CN201419084Y - Magnetic force stirring device for bioreactor - Google Patents
Magnetic force stirring device for bioreactor Download PDFInfo
- Publication number
- CN201419084Y CN201419084Y CN2009200699542U CN200920069954U CN201419084Y CN 201419084 Y CN201419084 Y CN 201419084Y CN 2009200699542 U CN2009200699542 U CN 2009200699542U CN 200920069954 U CN200920069954 U CN 200920069954U CN 201419084 Y CN201419084 Y CN 201419084Y
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- magnet steel
- stirring
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- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
The utility model relates to a magnetic force stirring device for bioreactor, which is composed of a paddle, a stirring shaft, a locating sleeve, a locating shaft, a bearing, a driven sleeve, a drivemagnetic steel, a driven magnetic steel, a separating sleeve, a rack, a transmission shaft, a coupler, a motor, a speed reducer and a cleaning pipeline; the motor and the speed reducer drive the drivemagnetic steel to rotate, and another group of permanent magnets and a rotor, which are closed in the separating sleeve, are driven to rotate synchronously in a coupling way, so as to lead external power to be transmitted to an internal rotor, and another group of the permanent magnets and the rotor are connected with the stirring shaft and the stirring paddle into one body by the coupler at thesame time, so as to realize the stirring purpose. The separating sleeve is used for completely separating mediums in the tank from the environment outside the tank, so as to realize a no-leakage sealing function of stirring transmission. The cleaning pipeline can wash the gap between the separating sleeve and the driven sleeve and the bearing, and the waste water for washing flows out from an opening of the bottom part of the driven sleeve, so as to reduce pollution level to the minimum risk; meanwhile, a magnetic force stirring mechanism is not contacted with nutrient solution in the tank, soas not to damage cells.
Description
Technical field:
The utility model relates to mechanical field, relates in particular to agitator, particularly a kind of magnetic stirring apparatus that is used for bioreactor.
Background technology:
Two kinds of kinds of drive are arranged in the mechanical agitation system usually, the one, motor shaft and shaft direct connection transmit moment of torsion, and axle adopts machinery or packing seal with the sealing of tank body; The 2nd, the non-direct connection of motor shaft and shaft transmits moment of torsion by magnetic force, and axle adopts fixedly close encapsulation with the sealing of tank body.For the mechanical agitation system of motor shaft and shaft direct connection, the axle and the movable sealing that is sealed into of reactor because there is leakage all the time in movable sealing, make such reactor have the possibility of leakage and microbiological contamination especially at aspects such as biological culture.And in the mechanical agitation system of magnetic drives, motor driving shaft and inside reactor shaft adopt magnetic drives, make the interior outer shaft of reactor be isolated fully by tank body, do not produce leakage, have solved leakage and microbiological contamination problem that microorganism is cultivated like this.But, in the prior art, also fail to solve ideally the lubricated and on-line cleaning problem (clean in Place is called for short CIP) that the magnetic drives place connects the bearing shell place.
Conventional at present magnetic agitation system mostly is arranged on reactor bottom.In such cases,, have guiding gutter at the bearing shell place of shaft usually, make the interior liquid of tank body enter bearing shell and it is lubricated and on-line cleaning in order to consider the lubricated or on-line cleaning at bearing shell place.But after a jar inner cell nutrient solution entered bearing shell in bioreactor, cell can be pulverized and be destroyed in the cell culture fluid, because the continuous stirring running, the liquid in jar constantly enters in the bearing shell, makes cell by considerable damage, thereby can't normally finish cultivation.
Summary of the invention:
The purpose of this utility model is to provide a kind of magnetic stirring apparatus that is used for bioreactor, and the described this magnetic stirring apparatus that is used for bioreactor will solve the technical problem that prior art bioreactor jar inner cell nutrient solution can be pulverized destruction by bearing shell.
This magnetic stirring apparatus of bioreactor that is used for of the present utility model is by blade, shaft, positioning sleeve, locating shaft, bearing, driven cover, the active magnet steel, driven magnet steel, separation sleeve, frame, power transmission shaft, shaft coupling, motor, reductor, pipe blow-through constitutes, wherein, the output shaft of described motor is connected with reductor, the output shaft of reductor is connected with power transmission shaft by described shaft coupling, reductor is fixedlyed connected with frame, separation sleeve is connected the downside of frame by screw, the lower end closed of separation sleeve, power transmission shaft is arranged on the axle center of separation sleeve, described active magnet steel is fixedly installed on the lower end of power transmission shaft and is positioned at the separation sleeve lower end, described positioning sleeve is fixedly connected on the lower end of separation sleeve, described driven cover is set in the outside of positioning sleeve, described driven magnet steel is fixedly installed on the upper end of driven cover, described bearing is connected between driven cover and the positioning sleeve, described shaft is connected with the lower end of driven cover by screw thread, described blade is connected with shaft by key, described locating shaft is arranged in the positioning sleeve, one end of described pipe blow-through is connected with frame, and the other end of pipe blow-through is arranged on the top in the gap between driven cover and the positioning sleeve.
Further, described active magnet steel and driven magnet steel are arranged in same sagittal plane.
Further, the bottom of described driven cover is provided with the emptying hole.
Further, described bearing is open hygiene-type bearing.
Operation principle of the present utility model is: the utility model is installed in the tank body top of bioreactor, motor, reductor drive initiatively, and magnet steel rotates, couple drive is enclosed in another group permanent magnet and the rotation synchronously of rotor do in the separation sleeve simultaneously, thereby external impetus is sent to inner rotator, and join together by shaft coupling and shaft and paddle, realize the purpose that stirs.Pressure in the reactor is born by withstand voltage reliable and static separation sleeve, and separation sleeve and tank body constitute the close encapsulation chamber, and a jar interior medium and a jar external environment are isolated fully, realizes stirring the inclusion seal function of transmission.Pipe blow-through can wash gap and the bearing between separation sleeve and the driven cover, waste water after the flushing is by flowing out in the driven cover bottom opening, just pollution level drops to priming the pump thus, and magnetic driving mechanism does not contact a jar interior nutrient solution simultaneously, can not damage by pair cell.
The utility model and prior art are compared, and its effect is actively with tangible.The utility model utilizes separation sleeve that a jar interior medium and a jar external environment are isolated fully, realizes stirring the inclusion seal function of transmission.Pipe blow-through can wash gap and the bearing between separation sleeve and the driven cover, waste water after the flushing is by flowing out in the driven cover bottom opening, just pollution level drops to priming the pump thus, and magnetic driving mechanism does not contact a jar interior nutrient solution simultaneously, can not damage by pair cell.
Description of drawings:
Fig. 1 is the structural representation that is used for the magnetic stirring apparatus of bioreactor of the present utility model.
The specific embodiment:
Embodiment 1:
As shown in Figure 1, the magnetic stirring apparatus that is used for bioreactor of the present utility model, by blade 1, shaft 2, positioning sleeve 3, locating shaft 4, bearing 5, driven cover 6, magnet steel 7, separation sleeve 8, frame 9, power transmission shaft 10, shaft coupling 11, motor 12, reductor 13, pipe blow-through 14 constitutes, wherein, the output shaft of described motor 12 is connected with reductor 13, the output shaft of reductor 13 is connected with power transmission shaft 10 by described shaft coupling 11, reductor 13 is fixedlyed connected with frame 9, separation sleeve 8 is connected the downside of frame 9 by screw, the lower end closed of separation sleeve 8, power transmission shaft 10 is arranged on the axle center of separation sleeve 8, magnet steel 7 includes initiatively magnet steel and driven magnet steel, described active magnet steel is fixedly installed on the lower end of power transmission shaft 10 and is positioned at separation sleeve 8 lower ends, described positioning sleeve 3 is fixedly connected on the lower end of separation sleeve 8, described driven cover 6 is set in the outside of positioning sleeve 3, described driven magnet steel is fixedly installed on the upper end of driven cover 6, described bearing 5 is connected between driven cover 6 and the positioning sleeve 3, described shaft 2 is connected by the lower end of screw thread with driven cover 6, described blade 1 is connected with shaft 2 by key, described locating shaft 4 is arranged in the positioning sleeve 3, one end of described pipe blow-through 14 is connected with frame 9, and the other end of pipe blow-through 14 is arranged on the top in the gap between driven cover 6 and the positioning sleeve 3.
Further, described active magnet steel and driven magnet steel are arranged in same sagittal plane.
Further, the bottom of described driven cover 6 is provided with the emptying hole.
Further, described bearing 5 is open hygiene-type bearings 5.
The course of work of present embodiment is: the utility model is installed in the tank body top of bioreactor, motor 12, reductor 13 drive initiatively, and magnet steel rotates, couple drive is enclosed in another group permanent magnet and the rotation synchronously of rotor do in the separation sleeve 8 simultaneously, thereby external impetus is sent to inner rotator, and join together by shaft coupling 11 and shaft 2 and paddle, realize the purpose that stirs.Pressure in the reactor is born by withstand voltage reliable and static separation sleeve 8, and separation sleeve 8 constitutes the close encapsulation chamber with tank body, and a jar interior medium and a jar external environment are isolated fully, realizes stirring the inclusion seal function of transmission.Pipe blow-through 14 can wash gap between separation sleeve 8 and the driven cover 6 and bearing 5, waste water after the flushing is by flowing out in driven cover 6 bottom opening, just pollution level drops to priming the pump thus, and magnetic driving mechanism does not contact a jar interior nutrient solution simultaneously, can not damage by pair cell.
Claims (4)
1. magnetic stirring apparatus that is used for bioreactor, by blade, shaft, positioning sleeve, locating shaft, bearing, driven cover, the active magnet steel, driven magnet steel, separation sleeve, frame, power transmission shaft, shaft coupling, motor, reductor, pipe blow-through constitutes, it is characterized in that: the output shaft of described motor is connected with reductor, the output shaft of reductor is connected with power transmission shaft by described shaft coupling, reductor is fixedlyed connected with frame, separation sleeve is connected the downside of frame by screw, the lower end closed of separation sleeve, power transmission shaft is arranged on the axle center of separation sleeve, described active magnet steel is fixedly installed on the lower end of power transmission shaft and is positioned at the separation sleeve lower end, described positioning sleeve is fixedly connected on the lower end of separation sleeve, described driven cover is set in the outside of positioning sleeve, described driven magnet steel is fixedly installed on the upper end of driven cover, described bearing is connected between driven cover and the positioning sleeve, described shaft is connected with the lower end of driven cover by screw thread, described blade is connected with shaft by key, described locating shaft is arranged in the positioning sleeve, one end of described pipe blow-through is connected with frame, and the other end of pipe blow-through is arranged on the top in the gap between driven cover and the positioning sleeve.
2. the double-deck agitator of multifunctional filtering drying device according to claim 1 is characterized in that: described active magnet steel and driven magnet steel are arranged in same sagittal plane.
3. the double-deck agitator of multifunctional filtering drying device according to claim 1, it is characterized in that: the bottom of described driven cover is provided with the emptying hole.
4. the double-deck agitator of multifunctional filtering drying device according to claim 1 is characterized in that: described bearing is open hygiene-type bearing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200699542U CN201419084Y (en) | 2009-04-07 | 2009-04-07 | Magnetic force stirring device for bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200699542U CN201419084Y (en) | 2009-04-07 | 2009-04-07 | Magnetic force stirring device for bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201419084Y true CN201419084Y (en) | 2010-03-10 |
Family
ID=41805731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200699542U Expired - Fee Related CN201419084Y (en) | 2009-04-07 | 2009-04-07 | Magnetic force stirring device for bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201419084Y (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101979495A (en) * | 2010-09-08 | 2011-02-23 | 上海国强生化工程装备有限公司 | Magnetic stirring bioreactor and magnetic stirring system |
| CN102145934A (en) * | 2011-02-28 | 2011-08-10 | 重庆大学 | Sewage treatment bidirectional undercurrent flow pushing device |
| CN102319547A (en) * | 2011-05-06 | 2012-01-18 | 张明 | High-precision and low-speed stirring system with low heat quantity |
| CN104379722A (en) * | 2012-06-15 | 2015-02-25 | 艾本德有限公司 | Single-use bioreactor and head plate, and a process for manufacturing same |
| CN107469717A (en) * | 2017-08-11 | 2017-12-15 | 天津吉玄节能技术股份有限公司 | A kind of double-speed mixing transmission device |
| CN107683766A (en) * | 2016-08-05 | 2018-02-13 | 通化东宝药业股份有限公司 | Ginseng tissue culture adventitious root biological reaction apparatus |
| CN111621401A (en) * | 2020-06-11 | 2020-09-04 | 连云港百仑生物反应器科技有限公司 | Magnetic stirring fermentation tank |
| CN111704988A (en) * | 2020-05-27 | 2020-09-25 | 上海璟良生物工程技术有限公司 | Built-in magnetic driving stirring device and biological reaction equipment |
| CN112408611A (en) * | 2019-08-21 | 2021-02-26 | 艾欧史密斯（中国）环境电器有限公司 | Water purification device, water purification system and water purification method |
| CN113617271A (en) * | 2021-07-29 | 2021-11-09 | 浙江长城搅拌设备股份有限公司 | Anti-caking magnetic transmission stirring device for high-viscosity kettle |
| CN113897286A (en) * | 2021-10-11 | 2022-01-07 | 乐匀生物科技(南通)有限公司 | Disposable bioreactor stirring system |
| US20220219128A1 (en) * | 2021-01-12 | 2022-07-14 | Sedna Eng Co., Ltd. | Magnetic mixer and mixing system including the same |
| CN115069141A (en) * | 2022-08-03 | 2022-09-20 | 安徽灿实生物工程有限公司 | Sanitary-grade magnetic stirring equipment |
-
2009
- 2009-04-07 CN CN2009200699542U patent/CN201419084Y/en not_active Expired - Fee Related
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101979495A (en) * | 2010-09-08 | 2011-02-23 | 上海国强生化工程装备有限公司 | Magnetic stirring bioreactor and magnetic stirring system |
| CN101979495B (en) * | 2010-09-08 | 2013-06-19 | 上海国强生化工程装备有限公司 | Magnetic stirring bioreactor and magnetic stirring system |
| CN102145934A (en) * | 2011-02-28 | 2011-08-10 | 重庆大学 | Sewage treatment bidirectional undercurrent flow pushing device |
| CN102319547A (en) * | 2011-05-06 | 2012-01-18 | 张明 | High-precision and low-speed stirring system with low heat quantity |
| CN102319547B (en) * | 2011-05-06 | 2013-07-17 | 张明 | High-precision and low-speed stirring system with low heat quantity |
| CN104379722B (en) * | 2012-06-15 | 2018-11-09 | 艾本德有限公司 | Disposable bioreactor and top plate and their manufacturing method |
| CN104379722A (en) * | 2012-06-15 | 2015-02-25 | 艾本德有限公司 | Single-use bioreactor and head plate, and a process for manufacturing same |
| CN107683766A (en) * | 2016-08-05 | 2018-02-13 | 通化东宝药业股份有限公司 | Ginseng tissue culture adventitious root biological reaction apparatus |
| CN107469717A (en) * | 2017-08-11 | 2017-12-15 | 天津吉玄节能技术股份有限公司 | A kind of double-speed mixing transmission device |
| CN112408611A (en) * | 2019-08-21 | 2021-02-26 | 艾欧史密斯（中国）环境电器有限公司 | Water purification device, water purification system and water purification method |
| CN111704988A (en) * | 2020-05-27 | 2020-09-25 | 上海璟良生物工程技术有限公司 | Built-in magnetic driving stirring device and biological reaction equipment |
| CN111621401B (en) * | 2020-06-11 | 2022-06-07 | 连云港百仑生物反应器科技有限公司 | Magnetic stirring fermentation tank |
| CN111621401A (en) * | 2020-06-11 | 2020-09-04 | 连云港百仑生物反应器科技有限公司 | Magnetic stirring fermentation tank |
| US20220219128A1 (en) * | 2021-01-12 | 2022-07-14 | Sedna Eng Co., Ltd. | Magnetic mixer and mixing system including the same |
| US12090456B2 (en) * | 2021-01-12 | 2024-09-17 | Sedna Eng Co., Ltd. | Magnetic mixer and mixing system including the same |
| CN113617271A (en) * | 2021-07-29 | 2021-11-09 | 浙江长城搅拌设备股份有限公司 | Anti-caking magnetic transmission stirring device for high-viscosity kettle |
| CN113897286A (en) * | 2021-10-11 | 2022-01-07 | 乐匀生物科技(南通)有限公司 | Disposable bioreactor stirring system |
| CN113897286B (en) * | 2021-10-11 | 2023-08-22 | 乐匀生物科技(南通)有限公司 | Disposable Bioreactor Stirring System |
| CN115069141A (en) * | 2022-08-03 | 2022-09-20 | 安徽灿实生物工程有限公司 | Sanitary-grade magnetic stirring equipment |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100310 Termination date: 20160407 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |