CN107648665A - It is a kind of to implant for the prosthese for repairing meniscus injury - Google Patents
It is a kind of to implant for the prosthese for repairing meniscus injury Download PDFInfo
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- CN107648665A CN107648665A CN201710212986.2A CN201710212986A CN107648665A CN 107648665 A CN107648665 A CN 107648665A CN 201710212986 A CN201710212986 A CN 201710212986A CN 107648665 A CN107648665 A CN 107648665A
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- meniscus
- prosthese
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
- C08J3/246—Intercrosslinking of at least two polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Abstract
Implanted the invention discloses a kind of for the prosthese for repairing meniscus injury, the prosthese can be prepared into various shapes and be used for polishing meniscus missing or damage location.The prosthese is formed by the crosslinking of natural polymer, polysaccharide, growth factor and adhesion factor, is a kind of supporting structure, and internal stent has dry aperture, and aperture is between 50 microns to 500 microns.Meniscus prosthetic provided by the invention, good biocompatibility and part are can absorb；The pore size of its support is adapted to meniscal fibrocartilage cells to grow into, the cartilage cell grown into and support shared meniscus stress；And in Using prosthesis body after with damage meniscus composition outer surface and without damage meniscus it is basically identical.
Description
Art
Patent of the present invention is related to a kind of implant for the prosthese for repairing meniscus injury.
Background technology
Meniscus is the wedge-shaped fibre cartilage of C-shaped, and its cross section is triangular in shape, it is outer thickness in it is thin, upper surface it is concave so as to
Matched with condyle of femur, lower surface is that plane connects with tibial plateau.Meniscus is thicker close to synovial membrane part, positioned at area vasculosa
Interior, blood fortune is well advantageous to wound healing；Meniscus free fraction is relatively thin to belong to avascular area, once damage is difficult to heal；In
Between transition region that a small amount of blood vessel is distributed with is helpful to meniscus wound healing.When knee joint trauma clinically occurs, often
Meniscus injury can be run into.Meniscus is the crucial stabilising arrangement that knee joint disperses stress effect, spreads knee joint load, is lubricated
Connection between femur and shin bone.Meniscus injury is caused by torquing forces more, damage location can occur meniscus anterior angle, after
Angle, middle part or edge part.The shape of damage can be transverse fissure, lobe, level splits or irregular shape, or even be broken into intra-articular free
Body.The function of meniscus is lost, pressure concentrates on kneed junction, joint is no longer had normal connection mechanism, can lead
Cause premature arthritis.
Since half a century in past, the treatment of meniscus injury is there occurs surprising change, after expectant treatment to operation
Treatment, meniscus is cut off completely, Partial Resection to suture repair, open surgery to Arthroscopic management, and transplanting is reconstructed into tissue
It is engineered the stages such as cartilage regeneration.Different treatment methods is taken according to meniscus injury position, scope, type difference, it is clinical
Upper generally use arthroscope lower meniscus resection and meniscus suture and neoplasty.Obtained in spite of a considerable amount of meniscus injuries
Repaired with suturing, but clinically still some damage can only consider row partial meniscectomy, secondary full excision and total resection,
Such as 1, meniscus tissue loss early stage ＞ 25%；2nd, the meniscus tear that can not be sutured；3rd, the meniscus of wound or chronic trauma
Tear；4th, meniscus injury causes the meniscal tissues of ＞ 25% to remove；5th, complete front and rear connection is kept (to need to connect
Connect)；6th, complete circumferential edges (Chu popliteal lateral meniscus is kept).
Meniscus bearing load increases after carrying out arthroscope lower meniscus resection, is applied to the maximum pressure of tibial plateau
Increase, joint space can be caused to narrow, femur ankle becomes equality joint degeneration；And meniscus stress is irregular easily causes secondary tear,
There is the performance such as osteoarthritis.Now, it is increasingly recognised that the importance of meniscus biomechanical function, it is believed that unsuitable letter
To singly damage Meniscectomy, and them should be repaired and carry out meniscus reconstruction, retain as far as possible meniscus form, function and
Biomechanics characteristic has turned into the target of clinical treatment.
Meniscus Reconstruction mainly has allosome meniscal implantation, autograft to rebuild meniscus and engineered first quarter moon
Three kinds of modes of plate.Allosome meniscal implantation obtains certain progress in terms of function of joint is improved, but still can not prevent joint space
It is narrow；Build tissue engineering bracket and rebuild meniscus using Porcine HGF regulation and control seed cell, carried for Meniscectomy
New treatment is supplied.
Organizational project meniscus, which is rebuild, mainly synthesis high score subclass (polycaprolactone, aliphatic urethane), natural biological
Material and the class of Hydrogels timbering material three.Synthesis high score subclass material has good biocompatibility and mechanical strength, its
Degradation rate can be controlled by changing the ratio of polymer, and shortcoming is that hydrophily is poor, weak to the affinity of cell, is unfavorable for cell
Adhesion, growth and migration in stent inner surface and hole；The good biocompatibility of natural biologic material, cell can be promoted to stick
Propagation is echoed, catabolite can be fully absorbed by body, and can maintain the state of cell differentiation, and shortcoming is that mechanical strength is poor, drop
Solution speed is difficult to control；Hydrogels material moisture content is high, and structure is similar with internal extracellular matrix, good biocompatibility, lacks
Point is that mechanical strength is poor, the bad control of degradation rate.
Therefore, developing a kind of has good biocompatibility and mechanical property, with good material surface interface, energy shape
Cheng Sanwei loose structures are just particularly important in favor of the timbering material that cell migration is bred and biodegradation is controllable.
The content of the invention
For overcome the deficiencies in the prior art, implanted the invention provides a kind of for the vacation for repairing meniscus injury
Body, when the meniscus tear or meniscal tissue defect for occurring to suture, the Using prosthesis meniscus deleted areas makes
The meniscus of damage keeps normal joint motion and intensity, it is characterised in that the prosthese forms meniscal fibrocartilage cells
The support grown into, the prosthese are made up of good biocompatibility and partially absorbable fiber, and the prosthese has loose structure,
From 50 microns to 500 microns, the aperture of the prosthese is adapted to meniscal fibrocartilage in the aperture of the prosthese loose structure
Cell is grown into, the fibrocartilage cells and the stress of support shared meniscus grown into, and Using prosthesis meniscus missing portion
Its configuration of surface is consistent with the surface of unmarred meniscus behind position.
It is preferred that the density of the prosthese is between 0.05-0.45g/ml.
It is preferred that there is loose structure inside the prosthese.
It is preferred that the prosthese is made up of natural polymer or its mixture.
It is preferred that the natural polymer be probably chitosan, chitin, sodium alginate, collagen, elastin laminin,
One or more of mixtures formed in the analogs such as reticuloprotein, cellulose.
It is preferred that the chitosan is the chitosan derivatives such as carboxymethyl chitosan, sulfonic group chitosan, or its mixing
Thing.
It is preferred that the molecular weight of the cellulose is between 10000 to 2500000.
It is preferred that by crosslinking or partial cross-linked between the natural polymer of the prosthese.
It is preferred that the prosthese includes glycosaminoglycan.
It is preferred that the glycosaminoglycan in the prosthese is probably chondroitin-4-suleate, and 6- chondroitin sulfates, keratosulfate
Element, Heparan sulfate, heparin, hyaluronic acid or their mixture.
It is preferred that at least partly it is crosslinked between glycosaminoglycan and natural polymer in the prosthese.
It is preferred that the crosslinking is carried out by chemical cross-linking agent.
It is preferred that the crosslinking agent is probably formaldehyde, glutaraldehyde, the difunctional aldehyde of bio-compatible, carbodiimide, second two
One or more of mixtures formed in aldehyde, hexamethylene diisocyanate.
It is preferred that also include growth factor in the prosthese.
It is preferred that the growth factor is probably α-growth factor, and β-growth factor, fibroblast growth factor, table
Skin cell growth factor, platelet derived growth factor, or their mixture.
It is preferred that also include adhesion factor in the prosthese.
It is preferred that institute's adhesion factor is probably fibronectin, and chondronectin, osteonectin, or their mixing
Thing.
The present invention is due to using above technical scheme so that meniscus prosthetic has following at least one advantage：
(1) meniscus prosthetic is made up of good biocompatibility and partially absorbable fiber, is implanted into by surgical operation
After meniscus damaged site, the meniscus of damage is set to keep normal joint motion and intensity, its good mechanical property to ensure it
Support can be used as meniscal tissue reconstruction, the complex of formation support and damage meniscus, and compound external surface and do not had
There is the meniscus that defect occurs consistent；
(2) natural polymer forms dry, the porous matrix of support, and it is thin that loose structure is advantageous to meniscal fibrocartilage
Born of the same parents, endothelial cell or other cells being present in extracellular matrix are grown into, and are advantageous to the adhesion, growth and migration of cell；
(3) natural polymer fibre is organized from animal or people, and by partial cross-linked between fiber, these fibers are according to certain
Directional spreding in the matrix of meniscus prosthetic, the discrepant stress of prosthese of different loci can be born, while provide lubrication
Effect and enough mechanical strengths；
(4) make prosthese that there is enough hydrophilies by crosslinking between the natural polymer fibre and macromolecule polysaccharide in prosthese
And elasticity, the characteristic of primary meniscus is simulated, on the one hand plays a part of to bear mechanical stress, cushioning effect protection is on the one hand played and closes
Save surface；
Embodiment
Implanted the invention provides a kind of for the prosthese for repairing meniscus injury, when the first quarter moon that generation can not suture
When plate tear or meniscal tissue defect, the Using prosthesis deleted areas is subjected to meniscal tissue reconstruction, forms support and damage
Hinder the complex of meniscus, and compound external surface is consistent with unmarred meniscus, the meniscus of damage is kept normal and closes
Section activity and intensity.
In the preparation of meniscus prosthetic, the main manufacture craft using dehydration, freeze-drying and chemical crosslinking.First will
Fiber, is then placed in mould by multiple fiber dewater treatment, and mold shape position more to be repaired than meniscus injury is slightly larger, freezes
Fiber, lyophilized fiber is then crosslinked with chemical cross-linking agent, in a mold sizing dried, porous matrix.Mould defines
The outer surface of complementary prosthese with damaged portion.In many cases, the size of mould is bigger than the position to be repaired of determination, matrix
Outline can shear to meet the needs of meniscus.
Below with regard to specific embodiment, it is described further.Following examples are only used for carrying out technical scheme
For example, to help those skilled in the art to further appreciate that technical scheme, embodiment therein is to this
The protection domain of invention does not produce restriction effect.
Embodiment one
(1) extract and smash polymer fiber with stainless steel tissue mashing machine to pieces, make tissue size be advantageous to extract；
(2) purifying natural polymer, the moisture between polymer is removed using salting out method, 40 DEG C~60 DEG C of vacuum drying chamber is dry
It is dry；
(3) polymer fiber after dehydration is placed in mould, continues 60 DEG C of drying and dehydratings to constant weight, and pay attention to protecting
Hold the uniformity of moisture in fiber；
(4) by the fiber shaping after dehydration, -20 DEG C~-60 DEG C lyophilized 2h~48h；
(5) fiber of freezing is in -4 DEG C~-0 DEG C drys more than 100h, and holding vacuum is in more than 800mbar；
(6) matrix after freezing is chemically crosslinked, and is cleaned and removed uncrosslinked crosslinking agent；
(7) matrix is cut into required shape, and with apyrogenic distilled water flushing, until its biocompatibility conforms to
Ask；
(8) matrix after flushing is placed on filter screen and dried, packed and sterilize.
Embodiment two
The present embodiment is consistent with the description of embodiment one, simply added after the dehydration of (3) step before freeze-drying process growth because
Son simultaneously stirs.
Embodiment three
The present embodiment is consistent with the description of embodiment one, simply added after the dehydration of (3) step before freeze-drying process adhesion because
Son simultaneously stirs.
Example IV
The present embodiment is consistent with the description of embodiment one, and simply adding osamine before freeze-drying process after the dehydration of (3) step gathers
The polysaccharide such as sugar simultaneously stir.
Embodiment five
The present embodiment is consistent with the description of embodiment one, simply added after the dehydration of (3) step before freeze-drying process growth because
Son simultaneously stirs.
Claims (19)
1. a kind of implant for the prosthese for repairing meniscus injury, it is characterised in that the prosthese forms meniscus fiber
The support that cartilage cell grows into, the prosthese are made up of good biocompatibility and partially absorbable fiber, and the prosthese has
Loose structure, from 50 microns to 500 microns, the aperture is adapted to meniscal fibrocartilage cells length in the aperture of the loose structure
Enter, the fibrocartilage cells and the stress of support shared meniscus grown into, and its configuration of surface after Using prosthesis meniscus
It is consistent with the configuration of surface of unmarred meniscus.
2. meniscus prosthetic according to claim 1, it is characterised in that the density of the prosthese is in 0.05-0.45g/ml
Between.
3. meniscus prosthetic according to claim 1, it is characterised in that there is loose structure inside the prosthese.
4. meniscus prosthetic according to claim 1, it is characterised in that the prosthese is by natural polymer or its mixture
Form.
5. meniscus prosthetic according to claim 4, it is characterised in that the natural polymer is probably chitosan, first
One or more in the analogs such as shell element, sodium alginate, collagen, elastin laminin, reticuloprotein, cellulose.
6. meniscus prosthetic according to claim 5, it is characterised in that the chitosan be probably carboxymethyl chitosan,
One or more in the chitosan derivatives such as sulfonic group chitosan.
7. meniscus prosthetic according to claim 5, it is characterised in that the molecular weight of the cellulose arrives 10000
Between 2500000.
8. meniscus prosthetic according to claim 1, it is characterised in that by handing between the natural polymer of the prosthese
Connection is partial cross-linked.
9. meniscus prosthetic according to claim 8, it is characterised in that the crosslinking is carried out by chemical cross-linking agent.
10. meniscus prosthetic according to claim 9, it is characterised in that the crosslinking agent be probably formaldehyde, glutaraldehyde,
One or more in the difunctional aldehyde of bio-compatible, carbodiimide, glyoxal, hexamethylene diisocyanate.
11. meniscus prosthetic according to claim 1, it is characterised in that the prosthese includes glycosaminoglycan.
12. meniscus prosthetic according to claim 11, it is characterised in that the glycosaminoglycan in the prosthese is probably 4-
Chondroitin sulfate, 6- chondroitin sulfates, keratan sulfate, Heparan sulfate, heparin, the one or more in hyaluronic acid.
13. meniscus prosthetic according to claim 11, it is characterised in that the natural polymerization of the glycosaminoglycan and prosthese
At least partly it is crosslinked between thing.
14. meniscus prosthetic according to claim 13, it is characterised in that the crosslinking is carried out by chemical cross-linking agent.
15. meniscus prosthetic according to claim 14, it is characterised in that the crosslinking agent be probably formaldehyde, glutaraldehyde,
One or more in the difunctional aldehyde of bio-compatible, carbodiimide, glyoxal, hexamethylene diisocyanate.
16. meniscus prosthetic according to claim 1, it is characterised in that also include growth factor in the prosthese.
17. meniscus prosthetic according to claim 16, it is characterised in that the growth factor be probably α-growth because
Son, β-growth factor, fibroblast growth factor, epithelical cell growth factor, one kind in platelet derived growth factor
It is or several.
18. meniscus prosthetic according to claim 1, it is characterised in that also include adhesion factor in the prosthese.
19. meniscus prosthetic according to claim 18, it is characterised in that institute's adhesion factor is probably fibronectin, soft
One or more in the Fibronectins such as osteonectin, osteonectin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710212986.2A CN107648665A (en) | 2017-04-01 | 2017-04-01 | It is a kind of to implant for the prosthese for repairing meniscus injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710212986.2A CN107648665A (en) | 2017-04-01 | 2017-04-01 | It is a kind of to implant for the prosthese for repairing meniscus injury |
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| Publication Number | Publication Date |
|---|---|
| CN107648665A true CN107648665A (en) | 2018-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710212986.2A Pending CN107648665A (en) | 2017-04-01 | 2017-04-01 | It is a kind of to implant for the prosthese for repairing meniscus injury |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236739A (en) * | 2019-07-19 | 2019-09-17 | 北京万洁天元医疗器械股份有限公司 | A kind of articular cartilage recovery support molding machine and preparation method thereof |
-
2017
- 2017-04-01 CN CN201710212986.2A patent/CN107648665A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236739A (en) * | 2019-07-19 | 2019-09-17 | 北京万洁天元医疗器械股份有限公司 | A kind of articular cartilage recovery support molding machine and preparation method thereof |
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| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 100070, Beijing Beijing Daxing District biological engineering and pharmaceutical industry base, 9 Fu Tian Street Applicant after: BEIJING WANJIE MEDICAL DEVICE Co.,Ltd. Address before: 100070, Beijing Beijing Daxing District biological engineering and pharmaceutical industry base, 9 Fu Tian Street Applicant before: BEIJING WANJIE MEDICAL DEVICE Co.,Ltd. |
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| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Mei Inventor after: Shi Fengtian Inventor after: Zhao Rui Inventor before: Zhang Mei Inventor before: Zhao Rui |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180202 |