CN201273897Y - Carrier for supporting detection reagent strip - Google Patents
Carrier for supporting detection reagent strip Download PDFInfo
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- CN201273897Y CN201273897Y CNU2008201641690U CN200820164169U CN201273897Y CN 201273897 Y CN201273897 Y CN 201273897Y CN U2008201641690 U CNU2008201641690 U CN U2008201641690U CN 200820164169 U CN200820164169 U CN 200820164169U CN 201273897 Y CN201273897 Y CN 201273897Y
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Abstract
The utility model provides a carrier for supporting a detection reagent strip, which comprise a groove for containing the detection reagent strip. An opening for blocking the flowing of the liquid outside the detection reagent strip on the groove is arranged on the groove. The carrier has the advantages that he flowing of the liquid outside the detection reagent strip on the groove is blocked through the space arranged between the groove and the detection reagent strip, to ensure the liquid sample to uniformly flow on the detection reagent strip, the phenomenon of disconnection is prevented, and the detection sensibility and the detection accuracy are improved.
Description
Technical field
The utility model relates to a kind of carrier that supports the detectable bar, especially the storing apparatus of the detectable bar in the quick diagnosis field.
Background technology
At present, be used for detecting the pick-up unit whether sample contains analyte, be used for hospital or family in a large number, these pick-up units that are applied to quick diagnosis comprise one or more detectable bars, detect such as early pregnancy, and drug abuse detects or the like.The pick-up unit of this quick diagnosis is very convenient, can perhaps obtain testing result about ten minutes on the detectable bar at the most at one minute.
In these pick-up units, the detectable bar generally is positioned on certain carrier.Carrier can be the mould of plate shape or plate or the like.Carrier generally is made of draw-in groove, and a draw-in groove can hold a detectable bar.At present on the pick-up unit of using, on the surveyed area of detectable bar, we can read the zone in testing result usually and see that lines are inhomogeneous, and are deep mixed, or even the phenomenon that exists of some lines only, just said usually " broken string " phenomenon.As shown in Figure 1, be the lines of normal detection line among the N figure, and it is wired to have occurred two ends among the A figure on the detection line, the centre does not have the band of line; Wired in the middle of then having occurred among the B figure, two ends do not have the situation of line; The band depth is inhomogeneous among the C figure.Above-mentioned " broken string " situation can cause that all making the people be difficult to differentiate the result is the positive or feminine gender to the misreading of testing result.
Summary of the invention
In order to solve problems of the prior art, the utility model provides a kind of like this carrier that supports the detectable bar, comprise the draw-in groove that holds the detectable bar, comprise the opening that blocking-up detectable bar liquid in addition flows between draw-in groove and the detectable bar on draw-in groove.
Preferably, the marked region of the corresponding at least detectable bar of described opening.More preferred, described opening is a rectangular aperture.Draw-in groove also comprises fence.
Preferred in addition, the width of described draw-in groove is greater than the width of described detectable bar.More preferred, draw-in groove is than the wide at least 1mm of detectable bar.More preferred, draw-in groove is than between the wide 1mm to 15mm of detectable bar.In specific embodiment, draw-in groove can be than wide 1.4mm of detectable bar or 1.5mm.
In other concrete scheme, draw-in groove also comprises makes the fixed fixed part of described detectable bar.Preferably, fixed part is used for fixing the suction zone of detectable bar.More preferred, fixed part comprises the projection that is used for clamping detectable bar.
In addition, can also comprise on the carrier that makes the upright supporter of carrier.
The beneficial effects of the utility model are: by between draw-in groove and detectable bar the space being set, stop detectable bar liquid in addition flowing on draw-in groove, make the mobile uniformity of liquid sample on the detectable bar, prevent the generation of " broken string " phenomenon, improve the sensitivity and the accuracy that detect.
Description of drawings
Fig. 1 is the synoptic diagram that has the detectable bar of " broken string " phenomenon and show positive positive normal result's detectable bar;
Fig. 2 is the planimetric map of an embodiment of the utility model;
Fig. 3 is the planimetric map that the embodiment among Fig. 2 has the detectable bar;
Fig. 4 is the stereographic map that has the urine cup of the described embodiment of Fig. 2;
Fig. 5 is explosive decomposition figure embodiment illustrated in fig. 4;
Fig. 6 is the synoptic diagram of another embodiment of the present utility model;
Fig. 7 is a schematic rear view embodiment illustrated in fig. 6;
Fig. 8 is the synoptic diagram that embodiment has the detectable bar among Fig. 6;
Fig. 9 is the stereographic map that has the urine cup of embodiment shown in Figure 6;
Figure 10 is explosive decomposition figure embodiment illustrated in fig. 9.
Description of reference numerals: detectable bar 100, sample receiving pad 101, label pad 102, surveyed area 103, adsorptive pads 104, control line 105, detection line 106; First urine cup 2, test card 20, carrier 200, draw-in groove 201, fence 202, opening 203, projection 204, bakie 205, bowl cover 21, lid holder 210, caping 211, push rod 212, cup 22, collection well 221, the cup end 222, piston 223, plunger shaft 224, test chamber 225, pick-up unit 23, test chamber lid 231, panel 232; Second urine cup 3, test card 30, plate carrier 30 as one kind 0, draw-in groove 301, fence 302, opening 303, projection 304, rubber strip 306, heel 307, bowl cover 31, bowl cover screw thread 310, cup 32, collection well 321, test chamber 322, cup screw thread 323.
Embodiment
Structure or these the employed technical terms that the utility model is related to is described further below.
Detect
Detect the expression chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, detect the quantity of expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
Sample
The sample of the utility model indication refers to that those can be used for detecting, chemically examining or diagnose the material that whether has analyte of interest matter.Sample can be that for example, liquid sample, liquid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise that solid sample and semi-solid samples are through anticipating the liquid solution that the back forms.The sample of collecting can be used for methods such as immune detection, chemical detection, enzyme detection and detect whether there is analyte.
The detectable bar
Applying to detectable bar 100 of the present utility model can be usually said horizontal effluent reagent strip 100, and the concrete structure of these detectable bars 100 and detection principle are persons skilled in the art technique known in the prior art.Common detectable bar 100, comprise the sample collection zone, marked region 102, surveyed area 103 and suction zone 104, the sample collection zone comprises sample receiving pad 101, marked region 102 comprises label pad 102, and suction zone 104 can comprise adsorptive pads 104, wherein comprises on the surveyed area 103 and can detect the necessary chemical substance that whether contains analyte.General detectable bar 100 commonly used is a nitrocellulose filter reagent strip 100, be that surveyed area 103 comprises nitrocellulose filter, fixedly the specific bond molecule shows the result of detection on nitrocellulose filter, can also be cellulose acetate membrane or nylon membrane or the like.
Analyte
The example of the analyte of the pick-up unit stable detection that relates in the enough the utility model of energy comprises some haptens materials, and these haptens comprise drugs (as drug abuse)." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine AMP (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine MET (crank, meth, crystal, speed); Barbiturate BAR (as Valium, Roche Pharmaceuticals, Nutley, NewJersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Diformazan dioxy ylmethyl aniline MDMA; Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (be morphine MOP or, opium, cocaine COC; , heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines BZO (benzodiazepines), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne (as hydroxyl dihydrocodeinone OXY, methadone MTD), propanediol derivative one carbamates, fatty compound, anthracene derivative etc.Use pick-up unit of the present utility model also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Pick-up unit
Pick-up unit is meant and is used for detecting the device whether sample contains analyte.In the utility model, pick-up unit especially represents to be used for the pick-up unit in the quick diagnosis field, as detectable bar 100, and test card 20, test bar detects various forms of pick-up units such as cup.Pick-up unit can comprise test card 20 and and test card 20 matching used parts, as shown in Figure 4, urine cup 2 can be used as a kind of form of pick-up unit, in general, urine cup 2 can comprise collecting zone 221 and test card 20, and test card 20 can be made of jointly carrier 200 and detectable bar 100.Applying to detectable bar 100 of the present utility model can be usually said horizontal effluent reagent strip 100, the pick-up unit that applies in the utility model is to have comprised the test card 20 of reagent strip 100 or detected cup 2 (or claiming urine cup), and the concrete structure of these reagent strips 100 or test card 20, urine cup 2 etc. and detection principle are persons skilled in the art technique known in the prior art.
In the present detection, this cassette or cup type pick-up unit all needs carrier 200 of detectable bar 100 usefulness is supported, the function that competence exertion detects.Yet, in existing field, often produce " broken string " phenomenon, influence reading of testing result.Especially near the cut-off value, the signal on detection line 106 is original just more weak, if there is " broken string " phenomenon to exist again, just difficulty judges that testing result is " positive " or " feminine gender " on earth.We find, usually closely connect between detectable bar 100 and the carrier 200, cause capillarity extremely easily, produce detectable bar 100 liquid in addition flowing on draw-in groove 201, as between detectable bar 100 and draw-in groove 201 both sides, perhaps between detectable bar 100 behinds and the draw-in groove 201.This liquid flow is different from the liquid flow on the detectable bar 100, is easy to soak into one step ahead detectable bar 100, will cause the broken string phenomenon like this.Especially, in case marked region absorbs on the detected reagent strip 100 of liquid sample beyond the detectable bar 100, the mark substance on the detectable bar 100 will be dissolved earlier, causes the dissolving of mark substance inhomogeneous.The mark substance of the liquid dissolving beyond the detected reagent strip 100 can flow along detectable bar 100, arrive surveyed area 103 and and detection line 106 on the raw material combination.At this moment, part liquid (on the detectable bar) sample also not with the raw material combination, another part liquid (beyond the detectable bar) is gone ahead of the rest, and combine raw material, will on the detection line 106 of surveyed area 103, form deep mixed, perhaps lines are inhomogeneous, or even the phenomenon that exists of some lines only, just usually said " broken string " phenomenon.
In order to overcome this defective, the utility model adopts such carrier 200, can block detectable bar 100 liquid in addition flowing on draw-in groove 201, furtherly, can block liquid from the both sides of detectable bar 100 or the flowing of the back side, thereby prevent the generation of " broken string " phenomenon.
Carrier
Comprise the structure that blocking-up detectable bar 100 liquid in addition flows on the draw-in groove 201 on draw-in groove 201.In theory, liquid sample only can transmit on detectable bar 100 and flow when detecting, and this liquid flow mainly refers to because the capillarity of the very near generation of distance.And other spaces of draw-in groove 201, as the space, both sides between draw-in groove 201 and detectable bar 100, and on the space between detectable bar 100 behinds and the draw-in groove 201, the phenomenon that does not exist or seldom exist liquid on draw-in groove 201, to flow, when even liquid flow is arranged, also can be blocked the structure blocking-up, be unlikely to make combinations such as liquid and mark substance.
This blocking-up structure can be that draw-in groove 201 is own, as the draw-in groove 201 of width greater than detectable bar 100.Preferably, the width of draw-in groove 201 is greater than the width of detectable bar 100, and the cooperation of this form can produce the space between draw-in groove 201 and reagent strip 100, and the existence in this space can reduce the capillarity of detectable bar 100 both sides.Like this, accept in the process of sample at detectable bar 100, liquid sample can transmit liquid to other positions of detectable bar 100 only along the sample region of acceptance 101 of detectable bar 100.In the prior art, because the distance between detectable bar 100 and the draw-in groove 201 is very little, tiny space between them can produce very strong capillary action, make a part of liquid sample not circulate, but flow by the space between detectable bar 100 and the draw-in groove 201 by detectable bar 100.Like this, can cause the liquid sample on the detectable bar 100 to transmit unevenly, cause that mark substance contacts with sample near insufficient consequence, especially the cut-off value such as inhomogeneous, be more prone to cause " broken string " phenomenon, cause misreading of result.As Fig. 2 and shown in Figure 6, the width of the width of draw-in groove 201 greater than detectable bar 100 is set, and width between the two makes capillary action to produce, can make liquid sample only on detectable bar 100 uniformity ground flow.The width of draw-in groove 201, than detectable bar 100 wide 0.5mm, 0.6mm, 0.8mm, can also be than detectable bar 100 wide 1mm or more.Preferably, the width of draw-in groove 201 is 1mm-15mm than detectable bar 100 wide scopes.In detail, draw-in groove 201 can be than detectable bar 100 wide 1mm, 1.2mm, 1.4mm, 1.6mm, 1.8mm, 2mm, 2.4mm, 2.8mm or 3mm, 4mm, 6mm, 8mm, 10mm, 12mm, 14mm, 15mm or bigger.More preferred, the width distance between the various piece of draw-in groove 201 and the detectable bar 100 is uneven.For example, the clamping of the adsorptive pads 104 of the top of draw-in groove 201 and detectable bar 100 is more closely, but the sample receiving pad 101 of detectable bar 100, label pad 102 and surveyed area 103, and there is the distance that can prevent capillarity between the draw-in groove 201.The carrier 200 of this form, the bar of clamping detectable effectively 100 maintains static it on the one hand, also can also prevent capillarity at critical area on the other hand.
This blocking-up structure not only can be a draw-in groove itself, also can be a certain parts that are positioned on the draw-in groove.The circulation of liquid on draw-in groove 201 that capillarity between detectable bar 100 and the draw-in groove 201 produces, also there are other positions, between detectable bar 100 behinds and draw-in groove 201, if detectable bar 100 is close on the draw-in groove 201, when liquid sample exists, liquid sample is easy to by the finedraw between the behind of detectable bar 100 and the draw-in groove 201, produce very strong capillary action, this part liquid can be with than fast speeds transmission, mark substance on also can incorporation of markings zone 102, forming tangible or fuzzy short or long lines on the detection line on 106, influence the judgement of testing result, sensitivity and accuracy that final influence detects.Capillarity between blocking-up detectable bar 100 and the draw-in groove 201 can also comprise on the draw-in groove 201 that promptly the liquid mobile structure on draw-in groove 201 beyond the blocking-up detectable bar 100 is an opening 203 by the mode in draw-in groove 201 upper sheds 203.Opening 203 can provide a breach at liquid sample when mobile, make not smooth being stagnated of flowing of liquid.Opening 203 can be positioned at any position of draw-in groove 201.The quantity of opening 203 can be 1,2, and 3 or a plurality of.As Fig. 2, Fig. 6 and shown in Figure 7, preferred, comprise an opening 203 on each draw-in groove 201.Preferably, the position of opening 203 is positioned at the bottom of draw-in groove 201, like this, in the time of from liquid sample contact draw-in groove 201, just has been blocked.Preferred in addition, opening 203 is positioned at the Lower Half of draw-in groove 201, can just block the liquid flow that capillarity produces like this when liquid does not flow to surveyed area 103.More preferred, the position of opening 203 on draw-in groove 201 is corresponding near the position the marked region on the detectable bar 100 102.The opening of this form can prevent liquid sample effectively because capillarity and marked region 102 produce circulation.More preferred, the length of the big or small greater than flag pad 102 of opening is so that the mark substance on the maximum magnitude ground protection label pad 102 avoids mark substance to contact with improper flowing liquid sample.Better, the position of opening 203 is positioned on 101 corresponding draw-in grooves, 201 positions, sample region of acceptance with detectable bar 100.The opening 203 of this form, in sample region of acceptance 101, detectable bar 100 liquid communication behind just is blocked in sample flow, thereby can on this position, not produce capillarity, can guarantee the proper flow of liquid sample on detectable bar 100.More preferred, this opening 203 is for being positioned at the rectangular aperture 203 of draw-in groove 201 bottoms.This rectangular aperture 203 can be wide with detectable bar 100, and is more preferred, and this opening 203 and draw-in groove 201 are wide.This kind opening 203 is set, can makes the liquid flow on the detectable bar 100 compare uniformity.
This blocking-up structure can also be realized by other modes.For example, only fence 202 is set in a part of place of draw-in groove 201, preferably, on the top of draw-in groove 201 fence 202 is set, is used for clamping detectable bar 100, make it be in stationary state, bottom at draw-in groove 201, or/and surveyed area 103 is not provided with fence 202, make the detection of detectable bar 100 be in not disturbed state corresponding to the marked region 102 of detectable bar 100.Prevent detectable bar 100 and the capillary blocking-up structure between the draw-in groove 201 behind, the parts that whippletree etc. can support detectable bar 100 can also be set on draw-in groove 201, make detectable bar 100 " frame " on draw-in groove 201.Make reagent strip 100 be in " soaring aloft " state in this way, so just can not produce detectable bar 100 liquid in addition flowing on draw-in groove 201.Further, detectable bar 100 is in the state that " frame " rises, detectable bar 100 itself not too can be subjected to the influence of extraneous carrier 200 or housing so, detection sensitivity and accuracy also can keep higher level, especially near the cut-off value, can show relatively more normal testing result symbol, be not easy to cause result's the erroneous judgement of misreading.
In addition, as Fig. 2, Fig. 6 and shown in Figure 8 can also comprise on the draw-in groove 201 making detectable bar 100 fixed fixed parts.Preferably, this fixed part is used for fixing the suction zone 104 of detectable bar 100.Wide as draw-in groove 201 and detectable bar 100 in suction zone 104 parts of detectable bar 100, the bar of clamping detectable so tightly 100, but to other parts on the detectable bar 100, as surveyed area 103, marked region 102 and sample region of acceptance 101 do not produce any influence, the draw-in groove 201 that this part " is widened ", can block surveyed area 103, liquid beyond marked region 102 or the sample region of acceptance 101 flows on draw-in groove 201, be difficult for producing " broken string " phenomenon, like this, just can not misread testing result.Preferred in addition, fixed part comprises the projection 204 of clamping detectable bar 100, and the part that this projection 204 can clamping detectable bar 100 is as the surveyed area on the detectable bar 100 103, marked region 102, sample region of acceptance 101 or suction zone 104 or the like.More preferred, such projection 204 certain point on can clamping detectable bar 100, as certain the some position on surveyed area 103 or marked region 102 or the sample region of acceptance 101, by clamping among a small circle, fix detectable bar 100, guarantee can not cause the liquid flow between detectable bar 100 and draw-in groove 201 both sides again.Such projection 204 can be 1 or a plurality of, and is preferred, comprises a pair of corresponding projection 204 on each draw-in groove 201, and more preferred, respectively there is a pair of corresponding projection 204 upper and lower of each draw-in groove 201.
The carrier 200 that being used in the utility model held detectable bar 100 can independently detect, and also can cooperate other pick-up units to detect.The independent device that uses as test card 20, is equipped with various detectable bars 100 on carrier 200, can be directly used in and measure in the sample whether contain analyte.Preferably, test card 20 cooperates the lower part of a cover and this carrier 200 to cooperate, and oozes and contaminated environment after detection finishes in order to prevent liquid sample.Preferred in addition, can also comprise on this carrier 200 that makes the upright supporter of carrier 200, can make testing process need not rely on the tester and help by hand or other instruments.The form that cooperates other pick-up units to detect, as Fig. 4, Fig. 5, Fig. 9 and shown in Figure 10 can comprise test card 20 is assembled to use in the urine cup 2.The test card 20 that has carrier 200 and detectable bar 100 can be placed among the test chamber 225.Preferably, urine cup 2 also comprises collection well 221, is used for the collection of liquid sample, and this test chamber 225 can be communicated with collection well 221 directly or indirectly, and both are in liquid flowing state.The form of this urine cup 2 has a lot of descriptions in the prior art, is not described in detail at this.
Below in conjunction with concrete accompanying drawing examples of implementation of the present utility model are described in detail.These specific embodiment only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
Select for use a series of DOA products to carry out different detections in the utility model, mainly contain AMP (amphetamine), BAR (barbital), BZO (Benzodiazepine), COC (cocaine), MET (methyl amphetamine), MDMA (diformazan dioxy ylmethyl aniline), MOP (morphine), OPI (morphine), OXY (hydroxyl dihydrocodeinone), MTD (methadone), PCP (Hog), PPX (the third oxygen sweet smell), TCA (tricyclic antidepressant), THC (tetrahydrocannabinol), COT (nicotine), BUP (buprenorphine), ACE (paracetamol), KET (ketamine), MQL (methaqualone), EDDP (2-acetal-1,5 dimethyl-3,3-diphenyl pyrrolidine).
Embodiment 1
Present embodiment relates to a kind of test card 20.As shown in Figures 2 and 3, this test card 20 comprises carrier 200 and detectable bar 100 compositions.Comprise 6 draw-in grooves 201 on this carrier 200, the width of draw-in groove 201 is 5.4mm ± 0.2mm (wherein the width of detectable bar 100 is 4mm) that greater than detectable bar 100 draw-in groove is than the wide 1.4mm ± 0.2mm of detectable bar.Distance is evenly separated by 5 fence 202 between the draw-in groove 201 between draw-in groove 201 and the draw-in groove 201.A rectangular aperture 203 is set on each draw-in groove 201, and the position of marked region 102 is corresponding on the position of opening 203 and the detectable bar 100.Two pairs of jagged projections 204 are set on each draw-in groove 201, can be used for clamping reagent strip 100, play the effect of stable detection reagent strip 100.Wherein a pair of jagged projection 204 is positioned at the top of draw-in groove 201, and another is positioned at the bottom of draw-in groove 201 to jagged projection 204.In the bottom of each draw-in groove 201, also have the bakie 205 of an arch, the excess liquid sample can be spilt from the bakie 205 of arch.Detectable bar 100 in this test card 20 is used for detecting sample and whether contains drug materials, as hemp, and cocaine or the like material.When the detection, by the front end of detectable bar 100, promptly the sample region of acceptance 101, obtain liquid sample, as urine etc.In liquid sample, kept 1 minute, determine that enough samples are used for detecting.At this moment, liquid sample can be along the sample receiving pad 101 of detectable bar 100, arrive label pad 102, fully mix with the mark substance of label pad 102, arrive surveyed area 103 then, testing result zone at surveyed area 103 forms detected symbol, as control line 105 and detection line 106, is used for judging whether liquid sample contains analyte.On the one hand, because the width of draw-in groove 201 leaves certain space greater than the width of detectable bar 100 in draw-in groove 201 both sides, make liquid in this space, not form capillarity; On the other hand, behind at detectable bar 100, marked region 102 over against draw-in groove 201 positions on have rectangular aperture 203, can effectively must prevent or block liquid sample and produce capillary action, thereby can not influence the abundant mixing of the mark substance on liquid sample and the marked region 102 at the behind and the draw-in groove 201 of detectable bar 100.
According to test card 20 as above, we have carried out near the testing result experiment the cut-off value, comprise the integrality of sensitivity and T line 106.
1. sensitivity experiment
As shown in Table 1, select for use 120 test card 20 as statistical experiment respectively.The result shows, the standard that can reach G7 of all negative samples (the standard here is from G1 to G8, and the degree that naked eyes can be distinguished is remarkable more, is boundary with G4), illustrate that naked eyes can unquestionablely distinguish that the testing result of this batch test card 20 is wired, the expression negative findings; Most of concentration can reach the standard of G4 for the-sample of 50%cut-off value after detection, naked eyes can be distinguished has lines to exist on the detection line 106, represent that testing result is negative; Most of concentration also can be less than the standard of G3.5 for the+sample of 50%cut-off value after detection, naked eyes are distinguished does not have lines to exist on the detection line 106, represent that testing result is positive.According to showing in the table two that the result of above-mentioned sensitivity experiment is reasonable, all passed through to detect receptible scope.
Table one, sensitivity experiment
2. integrality experiment
In this experiment, comprise three groups of data, one group is the broken string quantity and the outage (table two) of the testing result of negative sample, one group is that concentration is-the pattern detection result's of 50%cut-off value broken string quantity and outage (table three), also has one group to be that concentration is+the pattern detection result's of 50%cut-off value broken string quantity and outage (table four).
Table two shows, in the detection of negative sample, the control experiment of two groups of test card is set, and these two groups of test card are respectively existing test card (U) commonly used on the market and according to the improved test card 20 of the utility model (I).Its standard has three, respectively according to the performance level on the detection line 106, a standard is to exist on the detection line 106 greater than 1/2, bar less than 1, another standard is to exist on the detection line 106 greater than 1/4, bar less than 1/2, also having a standard is the bar that exists on the detection line 106 less than 1/4.Experimental result shows do not have improved test card also to have various " broken string " phenomenon, and the test card 20 in the employing present embodiment then greatly reduces the quantity and the ratio of broken string, has not had the broken string phenomenon fully.
Table two, the negative T line integrality statistical form that detects
Table three shows, in concentration be-pattern detection of 50%cut-off value in, the control experiment of two groups of test card 20 is set equally, standard is identical with above-mentioned negative sample test experience.Do not have improved test card also to have various " broken string " phenomenon, the quantity and the ratio of detection line 106 broken strings seldom exist and have broken phenomenon when adopting test card 20 in the present embodiment then to greatly reduce concentration for-50%cut-off value.For example in BZO detects, do not have improved test card to compare with improved test card 20, the quantity of broken string between 1/2 to 1 is reduced to 17 from 97, and the broken string ratio is reduced to 14.2%, the obvious broken string phenomenon and the outage that must improve product from 80.8%.
Table three ,-50%cut-off value detection T line integrality statistical form
Table four shows, in concentration be+pattern detection of 50%cut-off value in, the control experiment of two groups of test card 20 is set, standard is the same.Do not have improved test card 20 also to have various " broken string " phenomenon, the quantity and the ratio of detection line 106 broken strings seldom exist and have broken phenomenon when adopting test card 20 in the present embodiment then to greatly reduce concentration for+50%cut-off value.For example in BZO detects, do not have improved test card to compare with improved test card 20, the quantity of broken string between 1/2 to 1 is reduced to 11 from 57, and the broken string ratio is reduced to 9.2%, the obvious broken string phenomenon and the outage that must improve product from 47.5%.
Table four ,+50%cut-off value detection T line integrality statistical form
What present embodiment and embodiment 1 were different is, present embodiment provides a kind of test card 20, and this test card 20 can also comprise a lid.Lid can be used for cooperating with test card carrier 200 bottoms, and the sample region of acceptance 101 of detectable bar 100 is enclosed in the lid, and like this, the liquid sample on the sample region of acceptance 101 does not pollute the environment or the testee.
Embodiment 3
Different with embodiment 2 is, present embodiment also comprises a supporter, and this supporter is positioned at the behind of test card 20, and test card 20 is erected, and is convenient to operation.
Embodiment 4
Different with embodiment 1 is that as shown in Figure 4 and Figure 5, the test card 20 in the present embodiment is placed in the test chamber 225 of a urine cup 2.This urine cup 2 comprises bowl cover 21, collection well 221, and plunger shaft 224 and test chamber 225 wherein can liquid communication between collection well 221 and the test chamber 225.Comprise lid holder 210 and caping 211 on the bowl cover 21, a recess is arranged on caping 211, can be used to deposit the push rod 212 of a circle.Test card 20 is by a carrier 200, detectable bar 100, and panel 232 and test chamber lid 231 are formed.Panel 232 is paperys, is used for the surface of carrier 200 is sealed, and prints a series of product informations etc.Test chamber lid 231 is transparent plastics, can cover on the outside of carrier 200.Be plunger shaft 224 between collection well 221 and the test chamber 225, its effect is that the liquid in the collection well 221 is transferred in the test chamber 225, plunger shaft 224 is equipped with piston 223, this piston 223 has the primary importance and the second place, when piston 223 is positioned at primary importance, be obstructed between collection well 221 and the test chamber 225; When promoting piston 223 with push rod 212, piston 223 can arrive the second place from primary importance, at this moment, is in the liquid communication state between collection well 221 and the test chamber 225, and can detects.
Embodiment 5
Present embodiment provides another kind of test card 30.Different with embodiment 1 is, as Fig. 6, Fig. 7 and shown in Figure 8, comprise 5 draw-in grooves 301 on the board plug type test card carrier 30 as one kind 0 in the present embodiment, the width of draw-in groove 301 is greater than 100 of detectable bars, be 5.4mm ± 0.2mm (wherein the width of detectable bar 100 is 4mm) that draw-in groove is than the wide 1.4mm ± 0.2mm of detectable bar.Distance is evenly separated by 4 fence 302 between the draw-in groove 301 between draw-in groove 301 and the draw-in groove 301.A rectangular aperture 303 is set on each draw-in groove 301, and the position of marked region 102 is corresponding on the position of opening 303 and the detectable bar 100.Two pairs of serrations 304 are set on each draw-in groove 301, can be used for clamping reagent strip 100, play the effect of stable detection reagent strip 100.Wherein a pair of serration 304 is positioned at the top of draw-in groove 301, and another is positioned at the bottom of draw-in groove 301 to serration 304.
Same, the test card in the present embodiment has been carried out the integrality of detection line 106 (T line) " broken string " and tested and sensitivity experiment.The result shows that the test card 30 of present embodiment also has the effect that improves broken string preferably.
1. sensitivity experiment
As shown in Table 5, select for use 100 test card 30 as statistical experiment respectively.The result shows, the standard that can reach G8 of all negative samples; Most of concentration can reach the standard of G4 or G3.5, negative result for the-sample of 50%cut-off value after detection; Most of concentration also can reach the standard of G3, positive result for the+sample of 50%cut-off value after detection.The result of above-mentioned sensitivity experiment is reasonable, has all passed through to detect receptible scope.
Table five, the experiment of T line sensitivity
2. integrality experiment
In this experiment, comprise three groups of data, one group is the broken string quantity and the outage (table six) of the testing result of negative sample, one group is that concentration is-the pattern detection result's of 50%cut-off value broken string quantity and outage (table seven), also has one group to be that concentration is+the pattern detection result's of 50%cut-off value broken string quantity and outage (table eight).
Table six shows, in the detection of negative sample, the control experiment of two groups of test card is set, and these two groups of test card are respectively existing test card (U) commonly used on the market and according to the improved test card 30 of the utility model (I).Its standard is with embodiment 1, there are three, respectively according to the performance level on the detection line 106, a standard is to exist on the detection line 106 greater than 1/2, bar less than 1, another standard is to exist on the detection line 106 greater than 1/4, the bar less than 1/2, and also having a standard is the bar that exists on the detection line 106 less than 1/4.Experimental result shows do not have improved test card also to have various " broken string " phenomenon, and the test card 30 in the employing present embodiment then greatly reduces the quantity and the ratio of broken string, has not had the broken string phenomenon fully.
Table six, the negative T line integrality statistical form that detects
Table seven shows, in concentration be-pattern detection of 50%cut-off value in, the control experiment of two groups of test card is set, standard is the same.Do not have improved test card also to have various " broken string " phenomenon, the quantity and the ratio of detection line 106 broken strings seldom exist and have broken phenomenon when adopting test card 30 in the present embodiment then to greatly reduce concentration for-50%cut-off value.For example in THC detects, do not have improved test card to compare with improved test card 30, the quantity of broken string between 1/2 to 1 is reduced to 61 from 95; In the detection of MDMA, the quantity of broken string between 1/2 to 1 is reduced to 29 from 73; In the detection of BUP, the quantity of broken string between 1/2 to 1 is reduced to 0 from 82.On the whole, more than the test card 30 obvious broken string phenomenons that must improve product in the present embodiment have been said in experiment, have reduced outage.
Table seven ,-50%cut-off value detection T line integrality statistical form
Table eight shows, in concentration be+pattern detection of 50%cut-off value in, the control experiment of two groups of test card is set, standard is the same.Do not have improved test card also to have various " broken string " phenomenon, the quantity and the ratio of detection line 106 broken strings seldom exist and have broken phenomenon when adopting test card 30 in the present embodiment then to greatly reduce concentration for+50%cut-off value.For example in THC detects, do not have improved test card to compare with improved test card 30, the quantity of broken string between 1/2 to 1 is reduced to 10 from 52; In the detection of AMP, the quantity of broken string between 1/2 to 1 is reduced to 0 from 26; In the detection of OXY, the quantity of broken string between 1/2 to 1 is reduced to 2 from 43.On the whole, more than the test card 30 obvious broken string phenomenons that must improve product in the present embodiment have been said in experiment, have reduced outage.
Table eight ,+50%cut-off value detection T line integrality statistical form
Embodiment 6
Different with embodiment 5 is that as Fig. 9 and shown in Figure 10, the test card 30 in the present embodiment is placed in the test chamber 322 of a urine cup 3.This urine cup 3 comprises bowl cover 31, cup 32 and test card 30.Screw thread 310 is arranged on the bowl cover 31, corresponding, also there are 323, two screw threads of screw thread to work in coordination in the cup, make collection well be in the state of sealing.Wherein, cup comprises collection well 321 and test chamber 322, and the bottom of collection well 321 and test chamber 322 communicates.Test card 30 can be inserted in the test chamber 322 of cup 32.A rubber strip 306 is arranged at the top of test card 30, can form the cavity of a sealing on the opening of test chamber 322.There is the heel 307 of strip at the back of test card 30, can be used for test card 30 is fixed on test chamber 322.When being used for detecting sample and whether containing analyte, collect liquid sample earlier to collection well 321, because test chamber 322 is airtight, liquid sample in collecting chamber 321, can only be by the thin channel of bottom between collection well 321 and the test chamber 322, make a part of sample carry out pattern delivery and transportation, reach the purpose of detection by the sample receiving pad 101 of detectable bar 100.Liquid flow in test chamber 322, because test card 30 is carried out as the setting among the embodiment 5, can not produce capillarity in the space between test card plate carrier 30 as one kind 0 and the detectable bar 100 and carry out liquid flow, also can on the behind of detectable bar 100 and the space between the test card plate carrier 30 as one kind 0, not carry out liquid flow.
Claims (12)
1. a carrier that supports the detectable bar comprises the draw-in groove that holds the detectable bar, it is characterized in that, comprises the opening that blocking-up detectable bar liquid in addition flows on draw-in groove on the described draw-in groove.
2. carrier as claimed in claim 1 is characterized in that, the marked region of the corresponding at least detectable bar of described opening.
3. carrier as claimed in claim 2 is characterized in that described opening comprises rectangular aperture.
4. carrier as claimed in claim 3 is characterized in that described draw-in groove also comprises fence.
5. carrier as claimed in claim 1 is characterized in that the width of described draw-in groove is greater than the width of described detectable bar.
6. carrier as claimed in claim 5 is characterized in that, described draw-in groove is than the wide at least 1mm of detectable bar.
7. carrier as claimed in claim 6 is characterized in that, described draw-in groove is than between the wide 1mm to 15mm of detectable bar.
8. carrier as claimed in claim 5 is characterized in that, described draw-in groove is than wide 1.4mm of detectable bar or 1.5mm.
9. carrier as claimed in claim 1 is characterized in that, described draw-in groove also comprises makes the fixed fixed part of described detectable bar.
10. carrier as claimed in claim 9 is characterized in that described fixed part is used for fixing the suction zone of detectable bar.
11. carrier as claimed in claim 9 is characterized in that, described fixed part comprises the projection that is used for clamping detectable bar.
12. carrier as claimed in claim 1 is characterized in that, comprises on the described carrier that makes the upright supporter of carrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201641690U CN201273897Y (en) | 2008-09-18 | 2008-09-18 | Carrier for supporting detection reagent strip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201641690U CN201273897Y (en) | 2008-09-18 | 2008-09-18 | Carrier for supporting detection reagent strip |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201556599U Division CN201421446Y (en) | 2008-09-18 | 2008-09-18 | Carrier for supporting test reagent strip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201273897Y true CN201273897Y (en) | 2009-07-15 |
Family
ID=40884243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008201641690U Expired - Lifetime CN201273897Y (en) | 2008-09-18 | 2008-09-18 | Carrier for supporting detection reagent strip |
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| Country | Link |
|---|---|
| CN (1) | CN201273897Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101354398B (en) * | 2008-09-18 | 2013-02-27 | 艾博生物医药(杭州)有限公司 | Carrier for containing detection reagent strip |
| CN105606828A (en) * | 2016-01-21 | 2016-05-25 | 浙江东方基因生物制品有限公司 | Economical environment-friendly pregnancy test kit |
-
2008
- 2008-09-18 CN CNU2008201641690U patent/CN201273897Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101354398B (en) * | 2008-09-18 | 2013-02-27 | 艾博生物医药(杭州)有限公司 | Carrier for containing detection reagent strip |
| CN105606828A (en) * | 2016-01-21 | 2016-05-25 | 浙江东方基因生物制品有限公司 | Economical environment-friendly pregnancy test kit |
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