CN201189181Y - No-wound human cannon-bone lead content measuring device using polarization X-ray beam - Google Patents
No-wound human cannon-bone lead content measuring device using polarization X-ray beam Download PDFInfo
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- CN201189181Y CN201189181Y CNU200820067022XU CN200820067022U CN201189181Y CN 201189181 Y CN201189181 Y CN 201189181Y CN U200820067022X U CNU200820067022X U CN U200820067022XU CN 200820067022 U CN200820067022 U CN 200820067022U CN 201189181 Y CN201189181 Y CN 201189181Y
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- lead content
- aligner
- ray
- human tibia
- tibia
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Abstract
The utility model discloses a device for minimally invasively measuring the lead content of a shinbone of a human body by utilizing a polarization X ray beam, which relates to a device for measuring the lead content of the human body. The structure of the utility model is as follows: the device comprises a high-voltage power supply(1), an X ray generating tube(2), a polarizer(4), a front calibrator(5), a back calibrator(7), a detector(8), a controller(9), a multi-channel analyzer(10) and a follower(12) which are orderly connected, wherein a micro computer(11) is connected with the multi-channel analyzer(10); the shinbone of the human body is arranged between the front calibrator(5) and the back calibrator(7); and an X ray shielding plate(3) covers on the X ray generating tube(2) and shields the tested object. The device not only realizes the non-traumatic, painless, quick, safe, quantitative measurement of the lead content of the leg shinbone of the human body in longer time, but also simultaneously measures microelements in the bone such as calcium, zinc, strontium, and the like.
Description
Technical field
This utility model relates to a kind of device of measuring the human body lead content, and relating in particular to a kind of polarization X-ray beam that utilizes does not have the device that wound is measured the human tibia lead content.
Background technology
Lead is that the mankind are subjected to industry and environmental pollution to poison one of serious heavy metal trace element.Excessive lead can be caused the multiple disease of human body by the human body absorption, can make nervous system, hemopoietic system, urinary system, reproductive system, Liver and kidney metabolic system, blood circulation generation pathological changes; The people there is higher carcinogenic probability; Especially severe influences the normal development of juvenile intelligence and health, leads to child's IQ and reduces, and height stagnates long.
On the clinical medicine, the normal both at home and abroad at present human peripheral blood of gathering is analyzed blood lead content (standard GB11504-89) with accurate biochemical instruments such as sampling Graphite Furnace Atomic Absorption instrument (or plasma emission spectrometer), determines that 100 μ g/L are normal person's blood lead higher limit.Yet (be about 10ppb～1ppm), and the biological half-life of blood lead lacks (only more than 20 day), so the blood lead value only can reflect that recent human body is subjected to the situation of lead contamination because blood lead content is lower.And skeleton is saturnine target organ, and about 95% the lead of being grown up accumulates in the skeleton, and its biological half-life very long (from several years to decades, about 25 years of meansigma methods).Thus, the lead content in the skeleton can be represented the saturnine accumulative effect of human body, and the lead in the skeleton can be discharged in blood and its hetero-organization under certain conditions, so the plumbous still saturnine endogenous polluter of bone.As seen have only the lead content of measuring in the skeleton to be only the index (Lillian J Somervaille et al, phys, Med, Biol., 1985, vol.30, No.9,939～943) of determining the human body lead poisoning order of severity.
About the no wound analytical technology of bone lead, abroad once the someone reports and uses the isotope γYuan
109Cd did to measure (Sang Hoon Lee et al, Applied Radiation and Isotopes, Vol.54, Issue 6,2001,893～904) to people's lower limb tibia.In recent years, the inventor did many researchs in this field, and " human body phalanges lead density does not have wound measuring method and device thereof " wherein (June 29 2005 applying date, patent No. ZL200510019009.8) be gain the national patent power.This patent is used the isotope γYuan
57Co irradiation human finger bone, no wound is measured the density of human body internal skeleton lead.Yet, because γYuan
57The physical half time of Co is shorter, is not easy to medical detecting Instrument and uses for a long time.And because the maniphalanx volume is less, accurately measuring has certain degree of difficulty.Therefore it is very necessary to develop a kind of device of the measurement human body shank tibia lead that the polarization X-ray beam excites that uses, and not only the instrument useful life extends greatly, and because of tibia lead content height, the sensitivity of measurement is improved.
Summary of the invention
The purpose of this utility model is to overcome the existing defective of measuring human body blood lead technology, and the deficiency of measuring human finger bone lead with isotopic source, provide a kind of polarization X-ray beam that utilizes not have the device that wound is measured the human tibia lead content, for the clinical diagnosis of crowd's lead poisoning and environmental pollution surveys provide a kind of can life-time service, measure highly sensitive, novel technology media.In the lead of this device in measuring tibia, also can measure the nutrient of elements such as calcium in the tibia, zinc, strontium with the researching human body skeleton; If after doing suitably to improve, also can measure two important heavy metal element cadmium and the hydrargyrum in addition in human kidney and the liver.For detecting multi-metal more the murder by poisoning of human body is laid the foundation.
The purpose of this utility model is achieved in that
Specifically, this utility model is to utilize the polarization X-ray beam to human tibia extracorporeal irradiation safely, measure the content of lead element in the skeleton fast, its physical process is: the extraordinary X-ray tube that excites through high pressure penetrates unpolarized X ray, convert the partial polarization X-ray beam to by polariser, shine on the lead element in the tibia, inspire characteristic X-ray fluorescence, use the energy and the intensity of detector and multichannel analyzer direct analysis characteristic X-ray, thereby determine lead content in the tibia.
This utility model is made up of three parts:
First for exciting the part of polarization X-ray beam generation;
The acquisition of signal of the second characteristic X-ray fluorescence of being excited to discharge for bone lead, optical signal amplify, the distortion shaping unit;
The 3rd for photosignal by different energy, implements the multi-channel analysis under computer program controlled, export bone lead content part.
The utlity model has following advantage and good effect
1, compare with external prior art, this utility model adopts the polarization X-ray tube to replace isotopic source
57Co or
109The X ray excited fluorescence of Cd gamma ray projector, overcome the isotopic source half-life short (
57Co T
1/2Be 0.74,
109Cd T
1/2Be 1.27) shortcoming, can the long period measure utilization, be more suitable for the art of this patent exploitation is become the needs of medical detecting Instrument.
2, compare with the human peripheral blood lead content detection method that the detection of China's medical treatment at present department is using, this utility model is a kind of checkout gear that does not have wound, no pain, human body is accepted the X-ray irradiation dose of the dosage of x-ray bombardment much smaller than the thigh bone film making, thereby fool proof.In addition, on behalf of recent human body, the blood lead value can only be subjected to the level of lead contamination, can not characterize lead at intravital accumulative effect of people and endogenous hazard conditions, and the bone lead measurement can reach this purpose.
3, from process of measurement, the blood lead measurement is wanted sample preparation, is handled sample, and obtaining a result at last, it is more to take; And this utility model is worked under the instruction of computer programming, but output directly, analysis result fast.
4, this utility model can not only be finished the detection by quantitative of people's lower limb tibia lead element satisfactorily, and can measure the same period trace element such as the calcium in the skeleton, zinc, strontiums, for the nutrition of studying skeleton lays the foundation.
5, this utility model is suitably improved to measure in addition two important heavy metal pollution element cadmium, the content of hydrargyrum in liver and kidney, for the live body environment measuring provides a cover complete sequence.
In a word, this utility model not only to people's lower limb tibia lead element do not have wound, no pain, fast, safety, the detection by quantitative of long period, and can the same period trace element such as the calcium in the skeleton, zinc, strontium be measured.
Description of drawings
Fig. 1 is this utility model structural representation;
Fig. 2 is an X ray generator tube structure chart;
Fig. 3 is prime aligner, back level aligner structure chart;
Fig. 4 is the semiconductor detector structural representation;
Fig. 5 is modulator 9 block diagram;
Fig. 6 is a personal computer control multichannel analyzer block diagram;
Fig. 7 is the PbL XRF spectrum that the polarization X-ray beam excites.
Wherein:
The 1-high voltage power supply.
2-X ray generator tube;
2.1-cooling water channel; 2.2-tube chamber; 2.3-cathode filament;
2.4-anode; 2.5-second electron shield; 2.6-conical target;
2.7-attaching plug.
3-X is ray shielding sheet used.
The 4-polariser.
Aligner before the 5-,
The 6-tibia.
Aligner behind the 7-,
7.1-annulus; 7.2-calibration hole; 7.3-open the hole aluminium flake;
7.4-aperture adjustment device; 7.5-pedestal; 7.6-tongue.
The 8-detector;
8.1-probe; 8.2-electric refrigeration case; 8.3-cable.
The 9-modulator;
9.1-time-delay amplifier; 9.2-linear amplifier; 9.3-analog-digital converter.
The 10-multichannel analyzer;
10.1-amplifier; 10.2-standard linear gate; 10.3-crest chronotron;
10.4-SCA circuit; 10.5-ADC circuit;
The 11-personal computer,
11.1-keyboard or Mus mark; 11.2-controller; 11.3-display;
11.4-depositor; 11.5-I/O interface.
The 12-follower.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is described in detail:
One, overall
As Fig. 1, target of the present utility model is a human tibia 6;
This utility model comprises high voltage power supply 1, X ray generator tube 2, X ray barricade 3, polariser 4, preceding aligner 5, back aligner 7, detector 8, modulator 9, multichannel analyzer 10, personal computer 11 and follower 12;
High voltage power supply 1, X ray generator tube 2, polariser 4, preceding aligner 5, back aligner 7, detector 8, modulator 9, multichannel analyzer 10 are connected successively with follower 12;
Two, parts
1, high voltage power supply 1
High voltage power supply 1 produces, 50kv is provided high pressure, and power 1kw produces X ray in order to excitation ray generator tube 2.
2, the ray generator tube 2
As Fig. 2, X ray generator tube 2 comprises cooling water channel 2.1, X tube chamber 2.2, cathode filament 2.3, anode 2.4, second electron shield 2.5, conical target 2.6 and attaching plug 2.7;
Its position and annexation are:
In X tube chamber 2.2, from left to right, be disposed with attaching plug 2.7, cathode filament 2.3, anode 2.4, second electron shield 2.5 and conical target 2.6;
Outer wall at anode 2.4 is provided with cooling water channel 2.1.
The operation principle of X ray generator tube 2 is:
Cathode filament 2.3 electrons emitted are beaten on anode 2.4, reflect unpolarized X ray light beam by second electron shield 2.5 and conical target 2.6.
Anode 2.4 is made by the argent material, exports a kind of unpolarized parallel X-ray light beam, and the cross section of light beam is circular, and diameter is 1cm, power 1kw.
3, the X ray barricade 3
4, polariser 4
5, preceding aligner 5 and back aligner 7
Before the structure of aligner 5 and back aligner 7 the same, the polarization X-ray beam is incident in the tibia 6 through the about 45 in preceding aligner 5 collimation backs, 135 ° of angle outgoing have excited the lead element PbL spectrum in the tibia, again through after aligner 7 export after collimating.
As Fig. 3, back aligner 7 is made up of annulus 7.1, calibration hole 7.2, a hole aluminium flake 7.3, aperture adjustment device 7.4, pedestal 7.5 and tongue 7.6;
Its position and annexation are:
Be arranged with tongue 7.6 at pedestal 7.5; Front and back on pedestal 7.5 are respectively arranged with annulus 7.1, be provided with a hole aluminium flake 7.3 and regulate the aperture adjustment device 7.4 of calibration hole 7.2 sizes in annulus 7.1.
The operation principle of back aligner 7 is:
The shutter structure of similar camera, the position of adjusting tongue 7.6, the centrage that makes two calibration holes 7.2 is along X-ray Shu Fangxiang, and adjustment aperture actuator 7.4 is accurately collimated the outgoing X ray.
6, detector 8
As Fig. 4, detector 8 is made up of the probe 8.1, cable 8.3 and the electric refrigeration case 8.2 that connect successively.
The operation principle of detector 8 is:
Described probe 8.1 is a kind of silicon lithium (Si-Li) quasiconductors.
Described electric refrigeration case 8.2 is a kind of X-COOLER
TMThe II electric refrigeration device makes probe 8.1 be in operation under the low temperature.
7, modulator 9
As Fig. 5, modulator 9 is made up of the time-delay amplifier 9.1, linear amplifier 9.2 and the analog-digital converter 9.3 that connect successively.
The operation principle of modulator 9 is:
By the photoimpact of detector 8 outputs, through behind the pre-amplifying circuit, input modulator 9 carries out the analysis of conversion, linear amplification, signal screening and the spoke degree of signal waveform, input multichannel analyzer 10.
Time-delay amplifier 9.1 is selected the time-delay amplifier Model of U.S. CANBERRA company 1457 for use, and linear amplifier 9.2 is selected Model 2022 for use, and analog-digital converter 9.3 is selected Model 2015 for use.
8, multichannel analyzer 10 and personal computer 11
Constituted the hardware system of multichannel analyzer 10 by multiple tracks card and personal computer 11.
As Fig. 6, the structure of multichannel analyzer 10 is:
Amplifier 10.1, standard linear gate 10.2, crest chronotron 10.3, ADC10.5, connection successively; SCA10.4 is connected with ADC10.5 with standard linear gate 10.2 respectively;
The structure of personal computer 11 is:
Keyboard or mouse 11.1, controller 11.2 and I/O interface 11.5 are connected successively; Display 11.3 is connected with depositor 11.4, controller 11.2 respectively; Depositor 11.4 is connected with I/O interface 11.5.
I/O interface 11.5 is connected with follower (printer) 12.
The software system that the programming of being implemented by personal computer forms (separate case is declared national software copyright registration) has replenished the insufficient software function of conventional x-ray fluorescence analysis.
9, follower 12
Three, this device operation principle is:
By the X ray excited generator tube 2 of the high pressure of high voltage power supply 1 generation, produce unpolarized X ray light beam, form the partial polarization X-ray beam after injecting polariser 4, again behind preceding aligner 5 collimations, on the irradiation human tibia 6, make lead element generation PbLX fluorescence in the tibia, this XRF through after aligner 7 collimate back input detector 8 again, fluorescence signal is converted to the signal of telecommunication, amplify through modulator 9 again, distortion, input multichannel analyzer 10, under the instruction control of personal computer 11 program development softwares, the multichannel analyzer screen display goes out PbLXRF spectrum (Fig. 7), and to composing the peak area integral counting in fact between the inducing region of interest, this area integral counting is stored in the personal computer, on " artificial leg " tibia that makes with phantom (phantoms), and the Pb of the lead element of the known content of Zhu Ruing generation in advance
BodyThe LXRF spectrum, the peak area integral counting compares, thereby prints people's lower limb tibia lead content value ρ (μ g Pb/g bone) in follower 12." artificial leg " tibia phantom Gypsum Fibrosum (CaSO
42H
2O) mixing variable concentrations respectively is 0,10,30,60,100,150,210 (μ g Pbg
-1Gypsum Fibrosum) lead element is made diameter 27mm, and the cylinder of height 90mm constitutes.
In addition, radiolabeled biotin dose equivalent EDE≤5 μ SV that lower limb tibia irradiation 10min accepts, minimum detection limit (MDL) ρ that can survey in the lower limb tibia≤25 μ g Pb/gbone.
Claims (8)
1, a kind of polarization X-ray beam that utilizes does not have the device that wound is measured the human tibia lead content, it is characterized in that:
Comprise high voltage power supply (1), X ray generator tube (2), X ray barricade (3), polariser (4), preceding aligner (5), back aligner (7), detector (8), modulator (9), multichannel analyzer (10), personal computer (11) and follower (12);
High voltage power supply (1), X ray generator tube (2), polariser (4), preceding aligner (5), back aligner (7), detector (8), modulator (9), multichannel analyzer (10) are connected successively with follower (12);
Personal computer (11) is connected with multichannel analyzer (10);
Human tibia (6) places between preceding aligner (5) and the back aligner (7);
X ray barricade (3) covers on X ray generator tube (2) and goes up and shield tested object.
2, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that:
X ray generator tube (2) comprises cooling water channel (2.1), X tube chamber (2.2), cathode filament (2.3), anode (2.4), second electron shield (2.5), conical target (2.6) and attaching plug (2.7);
In X tube chamber (2.2), from left to right, be disposed with attaching plug (2.7), cathode filament (2.3), anode (2.4), second electron shield (2.5) and conical target (2.6);
Outer wall at anode (2.4) is provided with cooling water channel (2.1).
3, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that:
Polariser (4) is the thick 2-methacrylic acid flat board of a kind of 0.8～1.2cm.
4, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that:
Preceding aligner (5) is the same with the structure of back aligner (7), is made up of annulus (7.1), calibration hole (7.2), a hole aluminium flake (7.3), aperture adjustment device (7.4), pedestal (7.5) and tongue (7.6);
Below pedestal (7.5), be provided with tongue (7.6); Front and back end on pedestal (7.5) is respectively arranged with annulus (7.1), is provided with a hole aluminium flake (7.3) and regulates the aperture adjustment device (7.4) of calibration hole (7.2) size in annulus (7.1).
5, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that:
Detector (8) is made up of the probe (8.1), cable (8.3) and the electric refrigeration case (8.2) that connect successively;
Described probe (8.1) is a kind of silicon lithium quasiconductor;
Described electric refrigeration case (8.2) is a kind of X-COOLER
TMThe II electric refrigeration device.
6, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that:
Modulator (9) is made up of the time-delay amplifier (9.1), linear amplifier (9.2) and the analog-digital converter (9.3) that connect successively.
7, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that the structure of multichannel analyzer (10) is:
Amplifier (10.1), standard linear gate (10.2), crest chronotron (10.3), ADC (10.5), connection successively; SCA (10.4) is connected with ADC (10.5) with standard linear gate (10.2) respectively;
8, by the device of the described measurement human tibia of claim 1 lead content, it is characterized in that the structure of personal computer (11) is:
Keyboard or mouse (11.1), controller (11.2) are connected successively with I/O interface (11.5); Display (11.3) is connected with depositor (11.4), controller (11.2) respectively; Depositor (11.4) is connected with I/O interface (11.5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200820067022XU CN201189181Y (en) | 2008-05-08 | 2008-05-08 | No-wound human cannon-bone lead content measuring device using polarization X-ray beam |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200820067022XU CN201189181Y (en) | 2008-05-08 | 2008-05-08 | No-wound human cannon-bone lead content measuring device using polarization X-ray beam |
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| Publication Number | Publication Date |
|---|---|
| CN201189181Y true CN201189181Y (en) | 2009-02-04 |
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|---|---|---|---|
| CNU200820067022XU Expired - Lifetime CN201189181Y (en) | 2008-05-08 | 2008-05-08 | No-wound human cannon-bone lead content measuring device using polarization X-ray beam |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854131A (en) * | 2017-11-03 | 2018-03-30 | 武汉瑞博恩科技发展有限公司 | The noninvasive method of testing of tissue multielement and its device |
-
2008
- 2008-05-08 CN CNU200820067022XU patent/CN201189181Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854131A (en) * | 2017-11-03 | 2018-03-30 | 武汉瑞博恩科技发展有限公司 | The noninvasive method of testing of tissue multielement and its device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Wuhan Jianghan Meisi Technology Development Co., Ltd. Assignor: Wang Haiying Contract record no.: 2017420000011 Denomination of utility model: No-wound human cannon-bone lead content measuring device using polarization X-ray beam Granted publication date: 20090204 License type: Exclusive License Record date: 20170405 |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090204 |