CN202236530U - Leucocyte removal blood bag capable of inactivating viruses - Google Patents
Leucocyte removal blood bag capable of inactivating viruses Download PDFInfo
- Publication number
- CN202236530U CN202236530U CN2011203703335U CN201120370333U CN202236530U CN 202236530 U CN202236530 U CN 202236530U CN 2011203703335 U CN2011203703335 U CN 2011203703335U CN 201120370333 U CN201120370333 U CN 201120370333U CN 202236530 U CN202236530 U CN 202236530U
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- Prior art keywords
- blood
- bag
- filter
- conduit
- plasma
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- 210000004369 blood Anatomy 0.000 title claims abstract description 110
- 239000008280 blood Substances 0.000 title claims abstract description 108
- 241000700605 Viruses Species 0.000 title claims abstract description 33
- 230000000415 inactivating effect Effects 0.000 title abstract 2
- 230000002779 inactivation Effects 0.000 claims abstract description 24
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960000907 methylthioninium chloride Drugs 0.000 claims abstract description 19
- 210000002381 plasma Anatomy 0.000 claims description 49
- 210000000265 leukocyte Anatomy 0.000 claims description 18
- 238000010521 absorption reaction Methods 0.000 claims description 11
- 238000001914 filtration Methods 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 12
- 238000012546 transfer Methods 0.000 abstract description 9
- 238000000926 separation method Methods 0.000 abstract description 7
- 239000010836 blood and blood product Substances 0.000 abstract description 5
- 229940125691 blood product Drugs 0.000 abstract description 5
- 238000011109 contamination Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- 230000010100 anticoagulation Effects 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000005484 gravity Effects 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 238000010241 blood sampling Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029036 donor selection Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940027990 methylene blue injection Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
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Abstract
The utility model relates to a leucocyte removal blood bag capable of inactivating viruses, which comprises a close type blood taking needle and an anticoagulation whole blood bag, wherein the lower part of the anticoagulation whole blood bag is sequentially connected with a filtration dropping funnel, a flow regulator, a leucocyte removal filter and an after-filtration transfer bag in series through guide tubes; the after-filtration transfer bag is sequentially connected with a first plasma transfer bag, a second plasma transfer bag and a blood storage bag in series through guide tubes; the guide tube between the first plasma transfer bag and the second plasma transfer bag is connected with a methylene blue releaser; and the guide tube between the second plasma transfer bag and the blood storage bag is connected with an adsorption filter. The utility model combines the leucocyte removal plastic blood bag and the virus inactivation, so that the whole blood collection and separation and virus inactivation process is carried out in a closed environment, thereby lowering the bacterial contamination possibility and effectively enhancing the safety of blood products. The leucocyte removal blood bag has a reasonable structure, is convenient to operate and use, and is applicable to disposable blood taking, blood composition separation and virus inactivation.
Description
Technical field
This utility model relates to a kind of disposable use medical disposable material, but a kind of leukocyte depleted blood bag of inactivation of virus specifically.
Background technology
We know that blood transfusion is a kind of requisite clinical treatment measure.But the same with other clinical treatment methods, blood transfusion (comprising blood constituent) also possibly cause the infectious disease that untoward reaction, complication and blood transfusion are relevant.Along with the component blood transfusion continuous advancement in technology, the safety of blood more and more receives publicity.And one of blood plasma blood constituent that to be viral level more influences transfusion safety without the normal transmitted virus of the blood plasma of viral inactivation treatment.According to statistics, the degree of danger of blood plasma infusion is that 7.5 untoward reaction can take place in 10000 units, and per 1000 patients that accept blood transfusion have 3.7 untoward reaction to take place.A report from the U.S. shows that the viral infection rate of the whole blood blood constituent of a unit of infusion: HBV is about 1/63000, and HCV is about 1/100000, and HIV is 1/68000.Although at present the detection of blood donor's selection and blood sample is effectively raised the safety of blood transfusion,, the spread disease danger of toxicity disease of blood transfusion still exists, because the sensitivity of the detection method of 1. using always now is limited.2. the probability for the omission of the blood of " window phase " is very big.3. constantly have new virus and occur, 4. can only detect several kinds of limited viruses for blood sample, like HIV-1/2, HBV, HCV etc., the negative blood of testing result can not be got rid of the probability that has other virus to exist like this.It is reported that the omission blood of the U.S. about 90% is the reason owing to " window phase ", the situation of research prompting China of Shanghai Blood Center also is like this.So will safe blood or blood constituent be provided for clinical, must will strengthen examination and inactivation of virus combines, just can reach the purpose of transfusion safety.
The methylene blue photochemical method is considered to a kind of effective blood composition ablation method.China and European countries such as Germany, Switzerland have carried out deep research to method, effect and the safety of methylene blue blood-plasma virus killing respectively; And be used for single bag of blood-plasma virus killing, be that present Blood Transfusion Services uses the most a kind of blood-plasma virus killing technology.It is professional that the Blood Transfusion Services of China nearly 1/3 has carried out blood-plasma virus killing, and clinical practice proves, the blood plasma that carries out preparing behind the blood-plasma virus killing through the methylene blue photochemical method has not been found the report of untoward reaction since clinical practice.The inactivation of virus product that existing market is used is connected to form through conduit by perforator, flow-stopping clip, methylene blue release, absorption filter, illumination bag and storage blood bag.In use, perforator is connected with the blood transfusion socket of the plasma bags for preparing, because this kind connected mode connects, perforator is an open process in the process of puncture, so this process need is operated between the sterile working.
Summary of the invention
This utility model technical problem to be solved is the deficiency that overcomes above-mentioned prior art; Provide a kind of structure reasonable, operation, easy to use can be carried out leukoreduction filter to the blood of gathering; And can conveniently carry out inactivation of virus; Whole blood collection, separation process all are under an airtight environment, to carry out, and can reduce the germ contamination chance, but effectively improve the leukocyte depleted blood bag of the inactivation of virus of blood products safety.
The technical scheme that this utility model solves the problems of the technologies described above employing is: but a kind of leukocyte depleted blood bag of inactivation of virus; Comprise closed blood taking needle, anticoagulated whole blood bag; Anticoagulated whole blood bag bottom is connected with successively through conduit and filters dropping funnel, flow regulator, leucocyte-removing filter, filter back transfering bag; Filter back transfering bag is connected with the first blood plasma transfering bag, the second blood plasma transfering bag and storage blood bag successively through conduit; It is characterized in that: connect a methylene blue release on the conduit between the said first blood plasma transfering bag and the second blood plasma transfering bag, connect an absorption filter on the conduit between the second blood plasma transfering bag and the storage blood bag.
The said leucocyte-removing filter of this utility model and absorption filter be the conduit through the parallelly connected belt switch clamp of threeway respectively.
This utility model connects methylene blue release and absorption filter in the leukocyte plastic blood bag that traditional close is used, can conveniently carry out inactivation of virus, and white blood cell removing plastic blood bag and inactivation of virus combine, and form the product of an integral body.Against existing technologies; But the white blood cell removing plastic blood bag of the disposable use inactivation of virus of this utility model in whole blood collection, separation preparation process, comprises that leucocyte-removing, blood separation, methylene blue add and the methylene blue filtering; All be under an airtight environment, to carry out; Can reduce to the process of aseptic operation, reduce the chance of germ contamination, can effectively improve the safety of blood products.Its structure rationally, and is easy for operation, is applicable to disposable blood sampling, blood constituent separation, inactivation of virus, blood transfusion use.
Description of drawings
Below in conjunction with accompanying drawing this utility model is done further to describe.
Fig. 1 is the composition structural representation of this utility model.
1. blood taking needles among the figure, 2. conduit 3. filters dropping funnel, 4. switch clamp; 5. filter back transfering bag, 6. anticoagulated whole blood bag, 7. flow regulator, 8. leucocyte-removing filter; 9. intermediate plate clamp, the 10. first blood plasma transfering bag, 11. methylene blue releases; 12. the second blood plasma transfering bag, 13. absorption filters, 14. storage blood bags.
The specific embodiment
As can be seen from Figure 1, but the leukocyte depleted blood bag of a kind of inactivation of virus of this utility model is provided with closed blood taking needle 1, anticoagulated whole blood bag 6.Use when closed blood taking needle 1 is used for taking a blood sample, the helmet on it of fractureing just can carry out the puncture blood collecting of routine.Anticoagulated whole blood bag 6 is used for collecting whole blood.Anticoagulated whole blood bag 6 bottoms are connected with successively through conduit 2 and filter dropping funnel 3, flow regulator 7, leucocyte-removing filter 8, filter back transfering bag 5, and filter back transfering bag 5 is connected with the first blood plasma transfering bag 10, the second blood plasma transfering bag 12 and storage blood bag 14 successively through conduit.Storage blood bag 14 also is the alserver's solution bag.
This utility model filters dropping funnel 3 and is used for grumeleuse and impurity in the filtering blood.Flow regulator 7 is used for regulating, the flow of controlled filter blood.Filter back transfering bag 5 is used for collecting filter back leucocyte-removing blood, and uses when being used for match, blood transfusion.
8 pairs of whole bloods of this utility model leucocyte-removing filter or blood constituent carry out leucocyte-removing and filter.For the convenience of totally closed operation, leucocyte-removing filter 8 is through the conduit of threeway parallel connection one belt switch clamp 4.During the operation of leukocyte in the filtering blood, close switch clamp 4, the blood in the anticoagulated whole blood bag 6 through filtration dropping funnel 3, leucocyte filter 8 gets in the transfering bags 5 of filter back.Open switch clamp 4 after filtration finishes, get rid of the gas in the transfering bag 5 of filter back, after the air scavenge, close switch clamp 4 again.Heat seal sealing filter back transfering bag 5 supplies match, blood transfusion to use.
This utility model anticoagulated whole blood bag 6, filter back transfering bag 5 can add anticoagulant and the alserver's solution that meets the pharmacopeia regulation according to the rules, and have and supporting formula conduction element easy to break and the socket of blood bag simultaneously.Alserver's solution begins to be stored in the storage blood bag 14, and therefore, storage blood bag 14 also is the alserver's solution bag.
This utility model first blood plasma transfering bag 10, the second blood plasma transfering bag 12 are used for blood plasma deposit, transfer after the centrifugalize.
Connect on the conduit between the said first blood plasma transfering bag 10 of this utility model and the second blood plasma transfering bag 12 on the conduit between a methylene blue release 11, the second blood plasma transfering bags 12 and the storage blood bag 14 and connect an absorption filter 13.
Contain methylene blue in the said methylene blue release 11 of this utility model, 11 liang of end connectors of methylene blue release are connected with conduit respectively.Said methylene blue release 11, absorption filter 13 all are commercial standard components, belong to existing known technology.Said absorption filter 13 is the conduit through threeway parallel connection one belt switch clamp also.So that after filtration finishes, get rid of the gas in the storage blood bag 14.
On the conduit between this utility model filter back transfering bag 5 and the first blood plasma transfering bag 10; On the conduit between the first blood plasma transfering bag 10 and the second blood plasma transfering bag 12; Be separately installed with intermediate plate clamp 9 on the conduit between the second blood plasma transfering bag 12 and the storage blood bag 14; Be used for by the operating process requirement circulation of control respective liquid composition.
The use of this utility model is: with closed blood taking needle 1 whole blood is collected in the anticoagulated whole blood bag 6.Blood heat is reduced to 4 ℃; With 6 reversals of the natural order of things of anticoagulated whole blood bag, with action of gravity whole blood is flowed through and filter dropping funnel 3, leucocyte-removing filter 8, begin to filter leukocyte; This moment filtering mainly be the leukocyte in the whole blood; Blood constituent after filter is white enters in the transfering bag 5 of filter back, and white device of filter and anticoagulated whole blood bag 6 are removed in heat seal.This utility model can prepare Red Blood Cells Suspension Leukocyte Reduced, and it is with the alserver's solution in the storage blood bag 14, transfers in the transfering bag 5 of filter back, and heat seal separates filter back transfering bag 5, and the blood products in this bag is Red Blood Cells Suspension Leukocyte Reduced.Alserver's solution in the storage blood bag 14 becomes empty bag after pouring out, and uses in order to follow-up storage blood.Blood constituent to filtering in the back transfering bag 5 carries out centrifugalize immediately, and blood plasma is transferred in the first blood plasma transfering bag 10.Blood plasma in the first blood plasma transfering bag 10 is centrifugal again; Supernatant is flowed through under action of gravity in the methylene blue release 11 entering second blood plasma transfering bag 12; Remove the first blood plasma transfering bag 10, at this moment, added the methylene blue injection in the blood plasma of the second blood plasma transfering bag 12; The second blood plasma transfering bag 12 is put into the time irradiation according to the rules of blood illuminator cabinet, carry out inactivation of virus.After irradiation finishes; To pass through blood plasma in the second blood plasma transfering bag 12 of the irradiation absorption filter 13 of under action of gravity, flowing through; The methylene blue that adsorption filter 13 adds in can adsorption filtration blood plasma; Methylene blue that adds in the removal blood plasma and the leukocyte in the blood plasma will pass through the plasma collection of viral inactivation treatment and in storage blood bag 14, preserve.
This utility model combines white blood cell removing plastic blood bag and inactivation of virus, and whole blood collection, separation, inactivation of virus process all are under an airtight environment, to carry out, and have reduced the germ contamination chance, have effectively improved the blood products safety.Its structure rationally, and is easy for operation, is applicable to that disposable blood sampling, blood constituent separate, inactivation of virus uses.
Claims (3)
1. but the leukocyte depleted blood bag of an inactivation of virus; Comprise closed blood taking needle, anticoagulated whole blood bag; Anticoagulated whole blood bag bottom is connected with successively through conduit and filters dropping funnel, flow regulator, leucocyte-removing filter, filter back transfering bag; Filter back transfering bag is connected with the first blood plasma transfering bag, the second blood plasma transfering bag and storage blood bag successively through conduit; It is characterized in that: connect a methylene blue release on the conduit between the said first blood plasma transfering bag and the second blood plasma transfering bag, connect an absorption filter on the conduit between the second blood plasma transfering bag and the storage blood bag.
2. but the leukocyte depleted blood bag of inactivation of virus according to claim 1 is characterized in that: said leucocyte-removing filter is through the conduit of threeway parallel connection one belt switch clamp.
3. but the leukocyte depleted blood bag of inactivation of virus according to claim 1 is characterized in that: said absorption filter is through the conduit of threeway parallel connection one belt switch clamp.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203703335U CN202236530U (en) | 2011-09-28 | 2011-09-28 | Leucocyte removal blood bag capable of inactivating viruses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011203703335U CN202236530U (en) | 2011-09-28 | 2011-09-28 | Leucocyte removal blood bag capable of inactivating viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202236530U true CN202236530U (en) | 2012-05-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011203703335U Expired - Lifetime CN202236530U (en) | 2011-09-28 | 2011-09-28 | Leucocyte removal blood bag capable of inactivating viruses |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202236530U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103203046A (en) * | 2013-04-15 | 2013-07-17 | 梁文飙 | blood bag system for decreasing collection damage and matched blood collection method |
| CN104337524A (en) * | 2014-10-27 | 2015-02-11 | 王炎 | Blood collection container |
| CN107551338A (en) * | 2017-09-29 | 2018-01-09 | 曹汝安 | Disposable cell and slurry separation method and separator |
| CN108295323A (en) * | 2018-02-08 | 2018-07-20 | 中国人民解放军陆军军医大学第附属医院 | The preparation method of rich platelet gel |
| CN114366831A (en) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | Plasma pathogen inactivation treatment method based on riboflavin photochemical method |
-
2011
- 2011-09-28 CN CN2011203703335U patent/CN202236530U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103203046A (en) * | 2013-04-15 | 2013-07-17 | 梁文飙 | blood bag system for decreasing collection damage and matched blood collection method |
| CN104337524A (en) * | 2014-10-27 | 2015-02-11 | 王炎 | Blood collection container |
| CN107551338A (en) * | 2017-09-29 | 2018-01-09 | 曹汝安 | Disposable cell and slurry separation method and separator |
| CN108295323A (en) * | 2018-02-08 | 2018-07-20 | 中国人民解放军陆军军医大学第附属医院 | The preparation method of rich platelet gel |
| CN114366831A (en) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | Plasma pathogen inactivation treatment method based on riboflavin photochemical method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120530 |
|
| CX01 | Expiry of patent term |