CN201993241U - Quantitative biological sampling flocked swab - Google Patents

Quantitative biological sampling flocked swab Download PDF

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Publication number
CN201993241U
CN201993241U CN201020679116XU CN201020679116U CN201993241U CN 201993241 U CN201993241 U CN 201993241U CN 201020679116X U CN201020679116X U CN 201020679116XU CN 201020679116 U CN201020679116 U CN 201020679116U CN 201993241 U CN201993241 U CN 201993241U
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China
Prior art keywords
swab
flocking
annular support
cashmere
biological sampling
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Expired - Lifetime
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CN201020679116XU
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Inventor
李安生
吴窈画
谈书华
何中华
范超超
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CITOTEST LABWARE MANUFACTURING Co Ltd
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CITOTEST LABWARE MANUFACTURING Co Ltd
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Priority to CN201020679116XU priority Critical patent/CN201993241U/en
Priority to PCT/CN2011/000203 priority patent/WO2012083572A1/en
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Publication of CN201993241U publication Critical patent/CN201993241U/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/02—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by impregnation, e.g. using swabs or loops
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The utility model provides a quantitative biological sampling flocked swab, which comprises a swab rod and a swab head. The swab head adopts a flocked layer covering the end of the swab rod, one end or two ends of the swab rod is/are provided with a ring-shaped bracket structure, and the flocked layer covers the surface of the ring-shaped bracket(s). By adopting the technical scheme, large-volume sampling can be achieved, and the volume of liquid to be absorbed quantitatively can be controlled at a fixed value within the range of 10-200 uml. Moreover, the swab head cannot easily fall off, and the swab is convenient to use and has good safety.

Description

Quantitative biological sampling flocking swab
Technical field
The utility model relates to a kind of biological experiment equipment, especially relates to a kind of quantitative biological sampling flocking swab.
Background technology
In field of biology, can the collection of biological specimen (comprising biological cell and biomolecule) and transmission be the most important condition that carry out effective laboratory examination.In numerous biological specimen collections and transmission technology, swab sampling is a kind of the most frequently used and Sampling techniques the most easily, and the swab of wherein sampling is the sampling equipment of most critical.Forming sampling transmission system equipment around the sampling swab can finish by the sampling position and reliably gather biological specimen and safe transfer to breadboard experimentation.
At present, the structure of biological sampling swab commonly used comprises swab handle and swab head.Swab handle is a bar-shaped cylinder, and by tool certain degree of hardness and resilient material, an end is a handgrip part, and one or both ends all can be used as the position that makes the swab head.The swab head is the part that can effectively adsorb biological specimen that is fixed on the swab handle one or both ends, is divided into winding, flocking and foaming three classes.Relatively comprehensive, there is following defective in existing three class biological sampling swabs: (1) winding, flocking or foaming swab head all are distributed in swab handle one end along the swab handle major axis, half of the not enough whole swab head of effective contact portion at swab head and sampling position when reality is used, often effective collection liquid sample causes effective adsorbance of swab to reduce; (2) by twining or the swab head of expanded material parcel combines insecurely with swab handle, the swab head takes place easily come off; (3) existing three class swabs can only saturated samplings and are not possessed the performance of quantitative collection biological specimen; The sampling position might be damaged in the right cylinder top of the swab handle of (4) three class swabs.
Summary of the invention
The purpose of this utility model be solve traditional biological sampling swab can not quantitative sampling, the sample adsorbance is low, and solve the swab head and easily come off and unsafe problem.
To achieve these goals, the utility model provides a kind of quantitative biological sampling flocking swab, comprise swab handle and swab head, the swab head is the cashmere-planted layer that covers the swab handle end, it is characterized in that: the end of the one or both ends of swab handle is set to the annular support structure, and cashmere-planted layer covers the surface of annular support.
Ring diameter is 1.25～10 mm in the annular support, and annular support cylinder cross-sectional diameter is 0.2～3 mm.
Annular support is 2.5～296 mm as effective flocking area of flocked substrates 2
Annular support is arranged to the above polygon annular in annular, oval ring, three side ring shapes or at least three limits, and annular support cylinder xsect is arranged to circle, ellipse or polygon.
The fibre length of cashmere-planted layer is 0.2～3.0 mm, and the fibre number of cashmere-planted layer is 0.33～7.0 dtex, and the fibre density of cashmere-planted layer is 1.5～350 μ g/mm 2
The material of swab handle is acrylic plastering, vinyon, poly terephthalic acid class plastics, polystyrene plastics or engineering plastics.
Cashmere-planted layer adopts natural fiber, perhaps man-made fiber, and perhaps the composite fibre of the two covers the surface of annular support.
Cashmere-planted layer adopts nylon fiber to cover the surface of annular support.
Swab handle is provided with the mouth that fractures of the swab handle of being convenient to fix a point to fracture, or does not establish the mouth that fractures on the swab handle that can the arbitrfary point fractures with the polystyrene modified plastic production.
Quantitatively ring diameter and annular support cylinder cross-sectional diameter are the effective flocking area of decision and then control collected specimens volume and the principal element that realizes the quantitative collection sample in the annular support of biological sampling flocking swab.In addition, the swab volume that can gather sample also is subjected to the influence of fibre length, fibre number and the fibre density of cashmere-planted layer.With common end is that columned traditional swab head is compared, and is long-pending the increasing of flocked surface of the base material that base material obtained with the annular support, has just increased the efficiently sampling amount by increasing effective flocking area.The utility model is by ring diameter and annular support cylinder cross-sectional diameter in the control annular support, the surface area of flocked substrates is implemented in control, further regulate the variation of fibre number, fibre length and the fibre density of cashmere-planted layer, finally make the swab head possess the quantitative sampling function.According to the swab that principle of the present utility model is made, gravimetry (H absorbs water under 25 ℃ of environmental baselines 2O@25 ℃) detected may command quantitative sampling volume is a definite value of 10～200 μ l scopes.
Because the efficiently sampling position of the flocking that the utility model obtains sampling swab concentrates on the swab handle end, can contact fully with being sampled the position when implementing sampling, guarantees fully to gather sample; Owing to adopt the annular support structure, no longer adopt the simple column design of the swab handle end of following for many years, make the swab head both be difficult for coming off and also effectively eliminated the possibility that the swab of sampling causes the injury of sampling position.
The quantitative biological sampling flocking swab that the utility model obtains has the following advantages:
(1) can select the quantitative biological sampling flocking swab of different sampling quantities according to the needs of gathering sample.
(2) quantitatively the swab head active component of biological sampling flocking swab contacts fully with the sampling position, guarantees the sampling quantity maximization.
(3) quantitatively biological sampling flocking swab can the quantitative collection sample, helps to realize that experiment detects directly result of calculation of back.
(4) quantitatively biological sampling flocking swab has solved the loosening and problem that comes off of swab head effectively.
(5) quantitatively biological sampling flocking swab has overcome the problem that swab damages sampling position (as human body) fully.
Description of drawings
Fig. 1 is the structure cut-open view of the utility model embodiment one.
Fig. 2 is the annular support cylinder cross sectional representation of the utility model embodiment one.
Fig. 3 is the cut-open view of the annular support of the utility model embodiment one.
The swab structure cut-open view that Fig. 4 produces for prior art.
Wherein: 1-swab handle, 2-cashmere-planted layer, the 3-mouth that fractures, 4-annular support.
Embodiment
Describe preferred embodiment of the present utility model below with reference to the accompanying drawings in detail.
Embodiment is just like Fig. 1, Fig. 2, shown in Figure 3, and present embodiment provides a kind of quantitative biological sampling flocking swab to comprise swab handle 1 and swab head.Annular support 4 is arranged in the end of one end of swab handle 1, perhaps also the end at swab handle 1 two ends can be arranged to annular support 4 respectively, the ring-type of the annular support 4 of present embodiment is arranged to annular, perhaps also can be arranged to the above polygon annular in oval ring, three side ring shapes or at least three limits; Annular support 4 cylinder xsects are arranged to circle, perhaps also can be arranged to ellipse or polygon.
Ring diameter can be arranged between 1.25～10 mm scopes in the annular support 4 of present embodiment, and present embodiment is set to 3.91 mm; Annular support 4 cylinder cross-sectional diameters can be arranged between 0.2～3 mm scope, and present embodiment is set to 1.19 mm; Swab handle 1 and annular support 4 can adopt vinyon, poly terephthalic acid class plastics or engineering plastics, present embodiment adopts the acrylic plastering material to make, and fracture mouthfuls 3 what swab handle 1 part was provided with the swab handle 1 of being convenient to fix a point to fracture as required, use with the transmission after the convenient sampling; Perhaps also can adopt the swab handle 1 of polystyrene modified made to fracture to be implemented in the arbitrfary point.
With annular support 4 is base material, makes cashmere-planted layer 2 cover the surface of annular support 4 base materials, and effective cashmere-planted layer area of annular support 4 substrate surfaces can be arranged on 2.5～296 mm 2Between the scope, present embodiment is 46 mm 2The fibre length of cashmere-planted layer 2 can be arranged between 0.2～3.0 mm scope, and present embodiment is 0.6 mm; The fibre number of cashmere-planted layer 2 can be arranged between 0.33～7.0 dtex scope, and present embodiment is 1.5 dtex; The fibre density of cashmere-planted layer 2 can be arranged on 1.5～350 μ g/mm 2Between the scope, present embodiment is 17 μ g/mm 2The material that swab head cashmere-planted layer 2 relates to is a natural fiber, perhaps man-made fiber, and the perhaps composite fibre of the two, present embodiment is a nylon fiber.
Compare with traditional swab shown in Figure 4, the advantage of present embodiment show as sampling quantity big, can determine that quantitatively the liquid volume of absorption is 55 μ l(H 2O@25 ℃), swab head difficult drop-off, easy to use and security good.
Embodiment two, ring diameter 5 mm in the annular support 4, and annular support 4 cylinder cross-sectional diameters 1.5 mm, the effective flocking area of the base material of annular support is 74 mm 2, nylon fiber length 1.5 mm, fibre number 6.67 dtex, the fibre density 328 μ g/mm of cashmere-planted layer 2 2, adsorptive liquid volume 110 μ l(H 2O@25 ℃), all the other are with embodiment one.
Embodiment three, ring diameter 1.5 mm in the annular support 4, and annular support 4 cylinder cross-sectional diameters 0.5 mm, the effective flocking area of the base material of annular support 4 is 7.39 mm 2, nylon fiber length 1.0 mm, fibre number 1.5 dtex, the fibre density 109 μ g/mm of cashmere-planted layer 2 2, adsorptive liquid volume 20 μ l(H 2O@25 ℃), all the other are with embodiment one.

Claims (9)

1. quantitative biological sampling flocking swab, comprise swab handle (1) and swab head, the swab head is for covering the cashmere-planted layer (2) of swab handle (1) end, it is characterized in that: the end of the one or both ends of swab handle (1) is set to annular support (4) structure, and cashmere-planted layer (2) covers the surface of annular support (4).
2. quantitative biological sampling flocking swab according to claim 1 is characterized in that: the interior ring diameter of annular support (4) is 1.25～10 mm, and annular support (4) cylinder cross-sectional diameter is 0.2～3 mm.
3. quantitative biological sampling flocking swab according to claim 1 is characterized in that: annular support (4) is 2.5～296 mm as effective flocking area of flocked substrates 2
4. according to claim 1 or 2 or 3 described quantitative biological sampling flocking swabs, it is characterized in that: annular support (4) is arranged to the above polygon annular in annular, oval ring, three side ring shapes or at least three limits, and annular support (4) cylinder xsect is arranged to circle, ellipse or polygon.
5. according to claim 1 or 2 or 3 described quantitative biological sampling flocking swabs, it is characterized in that: the fibre length of cashmere-planted layer (2) is 0.2～3.0 mm, the fibre number of cashmere-planted layer (2) is 0.33～7.0 dtex, and the fibre density of cashmere-planted layer (2) is 1.5～350 μ g/mm 2
6. quantitative biological sampling flocking swab according to claim 1 is characterized in that: the material of swab handle (1) is acrylic plastering, vinyon, poly terephthalic acid class plastics, polystyrene plastics or engineering plastics.
7. quantitative biological sampling flocking swab according to claim 1 is characterized in that: cashmere-planted layer (2) adopts natural fiber, and perhaps man-made fiber covers the surface of annular support (4).
8. according to claim 1 or 7 described quantitative biological sampling flocking swabs, it is characterized in that: cashmere-planted layer (2) adopts nylon fiber to cover the surface of annular support (4).
9. quantitative biological sampling flocking swab according to claim 6, it is characterized in that: swab handle (1) is provided with is convenient to fracture fracture mouthful (3) of swab handle (1) of fixed point, or does not establish the mouth (3) that fractures on the swab handle (1) that can the arbitrfary point fractures with the polystyrene modified plastic production.
CN201020679116XU 2010-12-24 2010-12-24 Quantitative biological sampling flocked swab Expired - Lifetime CN201993241U (en)

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Application Number Priority Date Filing Date Title
CN201020679116XU CN201993241U (en) 2010-12-24 2010-12-24 Quantitative biological sampling flocked swab
PCT/CN2011/000203 WO2012083572A1 (en) 2010-12-24 2011-02-09 Flocking swab for biological sampling quantitatively and method for making the same

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CN201020679116XU CN201993241U (en) 2010-12-24 2010-12-24 Quantitative biological sampling flocked swab

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102087172A (en) * 2010-12-24 2011-06-08 江苏世泰实验器材有限公司 Quantitative biological sampling flocking swab
US8631715B2 (en) 2010-06-09 2014-01-21 Copan Italia S.P.A. Method for quantitative transfer of analytes
ITMI20121603A1 (en) * 2012-09-25 2014-03-26 Copan Italia Spa DEVICE AND METHOD FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL
US9504452B2 (en) 2011-01-05 2016-11-29 Copan Italia S.P.A. Process for realising a device for collecting and transferring samples for molecular biology
CN108359186A (en) * 2018-01-04 2018-08-03 浙江润兰科技有限公司 A kind of sampling rod
US10327741B2 (en) 2003-04-01 2019-06-25 Copan Italia S.P.A. Swab for collecting biological specimens
EP4282341A1 (en) * 2022-05-27 2023-11-29 Hangzhou Biotest Biotech Co., Ltd. Sample collector

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10327741B2 (en) 2003-04-01 2019-06-25 Copan Italia S.P.A. Swab for collecting biological specimens
US11364018B2 (en) 2003-04-01 2022-06-21 Copan Italia S.P.A. Swab for collecting biological specimens
US11446012B2 (en) 2003-04-01 2022-09-20 Copan Italia S.P.A. Swab for collecting biological specimens
US8631715B2 (en) 2010-06-09 2014-01-21 Copan Italia S.P.A. Method for quantitative transfer of analytes
CN102087172A (en) * 2010-12-24 2011-06-08 江苏世泰实验器材有限公司 Quantitative biological sampling flocking swab
US9504452B2 (en) 2011-01-05 2016-11-29 Copan Italia S.P.A. Process for realising a device for collecting and transferring samples for molecular biology
US10092275B2 (en) 2011-01-05 2018-10-09 Copan Italia S.P.A. Process for realising a device for collecting and transferring samples for molecular biology
ITMI20121603A1 (en) * 2012-09-25 2014-03-26 Copan Italia Spa DEVICE AND METHOD FOR THE COLLECTION AND TRANSFER OF SAMPLES OF BIOLOGICAL MATERIAL
WO2014049460A1 (en) * 2012-09-25 2014-04-03 Copan Italia S.P.A. A device and a method for collecting and transferring samples of biological material
EP3738516A1 (en) * 2012-09-25 2020-11-18 Copan Italia S.P.A. A device and a method for collecting and transferring samples of biological material
CN108359186A (en) * 2018-01-04 2018-08-03 浙江润兰科技有限公司 A kind of sampling rod
EP4282341A1 (en) * 2022-05-27 2023-11-29 Hangzhou Biotest Biotech Co., Ltd. Sample collector

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Granted publication date: 20110928