CN201481402U - Time/space beam split-based broad-spectrum high-resolution probe system in OCT system - Google Patents

Time/space beam split-based broad-spectrum high-resolution probe system in OCT system Download PDF

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CN201481402U
CN201481402U CN2009201907650U CN200920190765U CN201481402U CN 201481402 U CN201481402 U CN 201481402U CN 2009201907650 U CN2009201907650 U CN 2009201907650U CN 200920190765 U CN200920190765 U CN 200920190765U CN 201481402 U CN201481402 U CN 201481402U
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spectrum
resolution
spectral
optical fiber
light
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丁志华
王川
王凯
孟婕
陈明惠
吴彤
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Zhejiang University ZJU
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Zhejiang University ZJU
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Abstract

The utility model discloses a time/space beam split-based broad-spectrum high-resolution probe system in an OCT system. Low-coherence light emitted by a broadband light source enters a broadband optical fiber coupler from an optoisolator and is split by the coupler, and the separate light beams enter a surface scanning probe and a reference arm; reflected light generates interference in the broadband optical fiber coupler; a probe arm discomposes an interference signal into different spectrum components and probe is performed; and spectrum signals are transmitted to a computer to reconstruct a sample image. In the probe arm, an interference spectrum signal first passes through a low-resolution and wide-free-spectrum-range time domain beam splitter and then passes through a high-resolution and narrow-free-spectrum-range space domain beam splitter, and then a spectrum imaging system probes a spectrum. The time/space beam split-based broad-spectrum high-resolution probe system, on the premise of meeting high resolution, can reduce the view field of the spectrum imaging system and solves the problems, such as field curvature and spectrum overlapping, appearing in large view-field spectrum imaging, thereby realizing high-signal-to-noise ratio and high-resolution spectrum domain OCT imaging.

Description

Among a kind of OCT based on the wide spectrum high-resolution detection system of space-time light splitting
Technical field
This utility model relates to optical coherent chromatographic imaging (OCT) technology, relates in particular among a kind of OCT the wide spectrum high-resolution detection system based on space-time light splitting.
Background technology
Optical coherent chromatographic imaging (Optical Coherence Tomography is called for short OCT) can be implemented noncontact, not damaged, the high-resolution imaging in vivo of live body internal organizational structure and physiological function, has a wide range of applications in the biomedical imaging field.
Present spectral coverage OCT system comes the spectral components of parallel acquisition interference signal by high speed linear array CCD, need not the depth information that axial scan just can obtain sample, has quick and highly sensitive characteristics, and its system core is the rapid spectrometer in the feeler arm.In the OCT system, the axial resolution of system is to be inversely proportional to the light source bandwidth, and the light source bandwidth is wide more, and corresponding coherence length is just short more, and axial resolution is just high more.In subjects such as ophthalmology, skin, tumor, the medical image of ultrahigh resolution (2-3um) has significance to clinical disease diagnosis.Therefore, spectral coverage OCT must adopt the more light source of wide spectral range, and the grating spectrograph of feeler arm must be surveyed wideer spectral component simultaneously, could improve the axial resolution of system.External a lot of scientific research institution has all carried out the research of this respect, N.A.Nassif group as U.S. Harvard Medical School has made up the centre wavelength based on 890nm, the ultrahigh resolution spectral coverage OCT system of the SLD of bandwidth 150nm (super luminescence diode) light source, axial resolution is 2.9um; The J.G.Fujimoto group of masschusetts, u.s.a science and engineering has made up the centre wavelength based on 850nm, the super spectral coverage OCT of the ultrahigh resolution of the femto-second laser of bandwidth 144nm system, and axial resolution is 2.1um.Feeler arm part in ultrahigh resolution spectral coverage OCT system, traditional method is to adopt the line array CCD of more pixel counts to survey more spectral components, perhaps survey wideer spectral region based on the line array CCD of limited pixel count, but the spectral resolution of sacrificial light spectrometer.Because the increase of line array CCD pixel count means the increase of visual field, unless the optical imaging system that design is complicated more, otherwise serious curvature of field phenomenon inevitably can appear in (CCD photosurface) on image planes, simultaneously because spectral region is too wide, dispersion phenomenon is serious, causes the focal position difference of different color light, makes spectrogrph to separate various coloured light fully and introduces crosstalk (cross-talk), survey signal to noise ratio and descend then that system axial resolution descends, finally reduced image quality.And the spectral resolution that reduces spectrogrph means the reduction of the spectral coverage OCT imaging degree of depth.Therefore, how making grating spectrograph high-resolution ground measure broader spectral region under the situation of limited imaging viewing field is big technological difficulties of ultrahigh resolution spectral coverage OCT system development.
Summary of the invention
In order to overcome the deficiency of above-mentioned technological difficulties, wide spectrum high-resolution detection system based on space-time light splitting has been provided to provide among a kind of OCT the purpose of this utility model, feeler arm part in the spectral coverage OCT system of ultrahigh resolution adopts the structure of time domain and the beam split of spatial domain two-stage to realize that the ultra broadband spectrum of high spectral resolution surveys.
The purpose of this utility model is achieved by the following technical solution:
One, among a kind of OCT based on the wide spectrum high-resolution detection method of space-time light splitting:
Feeler arm in the spectral coverage OCT system adopts time domain and the beam split of spatial domain two-stage, realizes that the broadband spectral high-resolution of spectral coverage OCT is surveyed; Its concrete steps are as follows:
1) in the feeler arm of spectral coverage OCT system, pass through acousto-optic modulator (the acousto-optic tunable filter that Free Spectral Range is big, spectral resolution is low earlier, AOTF) carry out first order beam split on the time domain as the one-level light-splitting device, broadband spectral is divided into the sequence narrow-band spectrum in time exports successively;
2) in the feeler arm of spectral coverage OCT system, after the one-level light-splitting device, carry out second level beam split by spectral resolution height, the narrow spatial domain light-splitting device of Free Spectral Range again, will on spatial domain, implement further beam split from the sequence narrow-band spectrum of acousto-optic modulator; Spatial domain light-splitting device virtual image phased array (Virtual Imaged Phased Array, Free Spectral Range VIPA) is greater than the spectral resolution of acousto-optic modulator;
3) in the feeler arm of spectral coverage OCT system, utilize the spectrum behind the two-stage light-splitting device space-time light splitting, implement light spectrum image-forming and parallel detecting by the spectrum imaging system of forming by condenser lens and high speed linear array CCD.
Two, among a kind of OCT based on the wide spectrum high-resolution detection system of space-time light splitting:
This utility model comprises wideband light source, optoisolator, broadband optical fiber coupler, four Polarization Controllers, reference arm, scanheads and feeler arms; The low-coherent light that comes out from wideband light source, incide broadband optical fiber coupler through first Polarization Controller, optoisolator, one the tunnel enters scanheads through second Polarization Controller after beam split, another Lu Jingdi three Polarization Controllers enter reference arm, after the light that returns is interfered in broadband optical fiber coupler, through the 4th Polarization Controller, enter feeler arm interference signal is resolved into spectral signal, last these spectral signals import computer into, handle at computer, by the inverse Fourier transform reconstructed image.Described feeler arm: comprise acousto-optic modulator, collimating lens, cylindrical focusing lens, virtual image phased array, condenser lens and high speed linear array CCD composition; Interference light is earlier by behind the acousto-optic modulator that Free Spectral Range is big, spectral resolution is low, through collimating lens and cylindrical focusing lens, incide a spectral resolution height, the narrow virtual image phased array of Free Spectral Range, carry out parallel detecting by condenser lens imaging and high speed linear array CCD again, realize that the wide spectrum high-resolution of spectral coverage OCT is measured.
Described scanheads: comprise collimating lens, scanning galvanometer and condenser lens; Behind second Polarization Controller, collimating lens, scanning galvanometer and condenser lens, shine sample through the light after the broadband optical fiber coupler beam split, return through second Polarization Controller to broadband optical fiber coupler by former road.
Described reference arm: comprise collimating lens, dispersion compensator, neutral colour filter and plane mirror; Light after the broadband optical fiber coupler beam split is returned through the 3rd Polarization Controller to broadband optical fiber coupler by former road through the 3rd Polarization Controller, collimating lens, dispersion compensator, neutral colour filter and plane mirror.
Described feeler arm: form by acousto-optic modulator, collimating lens, cylindrical focusing lens, virtual image phased array, condenser lens and high speed linear array CCD; Acousto-optic modulator big by Free Spectral Range, that spectral resolution is low carries out the first order beam split on the time domain earlier, broadband spectral is divided into the sequence narrow-band spectrum in time exports successively.Through collimating lens and cylindrical focusing lens, incide a spectral resolution height, the narrow virtual image phased array of Free Spectral Range carries out the second level beam split on the spatial domain from the sequence narrow-band spectrum of acousto-optic modulator outgoing.The Free Spectral Range of virtual image phased array is greater than the spectral resolution of acousto-optic modulator, and it spatially carries out the high-resolution beam split with the sequence narrow-band spectrum of acousto-optic modulator output.Spectrum behind front and back stages light-splitting device space-time light splitting, the line focus lens imaging adopts high speed linear array CCD to carry out parallel detecting, realizes that the wide spectrum high-resolution of spectral coverage OCT is measured.Last these spectral signals import computer into, and implement processing reconstructed sample image such as inverse Fourier transform in computer.
Compare with background technology, the beneficial effect that the utlity model has is:
1, the two-stage beam split on time domain and spatial domain by acousto-optic modulator and virtual image phased array can realize that the broadband spectral of high spectral resolution is surveyed.Compare traditional grating spectrograph, spectral signal has obtained anticipating on time domain, has therefore reduced the visual field of CCD in the spectrum imaging system.Because imaging viewing field diminishes, can eliminate that spectrum that the spectrogrph of traditional spectral coverage OCT system exists is crosstalked and out of focus phenomenon that the curvature of field, distortion and the chromatic dispersion that exist during big visual field cause when big spectral region is surveyed, can significantly improve the signal to noise ratio of spectrographic detection.Simultaneously, because the light spectrum image-forming visual field reduce the easier realization miniaturization of whole spectrum investigating system and integrated.
2, because the acousto-optic modulator Free Spectral Range is very wide, the spectral resolution of virtual image phased array is very high, the space-time light splitting assembling device that both cascades form can be broken through the restricting relation of spectral region and spectral resolution in traditional imaging spectrometer, realizes that the high-resolution of broadband spectral is surveyed.
3, wide spectrum high-resolution detection method that the utility model proposes and system also can be applied to other spectrographic detection application except being applied in the ultrahigh resolution spectral coverage OCT system, as astronomy, and elementary analysis, and in other spectrum imaging system.
Description of drawings
Fig. 1 is a system structure principle schematic of the present utility model.
Fig. 2 is the enlarged diagram of this utility model feeler arm.
Fig. 3 is a sequential chart of the present utility model.
Among the figure: 1, wideband light source, 2, optoisolator, 3, broadband optical fiber coupler, 4, Polarization Controller, 5, collimating lens, 6, scanning galvanometer, 7, condenser lens, 8, sample, 9, collimating lens, 10, dispersion compensator, 11, neutral colour filter, 12, plane mirror, 13, acousto-optic modulator, 14, collimating lens, 15, cylindrical lens, 16, virtual image phased array, 17, condenser lens, 18, high speed linear array CCD, 19, reference arm, 20, scanheads, 21, feeler arm.
The specific embodiment
Below in conjunction with accompanying drawing and exemplifying embodiment this utility model is further described:
As shown in Figure 1 and Figure 2, this utility model comprises wideband light source 1, optoisolator 2, broadband optical fiber coupler 3, four Polarization Controllers 4, reference arm 19, scanheads 20 and feeler arms 21.The low-coherent light that comes out from wideband light source 1, incide broadband optical fiber coupler 3 through first Polarization Controller 4, optoisolator 2, after beam split, one the tunnel enters scanheads 20 through second Polarization Controller 4, behind collimating lens 5, scanning galvanometer 6 and condenser lens 7, shine sample 8, return through second Polarization Controller 4 to broadband optical fiber coupler 3 by former road; Another Lu Jingdi three Polarization Controllers 4 enter reference arm 19, through collimating lens 9, dispersion compensator 10, neutral colour filter 11 and plane mirror 12, are returned through the 3rd Polarization Controller 4 to broadband optical fiber coupler 3 by former road.After the light that returns from scanheads 20 and reference arm 19 is interfered,, enter feeler arm 21 through the 4th Polarization Controller 4 broadband optical fiber coupler 3.
In feeler arm 21, interference light at first enters acousto-optic modulator 13, by the output frequency range of guide sound photomodulator, the optical signal in the whole broadband spectral scope is divided into the sequence narrow-band spectrum in time exports successively, realizes the beam split first time on the time domain.The narrow-band spectrum of acousto-optic modulator output, through collimating lens 14, incident cylindrical lens 15 is pooled straight line, converges on the lower surface of virtual image phased array 16, and the Free Spectral Range of virtual image phased array 16 is greater than the spectral resolution of acousto-optic modulator 13.Except incidence window, the upper surface of virtual image phased array 16 is coated with the reflectance coating of reflectance 100%, the whole reflected back lower surfaces of energy with the lower surface reflection, lower surface then is coated with highly reflecting films, the multiple reflection of upper and lower surface has formed a series of directional lights that focused on by cylindrical lens 15 and has converged the collinear virtual image that forms, i.e. virtual image array.Interfere with each other the effect that has produced the space beam split between these virtual images.Utilize the spectrum of front and back stages light-splitting device behind space-time light splitting, 17 imagings of line focus lens adopt high speed linear array CCD 18 to carry out spectrographic parallel detecting, thereby the high-resolution of realizing ultra broadband spectrum is measured.The measurement result of last these spectral signals is imported computer into, carries out processing such as inverse Fourier transform and rebuild sample image in computer.
As shown in Figure 3, in described feeler arm, be carried in rf frequency on the acousto-optic modulator 13 by control, change the output frequency range of acousto-optic modulator 13, optical signal in the whole broadband spectral scope is divided into the sequence narrow-band spectrum in time exports successively, realize the beam split first time on the time domain.Virtual image phased array 16 is done the beam split of further space to the arrowband output signal of each acousto-optic modulator 13, realizes the detection of wide spectrographic high-resolution time-space domain.
The effect of Polarization Controller 4 is polarization modes of being convenient to adjust each passage in the system, drops to minimumly with the influence with polarization mode dispersion, improves image quality.
The wide spectrum high-resolution detection method and the system of the disclosed a kind of spectral coverage OCT of this utility model, can be under the situation of limited visual field, ultra-wide spectrum is carried out high-resolution to be measured, thereby can realize the superelevation axial resolution of spectral coverage OCT, can improve simultaneously in traditional spectral coverage OCT system spectrum detection by degradation problem under the signal to noise ratio of curvature of field introducing and the axial resolution, significant in the spectrographic detection of ultrahigh resolution spectral coverage OCT, also can be used for the wide spectrum high-resolution detection system in other field.

Claims (3)

  1. Among the OCT based on the wide spectrum high-resolution detection system of space-time light splitting, comprise wideband light source (1), optoisolator (2), broadband optical fiber coupler (3), four Polarization Controllers (4), reference arm (19), scanheads (20) and feeler arm (21); The low-coherent light that comes out from wideband light source (1), through first Polarization Controller (4), optoisolator (2) incides broadband optical fiber coupler (3), one the tunnel enters scanheads (20) through second Polarization Controller (4) after beam split, another Lu Jingdi three Polarization Controllers (4) enter reference arm (19), after the light that returns is interfered in broadband optical fiber coupler (3), through the 4th Polarization Controller (4), enter feeler arm (21) interference signal is resolved into spectral signal, last these spectral signals import computer into, handle at computer, by the inverse Fourier transform reconstructed image; It is characterized in that described feeler arm (21): comprise acousto-optic modulator (13), collimating lens (14), cylindrical focusing lens (15), virtual image phased array (16), condenser lens (17) and high speed linear array CCD (18) composition; Interference light is earlier by behind the acousto-optic modulator (13) that Free Spectral Range is big, spectral resolution is low, through collimating lens (14) and cylindrical focusing lens (15), incide a spectral resolution height, the narrow virtual image phased array (16) of Free Spectral Range, carry out parallel detecting by condenser lens (17) imaging and high speed linear array CCD (18) again, realize that the wide spectrum high-resolution of spectral coverage OCT is measured.
  2. 2. based on the wide spectrum high-resolution detection system of space-time light splitting, it is characterized in that among a kind of OCT according to claim 1: described reference arm (19) comprises collimating lens (9), dispersion compensator (10), neutral colour filter (11) and plane mirror (12); Light after beam split is returned through the 3rd Polarization Controller (4) to broadband optical fiber coupler (3) by former road from the 3rd Polarization Controller (4), through collimating lens (9), dispersion compensator (10), neutral colour filter (11) and plane mirror (12).
  3. 3. based on the wide spectrum high-resolution detection system of space-time light splitting, it is characterized in that among a kind of OCT according to claim 1: described scanheads (20) comprises collimating lens (5), scanning galvanometer (6) and condenser lens (7); Behind collimating lens (5), scanning galvanometer (6) and condenser lens (7), shine sample (8) from second Polarization Controller (4) through the light after the beam split, return through second Polarization Controller (4) to broadband optical fiber coupler (3) by former road.
CN2009201907650U 2009-08-06 2009-08-06 Time/space beam split-based broad-spectrum high-resolution probe system in OCT system Expired - Lifetime CN201481402U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846306A (en) * 2011-06-28 2013-01-02 佳能株式会社 Optical coherence tomography apparatus
CN109620131A (en) * 2018-12-14 2019-04-16 佛山科学技术学院 Optical path microlens array multiple beam optical coherence elasticity measurement system and method altogether

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846306A (en) * 2011-06-28 2013-01-02 佳能株式会社 Optical coherence tomography apparatus
CN102846306B (en) * 2011-06-28 2015-04-01 佳能株式会社 Optical coherence tomography apparatus
CN109620131A (en) * 2018-12-14 2019-04-16 佛山科学技术学院 Optical path microlens array multiple beam optical coherence elasticity measurement system and method altogether
CN109620131B (en) * 2018-12-14 2021-08-03 佛山科学技术学院 Common-path micro-lens array multi-beam optical coherence elasticity measurement system and method

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