CN201876384U

CN201876384U - Novel automatic respiratory tract sample processor

Info

Publication number: CN201876384U
Application number: CN201020505602XU
Authority: CN
Inventors: 徐新; 张陆军; 王礼文
Original assignee: Sinnowa Medical Science and Technology Co Ltd
Priority date: 2010-08-26
Filing date: 2010-08-26
Publication date: 2011-06-22
Anticipated expiration: 2020-08-26

Abstract

The utility model relates to a novel automatic respiratory tract sample automatic processor, belonging to the field of a related automatic instrument used for the pretreatment of the respiratory tract specimen in clinical medicine. The instrument mainly consists of a primary sample processing unit and a centrifugal concentration unit, and treatment before respiratory tract sample examination can be automatically completed under the control and coordination of a control unit, so that the infection risk caused by manual operation can be reduced.

Description

A kind of novel automatic processing instrument of respiratory tract sample

One, technical field

The present invention relates in the clinical medicine relevant automatic instrument field to respiratory tract sample to be checked (secretion, the phlegm) pre-treatment of testing.

Two, background technology

Directly respiratory tract sample (secretion, phlegm) is checked it is the important diagnostic method of many breathing problem diagnosis, for example directly detecting Much's bacillus or detect the tubercle bacillus gene dna molecular in such sample is that pulmonary tuberculosis is diagnosed the most key reliable foundation.The respiratory tract sample is detected pre-treatment, and effectively concentrate pathogen or pathological cells are the important steps that improves quality inspection and efficient.At present, pre-treatment still relies on manual operations to the respiratory tract pattern detection, and some check units even with respiratory tract sample direct smear or directly inoculation, do not cause recall rate low excessively to sample preparation.Adopt manually loaded down with trivial details to respiratory tract sample survey pre-treatment operating process, efficient is not high, quality is wayward, and the operator is had higher infection risk, and influences operator's job enthusiasm.These factors all cause positive rate low, not only incur loss through delay patient's diagnosis and treatment, and the failing to pinpoint a disease in diagnosis as pulmonary tuberculosis of infectious respiratory disease, and the actual infection sources that causes is out of control, form the serious harm to public health and social safety.For improving respiratory tract specimen examination work quality and efficient, reduce the risk that the operator infects, improve medical test personnel condition of work, we have designed a kind of novel automatic processing instrument of respiratory tract sample at special invention, infect risk, improve quality inspection and work efficiency to realize robotization, to reduce respiratory tract specimen examination pre-treatment process.

Three, summary of the invention

The invention provides a kind of novel automatic processing instrument of respiratory tract sample, this instrument can be finished respiratory tract sample inspection pre-treatment process automatically, and can improve the recovery of target pathogen or pathological cells.This instrument is by the control of computing machine or single-chip microcomputer (control module), has the respiratory tract sample is added reagent (digestive juice etc.), the short digestion of automatic temperature-control or sterilization, low speed/high speed centrifugation functions such as pathogeny bacterium or cell that concentrate automatically.Instrument can be finished the digestion (liquefaction) of respiratory tract sample to be checked, centrifugal concentrated bacterium/pathological cells, sample separation and sterilization automatically, prepare smear and automatic vaccination automatically under the control of control module is coordinated.Instrument mainly can by: elementary sample process unit, the centrifugal unit that concentrates, be coated with blade unit, five big major parts such as inoculation unit, control module are formed.Detailed structure part can comprise: elementary sample process dish, add reagent station, sample transfer arm, the centrifugal dish that concentrates, supply cabin, suction nozzle position, removal waste fluid station, smear arm, automatic vaccination arm, the disposable structures compositions such as head supply station, smear supply station, heating unit that are coated with.Be placed with stirrer in advance in the sample hose on the primary sample process disk of primary sample processing unit, and position, counter sample position is provided with magnetic stirring apparatus under each sample position or sample segment position, and the stirrer stirring makes sample be stirred fully when primary treatment and processing completely in the sample hose thereby magnetic stirring apparatus makes.In the primary sample processing unit sample hose automatic lid closing/opening apparatus can be set, and sample hose liquid level detector (add amount of reagent with control and guarantee that sample does not overflow sample hose) and add the reagent device automatically.On the primary sample processing unit of instrument and the centrifugal unit that concentrates respectively design the sample cup position and the centrifuge tube position of equal amount are arranged, around the primary sample process disk, centrifugal concentrate dish also design reagent position/add reagent station, removal waste fluid station, sample inoculation unit, be coated with blade unit is arranged.

A kind of novel automatic processing instrument of respiratory tract sample, its engineering process roughly comprises: at first, sample adds reagent to each sample tube respectively by adding the reagent arm on elementary sample process unit, and be warming up to behind the design temperature agitating function in addition in the elementary sample process dish, make sample obtain comprehensively, handle completely; Then, sample after the primary treatment cell processing is transferred in the centrifugal centrifuge tube that concentrates on coiling with centrifugal function by transfer arm respectively by sample, through centrifugal and separation of supernatant, realize concentrate (sample for preparing) to pathogenic microorganism or pathological cells.The sample for preparing can be according to checking needs, automatically finish microbe growth operation (centrifugal sediment is inoculated into bacteria culture media) by instrument, and smear staining (sample for preparing is spread upon on the microslide, oven dry fix, dye or heat dyeing and decolouring, processing such as oven dry again).Do other inspection as needs, can collect the centrifuge tube sample, do other detection by operating personnel.Instrument also can be automatically to inner disinfection automatically such as elementary sample process unit, the centrifugal unit that concentrates (as ultraviolet ray, high temperature) after finishing sample process.

In addition, bar code can also be set instrument or electronic tag is made and recognition system, be arranged on elementary sample process unit, the centrifugal unit that concentrates as required, be coated with blade unit and inoculation unit etc., pattern delivery process (centrifuge tube, inoculated tube, smear etc.) is carried out trace labelling.Instrument is carried out sample process according to the workflow of operator's layout, and under the control of instrument control module, instrument is finished whole pre-treatment processes to sample by the Automatic Program of compiling and editing.

Four, description of drawings

Accompanying drawing is the automatic processing instrument structural representation of a kind of novel respiratory tract sample.

Among the figure: 1, add the reagent arm, 2, elementary sample process dish, 3, the centrifugal dish that concentrates, 4, disposable inoculation supply station, 5, add a cover arm automatically, 6, the automatic vaccination arm, 7, take off automatically and cover arm, 8, inoculation head is abandoned the storehouse, and 9, be coated with head and abandon the station, 10, the smear arm, 11, disposable smear supply station, 12, disposable tip mouth supply station, 13, the sample transfer arm, 14, the disposable tip mouth abandons the storehouse.

Five, embodiment

Now with the example that is treated to of tubercular's sputum sample, in conjunction with the accompanying drawings.At first, by control module (computing machine or single-chip microcomputer) layout instrument working routine; The specimen tube that sample is housed is placed on the sample position of elementary sample process unit, start instrument then instrument by adding reagent (digestive juice) in the elementary sample tube that adds on 1 pair of elementary sample process dish 2 of reagent arm, magnetic stirring apparatus starts stirring, and elementary sample process heats up according to design temperature in the unit.After primary treatment finishes, sample transfer arm 13 is transferred to the sample handled in the elementary sample tube in the centrifuge tube on the centrifugal dish 3 that concentrates with centrifugal function one by one according to set amount, sample size equates in each centrifuge tube, and revolution moves a sample and moves the liquid arm and change a disposable tip mouth, or pin thoroughly cleans to avoid cross pollution on the sample arm to moving.The centrifugal then unit that concentrates is automatically centrifugal to be concentrated Much's bacillus to be precipitated at the bottom of the centrifuge tube, and after the centrifugal end, instrument removal waste fluid station dumps the supernatant in the centrifuge tube, whenever dumps a supernatant, moves certainly inside and outside a new suction nozzle or the cleaning removal waste fluid pin.After supernatant dumps, instrument carries out the microbe growth inoculation automatically, and (instrument is opened the nutrient culture media lid automatically, getting a new inoculation head by the automatic vaccination arm before the inoculation is inoculated into centrifugal sediment in the bacteria culture media, cover the nutrient culture media lid again, nutrient culture media is turned on each processing position by the cultivation basal disc and finishes said process).Instrument also can be carried out smear staining (smear to the centrifuge tube sample by the automatic smear unit, the oven dry fix, dye or heat dyeing and the decolouring, again the oven dry etc.), specifically can the slide that load be turned on each processing position by the smear dish and finish said process, instrument is whenever finished a sample smear, and just exchanging one for automatically newly is coated with head.Instrument also makes marks to each inoculated and cultured pipe and smear, so that trace to the source the sample source.Also can directly collect the centrifuge tube for preparing sample in addition, do the extraction of Much's bacillus gene DNA or other molecular biology, immunology detection according to checking needs.Instrument can also be disinfected (high temperature, ultraviolet ray) automatically to instrument internal after hours.

Claims

1. novel automatic processing instrument of respiratory tract sample, it is characterized in that: this instrument mainly is made up of primary sample processing unit and the centrifugal unit that concentrates.

2. a kind of novel automatic processing instrument of respiratory tract sample according to claim 1, it is characterized in that: be placed with stirrer in advance in the sample hose on the primary sample process disk of primary sample processing unit on the instrument, and position, counter sample position is provided with magnetic stirring apparatus under each sample position or sample segment position, and magnetic stirring apparatus makes the interior stirrer stirring of sample hose that sample is stirred when primary treatment fully and handles completely.

3. a kind of novel automatic processing instrument of respiratory tract sample according to claim 1 is characterized in that: be provided with the sample hose automatic lid closing/opening apparatus in its primary sample processing unit, and sample hose liquid level detector and add the reagent device automatically.

4. a kind of novel automatic processing instrument of respiratory tract sample according to claim 1, it is characterized in that: design has the sample cup position and the centrifuge tube position of equal amount respectively on the primary sample processing unit of instrument and the centrifugal unit that concentrates, around the primary sample process disk, centrifugal concentrate dish also design reagent position/add reagent station, removal waste fluid station, sample inoculation unit, be coated with blade unit is arranged.

5. a kind of novel automatic processing instrument of respiratory tract sample according to claim 1 is characterized in that: this instrument also is provided with bar code or electronic tag is made and the recognition functional entity, makes sample transmit, keep correct identification marking all the time in handling transmittance process.