CN201548033U - Effectiveness-aiding device and vacuum freeze drier with the same - Google Patents
Effectiveness-aiding device and vacuum freeze drier with the same Download PDFInfo
- Publication number
- CN201548033U CN201548033U CN2009202628541U CN200920262854U CN201548033U CN 201548033 U CN201548033 U CN 201548033U CN 2009202628541 U CN2009202628541 U CN 2009202628541U CN 200920262854 U CN200920262854 U CN 200920262854U CN 201548033 U CN201548033 U CN 201548033U
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- freeze
- effect aid
- drying dish
- aid
- vacuum dryer
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Abstract
The utility model discloses an effectiveness-aiding device and a vacuum freeze drier with the same. The effectiveness-aiding device is arranged in a freeze-drying tray, and an effectiveness aiding device is in a spatial grid shape, and the spatial grid comprises a planar grid and upright posts vertical to the planar grid. The effectiveness aiding device in the vacuum freeze drier can be overlapped with one layer and two layers or multiple layers; the height of the post is 1 to 40mm, and the height of the post is the same as that of the vacuum freeze drier or lower than that of the vacuum freeze drier by 1 to 30mm or higher than that of the vacuum freeze drier by 1 to 30mm. The utility model utilizes the effectiveness aiding device, greatly optimizes the freeze-drying process, makes the freeze-drying process more easy and controllable, shortens the freeze-drying period by 30 percent to 80 percent, reduces the energy consumption by 30 percent to 80 percent and increases the production efficiency by 100 percent to 150 percent.
Description
Technical field
The utility model belongs to biological medicine, industrial chemicals and food deep processing field, particularly a kind of effect aid and have the frozen vacuum dryer of effect aid.
Background technology
Vacuum freezedrying is applied to the refining deep processing aspect of biologics, medicinal chemicals and preparation thereof, traditional Chinese medicine and inflight meal at present, and this method does not change the machined article primary characteristic is converted into civilian science and technology gradually by high-end science and technology universal process because of it can keep the height biologically active.Can vacuum freezedrying be produced and successful key factor be whether the vacuum freezedrying article have the crystal framework of enough loose pore, but in fact machined article can rely on the crystal framework of self to cause the few of pore in the Nature and the industrial production, so in the industrialization vacuum freezedrying is produced, generally add various pore-foaming agents, excipient, as chemical pore excipient, as sweet mellow wine, sorbierite; Plant pore excipient such as sucrose; Biological pore excipient is as albumin, gelatin etc.And existing vacuum freezedrying method is confined to factor affecting such as machined article self crystal structure and excipient characteristic and fails to bring into play due potential, thus can not better service in human material progress, social civilization.
The utility model content
In order to solve above-mentioned the deficiencies in the prior art part, primary and foremost purpose of the present utility model is to provide a kind of effect aid; The use of this effect aid can overcome existing Lyophilisation technique for making and be confined to machined article self crystal structure and excipient properties influence, reach and make the direct lyophilization of machined article, and then increase substantially efficient, and shorten the machined article cycle, reduce the purpose of energy consumption.
Another purpose of the present utility model is to provide a kind of frozen vacuum dryer that has above-mentioned effect aid.
The purpose of this utility model is achieved through the following technical solutions: a kind of effect aid, described effect aid are positioned in the freeze-drying dish in the frozen vacuum dryer, and effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column vertical with plane grid.
Described freeze-drying dish is circle, ellipse, rectangle, trapezoidal or triangle, and the shape of effect aid and freeze-drying dish is complementary, and column is arranged at the lines joining place in the plane grid.
Described effect aid is welded to each other or casts formation mechanical type effect aid by metal tube.
Described effect aid is welded to each other or is cast by metal tube and forms, and is embedded with the semiconductor or the wire that are used for heating and refrigerating in the metal tube, and semiconductor or wire external power supply control system form the electronic type effect aid.
A kind of frozen vacuum dryer that has above-mentioned effect aid, effect aid in the described freeze-drying dish is one deck, two-layer stack or multilayer stacks, the height of column is 1～40mm, and column and freeze-drying dish are equal height or than the low 1～30mm of freeze-drying dish or than the high 1～30mm of freeze-drying dish.
Principle of the present utility model: when using the frozen vacuum dryer that has effect aid that machined article is carried out vacuum freezedrying, the effect aid that installs additional helps cold effect conduction when the machined article sharp freezing, thereby accelerate the machined article freezing speed, shorten freeze-off time; Same principle, when the machined article lyophilization, effect aid has served as the heat conduction of machined article again, thus the lyophilization speed and the lyophilization time of having accelerated machined article; In addition, effect aid efficiently solves or lacks between machined article molecule and the molecule when greatly having improved machined article from solution shape or the aqueous glaciation shape of suspendible solid the present situation of loose pore.
The relative prior art of the utility model, have following advantage and beneficial effect: adopt the frozen vacuum dryer that has effect aid to carry out vacuum freezedrying, the situation that lacks loose pore in the time of improving machined article from solution shape or the aqueous glaciation shape of suspendible solid between machined article molecule and the molecule overcomes and avoids even stop to add chemistry, plant, biological pore excipient class material; The utility model utilizes effect aid to be the basis, optimizes freeze-dry process energetically, makes freeze-dry process more simple and easy controlled, and lyophilization cycle shortens 30% to 80%.Energy consumption reduces by 30% to 80%; Production efficiency increases by 100% to 150%; Perhaps along with the disclosing of this utility model, can cause the fundamental change of freeze-drying methods such as high-end food, health protection product, industrial chemicals, pharmaceutical raw material, its social effect and economic worth are conspicuous.
Description of drawings
Fig. 1 is the structural representation of the utility model effect aid, and wherein 1 is the freeze-drying dish, and 2 is plane grid, and 3 is column.
Fig. 2 is for adopting freezing speed and the freeze-off time tendency chart of existing frozen vacuum dryer to machined article.
Fig. 3 is for adopting freezing speed and the freeze-off time tendency chart of the utility model frozen vacuum dryer to machined article.
Fig. 4 is for adopting lyophilization speed and the lyophilization time trend figure of existing frozen vacuum dryer to machined article.
Fig. 5 is for adopting lyophilization speed and the lyophilization time trend figure of the utility model frozen vacuum dryer to machined article.
The specific embodiment
Below in conjunction with embodiment the utility model is described in further detail, but the embodiment of utility model is not limited thereto.
Honeybee royal larva meal is mixed with suspension with purified water, and splendid attire is installed effect aid again in the freeze-drying dish of splendid attire solution or suspension in the freeze-drying dish, then the freeze-drying dish is placed on the freeze drying box flaggy; Start frozen vacuum dryer, material to be machined is frozen into-60 ℃ ice shape solid, kept 30 minutes; Start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum reaches 60Pa, start the heater of frozen vacuum dryer, the silicone oil under the freeze drying box flaggy is heated to 25 ℃, kept 8 hours, ice shape solid is directly distilled; Close the heater of frozen vacuum dryer, import pure air, discharging obtains dry material to be machined.
One deck effect aid is arranged on the described frozen vacuum dryer, described effect aid is positioned in the freeze-drying dish, the shape of effect aid and freeze-drying dish is complementary, and described effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column (column height be 40mm) vertical with plane grid; Described freeze-drying dish is a rectangle, and column is arranged at the lines joining place in the plane grid, and column and freeze-drying dish are equal height; Described effect aid is welded to each other or casts formation mechanical type effect aid by metal tube; Effect aid as shown in Figure 1, wherein 1 for the freeze-drying dish, 2 is plane grid, 3 is column.
Honeybee royal larva meal is mixed with solution or suspension with purified water, and splendid attire is installed effect aid again in the freeze-drying dish of splendid attire solution or suspension in the freeze-drying dish, then the freeze-drying dish is placed on the freeze drying box flaggy; Start frozen vacuum dryer, material to be machined is frozen into 0 ℃ ice shape solid, kept 1 hour; Start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum reaches 60Pa, start the heater of frozen vacuum dryer, the silicone oil under the freeze drying box flaggy is heated to 80 ℃, kept 15 hours, ice shape solid is directly distilled; Close the heater of frozen vacuum dryer, import nitrogen, discharging obtains dry material to be machined.
The two-layer effect aid that stacks is arranged on the described frozen vacuum dryer, described effect aid is positioned in the freeze-drying dish, the shape of effect aid and freeze-drying dish is complementary, and described effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column (column height be 20mm) vertical with plane grid; Described freeze-drying dish is circular, and column is arranged at the lines joining place in the plane grid, and column is than the high 30mm of freeze-drying dish; Described effect aid is welded to each other or is cast by metal tube and forms, and is embedded with the semiconductor that is used for heating and refrigerating in the metal tube, and semiconductor external power supply control system forms the electronic type effect aid; First unlocking electronic formula effect aid before starting frozen vacuum dryer.
Embodiment 3
Honeybee royal larva meal is mixed with solution or suspension with purified water, and splendid attire is installed effect aid again in the freeze-drying dish of splendid attire solution or suspension in the freeze-drying dish, then the freeze-drying dish is placed on the freeze drying box flaggy; Start frozen vacuum dryer, material to be machined is frozen into-10 ℃ ice shape solid, kept 5 hours; Start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum reaches 60Pa, start the heater of frozen vacuum dryer, the silicone oil under the freeze drying box flaggy is heated to 60 ℃, kept 12 hours, ice shape solid is directly distilled; Close the heater of frozen vacuum dryer, import nitrogen, discharging obtains dry material to be machined.
The three stacked effect aids of putting are arranged on the described frozen vacuum dryer, described effect aid is positioned in the freeze-drying dish, the shape of effect aid and freeze-drying dish is complementary, and described effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column (column height be 5mm) vertical with plane grid; Described freeze-drying dish is oval, and column is arranged at the lines joining place in the plane grid, and column is than the low 1mm of freeze-drying dish; Described effect aid is welded to each other or is cast by metal tube and forms, and is embedded with the wire that is used for heating and refrigerating in the metal tube, and wire external power supply control system forms the electronic type effect aid; First unlocking electronic formula effect aid before starting frozen vacuum dryer.
Honeybee royal larva meal is mixed with solution or suspension with purified water, and splendid attire is installed effect aid again in the freeze-drying dish of splendid attire solution or suspension in the freeze-drying dish, then the freeze-drying dish is placed on the freeze drying box flaggy; Start frozen vacuum dryer, material to be machined is frozen into-40 ℃ ice shape solid, kept 3 hours; Start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum reaches 60Pa, start the heater of frozen vacuum dryer, the silicone oil under the freeze drying box flaggy is heated to 60 ℃, kept 10 hours, ice shape solid is directly distilled; Close the heater of frozen vacuum dryer, import nitrogen, discharging obtains dry material to be machined.
Four layers of effect aid are arranged on the described frozen vacuum dryer, described effect aid is positioned in the freeze-drying dish, the shape of effect aid and freeze-drying dish is complementary, and described effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column (column height be 1mm) vertical with plane grid; Described freeze-drying dish is circle, ellipse, rectangle, trapezoidal or triangle, and column is arranged at the lines joining place in the plane grid, and column is than the low 20mm of freeze-drying dish; Described effect aid is welded to each other or is cast by metal tube and forms, metal tube or in be embedded with the semiconductor that is used for heating and refrigerating, semiconductor external power supply control system forms the electronic type effect aid; First unlocking electronic formula effect aid before starting frozen vacuum dryer.
Embodiment 5: adopt the investigation to the material to be machined lyophilization cycle of the utility model frozen vacuum dryer and existing frozen vacuum dryer
Honeybee royal larva meal is mixed with suspension with purified water, be divided into two parts, a copy of it splendid attire is in the freeze-drying dish, embodiment 1 described effect aid is installed in the freeze-drying dish of splendid attire solution or suspension again, then the freeze-drying dish is placed on the freeze drying box flaggy, start frozen vacuum dryer, material to be machined is frozen into 0 ℃ to-60 ℃ ice shape solid (freezing speed of machined article and freeze-off time tendency chart are as shown in Figure 2); Another part splendid attire places the freeze-drying dish on the freeze drying box flaggy in the freeze-drying dish then, starts frozen vacuum dryer, material to be machined is frozen into 0 ℃ to-60 ℃ ice shape solid (freezing speed of machined article and freeze-off time tendency chart are as shown in Figure 3);
From Fig. 2 and 3 as seen, adopting the freeze-off time of the utility model frozen vacuum dryer is 146min, and adopt the freeze-off time of existing frozen vacuum dryer is 210min, adopts the utility model frozen vacuum dryer freeze-off time can have been shortened 64 minutes, and freezing speed improves 30.5%.
Embodiment 6: adopt the investigation to the material to be machined lyophilization cycle of the utility model frozen vacuum dryer and existing frozen vacuum dryer
Honeybee royal larva meal is mixed with suspension with purified water, be divided into two parts, a copy of it splendid attire is in the freeze-drying dish, embodiment 2 described effect aids are installed in the freeze-drying dish of splendid attire solution or suspension again, then the freeze-drying dish is placed on the freeze drying box flaggy, open effect aid, start frozen vacuum dryer, material to be machined is frozen into 0 ℃ to-60 ℃ ice shape solid, kept 1 hour, start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum during less than 60Pa, start the heater of frozen vacuum dryer, the silicone oil under the freeze drying box flaggy is heated to 25 ℃～80 ℃, kept 8～15 hours, ice shape solid is directly distilled (the lyophilization speed of machined article and lyophilization time trend figure are as shown in Figure 4); Another part splendid attire is in the freeze-drying dish, then the freeze-drying dish is placed on the freeze drying box flaggy, start frozen vacuum dryer, material to be machined is frozen into 0 ℃ to-60 ℃ ice shape solid, kept 1 hour, start the lyophilization program that vacuumizes of frozen vacuum dryer, when vacuum during less than 60Pa, start the heater of frozen vacuum dryer, silicone oil under the freeze drying box flaggy is heated to 25 ℃～80 ℃, kept 8～15 hours, ice shape solid is directly distilled (the lyophilization speed of machined article and lyophilization time trend figure are as shown in Figure 5);
From Figure 4 and 5 as seen, the machined article under the same terms utilizes the utility model frozen vacuum dryer and existing frozen vacuum dryer to carry out drying and compares, and its lyophilization speed has improved 52.4%, and the lyophilization time has also shortened more than 30%.
Above-mentioned preparation embodiment is the utility model preferred implementation; but embodiment of the present utility model is not restricted to the described embodiments; other any do not deviate from change, the modification done under spiritual essence of the present utility model and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within the protection domain of the present utility model.
Claims (5)
1. effect aid is characterized in that: described effect aid is positioned in the freeze-drying dish in the frozen vacuum dryer, and effect aid is the stereoscopic grid shape, and stereoscopic grid comprises plane grid and the column vertical with plane grid.
2. effect aid according to claim 1 is characterized in that: described freeze-drying dish is circle, ellipse, rectangle, trapezoidal or triangle, and the shape of effect aid and freeze-drying dish is complementary, and column is arranged at the lines joining place in the plane grid.
3. effect aid according to claim 1 is characterized in that: described effect aid is welded to each other or casts formation mechanical type effect aid by metal tube.
4. effect aid according to claim 1, it is characterized in that: described effect aid is welded to each other or is cast by metal tube and forms, be embedded with the semiconductor or the wire that are used for heating and refrigerating in the metal tube, semiconductor or wire external power supply control system form the electronic type effect aid.
5. frozen vacuum dryer that has the described effect aid of claim 1, it is characterized in that: the effect aid in the described freeze-drying dish is one deck, two-layer stack or multilayer stacks, the height of column is 1～40mm, and column and freeze-drying dish are equal height or than the low 1～30mm of freeze-drying dish or than the high 1～30mm of freeze-drying dish.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202628541U CN201548033U (en) | 2009-11-17 | 2009-11-17 | Effectiveness-aiding device and vacuum freeze drier with the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202628541U CN201548033U (en) | 2009-11-17 | 2009-11-17 | Effectiveness-aiding device and vacuum freeze drier with the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201548033U true CN201548033U (en) | 2010-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009202628541U Expired - Fee Related CN201548033U (en) | 2009-11-17 | 2009-11-17 | Effectiveness-aiding device and vacuum freeze drier with the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201548033U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2519484C1 (en) * | 2013-06-14 | 2014-06-10 | Закрытое акционерное общество "ХимИнвестТранс" | System for sampling and level control for fluid product |
| WO2022202938A1 (en) * | 2021-03-26 | 2022-09-29 | 富士フイルム株式会社 | Freeze-drying container |
-
2009
- 2009-11-17 CN CN2009202628541U patent/CN201548033U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2519484C1 (en) * | 2013-06-14 | 2014-06-10 | Закрытое акционерное общество "ХимИнвестТранс" | System for sampling and level control for fluid product |
| WO2022202938A1 (en) * | 2021-03-26 | 2022-09-29 | 富士フイルム株式会社 | Freeze-drying container |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100811 Termination date: 20141117 |
|
| EXPY | Termination of patent right or utility model |