CN201773519U - Myocardial bridge compression coronary artery simulation device for myocardial bridge in-vitro simulation experiment - Google Patents

Myocardial bridge compression coronary artery simulation device for myocardial bridge in-vitro simulation experiment Download PDF

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Publication number
CN201773519U
CN201773519U CN2010201603516U CN201020160351U CN201773519U CN 201773519 U CN201773519 U CN 201773519U CN 2010201603516 U CN2010201603516 U CN 2010201603516U CN 201020160351 U CN201020160351 U CN 201020160351U CN 201773519 U CN201773519 U CN 201773519U
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China
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myocardial bridge
myocardial
flow control
control chamber
dimensional flow
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Expired - Fee Related
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CN2010201603516U
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Chinese (zh)
Inventor
丁皓
尚昆
徐萌
赵灵犀
沈力行
李萌
陈齐欧
徐晶晶
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University of Shanghai for Science and Technology
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University of Shanghai for Science and Technology
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Abstract

The utility model relates to a myocardial bridge compression coronary artery simulation device for a myocardial bridge in-vitro simulation experiment. The simulation device comprises an air compressor, an air storage tank, a proportion pressure valve, a sealed three-dimensional flow control chamber and a driving motor, and is characterized in that: a tubular elastic cavity is formed in the middle of the sealed three-dimensional flow control chamber; a myocardial bridge compression block is arranged on two sides of the tubular elastic cavity respectively; and the two myocardial bridge compression blocks are respectively positioned on guide rails on two radial sides of the tubular elastic cavity and are connected with an output shaft of the driving motor which is fixed on a side panel. The simulation device can simulate different types of myocardial bridge compression coronary arteries in vitro, realizes control and adjustment of shearing stress, circumferential stress and normal stress, acquires parameters, and provides experimental means for researching pathogenesis of various vascular diseases caused by myocardial bridge in vitro.

Description

The myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment
Technical field
The utility model relates to a kind of device of myocardial bridge extracorporeal simulating experiment, especially a kind of myocardial bridge compressing coronary artery simulator.
Background technology
The cardiac muscle bundle that covers on the myocardial surface coronary artery is known as myocardial bridge.The coronary flow dynamic characteristic that the research myocardial bridge causes changes for the clinical meaning of estimating myocardial bridge very important.Hemodynamic shearing stress refers to the friction force of blood flow for the unit area vascular wall; Circumferential stress refers to along the stress of tube wall transversal section tangential direction; Normal stress is the wall pressure of blood flow for the unit area vascular wall.Bear the effect of shearing stress, circumferential stress and the normal stress of pulsatile blood flow generation simultaneously at body arteries endothelial cell, and can discern these mechanical forces, these signals are delivered to cell interior, cause changes such as cellular morphology, function and gene expression.
The research myocardial bridge exists some inevitable limitation for mechanism of action coronarius in clinical patient and zoopery, is difficult to guarantee as controllability, the repeatability of testing condition, and there is individual difference in the experiment body.Present parallel flat flow chamber system can only provide independent fluid shear stress environment, and strain chamber system then can only provide independent drawing stress environment.
Summary of the invention
The utility model is that a kind of myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment will be provided, for the tubulose elastic cavity of implanting endothelial cell provides near three-dimensional flow field and corresponding ambient stress (shearing stress, circumferential stress, normal stress) at body, and can apply the contention effect of myocardial bridge, according to experiment control myocardial bridge compressing wall hemodynamic parameter coronarius, inquire into the clinical manifestation of dissimilar myocardial bridges under different condition with system.
For achieving the above object, the technical solution of the utility model is: a kind of myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment, comprise air compressor, gas-holder, proportional pressure valve, airtight three-dimensional Flow Control chamber, drive motor, be characterized in: be provided with the tubulose elastic cavity in the middle of the airtight three-dimensional Flow Control chamber, tubulose elastic cavity both sides are separately installed with the myocardial bridge briquetting, and two myocardial bridge briquettings lay respectively at the tubulose elastic cavity radially on the guide rail of both sides, and are connected with drive motor output shaft on being fixed on side panel.
Airtight three-dimensional Flow Control chamber is a rectangular parallelepiped, the long 125mm of inwall, and wide 110mm, high 55mm, volume are 756250mm 3The gas-holder top is connected with pressure transducer; Airtight three-dimensional Flow Control chamber body is provided with case lid, and uses silicone rubber pad and nut fixed seal connection between case lid and the casing; Airtight three-dimensional Flow Control chamber body cover plate and base plate are the transparent panel that pmma material is made.
The beneficial effects of the utility model:
The utility model device can be realized:
1. regulate shearing stress by the flow of regulating liquid in the tubulose elastic cavity;
2. regulate circumferential stress by regulating tubulose elastic cavity inside and outside differential pressure;
3. regulate normal stress by the back loading of regulating the tubulose elastic cavity;
4. simulate dissimilar myocardial bridges by the mode of regulating myocardial bridge briquetting compressing tubulose elastic cavity;
5. the variation of hemodynamic parameter in the collection said process.
Therefore, can the be in-vitro simulated dissimilar myocardial bridges compressing of the utility model coronary arteries are realized the controllable of shearing stress, circumferential stress, normal stress, and acquisition parameter.The pathogenesis of the various vascular diseases that cause for the in vitro study myocardial bridge provides laboratory facilities.
Description of drawings
Fig. 1 is a structured flowchart of the present utility model;
Fig. 2 is the three-dimensional Flow Control chamber surface level structural representation of band drive motor;
Fig. 3 is the three-dimensional Flow Control chamber sagittal plane structural representation of band drive motor.
Embodiment
Below in conjunction with accompanying drawing and embodiment the utility model is further described.
As shown in Figure 1, the myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment of the present utility model comprises air compressor, gas-holder, proportional pressure valve, airtight three-dimensional Flow Control chamber 1, drive motor 4 etc.
As Fig. 2, shown in 3, be provided with tubulose elastic cavity 2 in the middle of the airtight three-dimensional Flow Control chamber 1, tubulose elastic cavity 2 both sides are separately installed with myocardial bridge briquetting 3, and two myocardial bridge briquettings 3 lay respectively at tubulose elastic cavity 2 radially on the guide rail of both sides, and are connected with drive motor 4 output shafts on being fixed on side panel 7.
Air compressor is inflated, gas is by the gas-holder voltage stabilizing, and gas-holder top placement force sensor is in order to measure a jar internal pressure, and gas stream is through proportional pressure valve, finally enter airtight three-dimensional Flow Control chamber 1 from through way valve 8, promptly simulate the wall coronary artery for the tubulose elastic cavity external pressure is provided.Drive motor 4 drives myocardial bridge briquetting 3 compressing tubulose elastic cavities 2.
The flow size of liquid can be regulated in the tubulose elastic cavity 2, and promptly the shearing stress size can be regulated; Change the back loading of tubulose elastic cavity 2, can regulate the normal stress size; Change tubulose elastic cavity 2 outer wall pressure, thereby regulate the circumferential stress that tubulose elastic cavity 2 is subjected to.Arrive 30kpa when pressure transducer records the gas-holder internal pressure, air compressor stops air feed; When three-dimensional Flow Control chamber 1 internal gas pressure less than predetermined value, the gas passing ratio pressure valve of gas-holder stored continues to its air feed; When three-dimensional Flow Control chamber 1 internal gas pressure greater than predetermined value, gas-holder stops air feed, the ratio pressure opening of valves discharges gases to realize decompression by through way valve 8.
The whole cavity of three-dimensional Flow Control chamber 1 is a rectangular parallelepiped, the long 125mm of inwall, and wide 110mm, high 55mm, volume are 756250mm 31 space, three-dimensional Flow Control chamber is much larger than tubulose elastic cavity 2 own vols.Liquid inflow and outflow end and tubulose elastic cavity 2 junctions coincide intact, can finish internal diameter 4~5mm, the blood vessel experiment of long 80mm.Cavity case lid 6, base plate 5 are all selected pmma material for use, are convenient to observe inner case in the experiment, and case lid 5 hold-down nut places seal with silicone rubber pad, prevent that gas from leaking.Myocardial bridge briquetting 3 is positioned at tubulose elastic cavity 2 radially on the guide rail of both sides, can change the different size briquetting according to the experiment needs.Drive motor 4 drives myocardial bridge briquetting 3 along the guide rail straight reciprocating motion by the default compressing degree of depth, realizes the compressing of simulation myocardial bridge to blood vessel, can apply bilateral or one-sided compressing.The frequency of exerting pressure of myocardial bridge is identical with the cardiac frequency of heart, and the compressing phase of the systole phase of heart and myocardial bridge keeps synchronously.
Gas flows into three-dimensional Flow Control chamber 1 through proportional pressure valve.Three-dimensional Flow Control chamber 1 internal pressure arrives 30kpa, and air compressor stops air feed, otherwise continues air feed.When three-dimensional Flow Control chamber 1 internal gas pressure greater than predetermined value, stop air feed, proportional pressure valve is driven valve and is discharged gas to realize decompression.

Claims (4)

1. a myocardial bridge that is used for the myocardial bridge extracorporeal simulating experiment is oppressed the coronary artery simulator, comprise air compressor, gas-holder, proportional pressure valve, airtight three-dimensional Flow Control chamber (1), drive motor (4), it is characterized in that: be provided with tubulose elastic cavity (2) in the middle of the described airtight three-dimensional Flow Control chamber (1), tubulose elastic cavity (2) both sides are separately installed with myocardial bridge briquetting (3), and two myocardial bridge briquettings (3) lay respectively at tubulose elastic cavity (2) radially on the guide rail of both sides, and are connected with drive motor (4) output shaft on being fixed on side panel (7).
2. the myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment according to claim 1, it is characterized in that: described airtight three-dimensional Flow Control chamber (1) is rectangular parallelepiped, the long 125mm of inwall, wide 110mm, high 55mm, volume are 756250mm 3
3. the myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment according to claim 1, it is characterized in that: described gas-holder top is connected with pressure transducer.
4. the myocardial bridge compressing coronary artery simulator that is used for the myocardial bridge extracorporeal simulating experiment according to claim 1 and 2, it is characterized in that: described airtight three-dimensional Flow Control chamber (1) cavity is provided with case lid, and uses silicone rubber pad and nut fixed seal connection between case lid and the casing; The transparent panel that airtight three-dimensional Flow Control chamber (1) cavity cover plate (6) and base plate (5) are made for pmma material.
CN2010201603516U 2010-04-15 2010-04-15 Myocardial bridge compression coronary artery simulation device for myocardial bridge in-vitro simulation experiment Expired - Fee Related CN201773519U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106591122A (en) * 2016-12-13 2017-04-26 上海理工大学 Simulation device for realizing continuous tensile stress and periodical compression of myocardial bridge through electronic cam
CN110211464A (en) * 2019-05-30 2019-09-06 上海健康医学院 A kind of in-vitro simulated system of mural coronary artery circumferential stress

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106591122A (en) * 2016-12-13 2017-04-26 上海理工大学 Simulation device for realizing continuous tensile stress and periodical compression of myocardial bridge through electronic cam
CN110211464A (en) * 2019-05-30 2019-09-06 上海健康医学院 A kind of in-vitro simulated system of mural coronary artery circumferential stress

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C17 Cessation of patent right
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Granted publication date: 20110323

Termination date: 20120415