CN201341209Y - Three-dimensional imaging data acquisition device - Google Patents
Three-dimensional imaging data acquisition device Download PDFInfo
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- CN201341209Y CN201341209Y CNU200920105510XU CN200920105510U CN201341209Y CN 201341209 Y CN201341209 Y CN 201341209Y CN U200920105510X U CNU200920105510X U CN U200920105510XU CN 200920105510 U CN200920105510 U CN 200920105510U CN 201341209 Y CN201341209 Y CN 201341209Y
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- data acquisition
- acquisition device
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- dimensional imaging
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Abstract
The utility model belongs to a three-dimensional imaging data acquisition device, which consists of a camera and a plane mirror group; wherein the plane mirror group comprises four plane mirrors; by utilizing the imaging principle of the plane mirror, the surface of the measured object images through the one reflection or double reflection of the plane mirror, and the camera can obtain four profiles of the measured object through double picture taking, so that the picture taking time is saved, three different surface images in one picture taking are arranged side by side, the CCD is fully used, and the object distance or the focal length of the camera is not needed to change in picture taking. The data acquisition device has simple structure, convenient operation, low cost, small volume, portableness and can be widely applied to biomedicine, molecular imaging and other fields.
Description
Technical field
The utility model relates to a kind of three-dimensional imaging data acquisition device, exactly, relates to a kind of device that utilizes level crossing to the object dimensional imaging, and this device can be applied to obtain three-dimensional object surface information.
Background technology
Along with developing rapidly of genomics, protein science and disease gene group, the diagnosis of disease is characterizing from traditional disease and is observing, conventional biochemical test detects, develop into the microscopic feature understanding of several genes and molecular level, wherein utilize the molecular image technology can be from generation, the evolution of gene, protein level heightened awareness disease, can realize integral body, continuous, noninvasive special detection method that existing micro-analysis institute can't replace, biology will provide brand-new prevention, diagnosis and treatment means in body molecular image theory and technology thereof.With traditional medical image technology comparatively speaking, the basis that molecular imaging is conceived to constitute disease or pathology changes and gene molecule level unusual, rather than the final result that is made of the gene molecule change is carried out imaging.Under the help of special molecular probe, the molecular image technology can realize organism internal physiological or pathologic process on cell, gene and molecular level nothing wound is dynamic imaging in vivo in real time, thereby grows and researchs such as the mechanism of action of mutation process, new drug development provide detailed qualitative, location, quantitative data and effective information to obtain means with analyzing and processing for disease related gene functional localization, cell.
The autofluorescence tomography technology is the emerging in recent years interior optical molecular image technology of living animal body.Archebiosis fluorescence is with luciferase gene labeled cell or DNA, and the Fluc gene integration is gone up with expressing luciferase to cell chromosome DNA.Under the situation that ATP and oxygen exist, if inject the substrate fluorescein to living animal, the oxidation reaction that luciferase will the catalysis fluorescein also produces photon.External at living animal, utilize highly sensitive optical detecting instrument, can directly capture the outer photon of effusion animal body, utilize effective fluorescence light source algorithm for reconstructing then, just can obtain the position and the intensity of fluorescence light source in the body, and then can observe cell behavior and gene behavior in the living animal body.
In order as often as possible to obtain overflowing the outer photon information of animal body, need carry out imaging to the three-dimensional surface of animal body with photoelectric detector.At present, the method of utilizing plane mirror to obtain the three-dimensional surface information of animal body has a lot, a kind of method is for using and object level crossing at 45, successively to the object side surface imaging, this quadrat method has many drawbacks, as: every shooting is once, all to adjust the relative position of primary event mirror and object, so not only the operation trouble is lost time again, the relative position of object changes again easily, to realizing that image Reconstruction provides adverse factors, and the optical information on animal body surface is along with the time decay, and this reconstruction error is just bigger.A kind of method is for using four plane mirrors, be placed on around the object, and become miter angle with object, obtain four profiles of object simultaneously, the shortcoming of this method is that the picture that becomes on CCD of object is little, and reconstruction error is big, and the image of CCD last 3/4 and body surface information are irrelevant, caused insufficient utilization of CCD, the waste resource.A kind of method is taken pictures to around the object simultaneously for using four cameras, increased the expense of equipment like this, and the performance of four cameras is incomplete same, has increased the error of rebuilding.
The four sides information that the related three-dimensional imaging data acquisition device of the utility model just can obtain object by using a camera to take pictures for twice, and three faces of object that obtain of taking pictures for the first time similarly is side by side, the centre does not have unnecessary information, increased the utilance of CCD, and take pictures for twice, do not need to change object distance or camera focus, saved and regulated the loaded down with trivial details of camera.
The utility model content
The purpose of this utility model is the drawback that overcomes existing mirror imaging system, provides a kind of and both saves time, and can make full use of CCD again, does not need to change the device that object distance or camera focus just can obtain object dimensional body surface information again.
For achieving the above object, the utility model adopts following technical scheme: a kind of three-dimensional imaging data acquisition device includes: level crossing group and camera, as shown in Figure 1, camera is positioned at the top of level crossing group.The level crossing group comprises four level crossings, it is characterized in that, the petty action object that body is contained fluorescence light source is put in the position of animal body 5 among Fig. 2, the petty action object is placed perpendicular to paper, twice catoptric imaging of speculum in top level crossing and left side passed through in the left side of object in its back, belly passes through twice catoptric imaging of speculum in following speculum and left side in the left side of object, with the back picture at grade, its left surface also images in the object left side by the direct reflection of left side speculum, camera is taken pictures from the top down, once obtain the picture on three surfaces, its right flank picture images in the right side of object by the plane mirror on right side, and camera is taken pictures from the top down and obtained the right flank picture of object.
The beneficial effects of the utility model are: just can obtain the fluorescence information of four faces of testee by twice shooting, save time, make that the fluorescence decay amplitude is little when taking pictures for twice; The image that once obtains three faces of measured object is form side by side, has made full use of the area of CCD; Do not need to change the focal length of object distance or camera in the process of taking pictures, simplified program, it is simple and convenient to take pictures.Information according to four surfaces of measured object that obtain, utilize the fluorescence light source algorithm for reconstructing, can rebuild accurately the position and the intensity of biological tissue's inside fluorescence light source, be the early diagnosis and the early treatment of disease, that the evaluation of curative effect of medication provides is qualitative accurately, location, quantitative data.
Description of drawings
Fig. 1 is the schematic diagram of three-dimensional imaging data acquisition device.
Fig. 2 is the schematic diagram of three-dimensional imaging data acquisition device.
Fig. 3 is the schematic diagram of three surperficial pictures obtaining of once photo taking.
Embodiment
By shown in Figure 1, the utility model is made up of camera and level crossing group, and Fig. 2 is the schematic diagram of three-dimensional imaging data acquisition device.
Below in conjunction with drawings and Examples the utility model is further specified.The step of utilizing the related three-dimensional imaging data acquisition device of the utility model to experimentize is as follows:
1. at autofluorescence tomography molecule imaging experiment a few days ago, give toy injected fluorescein enzyme; When experiment, to toy injection substrate fluorescein; Biochemical reaction takes place and produces fluorescent photon under the cooperation of ATP and oxygen in luciferase and fluorescein.
2. the toy with anesthesia is placed among Fig. 25 position on all fours, toy back picture at first images in 6 places by level crossing 3,6 through plane mirrors 1 image in 6 ', the belly picture images in 7 places by plane mirror 4,7 again by plane mirror 1 image in 7 ', toy left surface picture directly by plane mirror 1 image in 5 ', like this back as 6 ', left surface as 5 ' and belly as 7 ' placed side by side, once can photograph three profiles by the liquid nitrogen refrigerating camera from top.The dotted line camera is represented same camera, takes pictures for the second time.Fig. 3 is the schematic diagram of three profiles obtaining of once photo taking.1 is ccd detector, and 2 is toy back picture, and 3 is toy left surface picture, and 4 is toy belly picture.
3. the movable plane mirror group makes level crossing position, alignment lens toy right side, and toy right flank picture images in 8 by plane mirror 2, and camera is taken pictures and can be obtained toy right flank picture.
4. utilize the fluorescence light source algorithm for reconstructing, reconstruct the position and the intensity of the fluorescence light source in the animal body.
Claims (10)
1. three-dimensional imaging data acquisition device includes: camera and level crossing group, and the level crossing group is made up of four plane mirrors; It is characterized in that: described testee is placed perpendicular to paper, and four plane mirrors become different angles to place with testee, and taking pictures by twice to obtain four profiles of testee.
2. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that camera is a kind of photodetector.
3. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that two plane mirrors are positioned over the testee left and right sides in four plane mirrors, becomes miter angle with horizontal plane respectively.
4. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that in four plane mirrors that in addition two plane mirrors are positioned over the both sides up and down of testee, become miter angle with vertical plane respectively.
5. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that end face and twice catoptric imaging of underrun of testee, and left side and right side are by the primary event imaging.
6. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that once photo taking wherein can obtain three of the testee not pictures of ipsilateral simultaneously, three not the picture of ipsilateral be form side by side.
7. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that imaging is parallel with the ccd detector face.
8. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that in three Polaroid faces, left surface picture and end face, bottom surface picture need the width of the camera depth of field more than or equal to object not on same plane.
9. three-dimensional imaging data acquisition device as claimed in claim 1 is characterized in that camera only needs the position of translated plane mirror group in twice is taken pictures, and does not need to change object distance or camera focus.
10. three-dimensional imaging data acquisition device as claimed in claim 1, when it is characterized in that taking pictures for twice, the optical axis of camera lens will be aimed at the center of left surface or right flank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200920105510XU CN201341209Y (en) | 2009-02-19 | 2009-02-19 | Three-dimensional imaging data acquisition device |
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| Application Number | Priority Date | Filing Date | Title |
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| CNU200920105510XU CN201341209Y (en) | 2009-02-19 | 2009-02-19 | Three-dimensional imaging data acquisition device |
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| CN201341209Y true CN201341209Y (en) | 2009-11-04 |
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| CNU200920105510XU Expired - Fee Related CN201341209Y (en) | 2009-02-19 | 2009-02-19 | Three-dimensional imaging data acquisition device |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102254339A (en) * | 2011-03-28 | 2011-11-23 | 深圳市蓝韵实业有限公司 | Real-time medical ultrasonic three-dimensional imaging method |
| CN102626352A (en) * | 2012-04-28 | 2012-08-08 | 河南中医学院 | Murine photographing and fixing device |
| CN102667856A (en) * | 2009-12-18 | 2012-09-12 | 皇家飞利浦电子股份有限公司 | Multi-section alignment of imaging data |
| CN105662354A (en) * | 2016-03-31 | 2016-06-15 | 中国科学院自动化研究所 | Wide-viewing-angle optical molecular tomography navigation system and method |
| CN108451508A (en) * | 2018-04-28 | 2018-08-28 | 中国科学院自动化研究所 | Archebiosis fluorescent three-dimensional imaging method based on multi-layer perception (MLP) |
-
2009
- 2009-02-19 CN CNU200920105510XU patent/CN201341209Y/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102667856A (en) * | 2009-12-18 | 2012-09-12 | 皇家飞利浦电子股份有限公司 | Multi-section alignment of imaging data |
| CN102667856B (en) * | 2009-12-18 | 2016-06-01 | 皇家飞利浦电子股份有限公司 | Many parts alignment of imaging data |
| CN102254339A (en) * | 2011-03-28 | 2011-11-23 | 深圳市蓝韵实业有限公司 | Real-time medical ultrasonic three-dimensional imaging method |
| CN102626352A (en) * | 2012-04-28 | 2012-08-08 | 河南中医学院 | Murine photographing and fixing device |
| CN105662354A (en) * | 2016-03-31 | 2016-06-15 | 中国科学院自动化研究所 | Wide-viewing-angle optical molecular tomography navigation system and method |
| CN105662354B (en) * | 2016-03-31 | 2019-01-22 | 中国科学院自动化研究所 | A kind of wide viewing angle optical molecular tomographic navigation system and method |
| CN108451508A (en) * | 2018-04-28 | 2018-08-28 | 中国科学院自动化研究所 | Archebiosis fluorescent three-dimensional imaging method based on multi-layer perception (MLP) |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091104 Termination date: 20140219 |