CN201716315U - Detecting device with electronic timing device - Google Patents
Detecting device with electronic timing device Download PDFInfo
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- CN201716315U CN201716315U CN2010201847188U CN201020184718U CN201716315U CN 201716315 U CN201716315 U CN 201716315U CN 2010201847188 U CN2010201847188 U CN 2010201847188U CN 201020184718 U CN201020184718 U CN 201020184718U CN 201716315 U CN201716315 U CN 201716315U
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Abstract
The utility model provides a detecting device for detecting analyte in a liquid sample, comprising a non-water-absorbing carrier, an immune test paper strip with an end for contacting the liquid sample, and an electronic timing device; and the immune test paper strip is positioned on the non-water-absorbing carrier. The detecting device is characterized in that the electronic timing device comprises an electrode for contacting the liquid sample; the end of the immune test paper strip contacting the liquid sample and the electrode are set to be the position for contacting the liquid sample simultaneously, or the end of the immune test paper strip contacting the liquid sample is longer than the electrode.
Description
Technical field
The device of the utility model tracer liquid analyte in sample matter belongs to the checkout equipment that has electronic time unit especially.
Background technology
Traditional pick-up unit, particularly home-use when coming analyte in the specimen based on immunity principle, often need time keeping instrument of this preparation of operation to come the control time, when illustrating according to the operational manual of product can the read test result, and the test result that when reads is invalid.Usually in family oriented use operation, seem impracticable owing to prepare time keeping instrument separately.Proving installation provided by the invention do not need the operator provide separately calculagraph just can along than finish detection, simple to operate, and the result is accurate.
Summary of the invention
The utility model provides a kind of pick-up unit of tracer liquid analyte in sample, and this device comprises: non-water absorptivity carrier; The immunity test strip and the electronic time unit that have contact liq sample end, immunity test strip is positioned on the carrier, its spy is, electronic time unit comprises the electrode of contact liq sample, and it is longer than described electrode that the end of immunity test strip contact liq sample and described electrode are configured to the end of the position of contact liq sample simultaneously or immunity test strip contact liq sample.
In a preferred mode, the end of immunity test strip contact liq sample and described electrode horizontal alignment.
In another optional mode, electrode comprises two electrodes.Further, the electronic cue device comprises one when electrode and the time signal electronic component that sends time signal after fluid sample contacts.Time signal electronic component wherein can be a signal lamp, for example is light emitting diode.Light emitting diode can send the light of at least a color.
Selectable, carrier can be plastic carrier, has groove and carry described reagent strip on carrier.Reagent strip is the immunoreagent bar.
Optionally, comprise two immunity test strips on the carrier at least, described one of them electrode is positioned at the Far Left of carrier, and another carrier is positioned at the rightmost of carrier.The number of reagent strip is 1-15, or 1-10 or 1-8 or 2-8 or the like.
Selectable, pick-up unit can also comprise fluid sample collecting chamber and the test chamber that is communicated with the fluid sample collecting chamber, and wherein carrier is arranged in test chamber.Preferably, an end of contact liq sample is positioned at the bottom of test chamber on the electrode of contact liq sample and the test strips.Optionally, test chamber is transparent.
In another mode, the end of immunity test strip contact liq sample is longer than described electrode.The end of immunity test strip contact liq sample is in the position that shifts to an earlier date the contact liq sample than described electrode
Beneficial effect
Do not need extra time set by pick-up unit of the present invention, in addition, when an end of immunity test strip contact liq contacts with fluid sample, electronic time unit is waken up and begins the calculating of the time of carrying out immediately, the detection beginning of immunity test strip and electronic time unit carry out work simultaneously like this, not only,, allow the operator obtain result more accurately simultaneously for operation provides prompting function timely more accurately for the operator provides time control.
Description of drawings
Fig. 1 is the plan structure synoptic diagram of carrier and electronic cue device in examples of implementation of the utility model;
Fig. 2 is the planar structure synoptic diagram in the embodiment comprising of the utility model
Fig. 3 is the backsight structural representation of pick-up unit in embodiment of the utility model.
Fig. 4 is the perspective view of pick-up unit in embodiment of the utility model.
Fig. 5 is the right TV structure synoptic diagram of pick-up unit in another embodiment of the utility model.
Fig. 6 is the structural representation of testing element in embodiment of the utility model.
Description of reference numerals
Describe in detail
Structure or these employed technical terms to the fluid sample collection and detection device is described further below.
Detect
Detect the expression chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, detect the quantity of expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
Sample
The sample of the utility model indication refers to that those can be used for detecting, chemically examining or diagnose the material that whether has analyte of interest matter.Sample can be a fluid sample, and for example, fluid sample, fluid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise that solid sample and semi-solid sample are through anticipating the liquid solution that the back forms.The sample of collecting can be used for methods such as immune detection, chemical detection, enzyme detection and detect whether there is analyte.
Analyte
Can analyze any analyte with apparatus and method of the present utility model.Analyte can detect in any liquid or liquefied sample, urine for example, saliva, saliva, blood, blood plasma, perhaps serum.The example of the analyte of the enough apparatus and method stable detection of the present utility model of energy comprises (but not only comprising) human chorionic gonadotrophin (HCG), lutropin (LH), ovarian stimulation element (FSH), hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B surface antigen, the medicine of AIDS virus and any abuse.Analyte can also be some haptens materials, and these haptens comprise drugs (as drug abuse)." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Non-water absorptivity carrier
In another optional mode, on carrier, also comprise electronic time unit 20, the electrode of electronic time unit also is positioned at independent recessed Cao of another one on the carrier, and electrode also exposes, and with an end or the suction side 103 of the absorption fluid sample of test strips, horizontal alignment, the setting of position like this, when chemically examining fluid sample with pick-up unit, in the time of test strips contact liq sample, electrode is the contact liq sample also, and time set is waken up simultaneously, begin to calculate and detect the time that chemical examination need be read testing result on the test strips, the time of calculating can be 1 minute to 1 hour, 1-30 minute, 1-10 minute or 5-10 minute or the like.
Certainly, optionally, the electrode of test strips 102 and electronic time unit is positioned at same groove.Optionally, electronic time unit includes 202,203, two electrodes of two electrodes and also can lay respectively in two independently recessed Cao.Especially, when comprising a plurality of reagent strip on the carrier, reagent strip is arranged a row like this, and the pick-up unit that a plurality of reagent strips are installed on carrier is at United States Patent (USP) 7270959,7300633 like this, description is all arranged in 7560272.
Shown in Fig. 2-3, because carrier has certain width, when detecting, need be the liquid level 300 or 301 of the suction side of each reagent strip on carrier while contact liq sample, but usually owing to manually-operated reason, can not guarantee to allow contact liq sample of same time of each reagent strip, possible situation is a reagent strip B elder generation contact liq sample on one side, and contact liq sample or sometimes do not have the contact liq sample and do not carry out any detection (when collection cups is tilted) behind the another side A, but all be the testing result that in the identical time, together reads on each reagent strip when reading testing result, just may cause net result inaccurate at one time owing to the contact liq sample has priority to read testing result like this.Like this,, can lay respectively at two electrodes the both sides of carrier for convenient and testing result accurately, recessed Cao of rightmost that electrode 202 is positioned at the B place for example, another electrode 203 is positioned at leftmost recessed Cao.When in use, could start time set when having only fluid sample to contact the electrode of the right and left simultaneously, so just can carry out the prompting of time, otherwise not start, just can't finish reading of testing result.Like this be provided with one convenient can guarantee to detect normally carry out, can guarantee to allow all contact liq samples of each reagent strip on the other hand, normally finish detection.Certainly, electrode also can be in the same groove with reagent strip, and perhaps electrode is positioned at the back side of carrier, and reagent strip is positioned at the another side of carrier, aligns with reagent strip suction end 100 in the end 200 of electrode, and they can contact liquid sample between the while.
Except the electrode of time set can be positioned on the carrier, its other parts also can be positioned on the carrier, and other parts can be processors, and time signal electronic component and battery can allow whole time set be positioned on the carrier and one connects.When electrode is contacted by fluid sample, circuit turn-on, processor carries out calculation process and starts the clock, in the time of time that arrival sets in advance, the time signal element sends the signal indication time and arrives, and can begin/stop to read the testing result of test strips.Allow the fluid sample contact jaw while contact liq of electronic time unit and test strips also start simultaneously, when setting and traditional pick-up unit begin contact liq like this, need to begin separately in addition to compare with timer computing time together, do not need artificial other operation, but allow in test strips contact liq sample, to open automatically computing time.In some modes, when a plurality of recessed Cao is arranged on the carrier, in each recessed Cao, all place a reagent strip, this device is particularly suitable for those does not have kinsfolks of specialty operation background to use, and using method is simple.When the signal that far sends when the time signal electron is optical signal, can allow the signal electron element expose on the carrier, allow the operator perceive variation easily like this.
In some modes, the carrier that has test-strips and electronic time unit can individualism, can certainly constitute a new checkout equipment with other, for example can be installed in the test chamber.Such electronic time unit can be used with a plurality of gathering-devices, for example can be installed in picture United States Patent (USP) 7270959, on the test card 500 among Fig. 1 in 7300633, also can be installed on the card 100 in United States Patent (USP) 7560272 patents, whole then test card 100 is inserted in the test chamber 302 or is sealed and is stored in the test chamber.
Electronic time unit
In some concrete embodiments, electronic time unit can comprise and the fluid sample electrodes in contact, and processor, and the time signal electronic component that is connected with processor.These assemblies can connect by conductor or semiconductor, can make things convenient for the transmission of electronic signal between each assembly.In processor, can write the program software that writes and program circuit in advance and control processing and response each element signal.For example, when being used for whether containing analyte in the test sample, electrode on the time set contacts with fluid sample with test strips simultaneously, test strips contact liq sample also produces a test result in the regular hour scope, and the electrode on the time set contacts electronic signal of generation with fluid sample, this electronic signal allows processor accept and send another electronic signal, this another electronic signal can allow the time signal electronic component, for example signal lamp produces identification signal, it is expired whether for example light or sound, this light or auditory tone cues can begin to read time of the test result of immunity test strip or the test result that test strips is read in prompting.In a preferred mode, be at least 2 with the liquid electrodes in contact, for example electrode 202 and electrode 203 in the starting stage, apply a micro voltage between two electrodes; After two electrodes are by fluid communication, constituted current path, this current path is received the back by processor and produces an electronic signal, and this electronic signal allows the time signal element send identification signal, and expression can begin to read the test result on the surveyed area on the test strips.The time signal electronic component can pass through conductor, and for example electric wire is connected with processor; Electrode also can be connected with processor by conductor.
Program circuit is control signal and the program that is provided with.Program circuit can comprise and fluid sample electrodes in contact 200,201 that electrode is connected with processor by conductor wire, and the signal electron element also can be connected with controller by conductor wire.This program circuit is that existence is all arranged in the prior art, such as the utilization of electrify restoration circuit, and oscillatory circuit, the gimmick that wake-up circuit etc. are commonly used is not done unnecessary introduction here.
Time signal
The time signal electronic component can comprise and send the element that can be identified signal that signal can be a sound, light, perhaps other symbol that can be understood.Especially, identification signal can be understood easily by people institute or be acceptant, and the people can be child, adult etc.Luminous signal element can comprise light emitting diode; The element of sounding can be acoustical generator, for example loudspeaker etc.Identification signal can also be that other are various forms of, comprises change color, sound prompting, and light is reminded or the like, and the mode of generally selecting for use comparison to arouse attention is to reach the purpose of prompting.In the concrete embodiment, can be by sending specific sound, whether for example similar alarm clock sound is reminded the test result that when can begin to read on the test strips or is pointed out the test result that reads under special time effective or invalid.Preferably, can also realize,, also claim LED lamp such as selecting for use according to lumination of light emitting diode by the mode of selecting light to remind, light and shade change; Different conditions such as perhaps whether luminous, as to extinguish is pointed out different time phases.
Signal lamp is meant the parts that testing result can be showed intuitively.Signal lamp can send signal in reaction, also can send signal when testing result can read, and also can send signal when reaction result is invalid, can also send signal when the reaction failure.This depends on the needs of signal when detecting, and in a concrete embodiment, signal lamp is exported first signal when testing result can read, and is stopping exporting secondary signal when testing result reads.When testing result can read, send first signal, remind test result can obtain, and remind the detected person not miss the best time of reading.After in the effective time of reading above testing result, such as 1 minute, 3 minutes, 5 minutes, 10 minutes, 20 minutes, 30 minutes, 1 hour, even after the longer time, send secondary signal, illustrate that the result of this moment can not read, even perhaps read test result also is invalid test result, needs to detect again.Depend on that different pick-up units is to keeping the demand of testing result this effective time.In a concrete embodiment, can select for use light emitting diode (LED lamp) 201 as signal lamp, the LED lamp is bright in the time can beginning to read testing result once extinguishes then at once, the bright again one or many flicker of lamp is extinguished then when the testing result time for reading stops then, the test result that reads on the test strips in time period between twice bright lamp of light emitting diode is effective result, and all is invalid in the structure that the other times section reads.In another embodiment, can send section effective time that different colors comes the control detection result to read by LED lamp 201, for example the bright first kind of color showing of LED lamp can begin to read testing result; Such as, first signal is for giving a green light.After first kind of color continues for some time continuously, for example after 3-10 minute, when first kind of color becomes another kind of color, for example become redness or yellow the time from green, expression can not be read the testing result of test strips again, if the result who reads after this also is invalid result.
In other embodiments, the time signal element is at least two elements, and when very first time signal element sent first signal, prompting can begin the read test result; When the secondary signal element sent signal, expression can not be carried out reading of test result again.The alerting pattern of LED lamp 201 has multiple, can play effect regularly, and in actual applications, the LED lamp is more common, uses also more convenient.In a better embodiment, can also comprise a signal window that holds the LED lamp on the pick-up unit, so that the LED lamp can be exposed at the outside of pick-up unit, play tangible reminding effect.
Pick-up unit
Pick-up unit comprises can be used for the reagent strip 102 whether test sample contains analyte.Reagent strip can be with by sample region of acceptance 103 and surveyed area 109.Further, reagent strip can also comprise marked region 111 and control area 110.Fluid sample flows to surveyed area 109 from sample region of acceptance 103.In a concrete mode, sample region of acceptance 103 exposes on the carrier, and end 100 alignment of the end 200 of electrode and sample region of acceptance 103 simultaneously can allow fluid sample contact electrode and sample region of acceptance simultaneously like this.
The immunoreagent bar
The immunoassay bar can be selected the test strip of cross flow for use, and it can detect multiple analyte.Certainly, other suitable testing elements also can be used in the utility model.Various immunoassay bars can be combined in together and apply in the utility model.A kind of form is to detect test paper.The detection test paper that is used for the analyte (as drugs or show the metabolin of health) of analytic sample can be a various forms, as immunoassays or chemico-analytic form.Detect the analytical model that test paper can adopt non-competing method or competition law.Detect test paper and comprise absorbent material, reagent area and the test section with sample pipetting volume district.Add sample to the sample pipetting volume district, flow to reagent area by capillarity.At reagent area, if there is analyte, sample combines with reagent.Sample continues to flow to detection zone then.Other reagent are fixed on detection zone as the molecule that combines with analyte specially property.Analyte in these reagent and the sample (if existence) reacts and analyte is combined in this district, perhaps combines with the some reagent of reagent area.The label existence that is used to show detection signal and reagent area or the mark zone that separates.Typical non-competing method analytical model is that signal will produce if contain analyte in the sample, if do not comprise analyte, does not just produce signal.In competition law, if analyte is not present in the sample, signal produces, if there is analyte, does not then produce signal.
Test-strips is to detect test paper, the material that can select suction for use or not absorb water.Detect test paper and can comprise that multiple material is used for the fluid sample transmission.Wherein a kind of material that detects test paper can cover on the another kind of material, covers on the nitrocellulose filter as filter paper.A district detecting test paper can select one or more materials for use, and another district selects other one or more different materials for use.The detection test paper can be attached on certain holder or hard surface is used to improve the intensity of being affectedly bashful the detection test paper.
Analyte is detected by signal generating system, as utilization one or more enzymes with this analysis thing generation specific reaction, utilize and as described above specific combinating substance is fixed on the method that detects on the test paper, the composition of one or more signal generating systems is fixed on the analyte detection zone of detection test paper.The material that produces signal can be in sample application zone, reagent area, or detection zone, or on the whole detection test paper, this material can be full of on one or more materials that detect test paper.The solution that will contain the signal thing is added to the surface of test paper or one or more materials of test paper is immersed in the solution that contains the signal thing.Make and add the test paper drying that contains signal thing solution.
Each district of detecting test paper can arrange in the following manner: sample application zone, and reagent area, detection zone, the control zone determines whether sample mingles the district, the fluid sample uptake zone.The control zone is positioned at after the detection zone.All districts only can be arranged on the test paper with a kind of material.Also but different materials is not adopted in the same district.Each district can directly contact with fluid sample, or different districts arranges according to the direction that fluid sample flows, and the end in Jiang Ge district links to each other with the front end in another district and overlaps.Used material can be water absorptivity material such as a filter paper preferably, glass or nitrocellulose filter etc.Detect test paper and also can adopt other forms.
Below in conjunction with concrete accompanying drawing examples of implementation of the present utility model are described in detail.These specific embodiment only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
Embodiment 1: shown in Fig. 1-6, pick-up unit comprises a carrier 105, comprises 6 recessed Cao 101 on carrier, and a reagent strip 102 is installed in each recessed Cao, allows the end of contact liq sample of reagent strip is from outside to go out carrier, as shown in Figure 2.Electronic time unit 20 is positioned on the carrier, comprise two electrodes 202 and 203, they are connected with some other electronic component with processor on being positioned at pcb board 209 by lead, also be connected with a light emitting diode 201 on pcb board, wherein two electrodes are positioned on two adjacent reagent strips, keep aliging with an end 100 of contact liq sample simultaneously, on carrier, also comprise simultaneously battery 204, pcb board is by the nail on the carrier 106,107 in addition, and 108 are fixed on the carrier.When use detects, allow fluid sample contact the suction side of reagent strip, fluid sample while in this time two electrodes 202 of conducting and 203, starting electronic installation starts the clock, by the time 5 minutes the time, light emitting diode sends blue light, expression can begin to read the testing result on the surveyed area 109, when having waited until 10 minutes then, light emitting diode sends ruddiness and represents that the testing result that begins to read from this moment is invalid.Certainly in this example, light emitting diode can be two and send the diode of not sharing the same light respectively, also can be that same diode sends different light in different.
Embodiment 2: the difference of present embodiment and embodiment 1 is that in two electrodes, an electrode 202 is positioned at leftmost reagent strip place (B), and another electrode 203 is positioned at the rightmost reagent strip place (A) of carrier.
Embodiment 3: as shown in Figure 5, the difference of present embodiment and embodiment 1 is, the length of two electrodes is smaller than the end 100 of reagent strip contact liq sample, can guarantee to allow liquid have certain height liquid level 303 to contact the end of reagent strip like this, the only just calculating of 202 start-up times of conduction electrode after the certain liq height floods the end 103 of reagent strip simultaneously can guarantee that so sufficient fluid sample participates in reaction and avoids because the liquid risk of moistening reagent strip very little and not.
Claims (13)
1. the pick-up unit of a tracer liquid analyte in sample is characterized in that, this device comprises: non-water absorptivity carrier; The immunity test strip and the electronic time unit that have contact liq sample end, immunity test strip is positioned on the carrier, electronic time unit comprises the electrode of contact liq sample, its spy is, it is longer than described electrode that the end of immunity test strip contact liq sample and described electrode are configured to the end of the position of contact liq sample simultaneously or immunity test strip contact liq sample.
2. device according to claim 1 is characterized in that, the end of immunity test strip contact liq sample and described electrode horizontal alignment.
3. device according to claim 2 is characterized in that, described electrode comprises two electrodes.
4. device according to claim 3 is characterized in that, the electronic cue device comprises one when electrode and the time signal electronic component that sends time signal after fluid sample contacts.
5. device according to claim 4 is characterized in that, described time signal electronic component is a signal lamp.
6. device according to claim 5 is characterized in that, described signal lamp is a light emitting diode.
7. device according to claim 5 is characterized in that described light emitting diode sends the light of at least a color.
8. device according to claim 1 is characterized in that carrier is a plastic carrier, has groove and carry described reagent strip on carrier.
9. device according to claim 3 is characterized in that, comprises two immunity test strips on the carrier at least, and described one of them electrode is positioned at the Far Left of carrier, and another carrier is positioned at the rightmost of carrier.
10. device according to claim 1 is characterized in that, this device also comprises fluid sample collecting chamber and the test chamber that is communicated with the fluid sample collecting chamber, and wherein carrier is arranged in test chamber.
11. device according to claim 10 is characterized in that, an end of contact liq sample is positioned at the bottom of test chamber on the electrode of contact liq sample and the test strips.
12. device according to claim 10 is characterized in that, described test chamber is transparent.
13. device according to claim 1 is characterized in that, the end of immunity test strip contact liq sample is in the position that shifts to an earlier date the contact liq sample than described electrode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201847188U CN201716315U (en) | 2010-05-10 | 2010-05-10 | Detecting device with electronic timing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201847188U CN201716315U (en) | 2010-05-10 | 2010-05-10 | Detecting device with electronic timing device |
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|---|---|
| CN201716315U true CN201716315U (en) | 2011-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010201847188U Expired - Lifetime CN201716315U (en) | 2010-05-10 | 2010-05-10 | Detecting device with electronic timing device |
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| CN (1) | CN201716315U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109658794A (en) * | 2019-01-27 | 2019-04-19 | 重庆大学 | For automatically determining the experiment device for teaching in double reaction reagent system reaction time |
-
2010
- 2010-05-10 CN CN2010201847188U patent/CN201716315U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109658794A (en) * | 2019-01-27 | 2019-04-19 | 重庆大学 | For automatically determining the experiment device for teaching in double reaction reagent system reaction time |
| CN109658794B (en) * | 2019-01-27 | 2021-03-02 | 重庆大学 | Teaching experiment device for automatically measuring reaction time of double-reaction reagent system |
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