CN201160925Y - Degradable artificial tracheal tube stent with transverse pipeline - Google Patents
Degradable artificial tracheal tube stent with transverse pipeline Download PDFInfo
- Publication number
- CN201160925Y CN201160925Y CNU2008200558662U CN200820055866U CN201160925Y CN 201160925 Y CN201160925 Y CN 201160925Y CN U2008200558662 U CNU2008200558662 U CN U2008200558662U CN 200820055866 U CN200820055866 U CN 200820055866U CN 201160925 Y CN201160925 Y CN 201160925Y
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- trachea
- double
- monofilament
- bracket
- tube wall
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Abstract
The utility model relates to a degrade artificial trachea bracket with a transverse pipeline, which belongs to the technical field of biological medicines. The artificial trachea bracket is characterized in that a circular tube is formed by the weave of poly double-oxygen cyclohexanone monofilaments or poly glycolide monofilaments; the ordinate axis of the tube wall is transversely encircled by tubular small rings which are in monolayer and double-layer arrangement at intervals; the inner layer of the tube wall is evenly covered by collagen and chitosan in sequence. After the artificial trachea bracket is applied, the thrill of the sticking patch for the body tissue is decreased, and the infection resistant ability is strong; the reconstruction of the trachea is facilitated, the double-layer structure can contain a bracket which performs the restoration of a cartilage ring of the trachea, and the double restoration of an impairment trachea on the physiological anatomy and the function can be realized; the inner layer is provided with the chitosan coating, thereby facilitating the creeping restoration of the endodermis of the trachea.
Description
Technical field
This utility model relates to the biological medicine technology field, specifically a kind of degradable artificial trachea bracket.
Background technology
Trachea is because of reasons such as tumor or wounds, often need carry out the part excision, when the trachea resection length greater than 6cm, when being equivalent to 10-12 cartilaginous ring, can not carry out directly coincideing because of the anastomotic stoma overtension, just need repair at this moment with artificial trachea.Utilize the existing over half a century of research of artificial material displacement trachea, before nineteen ninety, the material of artificial trachea mostly is silicone rubber tube and rustless steel.The artificial trachea prosthese is divided into two big classes by the porose no sky of tube wall at present, and the anapsid artificial trachea is representative with silica gel tube (Neville pipe).Its advantage is pliable and tough flexible, and plasticity is strong, and the good and ne-leakage of air-tightness can be avoided infection, and the smooth secretions that helps of inner chamber is discharged, but comes off, suffocates easily, even corrodes trunk, and severe complications such as massive hemorrhage take place.Stainless steel silk, titanium net, Marlex net etc. are in succession as the research that the pass artificial trachea is arranged, but, in the long-term existence body, cause inevitable infection, trachea bed chronic ulcer, leakage and granulation tissue hyperplasia owing to can not degrade, cause luminal stenosis at last, cause dyspnea.Therefore engineered artificial trachea becomes the focus of present artificial trachea research, it is to utilize degradable biomaterial, in conjunction with cell separation and culture technique, make trachea regeneration, Vacanti etc. utilize cartilage tissue engineered technology successfully to prepare the piped cartilage of circle, but it can only guarantee the unobstructed of trachea, it is limited to repair length, can only reach 2.5cm, its inner face can not be climbed and be stretched tracheal epithelium in addition, and does not reach the reconstruction of anatomical structure.
Summary of the invention
This utility model provides and can guarantee the unobstructed of trachea, and artificial trachea reparation inner face can be climbed and be stretched tracheal epithelium, makes trachea regeneration can reach the degradable artificial trachea bracket of the band horizontal pipeline of anatomical structure reconstruction.
The technical scheme that this utility model is taked:
The degradable artificial trachea bracket of band horizontal pipeline, comprise the artificial trachea support, its scheme is: constitute the pipe shape by polydioxanone monofilament or the braiding of poly-Acetic acid, hydroxy-, bimol. cyclic ester monofilament, ground, tube wall longitudinal axis lateral separation is around the little ring of tubulose that is made of double-deck monofilament braiding; Between tube wall internal layer monofilament evenly bonding, monofilament surface evenly covers collagen protein, cover housing polysaccharide successively again on it.
Good effect behind enforcement this utility model is:
Because used Biodegradable material, so this sticking patch is little for the zest of tissue, anti-infection ability is stronger; Reconstruction for trachea, it has overcome the shortcoming that the conventional repair method is only carried out functional rehabilitation, its double-decker part (being horizontal pipeline) can be held the support that carries out the tracheal rings reparation, its single-layer portions can be repaired tissue between cartilaginous ring by growing into of fibrous tissue, the early stage stability of trachea is kept by the artificial trachea support of overall cylindrical structure like this, the stability in later stage then can be kept by regenerated cartilaginous ring and newborn fibrous connective tissue fully, finally reaches the dual reparation on damaged trachea dissect physiology and the function.Because internal layer has also carried out the coating of chitosan, help the reparation of creeping of trachea endothelium in addition.
Description of drawings
Fig. 1, be artificial trachea bracket perspective view,
Fig. 2, be artificial trachea bracket pipe planar development sketch map,
Fig. 3, part monolayer weave diagram,
Fig. 4, double-deck (the little ring of the tubulose) weave diagram of part,
Fig. 5, full width looming draft.
The specific embodiment
Now the utility model is described in further detail in conjunction with the accompanying drawings
The degradable artificial trachea bracket comprises the artificial trachea support, and its structure is: constitute pipe shape 2 by polydioxanone monofilament 1 or the braiding of poly-Acetic acid, hydroxy-, bimol. cyclic ester monofilament, ground, tube wall longitudinal axis lateral separation is around the little ring 3 of tubulose that is made of double-deck monofilament braiding; Between tube wall internal layer monofilament evenly bonding, monofilament surface evenly covers collagen protein 4, cover housing polysaccharide 5 successively again on it.
The manufacture method of degradable artificial trachea bracket is to operate according to the following steps to finish:
1. constitute pipe shape 2 by the braiding of polydioxanone monofilament 1 or poly-Acetic acid, hydroxy-, bimol. cyclic ester monofilament, ground, tube wall longitudinal axis lateral separation is around the little ring 3 of tubulose that is made of double-deck monofilament braiding,
2. be dipped in 2% collagen solution and take out after 3 minutes, drying,
3. evenly, closely be applied to the internal layer aspect with 2% chitosan solution,, keep air-tightness with the sealing mesh.
4. the sterilization, dry for standby.
Described solution concentration is percetage by weight concentration.
Embodiment 1
1. by being the poly-Acetic acid, hydroxy-, bimol. cyclic ester monofilament of diameter 0.15mm through the weft yarn raw material; A (E) partial width 2cm, 40 * 40/cm of thread count; B (F) partial width 1.5cm, 40 * 45/cm of thread count; Fabric consists of ABABABA;
2. in the little ring of the tubulose that constitutes by double-layer tube wall of tube wall longitudinal axis lateral circular, laxly fill in anti-blocking mould;
3. be dipped in 2% collagen solution and take out drying after 3 minutes;
4. evenly, closely be applied to the internal layer aspect with 2% chitosan solution,, keep air-tightness with the sealing mesh;
5. the final vacuum drying of sterilizing is sealed under 4 ℃ of conditions and preserves.
1. by being diameter 0.27mm polydioxanone monofilament through the weft yarn raw material, A (E) partial width 1.5cm, 20 * 20/cm of thread count; B (F) partial width 1cm, 20 * 22/cm of thread count; Fabric consists of ABABA;
2. in the little ring of the tubulose that constitutes by double-layer tube wall of tube wall longitudinal axis lateral circular, laxly fill in anti-blocking mould;
3. be dipped in 2% collagen solution and take out drying after 3 minutes;
4. evenly, closely be applied to the internal layer aspect with 2% chitosan solution,, keep air-tightness with the sealing mesh;
5. the final vacuum drying of sterilizing is sealed under 4 ℃ of conditions and preserves.
Claims (1)
1, the degradable artificial trachea bracket of band horizontal pipeline, comprise the artificial trachea support, it is characterized in that: constitute pipe shape (2) by polydioxanone monofilament (1) or the braiding of poly-Acetic acid, hydroxy-, bimol. cyclic ester monofilament, ground, tube wall longitudinal axis lateral separation is around the little ring of tubulose (3) that is made of double-deck monofilament braiding; Between tube wall internal layer monofilament evenly bonding, monofilament surface evenly covers collagen protein (4), cover housing polysaccharide (5) successively again on it.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200558662U CN201160925Y (en) | 2008-03-03 | 2008-03-03 | Degradable artificial tracheal tube stent with transverse pipeline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200558662U CN201160925Y (en) | 2008-03-03 | 2008-03-03 | Degradable artificial tracheal tube stent with transverse pipeline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201160925Y true CN201160925Y (en) | 2008-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008200558662U Expired - Fee Related CN201160925Y (en) | 2008-03-03 | 2008-03-03 | Degradable artificial tracheal tube stent with transverse pipeline |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201160925Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102011238A (en) * | 2010-11-11 | 2011-04-13 | 东华大学 | Machine woven artificial trachea |
| CN106344231A (en) * | 2016-10-27 | 2017-01-25 | 中国人民解放军第四军医大学 | 3D (three-dimensional) printing degradable trachea outer stent for treating tracheostenosis and manufacturing method thereof |
-
2008
- 2008-03-03 CN CNU2008200558662U patent/CN201160925Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102011238A (en) * | 2010-11-11 | 2011-04-13 | 东华大学 | Machine woven artificial trachea |
| CN106344231A (en) * | 2016-10-27 | 2017-01-25 | 中国人民解放军第四军医大学 | 3D (three-dimensional) printing degradable trachea outer stent for treating tracheostenosis and manufacturing method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081210 Termination date: 20110303 |