CN203824909U - Multi-element in-vivo in-situ noninvasive analyzer for human tissue - Google Patents
Multi-element in-vivo in-situ noninvasive analyzer for human tissue Download PDFInfo
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- CN203824909U CN203824909U CN201420242975.0U CN201420242975U CN203824909U CN 203824909 U CN203824909 U CN 203824909U CN 201420242975 U CN201420242975 U CN 201420242975U CN 203824909 U CN203824909 U CN 203824909U
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Abstract
The utility model disclosesa multi-element in-vivo in-situ noninvasive analyzer for human tissue, and relates to the analysis technologyfor content of multiple chemical elements in the human tissue. The multi-element in-vivo in-situ noninvasive analyzer is structurally characterized in that a detected body (11) is placed on a detected body support (12); X-ray of a small X-ray exciter (1) in a movable probe gun metal body (14) irradiates the detected body (11) in the 45-degree direction; and a silicon drift detector (2) is placed in the 90-degree direction of an incident ray of the X-ray to receive X-ray characteristicfluorescence signals of detected elements.The multi-element in-vivo in-situ noninvasive analyze can perform concurrent analysis on multiple tissue and multiple elements, a position with the highest concentration of each detected element is selected as a ray irradiation position,and in-situ andin-vivo analysis is implemented, so that the disease diagnosis credibility is higher; a result can be obtained directly and quickly; and the supportive technical means is provided for diagnosis and treatment of nutritional deficiency, cardiovascular and cerebrovascularanomaly, abnormal glucose metabolism or a heavy metal poisoning disease.
Description
Technical field
The utility model relates to the analytical technology of number of chemical constituent content in a kind of tissue, relates in particular to a kind of tissue multielement live body original position without wound analyser.Specifically, relate to a kind of to the nutrient Fe(iron in human body sebum layer, bone and parathyroid tissue), Cu(copper), Zn(zinc) and disease is there is to the Cr(chromium of specific function), Sr(strontium) and I(iodine) quantitative measurment.
Background technology
Medicine clinical research is pointed out: the Fe element in tissue is the Main Ingredients and Appearance of synthetic hemoglobin, and in human body sebum, Fe content is the means of directly diagnosing thalassemia; Cu element is the primary raw material of composition plurality of enzymes, and the shortage of Cu can cause anaemia and brain disorder; Zn element participates in immunologic function, is the important element that impels human body intelligent, body development; Cr element in human organ is the factor that affects human body sugar tolerance in addition, significant to diagnosing diabetes; Sr element can reduce the absorption of Na in vivo, can reduce the risk that people suffers from cardiovascular and cerebrovascular diseases; The content of I element is the important evidence of Diagnosis of Thyroid Diseases.
According to deriving from:
1, " trace element and relevant disease ", Miao Jian chief editor, Henan Medical Univ. publishes (1997) Zhengzhou;
2, " element biology " Lv Xuanzhong, write publishing house of Chinese University of Science and Technology (2011) Hefei in cosmos etc.
On clinical medicine, in conventional chemistry and instrument analytical method (as molecular spectrum, atomic emissions, absorption spectrum and electrochemical analysis method etc.) mensuration human body fluid peripheral blood, urine, hair and nail, above-mentioned constituent content is determined the shortage of above-mentioned chemical element or excessive and judge relevant disease indirectly.
Above-mentioned class methods are to belong in vitro, destructive analysis, mostly need to be engaged in advance complicated sample preparation, easily cause environmental factor to disturb and produce error.Secondly sample of surveying is not all taken from these elements main storage organ in vivo, and therefore content concn is lower, can not element that Complete Characterization is surveyed actual action effect in vivo.
On domestic medical market, also have one to be called " trace element detector ", utilize strong illumination unguis hominis, by video collection, amplification, occur that from image underworld, red point, bright spot, stain philosophy illustrate that human body lacks the elements such as Ca, Fe, Zn, Se with high resolution camera.This class device is a kind of instrument of qualitative analysis, in regular hospital inspection, there is no practical value.
For the clinical medical requirement of China, need to found one directly, measure multiple element live body, original position, the quantitative analysis instrument relevant to medical diagnosis in tissue without wound.Abroad once someone reports and uses isotope
238pu gamma ray projector, to human body irradiation, is measured the content of iron, copper and zinc in sebum layer.（Bradli.?S,“Measurement?of?Elements?of?Fe,?Cu?and?Zn?in?skin?by?XRF”，J?of?Redioanal.?Nucl.?Chem（2000）244:?213-7.）
In recent years, the inventor had once done many inventions in this near field: the patent of invention " human body phalanges lead density is without invasive measurements method and device thereof " of being authorized by country (ZL2005100190098); The utility model patent of being authorized by country " utilizes polarization x beam to survey the device of human tibia lead content without wound wound " (ZL20082006 7022X); " based on radionuclide source without wound Bone Lead content measurement device " (ZL20092008 51925).
In order to seek elements are contained application widely in clinical medicine, for the digitized measurement of the content of the multiple chemical element very relevant to disease in the several tissues of human body, spy create one more novel, easily Fe, Cu, Zn, Cr, Sr, I various element fast, without wound tissue live body, in-situ analyzer.
Summary of the invention
The purpose of this utility model is just to overcome shortcoming and the problem that prior art exists, and provides a kind of tissue multielement live body original position without wound analyser.
The purpose of this utility model is achieved in that
The utility model is to utilize small-sized integrated x optical excitation device to launch homogeneous x rays (or discharging monoenergetic gamma rays by isotope 238Pu source) to be radiated respectively the examined tissue of human body (as people's arm, shank, sebum and bone, thyroid gland) correspondence causes tested element (Fe in tissue, Cu, Zn, Cr, Sr, I etc.) in the change of electron level, and discharge the ray fluorescence with respective element characteristic of correspondence x, then use the sensitiveest contemporary semiconductor detector (SDD) to obtain this x ray fluorescence spectrum, premenstrual storing is large again, digital-to-analog conversion, design the manipulation of instruction by microcomputer program, in digital pulse processor and display, directly obtain the concentration value (ppm) of each element.
Specifically, the target of this analysis instrument is surveyed body: human arm, people's leg shin bone or human thyroglobulin tissue;
Be provided with mini X-ray energizer, silicon drifting detector, prime amplifier, digital pulse processor, power supply, alternating current converter, USB interface, RS232 interface, notebook computer, printout device; Surveyed body bearing, surveyed body bearing Gu Jin Luo Rod, packaged type probe rifle metallic object, the 1st, 2 probe rifle tensioning clips probe rifles tighten up groove, metallic shield casing, cable link outlet, cable link entrance;
Its position and annexation are:
Digital pulse processor, power supply, alternating current converter, USB interface and RS232 interface are all placed in metallic shield casing;
Be connected with in turn in the upper right corner of metallic shield casing and surveyed body bearing Gu Jin Luo Rod, surveyed body bearing, surveyed body and be placed in and surveyed on body bearing;
Be connected with the 1st, 2 probe rifle tensioning clips in turn in the upper right side of metallic shield casing and probe rifle tightens up groove, packaged type probe rifle metallic object is placed in that probe rifle tightens up in groove or is hand-held;
The pop one's head in X-ray of the mini X-ray energizer in rifle metallic object of packaged type is irradiated and surveyed body by 45 degree directions; Silicon drifting detector is placed in the feature X-fluorescence signal of the 90 degree directions reception elements of surveying of the incident ray of X-ray;
Silicon drifting detector, prime amplifier, digital pulse processor, USB interface, RS232 interface, notebook computer and printout device are connected successively;
Power supply is connected with alternating current converter, obtains various voltage, and provides power supply to above-mentioned each parts.
The utlity model has following advantage and good effect:
1, compared with external existing research work, the utility model utilize packaged type probe rifle by small-sized x optical excitation device (or
238pu gamma ray projector energizer) and silicon drift SDD detector integrated apparatus, be convenient to human body different tissues (as arm sebum layer bone, shin bone sebum layer bone and thyroid gland organ), select the irradiation of different anchor points, excite multiple element feature x ray the same period, accept photosignal through detector again, proceed to digital pulse processor in casing, analyze the content of various elements.Analyze the same period of many tissues, multielement is the optimum characteristic of this technology.
Chemistry and the instrumental analysis comparison of the human body fluid (blood, urine) that 2, and at present medical institutions have applied or nail, mineral contents in hair, the former is in vitro, destructive method of analysis (In Vitro), and the utility model is a kind of AT, the directly quantitative test (In vivo) of live body, original position in tissue; Because the utility model technology, the radioactive dosage equivalent that human body is accepted is less than 1 μ sv, approach with the dosage of environmental setting, below one of percentage of conventional x light chest film making dosage (about 100-200 μ SV), therefore negligible to injury of human, therefore be called non-invasive analytical technology.Secondly, the utility model radiation exposure position is chosen in the highest position of tested concentration of element, enforcement be original position, in-vivo analysis, therefore higher to the confidence level of medical diagnosis on disease.
3, from process of measurement, chemistry and instrument analytical method in human body fluid (blood, urine) or nail, hair all need sample preparation and sample pre-treatments, finally obtain a result and take more (at least needing 7-8 hour), and the utility model is worked under the instruction of computer programming, can be directly, obtain a result fast, provide data and approximately only need 10 minutes from detecting.
If 4 further develop the utility model device; may be used in skeleton and kidney; measure the concentration of element in human body target organ such as poisoning the serious heavy metal Pb of human body, Cd, Hg, Cr, As, for diagnosis and treatment nutritional deficiency, cardiovascular and cerebrovascular are abnormal, the technological means that provides support of abnormal carbohydrate metabolism or heavy metal poisoning disease.
Brief description of the drawings
Fig. 1 is the structural representation of this analysis instrument;
Fig. 2 is the structural representation of mini X-ray energizer;
Fig. 3 is the structural representation (exploded view) of silicon drifting detector SDD;
Fig. 4 is the block diagram of prime amplifier;
Fig. 5 is the block diagram of digital pulse processor;
Fig. 6 is that power supply is supplied with summary block scheme;
Fig. 7 is the spectrum that multielement EDXRF analyzes each element;
In figure:
1-mini X-ray energizer
1.1-optical filter; 1.2-x ray tube; 1.3-high-voltage power supply; 1.4-Hi pilot;
2-silicon drifting detector (SDD)
2.1-Be window; 2.2-probe cover; 2.3-silicon is surveyed body; 2.4-FET field effect transistor;
2.5-electric refrigerator; 2.6-installation double-screw bolt
3-prime amplifier
3.1-pre-amplification circuit; 3.2-replacement logical circuit; 3.3-low pass filter;
4-digital pulse processor (DP5)
Filter before 4.1-simulation; 4.2-analog to digital converter; 4.3-digit pulse reshaper;
4.4-pulse choice logic device; 4.5-histogram logical circuit; 4.6-microcontroller interface;
5-power supply (PCS)
5.1-PC5 steering logic and digital-to-analog converter; 5.2-3.3V power supply; 5.3-DP5 pedestal;
5.4-+LV power supply, 5.5-LV power supply; 5.6-HV bias voltage;
5.7-thermoelectric cooling power supply;
6-alternating current converter;
7-USB interface;
8-RS232 interface;
9-notebook computer;
10-printout device;
11-surveyed body (as human arm);
12-surveyed body bearing;
13-surveyed body bearing Gu Jin Luo Rod;
14-packaged type probe rifle metallic object;
15.1,15.2-the 1,2 probe rifle tensioning clips;
16-probe rifle tightens up groove;
17-metallic shield casing;
The outlet of 18-cable link;
19-cable link entrance.
Embodiment
Below in conjunction with drawings and Examples, the utility model is described in detail:
One, overall
As Fig. 1, the target of this analysis instrument is surveyed body 11: human arm, people's leg shin bone or human thyroglobulin tissue;
Be provided with mini X-ray energizer 1, silicon drifting detector 2, prime amplifier 3, digital pulse processor 4, power supply 5, alternating current converter 6, USB interface 7, RS232 interface 8, notebook computer 9, printout device 10; Surveyed body bearing 12, surveyed body bearing Gu Jin Luo Rod 13, packaged type probe rifle metallic object 14, the 1st, 2 probe rifle tensioning clips 15.1,15.2, probe rifle tighten up groove 16, metallic shield casing 17, cable link outlet 18, cable link entrance 19;
Its position and annexation are:
Digital pulse processor 4, power supply 5, alternating current converter 6, USB interface 7 and RS232 interface 8 are all placed in metallic shield casing 17;
Be connected with in turn in the upper right corner of metallic shield casing 17 and surveyed body bearing Gu Jin Luo Rod 13, surveyed body bearing 12, surveyed body 11 and be placed in and surveyed on body bearing 12;
Be connected with the 1st, 2 probe rifle tensioning clips 15.1,15.2 and probe rifle in the upper right side of metallic shield casing 17 in turn and tighten up groove 16, packaged type probe rifle metallic object 14 is placed in that probe rifle tightens up in groove 16 or is hand-held;
The pop one's head in X-ray of the mini X-ray energizer 1 in rifle metallic object 14 of packaged type is irradiated and surveyed body 11 by 45 degree directions; Silicon drifting detector 2 is placed in the feature X-fluorescence signal of the 90 degree directions reception elements of surveying of the incident ray of X-ray;
Silicon drifting detector 2, prime amplifier 3, digital pulse processor 4, USB interface 7, RS232 interface 8, notebook computer 9 and printout device 10 are connected successively;
Power supply 5 is connected with alternating current converter 6, obtains various voltage, and provides power supply to above-mentioned each parts.
Two, parts
1, small-sized integrated X-ray energizer 1
As Fig. 2, small-sized integrated X-ray energizer 1 comprises and connects successively high-voltage power supply 1.3, Hi pilot 1.4, X-ray tube 1.2 and X-ray optical filter 1.1.
High-voltage power supply 1.3 provides 10～50KV high direct voltage, and power 100W, in order to encourage X-ray tube (anode A g target) 1.2; High voltage control is completed by Hi pilot 1.4; X-ray exit portal has X-ray optical filter 1.1, makes to obtain good monochromaticity.
X-ray optical filter 1.1 is made up of metallic aluminium film.
X-ray tube (anode A g target) the 1.2nd, a kind of general-purpose device.
High-voltage power supply 1.3 is a kind of general-purpose devices.
Hi pilot 1.4 is a kind of general-purpose devices.
2, silicon drifting detector (SDD) 2
Silicon drifting detector (SDD) the 2nd, a kind of semiconductor detector, selects AXRSDDdetector.
As Fig. 3, silicon drifting detector 2 is surveyed body 2.3, FET field effect transistor 2.4, electric refrigerator 2.5 and double-screw bolt 2.6 is installed by beryllium window (Be) 2.1, probe cover 2.2, silicon and forms.
The principle of work of silicon drifting detector 2 is:
Silicon drifting detector 2 is a kind of silicon drift semiconductor detectors, implements the function of opto-electronic conversion, and the feature X-fluorescence that is about to receive converts electric pulse to; Utilize thermoelectric peltier refrigeration principle that silicon drifting detector 2 is applied at normal temperatures.
3, prime amplifier 3
Prime amplifier 3 is selected PA210,230 preamplifier.
As Fig. 4, prime amplifier 3 forms by connecting successively pre-amplification circuit 3.1, replacement logical circuit 3.2 and low pass filter 3.3, and photoimpact is implemented to preposition amplification.
4, digital pulse processor 4
Digital pulse processor 4 is selected DP5 Digital pulse processor.
As Fig. 5, the structure of digital pulse processor 4 is: before simulation, filter 4.1, analog to digital converter 4.2, digit pulse reshaper 4.3, histogram logic electrical equipment 4.5 are connected successively with microcontroller interface 4.6, pulse choice logic device 4.4 is exported from analog to digital converter 4.2, jumps to histogram logical circuit 4.5.
5, Power Supply Unit
Power Supply Unit is a kind of general-purpose device.
As Fig. 6, comprise ± 1.5KV HV bias voltage, ± 5V, ± 8.5VLV, ± 3.3V, 0～3.6V thermoelectric cooling supply voltage, unification completes power supply by PC5 steering logic and digital-to-analog converter under extraneous instruction.
6, notebook computer 9
Notebook computer 9 is selected the G510AT-1F1 of association implementation procedure design and control and measured spectrum screen display.
7, printout device 10
Printout device 10 selects Epson ME2 miniature laser printer directly to export surveyed constituent content (ppm).
Three, the principle of work of this analysis instrument is:
The high-voltage power supply 1.3 of being controlled by Hi pilot 1.4 is exported the X ray excited pipe 1.2 of 10～50KV high pressure and is produced X ray, exports the better X ray light of monochromaticity through optical filter 1.1, is radiated subject (as people's arm cortex and bone surface).Electron level by the atom in the element of X ray effect changes, discharge should be able to be differential with each element electron pair characteristic X-ray fluorescence, (as the Zn Element release in sebum layer goes out K
α8.60Kev, in bone, Sr discharges K
αthe characteristic X-ray of 14.1Kev).These rays are received by silicon drifting detector 2, and fluorescence signal is converted to electric pulse.Tentatively amplify through prime amplifier 3 again, send into digital pulse processor 4 and carry out analog to digital conversion, signal amplifies again, shaping pulse, and logic is selected, and under the control of personal computer program design instruction, implements Multi channel spectrum analysis.On computer screen, demonstrate the XRF collection of illustrative plates (see figure 7) of institute's analytical element.
To be surveyed the clean intergral counting rate of the peak area of certain tested element in power spectrum in body (human arm, people's leg shin bone or human thyroglobulin tissue), compare with the clean intergral counting rate of body mould (phantoms) peak area of control sample (known this concentration of element), can calculate the content (ppm) of being surveyed this element in body by computer.
Control sample (body mould) (phantoms) is divided into three types:
1) Sr in bone, Cr elements are contained: body mould application gypsum carrier is mixed Sr, Cr compound is made reference material; The animal sebum layer of outsourcing different-thickness.
2) measurement of Fe, Cu, Zn element in sebum layer, body mould and computing method and 1) similar, institute's difference be gypsum not make element carrier be only background body, cured Fe, Cu, the Zn compound formation sebum layer mixed of silica for the carrier of element.
3) the measurement body mould and method and 1 of the I element in thyroid gland) similar, institute's difference is for making element carrier, outsourcing animal sebum layer with the cured I of the mixing compound of silica.
Claims (4)
1. tissue multielement live body original position is without a wound analyser, and its target is surveyed body (11): human arm, people's leg shin bone or human thyroglobulin tissue;
It is characterized in that:
Be provided with mini X-ray energizer (1), silicon drifting detector (2), prime amplifier (3), digital pulse processor (4), power supply (5), alternating current converter (6), USB interface (7), RS232 interface (8), notebook computer (9), printout device (10); Surveyed body bearing (12), surveyed body bearing Gu Jin Luo Rod (13), packaged type probe rifle metallic object (14), the 1st, 2 probe rifle tensioning clips (15.1,15.2), probe rifle tighten up groove (16), metallic shield casing (17), cable link outlet (18), cable link entrance (19);
Its position and annexation are:
Digital pulse processor (4), power supply (5), alternating current converter (6), USB interface (7) and RS232 interface (8) are all placed in metallic shield casing (17);
Be connected with in turn in the upper right corner of metallic shield casing (17) and surveyed body bearing Gu Jin Luo Rod (13), surveyed body bearing (12), surveyed body (11) and be placed in and surveyed on body bearing (12);
Be connected with the 1st, 2 probe rifle tensioning clips (15.1,15.2) in turn in the upper right side of metallic shield casing (17) and probe rifle tightens up groove (16), packaged type probe rifle metallic object (14) is placed in probe rifle, and to tighten up groove (16) interior or hand-held;
The pop one's head in X-ray of the mini X-ray energizer (1) in rifle metallic object (14) of packaged type is irradiated and surveyed body (11) by 45 degree directions; Silicon drifting detector (2) is placed in the feature X-fluorescence signal of the 90 degree directions reception elements of surveying of the incident ray of X-ray;
Silicon drifting detector (2), prime amplifier (3), digital pulse processor (4), USB interface (7), RS232 interface (8), notebook computer (9) and printout device (10) are connected successively;
Power supply (5) is connected with alternating current converter (6), obtains various voltage, and provides power supply to above-mentioned each parts.
2. press tissue multielement live body original position claimed in claim 1 without wound analyser, it is characterized in that:
Described small-sized integrated X-ray energizer (1) comprises and connects successively high-voltage power supply (1.3), Hi pilot (1.4), X-ray tube (1.2) and X-ray optical filter (1.1).
3. press tissue multielement live body original position claimed in claim 1 without wound analyser, it is characterized in that:
Described prime amplifier (3) forms by connecting successively pre-amplification circuit (3.1), replacement logical circuit (3.2) and low pass filter (3.3).
4. press tissue multielement live body original position claimed in claim 1 without wound analyser, it is characterized in that:
The structure of described digital pulse processor (4) is: before simulation, filter (4.1), analog to digital converter (4.2), digit pulse reshaper (4.3), histogram logic electrical equipment (4.5) are connected successively with microcontroller interface (4.6), pulse choice logic device (4.4), from analog to digital converter (4.2) output, jumps to histogram logical circuit (4.5).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420242975.0U CN203824909U (en) | 2014-05-13 | 2014-05-13 | Multi-element in-vivo in-situ noninvasive analyzer for human tissue |
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| CN201420242975.0U CN203824909U (en) | 2014-05-13 | 2014-05-13 | Multi-element in-vivo in-situ noninvasive analyzer for human tissue |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854131A (en) * | 2017-11-03 | 2018-03-30 | 武汉瑞博恩科技发展有限公司 | The noninvasive method of testing of tissue multielement and its device |
| CN109106452A (en) * | 2018-10-11 | 2019-01-01 | 中国疾病预防控制中心辐射防护与核安全医学所 | It is a kind of for measuring the fixation bracket of human thyroglobulin iodine |
| WO2020047835A1 (en) * | 2018-09-07 | 2020-03-12 | Shenzhen Xpectvision Technology Co., Ltd. | Systems and methods for imaging the thyroid |
| CN111568382A (en) * | 2020-05-21 | 2020-08-25 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
-
2014
- 2014-05-13 CN CN201420242975.0U patent/CN203824909U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854131A (en) * | 2017-11-03 | 2018-03-30 | 武汉瑞博恩科技发展有限公司 | The noninvasive method of testing of tissue multielement and its device |
| WO2020047835A1 (en) * | 2018-09-07 | 2020-03-12 | Shenzhen Xpectvision Technology Co., Ltd. | Systems and methods for imaging the thyroid |
| CN109106452A (en) * | 2018-10-11 | 2019-01-01 | 中国疾病预防控制中心辐射防护与核安全医学所 | It is a kind of for measuring the fixation bracket of human thyroglobulin iodine |
| CN109106452B (en) * | 2018-10-11 | 2020-06-19 | 中国疾病预防控制中心辐射防护与核安全医学所 | Fixing support for measuring human body thyroid iodine |
| CN111568382A (en) * | 2020-05-21 | 2020-08-25 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
| CN111568382B (en) * | 2020-05-21 | 2023-04-07 | 中国计量科学研究院 | Intelligent measurement system for intra-thyroid irradiation iodine measurement |
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Granted publication date: 20140910 |
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| CF01 | Termination of patent right due to non-payment of annual fee |