and make the circulatory system freeze shelf (9);
The 4th step, when the temperature of shelf reaches 8 ℃-10 ℃, open the steam main valve, steam pressure is 0.15MPa-0.20MPa, temperature is that 128 ℃-134 ℃ pure steam is directed in the freeze drying box, and the pure steam of HTHP is run into 8 ℃-10 ℃ the shelf and the cold surface of freeze drying box wall, produces a large amount of condensed waters at once, condensed water produces a large amount of motive forces at shelf and tank wall surface, thereby shelf and tank wall are produced cleaning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810207292 CN101476815B (en) | 2008-12-18 | 2008-12-18 | In-place cleaning method for freeze drying machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810207292 CN101476815B (en) | 2008-12-18 | 2008-12-18 | In-place cleaning method for freeze drying machine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101476815A CN101476815A (en) | 2009-07-08 |
| CN101476815B true CN101476815B (en) | 2010-11-10 |
Family
ID=40837563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200810207292 Expired - Fee Related CN101476815B (en) | 2008-12-18 | 2008-12-18 | In-place cleaning method for freeze drying machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101476815B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102278872B (en) * | 2010-06-12 | 2014-12-17 | 王一田 | In-place automatic washing device for freeze dryer |
| ITMI20131447A1 (en) * | 2013-09-04 | 2015-03-05 | I M A Ind Macchine Automatic He S P A | LILO-FILTERING MACHINE INCLUDING AT LEAST ONE GUIDE ORGAN FOR LOADING DEVICES |
| CN108402490A (en) * | 2018-05-03 | 2018-08-17 | 贵州省凤冈县稀源食用菌种植有限公司 | The cleaning device of hickory chick |
-
2008
- 2008-12-18 CN CN 200810207292 patent/CN101476815B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101476815A (en) | 2009-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204865021U (en) | Use concentrated machine of heat pump technique low -temperature vacuum | |
| CN203928604U (en) | A kind of food vacuum frozing drier | |
| CN101476815B (en) | In-place cleaning method for freeze drying machine | |
| CN207035701U (en) | A kind of vacuum freeze drier | |
| CN214842083U (en) | Vacuum freeze drying equipment | |
| CN201233162Y (en) | Microwave freeze drier | |
| CN205843214U (en) | A kind of domestic freeze dryer | |
| CN208832857U (en) | A kind of vacuum freeze drier and its pallet | |
| CN109323536A (en) | A kind of vacuum freeze drier | |
| CN210569543U (en) | Freeze dryer | |
| CN2416463Y (en) | Vacuum freezing dryer | |
| CN208012138U (en) | A kind of integrated energy supply heat pump refrigerating system of production and living | |
| CN103868275A (en) | Air source heat pump system | |
| CN109430670A (en) | A kind of air heat source and thermal pump pasteurization system | |
| RU2309582C1 (en) | Energy-saving milk cooling system designed for farms and using natural cold | |
| CN101251309A (en) | Refrigerating method of vacuum freezing dryer | |
| CN202958676U (en) | Superhigh-temperature instant sterilizing device for biological extract | |
| CN206414144U (en) | A kind of steam heating and thermal insulation platform | |
| CN204540682U (en) | Constant temperature refrigerating plant in a kind of membrane distillation concentration fruit juice system | |
| CN205690805U (en) | A kind of utilize unit condensation heat as the vacuum freeze-drier of vacuum sublimation thermal source | |
| KR100723461B1 (en) | Hybrid type freezer dryer for extracting valuable material of the deep seawater | |
| CN207019385U (en) | Freeze drier | |
| CN206275066U (en) | A kind of pressure difference low temperature and high relative humidity thawing apparatus | |
| CN202675800U (en) | Integrated freeze dryer | |
| CN207456026U (en) | A kind of vacuum freeze drier system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101110 Termination date: 20191218 |