CN201154005Y - Knee joint cruciate ligaments for medical service - Google Patents
Knee joint cruciate ligaments for medical service Download PDFInfo
- Publication number
- CN201154005Y CN201154005Y CNU2007201318002U CN200720131800U CN201154005Y CN 201154005 Y CN201154005 Y CN 201154005Y CN U2007201318002 U CNU2007201318002 U CN U2007201318002U CN 200720131800 U CN200720131800 U CN 200720131800U CN 201154005 Y CN201154005 Y CN 201154005Y
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- ligament
- fibroin fiber
- knee joint
- cruciate ligaments
- cross ligament
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Abstract
The utility model provides a medical knee cross ligament, which is mainly formed by fibroin fiber cross ligament woven with silk and I-type collagen; the I-type collagen covers on the fibroin fiber cross ligament. The ligament has the advantages that the production is convenient, the cost is low, the transplant operation is simple, convenient, safe, and reliable during the use, etc. Since the fibroin fiber without sericin has fine mechanical property and biocompatibility, can undertake the functions of stabilizing the knee by the natural cross ligament, the load transmission, and the protection on articular cartilage at the early stage of the transplant, and can support the cell growth and the growth of the blood vessels at the late stage of the transplant, and can be degraded and absorbed along with the growth of the self-body tissue and the regeneration of the cross ligament, a new option is provided for the treatment of the patient having badly damaged knee cross ligament which loses the function.
Description
Technical field
This utility model relates to a kind of medical ligamentaum cruciatum, is specifically related to a kind of medical degradable, absorbable cruciate ligaments of knee joint, belongs to the prosthetic material field.
Background technology
Ligamentaum cruciatum is arranged in knee joint, plays the effect that toughness connects, and keeps the stable and coordination joint motions in joint, is most important regulator.Ligament still be various nutritional labelings transmission medium and accumulate the place, also be the extraneous albumen of opposing, comprise the mechanical barrier of antigen, virus and antibacterial.In daily life, the probability that damage appears in ligament is quite high, and its consequence then is the degeneration that causes its hetero-organization unstable and at a specified future date that causes the joint after hindering immediately.Especially in the osteoarthritis patient, ligament injury has been proved to be one of important early stage inducement.Along with to the going deep into of ligamentaum cruciatum 26S Proteasome Structure and Function cognition, the importance of ligamentaum cruciatum gains public acceptance, but the self-repairing capability of ligament is very poor, and the ligament after the damage must be by operating substitution to recover its function.The substitute of treatment ligament injury mainly comprises two big classes: a class is an alloplast, comprises autograft and allotransplant, and autograft is drawn materials conveniently, be need not sterilization, but exist big from the body wound, for distinguishing problems such as inflammation and graft atrophy; And the transplanting of allogeneic ligamentaum cruciatum exists source deficiency, immunological rejection, potential pathophoresis risk etc., thereby has also limited its clinical practice.Second class is the artificial ligament of exploitation thereafter, but it exists material and bone surface to wear and tear in clinical practice and problem such as stress fatigue thereby fail to obtain good effect.
In recent years, the development of tissue engineering technique demonstrates its great potential in ligament repair is rebuild.The utilization method of tissue engineering is a carrier with the timbering material, integrate to separate seed cell, makes up lived implantation body in advance external, plants in the human body damagedly with repair tissue, substitutes the back and rebuilds organ structure and keep and improve tissue organ function.Up to now, the timbering material that is used for the research of ligament injury reparation is broadly divided into two kinds of synthesized degradable material and natural biologic materials.The general cellular affinity of synthesized degradable material is relatively poor, compares natural biologic material, the synthetic material inducing cell the ability of sticking, growing and breaking up on its surface a little less than.
Summary of the invention
The purpose of this utility model is be to solve patient's cruciate ligaments of knee joint to damage apraxia, and a kind of degradable, absorbable medical knee joint cruciate ligaments of medical alternative damage ligamentaum cruciatum is provided.
Medical knee joint cruciate ligaments of the present utility model, its structure mainly comprise the fibroin fiber ligamentaum cruciatum and the type i collagen of silkworm silk braiding, and described type i collagen is coated on the fibroin fiber ligamentaum cruciatum.
Described fibroin fiber ligamentaum cruciatum is woven into the pigtail shape by three beams silkworm silk after come unstuck and form.
Have the following advantages with medical knee joint cruciate ligaments of the present utility model:
1, provides a kind of new selection approach for treating clinical ligamentaum cruciatum damage, be particularly useful for the patient of the badly damaged apraxia of cruciate ligaments of knee joint, filled up the blank in this field.
2, the artificial ligamentaum cruciatum prosthese of fibroin fiber-collagen-based composite is to integrate fibroin fiber and collagen, in line with the thought of learning from other's strong points to offset one's weaknesses, make the artificial ligamentaum cruciatum of fibroin fiber-collagen-based composite on mechanics, satisfy the ligamentaum cruciatum requirement, fibroin fiber after coming unstuck is as natural macromolecular material, possess the good mechanical performance, aspect biocompatibility, be better than traditional synthetic degradable high polymer material simultaneously again.Transplanting the early stage ligamentaum cruciatum of just bearing to the kneed protective effect of stablizing, loading conduction and articular cartilage.Possess simultaneously the effect of tissue engineering bracket again, transplant the later stage again can the sustenticular cell growth and blood vessel grow into, and be accompanied by the regeneration of genuine natural ligamentaum cruciatum and degraded and absorbed gradually.
3, the proteic knitting arrangement of silk fiber of the artificial ligamentaum cruciatum prosthese of fibroin fiber-collagen-based composite has the biomechanical property similar to the live body ligament, collagen is handled the back through lyophilizing can keep its form on the one hand, and a large amount of holes of its inner generation are beneficial to histiocyte and grow on the other hand.
4, also have prosthese transplant simple and convenient, safe and reliable, advantage such as patient tolerability is good, and immunogenicity is little and convenient for production, with low cost, be easy to popularize.
Description of drawings
Fig. 1 is a kind of structural representation of medical knee joint cruciate ligaments of the present utility model;
Fig. 2 is a medical knee joint cruciate ligaments of the present utility model structural representation when implanting knee joint.
The specific embodiment
Following structure accompanying drawing is further described this utility model.
Referring to accompanying drawing 1,1 among the figure is woven into the fibroin fiber ligamentaum cruciatum that the silk ribbon of pigtail shape forms through coming unstuck, the 2nd, type i collagen by three beams silkworm silk.Described type i collagen 2 is coated on the fibroin fiber ligamentaum cruciatum 1.During making, select the high-quality silkworm silk of suitable length earlier for use, calculate the radical that weaves silkworm silk according to the biomechanics requirement of ligament, it is divided into three parts, the pigtail shape is woven to rectangular rope sample silkworm silk ligamentaum cruciatum.Then the silkworm silk ligamentaum cruciatum is placed 0.5% sodium carbonate (Na
2CO
3) be heated to 100 ℃ of lasting half an hour in the solution, take out with behind the water rinse, place 0.5% sodium carbonate (Na of preparation again again
2CO
3) be heated to 100 ℃ of lasting half an hour in the solution, take out with water rinse, drying, silkworm silk is come unstuck be the fibroin fiber ligamentaum cruciatum.Again the fibroin fiber ligamentaum cruciatum is placed the mould identical to inject type i collagen solution with the cruciate ligaments of knee joint shape, place 4 ℃ of refrigerators to leave standstill a few hours earlier, type i collagen solution is fully immersed in the fibroin fiber ligamentaum cruciatum, change over to again in-80 ℃ of refrigerators and leave standstill typing, take out the demoulding then, change over to again in the freezer dryer after the drying, be the compound ligamentaum cruciatum of fibroin fiber-collagen.At last the compound ligamentaum cruciatum of fibroin fiber-collagen is stored with ethylene oxide gas sterilization back individual packaging and be medical knee joint cruciate ligaments.
During use, at first use locating apparatus to orient the ligamentaum cruciatum dead-centre position at knee joint peripheral tibia end and femur end, utilize guider to get out the osseous tunnel 5 of appropriate length in this position, as shown in Figure 2, the two ends of medical knee joint cruciate ligaments 4 are placed in respectively in the osseous tunnel 5 of tibia end and femur end, with can absorption screw 3 upwards screwing in the osseous tunnel along the lower port of osseous tunnel 5, reuse another can absorption screw 3 screw in the osseous tunnel downwards along the upper port of osseous tunnel 5, the two ends extruding of medical knee joint cruciate ligaments 4 can be fixed in the osseous tunnel 5, finish the replacement of medical knee joint cruciate ligaments.
Medical knee joint cruciate ligaments with this method makes has the advantages such as convenient for production, with low cost, During use, transfer operation is simple and convenient, and is safe and reliable, and patient tolerability is good, and immunogenicity is little. Because Silk after coming unstuck has good mechanical property and biocompatibility as natural macromolecular material, Transplant and just can bear the protective effect of stablizing, loading conduction, articular cartilage kneed in early days, moving Plant the later stage again can supportint cell growth and blood vessel grow into, and be accompanied by natural ligamentaum cruciatum regeneration and gradually Be degraded and absorbed. For the patient's of the badly damaged appraxia of cruciate ligaments of knee joint treatment provides a kind of new The selection approach.
Claims (1)
1, a kind of medical knee joint cruciate ligaments is characterized in that comprising the fibroin fiber ligamentaum cruciatum and the type i collagen of silkworm silk braiding, and described type i collagen is coated on the fibroin fiber ligamentaum cruciatum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201318002U CN201154005Y (en) | 2007-12-21 | 2007-12-21 | Knee joint cruciate ligaments for medical service |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201318002U CN201154005Y (en) | 2007-12-21 | 2007-12-21 | Knee joint cruciate ligaments for medical service |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201154005Y true CN201154005Y (en) | 2008-11-26 |
Family
ID=40101796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007201318002U Expired - Fee Related CN201154005Y (en) | 2007-12-21 | 2007-12-21 | Knee joint cruciate ligaments for medical service |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201154005Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107021A (en) * | 2010-08-10 | 2011-06-29 | 贾庆卫 | Silk ligament and preparation method thereof |
| CN103505762A (en) * | 2013-09-27 | 2014-01-15 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| WO2018121629A1 (en) * | 2016-12-28 | 2018-07-05 | 广州迈普再生医学科技有限公司 | Bionic ligament and bionic ligament system |
| CN108653811A (en) * | 2017-03-28 | 2018-10-16 | 上海微创医疗器械（集团）有限公司 | A kind of artificial ligament and preparation method thereof |
| CN110141398A (en) * | 2019-05-27 | 2019-08-20 | 中国人民解放军陆军军医大学第一附属医院 | Preparation method of artificial ligament and products thereof |
| CN110152063A (en) * | 2019-05-27 | 2019-08-23 | 中国人民解放军陆军军医大学第一附属医院 | A kind of artificial ligament regenerated cellulose fiber and its application |
-
2007
- 2007-12-21 CN CNU2007201318002U patent/CN201154005Y/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102107021A (en) * | 2010-08-10 | 2011-06-29 | 贾庆卫 | Silk ligament and preparation method thereof |
| CN102107021B (en) * | 2010-08-10 | 2014-04-16 | 泰山医学院附属医院 | Silk ligament and preparation method thereof |
| CN103505762A (en) * | 2013-09-27 | 2014-01-15 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| CN103505762B (en) * | 2013-09-27 | 2015-06-10 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| WO2018121629A1 (en) * | 2016-12-28 | 2018-07-05 | 广州迈普再生医学科技有限公司 | Bionic ligament and bionic ligament system |
| CN108653811A (en) * | 2017-03-28 | 2018-10-16 | 上海微创医疗器械（集团）有限公司 | A kind of artificial ligament and preparation method thereof |
| CN110141398A (en) * | 2019-05-27 | 2019-08-20 | 中国人民解放军陆军军医大学第一附属医院 | Preparation method of artificial ligament and products thereof |
| CN110152063A (en) * | 2019-05-27 | 2019-08-23 | 中国人民解放军陆军军医大学第一附属医院 | A kind of artificial ligament regenerated cellulose fiber and its application |
| CN110141398B (en) * | 2019-05-27 | 2021-06-22 | 中国人民解放军陆军军医大学第一附属医院 | Method for preparing artificial ligament and product thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081126 Termination date: 20101221 |