CN202054829U - Incubation reactor for biological chips - Google Patents
Incubation reactor for biological chips Download PDFInfo
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- CN202054829U CN202054829U CN2011201776863U CN201120177686U CN202054829U CN 202054829 U CN202054829 U CN 202054829U CN 2011201776863 U CN2011201776863 U CN 2011201776863U CN 201120177686 U CN201120177686 U CN 201120177686U CN 202054829 U CN202054829 U CN 202054829U
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- biochip
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- cover plate
- lower cover
- reaction cavity
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Abstract
The utility model discloses an incubation reactor for biological chips, which comprises a reaction cavity body, an upper cover plate and a lower cover plate. The upper cover plate and the lower cover plate are symmetrically arranged in the reaction cavity body, the inner wall of the reaction cavity body is provided with a boss which is integrated with the reaction cavity body by one-step forming, and the boss has a hollow structure serving as an incubation reaction cavity. A gap for installing the biological chips is reserved between the lower cover surface of the upper cover plate and the boss, and another gap for installing the biological chips is also reserved between the upper cover surface of the lower cover plate and the boss. The incubation reactor for the biological chips is simple and novel in structure and convenient to operate, can avoid volatilization of solutions in reaction processes, and realizes high-strength vibration, thereby improving reaction efficiency, shortening incubation time, and increasing sensitivity, specificity and reappearance of experiments. The biological chips can be adhered to the upper cover plate and the lower cover plate of the reactor, thereby simultaneously finishing incubation of double biological chips. Compared with traditional methods, more than one half of cost is saved.
Description
Technical field
The utility model belongs to biochip reaction device technical field, is specifically related to a kind of biochip incubation reaction device.
Background technology
Biochip (biochip) technology is the analytical technology of a Highgrade integration growing up phase early 1990s, can be divided into micro-array chip and micro-fluid chip two big classes according to its constructional feature.Wherein micro-array chip is the chip that is made of the biomaterial microarray, comprise DNA chip, protein chip, cell chip and organization chip etc., its ultimate principle all is that probe molecule is attached to certain surface of solid phase carriers, then with solution in sample molecule carry out affine association reaction, by detecting the signal power after enzyme, fluorescein or radio isotope amplify, and then the quantity of target molecule in the judgement sample.Biochip is integrated probe solid phase original position synthetic technology, photolithography technology, macromolecule synthesising technology, accurate control technique and laser scanning confocal microscopy, make synthetic, fixing highdensity ten hundreds of probe molecule and to hybridization signal carry out in real time, sensitivity, check and analysis accurately become practical.Biochip technology in the molecular biology research field, clinical medicine check field, field of biological pharmacy and environmental medicine field demonstrated great vitality.
Incubation step is one of important step in the biochip operation.In this process, free targeted molecular or identification molecule pass the liquid-solid interface barrier and discern mutually and combine with the probe molecule of solid surface in the liquid phase, and the speed of reaction of this process and efficient are subjected to solute and extend influence.For at utmost improving reaction efficiency and detection sensitivity, the routine process of hatching is to open wide or half opening wide under the system in biochemical incubator standing over night or auxiliary shaking table vibrates several hours.This process length consuming time can not adapt to the demand of clinical detection; Hatch for a long time and may cause sample sex change, inactivation; Non-closed system can cause solution evaporation, produces edge effect influence experiment accuracy.Above variety of problems all produces a very large impact repeatability, the reliability of experiment.Existing correlative study shows, be limited by liquid-solid barrier limit, even reaching leaving standstill of a couple of days hatches, its reaction efficiency still mixes not as the short period of time high strength hatches.Yet, realizing that the final method that the high strength mixing is hatched is to use automatic hybridization station, the price at this hybridization station is generally 30,000～60, and 000 dollar, extremely expensive, be not suitable for promoting the use of.
Therefore, develop a kind of novel easy to be generally, fast and stable is adapted to high strength blended biochip reaction device not only can save time cost and Financial cost, and can improve sensitivity, stability and the circulation ratio of biochip.
The utility model content
Technical problem to be solved in the utility model is to provide a kind of novelty simple in structure at above-mentioned deficiency of the prior art, easy to operate biochip incubation reaction device, and this reactor complete closed in the process of hatching can realize high-intensity oscillation.
For solving the problems of the technologies described above, the technical solution adopted in the utility model is: a kind of biochip incubation reaction device, it is characterized in that, and comprise that reaction cavity, symmetry are installed on intravital upper cover plate of reaction chamber and lower cover; Described reaction cavity inwall is provided with boss, one-body molded and the boss of described boss and reaction cavity has the hollow structure as the incubation reaction chamber, be provided with the gap that is used to install biochip between the following capping of described upper cover plate and the boss, also be provided with the gap that is used to install biochip between the last capping of described lower cover and the boss.
Above-mentioned a kind of biochip incubation reaction device, described upper cover plate biside plate all closely contacts with reaction cavity is inboard with the lower cover biside plate.
Above-mentioned a kind of biochip incubation reaction device, the following capping and the gap between the boss of described upper cover plate are 0.2mm～10mm, the last capping and the gap between the boss of lower cover are 0.2mm～10mm.
Above-mentioned a kind of biochip incubation reaction device, the distance between described boss inwall and the reaction cavity inwall is 0.2mm～10mm.
Above-mentioned a kind of biochip incubation reaction device, the thickness of described boss is 0.2mm～10mm.
Above-mentioned a kind of biochip incubation reaction device, described upper cover plate biside plate and lower cover biside plate are provided with raised ribs, reaction cavity each side has two grooves that match with raised ribs, and upper cover plate and lower cover all are installed in the reaction cavity by the raised ribs that snaps in the described groove.
Above-mentioned a kind of biochip incubation reaction device, the cross section of described upper cover plate and lower cover is the U type.
Above-mentioned a kind of biochip incubation reaction device, the front side of described reaction cavity has the U type groove of being convenient to add biochip incubation reaction liquid.
Above-mentioned a kind of biochip incubation reaction device, the both sides, front and back of described reaction cavity all have the U type groove of being convenient to add biochip incubation reaction liquid.
Above-mentioned a kind of biochip incubation reaction device, the both sides, front and back of described reaction cavity all have laterally zygomorphic two U type grooves of being convenient to add biochip incubation reaction liquid.
The utility model compared with prior art has the following advantages:
1, biochip incubation reaction device of the present utility model novelty simple in structure is easy to operate.
2, biochip incubation reaction device of the present utility model can be avoided the volatilization of solution in the reaction process, and can realize high-intensity oscillation (allowing the convertible high-intensity oscillation of 360 degree), thereby the raising reaction efficiency shortens incubation time, increases sensitivity, specificity and the circulation ratio of experiment.
3, biochip can both be pasted on the upper cover plate of biochip incubation reaction device of the present utility model and the lower cover, therefore hatching of double biochip can be finished simultaneously, than traditional method saving sample over half at least.
4, biochip incubation reaction device of the present utility model can Fast Installation and dismounting, and can utilize carriage to realize the synchronous operation and the detection of many bank of reactor, has saved labor service, has reduced energy consumption.
5, biochip incubation reaction device of the present utility model in use can reach the purpose of effectively avoiding cross reaction by changing reaction cavity, saves the reaction times.And reaction cavity is disposable use, can avoid the background interference that is caused by the protein non-specific adsorption on the reaction cavity sidewall.
6, biochip incubation reaction device of the present utility model is complete closed in the process of hatching, and has avoided the pollution of the nuisance in the reaction to the working space, has guaranteed staff's safety.
Below by drawings and Examples, the technical solution of the utility model is described in further detail.
Description of drawings
Fig. 1 is the perspective view of first kind of embodiment of the utility model.
Fig. 2 is the front view of first kind of embodiment of the utility model.
Fig. 3 is the vertical view of Fig. 2.
Fig. 4 is the A-A sectional view of Fig. 3.
Fig. 5 is the perspective view of second kind of embodiment of the utility model.
Fig. 6 is the front view of second kind of embodiment of the utility model.
Fig. 7 is the vertical view of Fig. 6.
Fig. 8 is the A-A sectional view of Fig. 7.
Fig. 9 is the perspective view of the third embodiment of the utility model.
Figure 10 is the front view of the third embodiment of the utility model.
Figure 11 is the vertical view of Figure 10.
Figure 12 is the A-A sectional view of Figure 11.
Figure 13 is first kind of user mode synoptic diagram of the utility model.
Figure 14 is second kind of user mode synoptic diagram of the utility model.
Figure 15 is the third user mode synoptic diagram of the utility model.
Description of reference numerals:
The 1-reaction cavity; The 2-upper cover plate; The 3-lower cover;
The 4-boss; The 5-raised ribs; 6-incubation reaction chamber;
The 7-biochip; The 8-seal washer.
Embodiment
As Fig. 1, Fig. 2, Fig. 3 and biochip incubation reaction device shown in Figure 4 comprise that reaction cavity 1, symmetry are installed on upper cover plate 2 and the lower cover 3 in the reaction cavity 1; Described reaction cavity 1 inwall is provided with boss 4, one-body molded and the boss 4 of described boss 4 and reaction cavity 1 has the hollow structure as incubation reaction chamber 6, be provided with the gap that is used to install biochip between the following capping of described upper cover plate 2 and the boss 4, also be provided with the gap that is used to install biochip between the last capping of described lower cover 3 and the boss 4; Described upper cover plate 2 biside plates all closely contact with reaction cavity 1 inboard with lower cover 3 biside plates; The following capping and the gap between the boss 4 of described upper cover plate 2 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The last capping and the gap between the boss 4 of lower cover 3 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Distance between described boss 4 inwalls and reaction cavity 1 inwall is 0.2mm～10mm, and described distance is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The thickness of described boss 4 is 0.2mm～10mm, and described thickness is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Described upper cover plate 2 biside plates and lower cover 3 biside plates are provided with raised ribs 5, reaction cavity 1 each side has two grooves that match with raised ribs 5, and upper cover plate 2 and lower cover 3 all are installed in the reaction cavity 1 by the raised ribs 5 that snaps in the described groove; The cross section of described upper cover plate 2 and lower cover 3 is the U type; The both sides, front and back of described reaction cavity 1 all have the U type groove of being convenient to add biochip incubation reaction liquid.
As Fig. 5, Fig. 6, Fig. 7 and biochip incubation reaction device shown in Figure 8 comprise that reaction cavity 1, symmetry are installed on upper cover plate 2 and the lower cover 3 in the reaction cavity 1; Described reaction cavity 1 inwall is provided with boss 4, one-body molded and the boss 4 of described boss 4 and reaction cavity 1 has the hollow structure as incubation reaction chamber 6, be provided with the gap that is used to install biochip between the following capping of described upper cover plate 2 and the boss 4, also be provided with the gap that is used to install biochip between the last capping of described lower cover 3 and the boss 4; Described upper cover plate 2 biside plates all closely contact with reaction cavity 1 inboard with lower cover 3 biside plates; The following capping and the gap between the boss 4 of described upper cover plate 2 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The last capping and the gap between the boss 4 of lower cover 3 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Distance between described boss 4 inwalls and reaction cavity 1 inwall is 0.2mm～10mm, and described distance is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The thickness of described boss 4 is 0.2mm～10mm, and described thickness is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Described upper cover plate 2 biside plates and lower cover 3 biside plates are provided with raised ribs 5, reaction cavity 1 each side has two grooves that match with raised ribs 5, and upper cover plate 2 and lower cover 3 all are installed in the reaction cavity 1 by the raised ribs 5 that snaps in the described groove; The cross section of described upper cover plate 2 and lower cover 3 is the U type; The front side of described reaction cavity 1 has the U type groove of being convenient to add biochip incubation reaction liquid.
As Fig. 9, Figure 10, Figure 11 and biochip incubation reaction device shown in Figure 12 comprise that reaction cavity 1, symmetry are installed on upper cover plate 2 and the lower cover 3 in the reaction cavity 1; Described reaction cavity 1 inwall is provided with boss 4, one-body molded and the boss 4 of described boss 4 and reaction cavity 1 has the hollow structure as incubation reaction chamber 6, be provided with the gap that is used to install biochip between the following capping of described upper cover plate 2 and the boss 4, also be provided with the gap that is used to install biochip between the last capping of described lower cover 3 and the boss 4; Described upper cover plate 2 biside plates all closely contact with reaction cavity 1 inboard with lower cover 3 biside plates; The following capping and the gap between the boss 4 of described upper cover plate 2 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The last capping and the gap between the boss 4 of lower cover 3 are 0.2mm～10mm, and described gap is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Distance between described boss 4 inwalls and reaction cavity 1 inwall is 0.2mm～10mm, and described distance is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; The thickness of described boss 4 is 0.2mm～10mm, and described thickness is preferably 0.2mm, 1.0mm, 2.0mm, 3.0mm, 4.0mm, 5.0mm, 6.0mm, 7.0mm, 8.0mm, 9.0mm, 10mm; Described upper cover plate 2 biside plates and lower cover 3 biside plates are provided with raised ribs 5, reaction cavity 1 each side has two grooves that match with raised ribs 5, and upper cover plate 2 and lower cover 3 all are installed in the reaction cavity 1 by the raised ribs 5 that snaps in the described groove; The cross section of described upper cover plate 2 and lower cover 3 is the U type; The both sides, front and back of described reaction cavity 1 all have laterally zygomorphic two U type grooves of being convenient to add biochip incubation reaction liquid.
As shown in figure 13, first kind of using method of the utility model biochip incubation reaction device is all to paste biochip on the capping on the following capping of upper cover plate 2 and the lower cover 3, the use of this method is: the lower cover 3 that will be pasted with biochip 7 earlier is installed in the reaction cavity 1, lower cover 3 will be pressed to boss 4 bottoms (for the biochip of hard substrate around the biochip 7, can between biochip and boss, install the seal washer that matches with boss additional), the mounting means of lower cover 3 is: pinch lower cover 3 both sides lower cover 3 is sent in the reaction cavity 1, the raised ribs 5 of lower cover 3 both sides snaps in the groove of reaction cavity 1, with lower cover 3 firm being installed in the reaction cavity 1; Then to boss 4 be used for add biochip incubation reaction liquid as the hollow structure in biochip incubation reaction chamber 6; The upper cover plate 2 that will be pasted with biochip 7 again is according to being installed in the reaction cavity 1 with lower cover 3 symmetrical manner, upper cover plate 2 will be pressed to boss 4 tops (for the biochip of hard substrate, can install the seal washer that matches with boss additional between biochip and boss) around the biochip 7; Placing biochemical incubator or high-speed oscillator to carry out biochip one or more mounted biochip incubation reaction devices at last hatches.
As shown in figure 14, second kind of using method of the utility model biochip incubation reaction device is only to paste biochip on the following capping of upper cover plate 2, the use of this method is: install the seal washer 8 that matches with boss 4 additional earlier on lower cover 3, lower cover 3 is installed in the reaction cavity 1; Then to boss 4 be used for add biochip incubation reaction liquid as the hollow structure in biochip incubation reaction chamber 6; The upper cover plate 2 that will be pasted with biochip 7 again is according to being installed in the reaction cavity 1 with lower cover 3 symmetrical manner, upper cover plate 2 will be pressed to boss 4 tops (for the biochip of hard substrate, can install the seal washer that matches with boss additional between biochip and boss) around the biochip 7; Placing biochemical incubator or high-speed oscillator to carry out biochip one or more mounted biochip incubation reaction devices at last hatches.
As shown in figure 15, the third using method of the utility model biochip incubation reaction device is only being pasted biochip on the capping on the lower cover 3, the use of this method is: the lower cover 3 that will be pasted with biochip 7 earlier is installed in the reaction cavity 1, lower cover 3 will be pressed to boss 4 bottoms (for the biochip of hard substrate, can install the seal washer that matches with boss additional between biochip and boss) around the biochip 7; Then to boss 4 be used for add biochip incubation reaction liquid as the hollow structure in biochip incubation reaction chamber 6; On boss 4, install the seal washer 8 that matches with it again additional, with upper cover plate 2 according to being installed in the reaction cavity 1 with lower cover 3 symmetrical manner; Placing biochemical incubator or high-speed oscillator to carry out biochip one or more mounted biochip incubation reaction devices at last hatches.
Biochip incubation reaction device of the present utility model can be avoided the volatilization of solution in the reaction process, and can realize high-intensity oscillation (allowing the convertible high-intensity oscillation of 360 degree), thereby the raising reaction efficiency shortens incubation time, increases sensitivity, specificity and the circulation ratio of experiment.Biochip can both be pasted on the upper cover plate of reactor and the lower cover, therefore hatching of double biochip can be finished simultaneously, than traditional method saving sample over half at least.Reactor in use can reach the purpose of effectively avoiding cross reaction by changing reaction cavity, saves the reaction times, and reaction cavity is disposable use, can avoid the background interference that is caused by the protein non-specific adsorption on the reaction cavity sidewall.
The above; it only is preferred embodiment of the present utility model; be not that the utility model is done any restriction; everyly any simple modification that above embodiment did, change and equivalent structure are changed, all still belong in the protection domain of technical solutions of the utility model according to the utility model technical spirit.
Claims (10)
1. a biochip incubation reaction device is characterized in that, comprises that reaction cavity (1), symmetry are installed on upper cover plate (2) and the lower cover (3) in the reaction cavity (1); Described reaction cavity (1) inwall is provided with boss (4), one-body molded and the boss (4) of described boss (4) and reaction cavity (1) has the hollow structure as incubation reaction chamber (6), be provided with the gap that is used to install biochip between the following capping of described upper cover plate (2) and the boss (4), also be provided with the gap that is used to install biochip between the last capping of described lower cover (3) and the boss (4).
2. a kind of biochip incubation reaction device according to claim 1 is characterized in that, described upper cover plate (2) biside plate all closely contacts with reaction cavity (1) inboard with lower cover (3) biside plate.
3. a kind of biochip incubation reaction device according to claim 1, it is characterized in that, gap between the following capping of described upper cover plate (2) and the boss (4) is 0.2mm～10mm, and the gap between the last capping of lower cover (3) and the boss (4) is 0.2mm～10mm.
4. a kind of biochip incubation reaction device according to claim 1 is characterized in that, the distance between described boss (4) inwall and reaction cavity (1) inwall is 0.2mm～10mm.
5. a kind of biochip incubation reaction device according to claim 1 is characterized in that the thickness of described boss (4) is 0.2mm～10mm.
6. a kind of biochip incubation reaction device according to claim 1, it is characterized in that, described upper cover plate (2) biside plate and lower cover (3) biside plate are provided with raised ribs (5), reaction cavity (1) each side has two grooves that match with raised ribs (5), and upper cover plate (2) and lower cover (3) all are installed in the reaction cavity (1) by the raised ribs (5) that snaps in the described groove.
7. a kind of biochip incubation reaction device according to claim 6 is characterized in that the cross section of described upper cover plate (2) and lower cover (3) is the U type.
8. a kind of biochip incubation reaction device according to claim 1 is characterized in that the front side of described reaction cavity (1) has the U type groove of being convenient to add biochip incubation reaction liquid.
9. a kind of biochip incubation reaction device according to claim 1 is characterized in that the both sides, front and back of described reaction cavity (1) all have the U type groove of being convenient to add biochip incubation reaction liquid.
10. a kind of biochip incubation reaction device according to claim 1 is characterized in that, the both sides, front and back of described reaction cavity (1) all have laterally zygomorphic two U type grooves of being convenient to add biochip incubation reaction liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201776863U CN202054829U (en) | 2011-05-30 | 2011-05-30 | Incubation reactor for biological chips |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201776863U CN202054829U (en) | 2011-05-30 | 2011-05-30 | Incubation reactor for biological chips |
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| Publication Number | Publication Date |
|---|---|
| CN202054829U true CN202054829U (en) | 2011-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011201776863U Expired - Fee Related CN202054829U (en) | 2011-05-30 | 2011-05-30 | Incubation reactor for biological chips |
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| Country | Link |
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| CN (1) | CN202054829U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102226147A (en) * | 2011-05-30 | 2011-10-26 | 苏州偲聚生物材料有限公司 | Biochip incubation reactor |
| CN105572379A (en) * | 2014-11-05 | 2016-05-11 | 苏州偲聚生物材料有限公司 | Kit capable of being used for diagnosis of vivax malaria and/or falciparum malaria |
-
2011
- 2011-05-30 CN CN2011201776863U patent/CN202054829U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102226147A (en) * | 2011-05-30 | 2011-10-26 | 苏州偲聚生物材料有限公司 | Biochip incubation reactor |
| CN102226147B (en) * | 2011-05-30 | 2013-01-23 | 苏州偲聚生物材料有限公司 | Biochip incubation reactor |
| CN105572379A (en) * | 2014-11-05 | 2016-05-11 | 苏州偲聚生物材料有限公司 | Kit capable of being used for diagnosis of vivax malaria and/or falciparum malaria |
| CN105572379B (en) * | 2014-11-05 | 2018-06-05 | 苏州偲聚生物材料有限公司 | Available for Plasmodium Vivax and/or the kit of malignant malaria |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111130 Termination date: 20150530 |
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| EXPY | Termination of patent right or utility model |