CN201512490U - Integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea - Google Patents
Integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea Download PDFInfo
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- CN201512490U CN201512490U CN2009200593285U CN200920059328U CN201512490U CN 201512490 U CN201512490 U CN 201512490U CN 2009200593285 U CN2009200593285 U CN 2009200593285U CN 200920059328 U CN200920059328 U CN 200920059328U CN 201512490 U CN201512490 U CN 201512490U
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- nanofiltration
- anthocyanogen
- cowberry
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Abstract
The utility model discloses an integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea. The device comprises an ultrasonic extraction device for extracting effective constituent of plants, a pressure filtration and bag filter separation device for solid-liquid separation and impurity removal of the extracted constituent. The device can work under low temperature, besides the characteristics of short extraction time, high efficiency, low energy consumption and simple process, the device is particularly suitable for heat-sensitive substance treatment and can prevent the phenomenon that the anthocyanin of the vaccinium vitis-idaea resolves during the extraction and separation process and causes lower content of the effective constituent. The device has the advantages of small volume, simple structure, low investment cost and running cost, higher recovery rate of the anthocyanin of the vaccinium vitis-idaea, and wide application range, and is suitable for the application of separation, purification, concentration, clarification and other technologies to the production of heat-sensitive substance.
Description
Technical field
The utility model belongs to the extraction separation concentration technique of pharmaceutical engineering cowberry anthocyanogen, the extraction of particularly a kind of cowberry anthocyanogen, separation, concentration integrated device.
Background technology
Vaccinium Ericaceae huckleberry plant is a kind of fruit with high economic worth.Cowberry contains compositions such as carbohydrate, organic acid, VITAMIN, super oxygen compound dismutase, amino acid, alkaloid, fat, tannin, pectin and anthocyanogen, wherein anthocyanogen is a main component, it has anti-eye strain, increase eyesight, and have reducing cholesterol, suppress lipoprotein oxidation, anti-oxidant, anti-ageing, anti-ly fester, anti-inflammatory and physiological function and significant pharmacological action such as anticancer, for many years, become one of the focus of natural product extraction Separation Research at home and abroad.
The extracting method of traditional anthocyanogen presses behind the juice fruit or pericarp with hydrochloric acid or alcohol immersion, soak extraction 2-3 hour at high temperature, this technology heated time is long, the temperature height, it is low to extract yield, and effective constituent such as anthocyanogen is decomposed easily simultaneously, use a large amount of organic solvents in the leaching process, extraction cost height, a large amount of organic solvents also can cause the pollution of environment, make the exploitation of anthocyanogen also be subjected to certain restriction.
The utility model content
At the shortcoming of prior art, the purpose of this utility model provides a kind ofly carries out at low temperatures, and energy consumption is low, can prevent the reduction of quality in the anthocyanogen extraction separation process, effective constituent ground decomposes extraction yield height, the extraction of free of contamination cowberry anthocyanogen, separation, concentration integrated device.
For achieving the above object, the technical solution of the utility model is: the extraction of a kind of cowberry anthocyanogen, separation, concentration integrated device, the press filtration that it comprises the ultrasonic extraction device that is used to extract effective ingredients in plant, carry out solid-liquid separation and Impurity removal with the composition that extracts with the bag type filtering tripping device and the composition after will separating carry out spissated nanofiltration concentrating unit.
Described ultrasonic extraction device comprises the supersound extraction device and first impeller pump that connects by pipeline, and first impeller pump is connected with the bag type filtering tripping device with press filtration.
Described press filtration comprises plate-and-frame filter press, material liquid tank, second impeller pump, first deep bed filter, second deep bed filter and first plate-type heat exchanger that is connected successively by pipeline with the bag type filtering tripping device, described plate-and-frame filter press also is connected with first impeller pump, and first plate-type heat exchanger is connected with the nanofiltration concentrating unit.
The aperture of first deep bed filter is that 25 microns, the aperture of second deep bed filter are 5 microns.
Described nanofiltration concentrating unit comprises that the circulation tank, the 3rd impeller pump, security personnel's strainer, the 4th impeller pump, the 5th impeller pump, nanofiltration membrane component, pressure regulating pump, the nanofiltration concentrated solution discharge that are in turn connected into a circulation loop by pipeline take into account second interchanger, and the dialyzate outlet of described nanofiltration membrane component also is connected with the nanofiltration dialysate flow meter.
Security personnel's strainer is a candle filter, and its aperture is 1 micron.
Described nanofiltration concentrating unit also is connected with the CIP cleaning system that a pair of nanofiltration concentrating unit cleans.
The utility model compared with prior art has following advantage and beneficial effect:
Supersound extraction, press filtration and the pocket type of the utility model employing cowberry anthocyanogen separates, the nanofiltration concentration integrated device, carry out not only time weak point at low temperatures, energy consumption is low, temperature is low, flow process is simple, energy efficient, and be particularly useful for the production of heat-sensitive substance, can prevent that the reduction of quality in the anthocyanogen extraction separation process, effective constituent ground from decomposing.Little and the simple structure of equipment volume is invested for a short time, and maintenance cost is low, and running cost is low, and anthocyanogen yield height is applied widely, applicable to separation, and purifying, clarification such as concentrates at technology, the application of developing membrane separation technique in China's Chinese medicine and natural product are produced.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
Embodiment
Below in conjunction with accompanying drawing the utility model is described in detail.
As shown in Figure 1, the utility model discloses the extraction of a kind of cowberry anthocyanogen, separation, concentration integrated device, the press filtration of comprise the ultrasonic extraction device that is used to extract effective ingredients in plant, the composition that extracts being carried out solid-liquid separation and Impurity removal with the bag type filtering tripping device and the composition after will separating carry out spissated nanofiltration concentrating unit.
Supersound extraction have extraction time short, productive rate is high, need not characteristics such as heating, extraction yield is higher simultaneously, low-consumption high-efficiency, it has obtained development greatly as a kind of extraction means.The leaching that supersound extraction utilizes cavitation effect of ultrasonic waves to quicken effective ingredients in plant is extracted, hyperacoustic in addition second-order effect, add mechanical vibration, emulsification, spread, smash, chemical effect etc., can quicken also that desire extracts that the diffusion of composition discharges and fully and solvent, raise the efficiency effectively, therefore, ultrasonic technique has good effect to the extraction of cowberry anthocyanogen.
As a kind of isolation technique, press filtration and bag type filtering are combined use, application in pharmaceutical industry comes extensively more, can remove non-active ingredients such as impurity, tannin effectively, can increase the clarity of solution effectively, be used for the isolation and purification of pharmaceutically active ingredient, high and few destruction of yield, can replace weak points such as the ultra-filtration technique investment is big, running cost is high, the easy pollution of film results in blockage, the new trend of pharmaceutically active ingredient isolation technique development in also will becoming.
The method that tradition concentrates the cowberry dilute solution adopts vacuum concentration, need expend a large amount of energy consumptions, the production cost height, and simultaneous temperature is higher, can cause the decomposition of effective constituents such as anthocyanogen.Adopt the nanofiltration membrane technology, can overcome the shortcoming of traditional production technique, whole process of production is carried out at low temperatures, the production efficiency height, and less energy-consumption has improved production efficiency significantly, has very highland industrial application value.
Described ultrasonic extraction device is connected to form by the supersound extraction device 1 and first impeller pump 2.
Described first impeller pump 2 is connected with plate-and-frame filter press 3 by pipeline, described plate-and-frame filter press 3 is connected with material liquid tank 4 by pipeline, described material liquid tank 4 is connected with second impeller pump 5 by pipeline, described second impeller pump 5 is connected with first deep bed filter 6, described first deep bed filter 6 is connected with second deep bed filter 7 by pipeline, described second deep bed filter 7 is connected with first plate-type heat exchanger 8 by pipeline, and aforesaid device has been formed press filtration and bag type filtering tripping device.
The aperture of first deep bed filter 6 is that 25 microns, the aperture of second deep bed filter 7 are 5 microns, and the effect of first plate-type heat exchanger 8 is that extracting solution is cooled to be lower than 45 ℃, because nanofiltration membrane generally can not be born high temperature.
Plate-and-frame filter press 3 can constitute one group of filter chamber by filter plate and the filter frame alternately arranged, by feeding stock liquid, washing water and draw filtrate to filter chamber.By first impeller pump 2 stock liquid is pressed into filter chamber, on filter cloth, forms filter residue, until being full of filter chamber.Filtrate pass filter cloth and along the filter plate trench flow to passage, concentrate to discharge.Filtration finishes, and can feed to clean to wash the water washing filter residue.After the washing, also feed pressurized air sometimes, remove remaining washings.Open pressure filter removal filter residue subsequently, clean filter cloth.The liquid deep bed filter is a kind of novel filtering system, the inner basket of being made by punched-plate is supporting the liquid filtering bag, and liquid is flowed into by water-in, flows out behind the liquid filtering bag filtration, impurity then is intercepted in the middle of the liquid filtering bag, the replaceable or cleaning of liquid filtering bag.
The deep bed filter system advantage: compact construction, size are reasonable, install and simple, convenient, and floor space is less.The filtering accuracy height is applicable to any fine particle or suspended substance, and filter area can be from 0.5～200 micron.The processing flow of unit filtration area is bigger, and filtration resistance is less, the filtration efficiency height.A liquid filtering bag filtration function is equivalent to 5～10 times of filter cores, can reduce cost greatly; Design discharge can satisfy 1～500cum/h requirement, and the cost cost is low.Of many uses, can be used for coarse filtration, middle filter or smart filter; Reaching under the situation of same filter effect, the equipment such as sheet frame fine filting machine, filer element type strainer that relatively rise have that cost of investment is lower, long service life and filtration low cost and other advantages.The filtering accuracy height, the filtration treatment amount is big, has characteristics such as cost is low, efficient height.The liquid deep bed filter exempts to clean, and changes the liquid filtering bag and can finish in 30 seconds, and is convenient and swift, saving of work and time.
Described first plate-type heat exchanger 8 is connected with circulation tank 9 by pipeline, circulation tank 9 is by pipeline and the 3rd impeller pump 11, the 3rd impeller pump 11 is connected with 1 μ m security personnel strainer 12 by pipeline, 1 μ m security personnel strainer 12 is connected with the 4th impeller pump 13 by pipeline, the 4th impeller pump 13 is connected with the 5th impeller pump 14 by pipeline, the 5th impeller pump 14 is connected by the import of pipeline with nanofiltration membrane component 15, the concentrated solution outlet of nanofiltration membrane component 15 and pressure regulating pump 16, nanofiltration concentrated solution discharge meter 17 polyphones, be connected with second interchanger 18 on the nanofiltration concentrated solution discharge meter 17, second interchanger 18 is connected with circulation tank 9, dialyzate outlet on the described nanofiltration membrane component 15 is connected with nanofiltration dialysate flow meter 19, and aforesaid device has been formed the nanofiltration concentrating unit.
The structure of nanofiltration membrane component 15 is a coiled reverse osmosis membrane, and skin is a stainless steel tube, and internal layer is a nanofiltration membrane film core, and the film material is poly-carbonic acid cellulose ester.
The effect of two under meters 17,19 is respectively the flow of control concentrated solution and dialyzate, and the result who measures is in order to prevent that nanofiltration membrane component 15 from occurring film too early and polluting and concentration polarization, to cause film to block.The effect of second interchanger 18 is the temperature that reduce the backflow concentrated solution, and its temperature is controlled at and is lower than 45 ℃.
Described nanofiltration concentrating unit also is connected with the CIP cleaning system 10 that a pair of nanofiltration concentrating unit cleans.Particularly, on circulation tank 9, be connected with CIP cleaning system 10.The CIP cleaning system is the on-line cleaning system, finish when concentrating, CIP cleaning system elder generation purified water is cleaned tubing system, use clean-out system (being generally alkali lye) that system is cleaned then, with purified water system is cleaned at last, requiring membrane flux is that dialysate flow reaches the flux before concentrating.
The raw material cowberry is extracted by supersound extraction device 1, start 2 superchargings of first impeller pump, in plate-and-frame filter press 3 solid-liquid separation, enter material liquid tank 4, extracting solution at material liquid tank 4 is carried by second impeller pump 5, separate with 5 μ m deep bed filter 7 through 25 μ m deep bed filter 6, remove impurity, again through first plate-type heat exchanger, 8 temperature controls, enter circulation tank 9 then, the solution of circulation tank 9 is carried through impeller pump 11, through 1 μ m security personnel strainer 12, through the 4th impeller pump 13 and 14 superchargings of the 5th impeller pump, enter in the nanofiltration membrane component 15, concentrate at nanofiltration membrane component 15, trapped fluid is through relief valve 16, the nanofiltration concentrated solution discharge meter 17 and second interchanger 18, be circulated back to circulation tank 9, the dialyzate on the nanofiltration membrane component 15 drains into through the liquid basin through the nanofiltration dialysate flow meter, and concentrating finishes uses 10 pairs of concentration systems of CIP cleaning system to clean.
Claims (7)
1. cowberry anthocyanogen extraction, separation, concentration integrated device, it is characterized in that: the press filtration of comprise the ultrasonic extraction device that is used to extract effective ingredients in plant, the composition that extracts being carried out solid-liquid separation and Impurity removal with the bag type filtering tripping device and the composition after will separating carry out spissated nanofiltration concentrating unit, ultrasonic extraction device is connected with the bag type filtering tripping device with press filtration, and press filtration also is connected with the nanofiltration concentrating unit with the bag type filtering tripping device.
2. cowberry anthocyanogen according to claim 1 extraction, separation, concentration integrated device, it is characterized in that: described ultrasonic extraction device comprises the supersound extraction device (1) and first impeller pump (2) that connects by pipeline, and first impeller pump (2) is connected with the bag type filtering tripping device with press filtration.
3. cowberry anthocyanogen according to claim 2 extraction, separation, concentration integrated device, it is characterized in that: described press filtration comprises plate-and-frame filter press (3), material liquid tank (4), second impeller pump (5), first deep bed filter (6), second deep bed filter (7) and first plate-type heat exchanger (8) that is connected successively by pipeline with the bag type filtering tripping device, described plate-and-frame filter press (3) also is connected with first impeller pump (2), and first plate-type heat exchanger (8) is connected with the nanofiltration concentrating unit.
4. cowberry anthocyanogen according to claim 3 extraction, separation, concentration integrated device is characterized in that: the aperture of first deep bed filter (6) is that 25 microns, the aperture of second deep bed filter (7) are 5 microns.
5. cowberry anthocyanogen according to claim 3 extraction, separation, concentration integrated device, it is characterized in that: described nanofiltration concentrating unit comprises circulation tank (9), the 3rd impeller pump (11), security personnel's strainer (12), the 4th impeller pump (13), the 5th impeller pump (14), nanofiltration membrane component (15), pressure regulating pump (16), nanofiltration concentrated solution discharge meter (17) and second interchanger (18) that is in turn connected into a circulation loop by pipeline, and the dialyzate outlet of described nanofiltration membrane component (14) also is connected with nanofiltration dialysate flow meter (19).
6. cowberry anthocyanogen according to claim 5 extraction, separation, concentration integrated device is characterized in that: security personnel's strainers (12) are candle filter, and its aperture is 1 micron.
7. according to each described cowberry anthocyanogen extraction of claim 1 to 6, separation, concentration integrated device, it is characterized in that: described nanofiltration concentrating unit also is connected with the CIP cleaning system (10) that a pair of nanofiltration concentrating unit cleans.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200593285U CN201512490U (en) | 2009-06-26 | 2009-06-26 | Integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200593285U CN201512490U (en) | 2009-06-26 | 2009-06-26 | Integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea |
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| Publication Number | Publication Date |
|---|---|
| CN201512490U true CN201512490U (en) | 2010-06-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009200593285U Expired - Lifetime CN201512490U (en) | 2009-06-26 | 2009-06-26 | Integrated device for extracting, separating and concentrating anthocyanin of vaccinium vitis-idaea |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198049A (en) * | 2011-05-10 | 2011-09-28 | 浙江中医药大学 | Traditional Chinese medicine preparation method and device |
| CN109432817A (en) * | 2018-11-02 | 2019-03-08 | 江阴天江药业有限公司 | A kind of the automation extraction separation method and granule preparation method of the Chinese medicine of the effective component containing thermal sensitivity |
| WO2020082587A1 (en) * | 2018-10-26 | 2020-04-30 | 汤臣倍健股份有限公司 | Application of cranberry or extract thereof in preparation of medications or health-care food for treating, delaying or alleviating ages-related diseases |
-
2009
- 2009-06-26 CN CN2009200593285U patent/CN201512490U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198049A (en) * | 2011-05-10 | 2011-09-28 | 浙江中医药大学 | Traditional Chinese medicine preparation method and device |
| WO2020082587A1 (en) * | 2018-10-26 | 2020-04-30 | 汤臣倍健股份有限公司 | Application of cranberry or extract thereof in preparation of medications or health-care food for treating, delaying or alleviating ages-related diseases |
| CN109432817A (en) * | 2018-11-02 | 2019-03-08 | 江阴天江药业有限公司 | A kind of the automation extraction separation method and granule preparation method of the Chinese medicine of the effective component containing thermal sensitivity |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: GUANGZHOU HANFANG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: HANFANG MODEM CHINESE TRADITIONAL MEDICINE RESEARCH DEVELOPMENT CO., LTD., GUANG |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 510240 Haizhuqu District Jiangnan Road, Guangdong, No. 134, No. Patentee after: Guangzhou Hanfang Pharmaceutical Co., Ltd. Address before: 510240 Haizhuqu District Jiangnan Road, Guangdong, No. 134, No. Patentee before: Hanfang Modem Chinese Traditional Medicine Research Development Co., Ltd., Guang |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20100623 |