CN201561961U - Sharing device for automatic sample injection and sample division collection - Google Patents
Sharing device for automatic sample injection and sample division collection Download PDFInfo
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- CN201561961U CN201561961U CN2009201785649U CN200920178564U CN201561961U CN 201561961 U CN201561961 U CN 201561961U CN 2009201785649 U CN2009201785649 U CN 2009201785649U CN 200920178564 U CN200920178564 U CN 200920178564U CN 201561961 U CN201561961 U CN 201561961U
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Abstract
The utility model discloses a sharing device for automatic sample injection and sample division collection, which comprises a machine seat, a probe, a loop system and a switching valve bank, wherein the machine seat bears a plurality of sample containers and a plurality of collecting containers; the probe slides on the machine seat; the loop system is communicated with the probe and any one sample container; and the switching valve bank is arranged in the loop system and is used for controlling the sample containers to form break circuit and a path with the probe, so that the probe is used for absorbing samples in the sample containers and injecting separated sample components into corresponding collecting containers. Consequently, the utility model achieves the aim that the same probe has different service functions, thereby not only simplifying assemblies, but also reducing the equipment cost and the integral volume.
Description
Technical field
The utility model relates to a kind of composite device, particularly relates to a kind of auto injection and the composite device that divides sample to collect that is used for the liquid chromatography (LC) separation detecting system.
Background technology
High performance liquid chroma-tography technology (High Performance Liquid Chromatography, HPLC) be most widely used a kind of chromatography in the analytical technology, mainly be applicable to all kinds of sample analysis such as chemistry, chemical industry, pharmaceutical test, agriculturalization, environmental test, biochemistry, food and drink.
Consult Fig. 1, with general liquid chromatography (LC) separation detecting system (HPLC) 1 is example, a pen recorder 17 that consist predominantly of the feeding unit 11 that is interconnected, one first probe 12, pump 13, pumping 14, chromatography pipe 15, analyzer 16, is electrically connected with this analyzer 16, and one collected unit 18.This feeding unit 11 is used to supply solvent or sample.The suction function that this first probe 12 is produced by this pump 13 extracts solvent or sample.This pumping 14 is used for producing the pressurization effect, makes the infiltration of solvent and sample by this chromatography pipe 15 and this analyzer 16.This chromatography pipe 15 is used for the composition of separating sample.This analyzer 16 is used for the analyzing samples composition.This pen recorder 17 is used for record and presents analysis result.This collection unit 18 has several collection containers 181 that are used to collect the sample composition, and is communicated with and the sample composition is injected to one second probe 182 of this collection container 181 with this analyzer 16.
Whereby, only needing with moving phase (mobile phase) is that solvent drives sample by being equipped with the chromatography pipe 15 of quiet phase (stationary phase), just can utilize compositions different in the sample to flowing through the quiet different affinity that has mutually, reach the effect of separation, then, further analyze isolated composition, just can obtain required sample information with this analyzer 16, at last, more different sample compositions is stored in different collection containers 181.
Only, because this liquid chromatography (LC) separation detecting system (HPLC) 1 has a plurality of collection containers 181, and sample is with in solvent normally is contained in different containers, therefore, for carrying out sample introduction with full-automatic operation for the liquid chromatography (LC) separation detecting system (HPLC) 1 that divides sample to collect, in order to make this first probe 12, this second probe 182 can be moved to preposition, reach the extraction solvent, sample, or the sample composition is injected to the purpose of this collection container 181, this liquid chromatography (LC) separation detecting system (HPLC) 1 must be provided with two groups of rail systems and drive system at least, whole assembly and manufacturing cost have not only significantly been promoted, and whole huge, quite do not meet economic benefit.
The utility model content
The purpose of this utility model be provide a kind of can simplified assembly, reduce cost and reduce the auto injection and the composite device that divides sample to collect of overall volume.
Auto injection of the present utility model and the composite device that divides sample to collect comprise a support, a probe, a circuit system, and a transfer valve group.This support mounting has at least several sampling receptacles of sampling receptacle and several collect container, and this sampling receptacle has been installed in sample, and this collection container is used to collect the composition after the sample separation.This probe slides against this support, and relatively this sampling receptacle and aforementioned collection container one of them.This circuit system is communicated with this probe and arbitrary sampling receptacle.This transfer valve group is arranged on this circuit system, and controls this sampling receptacle and this probe and form and open circuit and path, makes probe be used to draw sample in this sampling receptacle, and is used for the sample composition after separating is injected into corresponding collection container.
The beneficial effects of the utility model are to utilize this transfer valve group that this probe and this analyzer are formed to open circuit or path, make the program of drawing sample or injecting sample composition can shared same probe, reach simplified assembly, and reduce the purpose of equipment cost and overall volume.
Description of drawings
Fig. 1 is a synoptic diagram, and general auto injection and the composite device (HPLC) that divides sample to collect are described;
Fig. 2 is a stereographic map, and a preferred embodiment of the composite device that the utility model one auto injection and branch sample are collected is described;
Fig. 3 is the synoptic diagram that this preferred embodiment switches to a sampling loop;
Fig. 4 is the synoptic diagram that this preferred embodiment switches to a sample introduction loop;
Fig. 5 is the synoptic diagram that this preferred embodiment switches to an injection loop;
Fig. 6 is the synoptic diagram that intermixture is extracted in this preferred embodiment; And
Fig. 7 is that this preferred embodiment switches to the synoptic diagram that a branch sample is collected the loop.
Embodiment
Below in conjunction with drawings and Examples the utility model is elaborated:
Consult Fig. 2, Fig. 3, the utility model auto injection is mounted in a liquid chromatography (LC) separation detecting system 5 with composite device one preferred embodiment that divides sample to collect, this liquid chromatography (LC) separation detecting system 5 has a chromatography pipe 51 being filled with quiet phase (stationary phase, solid material or matrix) and being used for the separating sample composition, be used for a light analyzer 52 (ultraviolet light or visible light) of analyzing samples composition and be used for a mass spectrometer 53 of liquid-phase chromatographic analysis.This composite device comprises a support 2, probe 3, carrier element 4, a transfer valve group 6, and a circuit system 7.
This support 2 has for a support body 21 of this probe 3 suspentions, is arranged on a platform 22 in this support body 21, and mounts a power packages 23 at this support body 21.This power packages 23 is used to drive these probe 3 relative these platforms 22 along an X-direction, a Y direction, and a Z-direction displacement.
This carrier element 4 has several sampling receptacles of sampling receptacle 41, solvent container 42, intermixture container 43, pump 44, a cross-over valve 45, and several collect containers 46.This sampling receptacle 41 is arranged on this support 2 platforms 22, and has been installed in sample.This solvent container 42 is arranged on this support 2 and has been installed in solvent (mobile phase).This intermixture container 43 is arranged on this support 2 and has been installed in intermixture (salt class).This pump 44 is a syringe in this preferred embodiment.This cross-over valve 45 has several connectors 451, and can change and aforementioned connector 451 one of them translation interface 452 that are communicated with.Wherein three connectors 451 are connected with this sampling receptacle 41, this solvent container 42, this intermixture container 43 respectively.This translation interface 452 is connected with this pump 44.This collection container 46 is arranged on this support 2 platforms, and is used to collect the composition after the sample separation.
This transfer valve group 6 has a pressurizer 60, first transfer valve 61, and one second transfer valve 62.This pressurizer 60 is a pumping in this preferred embodiment.One the 3rd interface that this first transfer valve 61 has one first interface 611, one second interface 612 that is communicated with this pressurizer 60 that are communicated with this chromatography pipe 51, be communicated with this probe 3 613, the 4th interface 614, and one the 5th interface 615 and one the 6th interface 616 of being interconnected.This second transfer valve 62 has one first interface 621, one second interface 622 that is communicated with this first transfer valve 61 the 4th interface 614, one the 3rd interface 623 that is communicated with these cross-over valve 45 another connectors 451, one the 4th interface 624 that is communicated with this probe 3 that is communicated with this light analyzer 52, one the 5th interface 625 that is communicated with this mass spectrometer 53, and one the 6th interface 626 of formation closed state.
This circuit system 7 is communicated with this probe 3, this first transfer valve 61, this chromatography pipe 51, this light analyzer 52, this second transfer valve 62 and this cross-over valve 45.
When the 3rd interface 613, the 4th interface 614 of this first transfer valve 61 is communicated with the 5th interface 615, the 6th interface 616 of primary importance, and when first interface 621 of this second transfer valve 62 is blocked with second interface 622 of this primary importance, second interface 622 of this second transfer valve 62 is to be communicated with the 3rd interface 623 of primary importance, and sees through connector 451, sampling loop 71 of translation interface 452 and these pump 44 common construction formation of this cross-over valve 45.
Consult Fig. 4, when first interface 621 of this second transfer valve 62 is blocked with second interface 622 of this primary importance, first interface 611 of this first transfer valve 61, second interface 612 can be communicated with the 5th interface 615, the 6th interface 616 of primary importance, and see through first interface 621, the 5th interface 625 and this sample introduction loop 72 of mass spectrometer 53 common construction formation of this chromatography pipe 51, this light analyzer 52 and this second transfer valve 62.
Consult Fig. 5, when first interface 621 of this second transfer valve 62 is blocked with second interface 622 of this primary importance, the 3rd interface 613 of this first transfer valve 61, the 4th interface 614 can be blocked with the 5th interface 615, the 6th interface 616 of the second place, and be communicated with second interface 622, the 3rd interface 623 of this second transfer valve 62, and form an injection loop 73 with this pump 44 common construction through connector 451, the translation interface 452 of this cross-over valve 45.
Consult Fig. 7, when first interface 611 of this first transfer valve 61 is communicated with the 5th interface 615, the 6th interface 616 of the second place with this second interface 612, and first interface 621 of this second transfer valve 62 is blocked with the 5th interface 624 of the second place, first interface 621 of this second transfer valve 62, the 4th interface 624 are communicated with the second place second interface 622, the 3rd interface 623 respectively, and see through connector 451, a branch sample collection of translation interface 452 and these pump 44 common construction formation loop 74 of this cross-over valve 45.
Consult Fig. 2, Fig. 3, below promptly illustrate in conjunction with the embodiments as the back at the program of sampling of the present utility model, cleaning, collection sample composition:
When this circuit system 7 switches this sampling loop 71 of formation, the power packages 23 of this support 2 can drive this probe 3 and follow this support body 21 to be moved in this sampling receptacle 41, at this moment, first interface 621 of this second transfer valve 62 is to block with second interface 622 of primary importance, make this probe 3 and this chromatography pipe 51, this light analyzer 52, this mass spectrometer 63 form and open circuit, whereby, be subjected to the suction function of these pump 44 generations when this sampling loop 71, form pressure reduction with this sampling receptacle 41, just can utilize this probe 3 to extract quantitative sample and be filled in this sampling loop 71.
Consult Fig. 4, when this circuit system 7 switched this sample introduction loop 72 of formation, the solvent in this sample introduction loop 72 and samples can be because this chromatography pipe 51 be injected in the high pressure effect that this pressurizer 60 produces.Because the different composition of sample is different with the dissolution degree of solvent, and have different affinity mutually, therefore, permeate this chromatography pipe 51 and by in the process of stationary phase at sample with quiet, can be because of the speed difference of passing through, and reach the purpose of separation.Whereby, the composition that utilizes light analyzer 52 analyzing samples to separate, the composition classification that judgement sample comprised is carried out stratographic analysis with this mass spectrometer 53 again, sees through a pen recorder (figure does not show) at last and writes down and present analysis result.Simultaneously, this pump 44 can see through this cross-over valve 45 and be communicated with this solvent container 42, extracts the solvent in this solvent container 42.
Consult Fig. 5, when this circuit system 7 switched this injection loop 73 of formation, this pump 44 can inject this injection loop 73 with solvent, was discharged by this probe 3 then, at this moment, was full of clean solvent in this injection loop 73, whereby, reached the purpose of this probe 3 of cleaning.
Consult Fig. 6, then, this pump 44 can see through this cross-over valve 45 and be communicated with this intermixture container 43, extracts the intermixture in this intermixture container 43.
Consult Fig. 2, Fig. 7, when this circuit system 7 switches formation this minute sample collection loop 74, the power packages 23 of this support 2 can drive this probe 3 in regular turn and follow this support body 21 to be moved to the top that one of them collects container 46, at this moment, sample by this light analyzer 52 becomes branch to follow this minute sample to collect loop 74 and flow towards this probe 3 in regular turn, simultaneously, this pump 44 can inject intermixture this minute sample and collect loop 74, then in this probe 3 with after this sample mixes, be injected in regular turn in this collection container 46, reach the purpose of collecting the sample heterogeneity.
According to the above as can be known, auto injection of the present utility model has following advantages and effect with the composite device that divides sample to collect:
The utility model is under the situation of full-automatic operation, make this probe 3 with sample drawn, and the injecting sample composition is collected the double effects of container 46 to this, whereby, the utility model only need arrange probe 3 of a support 2 carryings, not only can simplified assembly, reduce equipment cost, and can significantly reduce whole volume, effectively promote economic benefit.
Claims (12)
1. auto injection and the composite device that divides sample to collect are installed in a liquid chromatography (LC) separation detecting system, it is characterized in that this composite device comprises:
A support, mounting have several sampling receptacles and several to collect container, and this sampling receptacle has been installed in sample, and this collection container is used to collect the composition after the sample separation;
A probe slides against this support, and relatively this sampling receptacle and aforementioned collection container one of them;
A circuit system is communicated with this probe and arbitrary sampling receptacle; And
A transfer valve group is arranged on this circuit system, and controls this sampling receptacle and this probe and form and open circuit and path, makes probe be used to draw sample in this sampling receptacle, and is used for the sample composition after separating is injected into corresponding collection container.
2. auto injection as claimed in claim 1 and the composite device that divides sample to collect, it is characterized in that, this support has a support body, and mount at this support body and be used to drive this probe, aforementioned sample container, aforementioned collection container one of them along an X-direction, a Y direction, an and power packages of a Z-direction displacement.
3. auto injection as claimed in claim 1 and the composite device that divides sample to collect, it is characterized in that, this composite device also includes a pump, this circuit system has a sampling loop that is communicated with this sampling receptacle and this pump, the suction function that this sampling loop is produced by this pump, form pressure reduction with this sampling receptacle, sample is filled in this sampling loop.
4. auto injection as claimed in claim 3 and the composite device that divides sample to collect, it is characterized in that, this composite device also includes a carrier element, this carrier element has this sampling receptacle, be installed in a solvent container of solvent, be installed in an intermixture container of intermixture, and cross-over valve, this cross-over valve has several connectors, and can change one of them translation interface that is communicated with aforementioned connector, wherein three connectors are connected with this sampling receptacle, this solvent container, this intermixture container respectively, and this translation interface and this pump are connected.
5. auto injection as claimed in claim 3 and the composite device that divides sample to collect, it is characterized in that, this transfer valve group has one first transfer valve, and pressurizer, this first transfer valve has one first interface, one second interface that is communicated with this pressurizer that are communicated with this chromatography pipe, is communicated with one the 3rd interface of this probe, one the 4th interface that is used for being communicated with this pump, and one the 5th interface and one the 6th interface of being interconnected.
6. auto injection as claimed in claim 3 and the composite device that divides sample to collect, it is characterized in that, the 3rd interface of this first transfer valve, the 4th interface are used for being communicated with the 5th interface, the 6th interface, this pump, and common formation compiles solvent and sample this sampling loop to this first transfer valve.
7. auto injection as claimed in claim 3 and the composite device that divides sample to collect, it is characterized in that, first interface of this first transfer valve, second interface are used for being communicated with the 5th interface, the 6th interface, form the sample introduction loop of supply sample to this liquid chromatography (LC) separation detecting system.
8. auto injection as claimed in claim 5 and the composite device that divides sample to collect, it is characterized in that, this transfer valve group also has one second transfer valve, this second transfer valve has one first interface, one second interface that is communicated with this first transfer valve the 4th interface that is communicated with this analyzer, one the 3rd interface that is communicated with this another connector of cross-over valve, and is communicated with one the 4th interface of this probe.
9. auto injection as claimed in claim 8 and the composite device that divides sample to collect, it is characterized in that, first interface of this second transfer valve is used for and this second interface blocking-up, and be communicated with first interface, this second interface, this liquid chromatography (LC) separation detecting system of this first transfer valve, form this sample introduction loop jointly.
10. auto injection as claimed in claim 8 and the composite device that divides sample to collect, it is characterized in that, the 3rd interface of this first transfer valve, the 4th interface can be blocked with the 5th interface, the 6th interface, and be communicated with second interface, the 3rd interface, this pump of this second transfer valve, form an injection loop jointly.
11. auto injection as claimed in claim 8 and the composite device that divides sample to collect, it is characterized in that, first interface of this second transfer valve, the 4th interface are used for being communicated with the 3rd interface, the 4th interface of this second interface, the 3rd interface, this first transfer valve respectively, and common construction forms a branch sample and collects the loop.
12. auto injection as claimed in claim 8 and the composite device that divides sample to collect, it is characterized in that, this second transfer valve also has one the 5th interface that is communicated with this liquid chromatography (LC) separation detecting system, when the 5th interface of this second transfer valve is used for forming path with first interface and opening circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201785649U CN201561961U (en) | 2009-10-16 | 2009-10-16 | Sharing device for automatic sample injection and sample division collection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201785649U CN201561961U (en) | 2009-10-16 | 2009-10-16 | Sharing device for automatic sample injection and sample division collection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201561961U true CN201561961U (en) | 2010-08-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201785649U Expired - Fee Related CN201561961U (en) | 2009-10-16 | 2009-10-16 | Sharing device for automatic sample injection and sample division collection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201561961U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106461629A (en) * | 2014-05-14 | 2017-02-22 | 通用电气健康护理生物科学股份公司 | Chromatography lab system |
| CN112472084A (en) * | 2020-11-30 | 2021-03-12 | 重庆医科大学附属第一医院 | Sterile blood sampling facility based on organ transplantation early detection |
-
2009
- 2009-10-16 CN CN2009201785649U patent/CN201561961U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106461629A (en) * | 2014-05-14 | 2017-02-22 | 通用电气健康护理生物科学股份公司 | Chromatography lab system |
| US10113996B2 (en) | 2014-05-14 | 2018-10-30 | Ge Healthcare Bio-Sciences Ab | Chromatography lab system for analyzing samples including a cooling compartment with an identifying device that identifies a fraction collector device |
| US10598638B2 (en) | 2014-05-14 | 2020-03-24 | Ge Healthcare Bio-Sciences Ab | Chromatography lab system including cooling compartment and identifying device |
| CN112472084A (en) * | 2020-11-30 | 2021-03-12 | 重庆医科大学附属第一医院 | Sterile blood sampling facility based on organ transplantation early detection |
| CN112472084B (en) * | 2020-11-30 | 2022-07-19 | 重庆医科大学附属第一医院 | Sterile blood sampling facility based on organ transplantation early detection |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100825 Termination date: 20111016 |