CN201102889Y - Automatic dilution split charging instrument of radionuclide liquid medicine - Google Patents
Automatic dilution split charging instrument of radionuclide liquid medicine Download PDFInfo
- Publication number
- CN201102889Y CN201102889Y CNU2007200265741U CN200720026574U CN201102889Y CN 201102889 Y CN201102889 Y CN 201102889Y CN U2007200265741 U CNU2007200265741 U CN U2007200265741U CN 200720026574 U CN200720026574 U CN 200720026574U CN 201102889 Y CN201102889 Y CN 201102889Y
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- dilution
- nucleic
- packing
- peristaltic pump
- stoste
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Abstract
The utility model discloses an automatic diluting and dividing instrument for the radionuclide medical solution, which belongs to the application field of radioactive medicine. The utility model comprises a PLC controller, a peristaltic pump, a pneumatic controlling device, a product bottle, an activity measuring cylinder and a diluting and dividing pipeline. The peristaltic pump, the pneumatic controlling device and the activity measuring cylinder are electrically connected with the PLC controller through the control line; the product bottle is arranged in the activity measuring cylinder, and the diluting and dividing pipeline is connected with the pneumatic controlling device. The automatic diluting and dividing instrument works under the control of the procedure, which does not only guarantees the accuracy and precision of the diluting and dividing, but also has excellent protection performance. The automatic diluting and dividing instrument has the advantages of reasonable structure, easy manufacture, flexible and convenient operation, excellent protection performance, high dividing decision and good repeatability, etc.
Description
Technical field
The utility model relates to the radiopharmaceutical application, and specifically a kind of radionuclide liquid medicine dilutes the packing instrument automatically.
Background technology
Radiopharmaceutical such as choline [C-11]-HOLINE, 2-[F-18 that present PET both domestic and external center needs]-fluoro-2-deoxyglucose (FDG) etc., all utilize cyclotron production, the medicine finished product is finally deposited in the sterile vials stand-by, finish in after this 9 hours from production, the staff needs the radiopharmaceutical of doses to be passed through manually to extract at every turn, inject in those who are investigated's body, dosage does not wait from 5 to 15mci.Check that required dosage size is the comparison strictness, there are three shortcomings when manually extracting: the one, can not accurately extract predetermined amount, the 2nd, poor repeatability, syringe can not all extract the soup of suitable volumes at every turn, the staff need be approximately from total amount and extract predetermined single dose the bottle of 350～1200mci fast and accurately, need that also the medicine that extracts is put into activity meter (instrument of metering nucleic activity) and measure the dosage size of this extraction, if can not reach predetermined value, must extract again, this makes the staff accept too many radiation; The 3rd, be inconvenient to dilute, specific activity was very high when especially medicine had just been produced, if do not dilute, the medicine liquid volume that installs to syringe when branch is seldom the time, activity remnants in the back syringe that finishes to patient injection are very high, and actual injection just reduces to the soup of human body.
From radioprotective angle, actv. protection principle has three: the one, reduce time of contact active source, and the 2nd, increase operating distance from active source, the 3rd, in addition actv. shielding.And the inaccuracy of manual packing, poor repeatability and accept too many radiation are three major defects of traditional method for filling.
The utility model content
Technical assignment of the present utility model is at above-mentioned the deficiencies in the prior art, provides that a kind of reasonable in design, easy to manufacture, flexible and convenient operation, barrier propterty are good, the radionuclide liquid medicine of packing precision height, good reproducibility dilutes the packing instrument automatically.
Technical assignment of the present utility model is realized in the following manner: a kind of radionuclide liquid medicine dilutes the packing instrument automatically, be characterized in that this packing instrument comprises PLC controller, peristaltic pump, air control unit, product bottle, activity meter measurement tube and dilution packing pipeline, peristaltic pump, air control unit and activity meter are measured tube and are electrically connected with the PLC controller by control line respectively, the product bottle is installed in activity meter and measures in the tube, and dilution packing pipeline is connected with air control unit.
Described PLC controller be have storage, actuating logic computing, sequence control, regularly, the Programmable Logic Controller of calculating and calculation function, the PLC controller is connected with touch-screen, chopping machine, peristaltic pump and air control unit, as the FX2N-32MT-001 Programmable Logic Controller.
Described dilution packing pipeline comprises that nucleic stoste effuser, dilution flow out pipe, the remaining Through Flow Line (TFL) of nucleic stoste, peristaltic pump pump line, dilution raffinate Through Flow Line (TFL) and syringe connection tube, nucleic stoste effuser is connected with the product bottle, dilution flows out pipe and is connected with the dilution bottle, the remaining Through Flow Line (TFL) of nucleic stoste is connected with nucleic soup raffinate returnable bottle, the peristaltic pump pump line is connected with peristaltic pump, dilution raffinate Through Flow Line (TFL) is connected with the remaining returnable bottle of dilution, and syringe connection tube is connected with syringe; Peristaltic pump pump line one end is connected with nucleic stoste effuser, nucleic stoste effuser, the remaining Through Flow Line (TFL) of nucleic stoste by four-way; The other end links to each other with syringe connection tube with dilution raffinate Through Flow Line (TFL) by threeway; Above-mentioned pipeline is provided with pilot piping conducting and the anchor clamps of closing, and anchor clamps are connected with air control unit.
Described air control unit mainly is made of source of the gas, compression indicator, threeway, cylinder and electromagnetic valve, connects by vent line between each parts, and electromagnetic valve is electrically connected with the PLC controller.
Described product bottle is connected with the soup production facilities by the pipeline that contains the aseptic filtration film, also links to each other with soup dilution packing transfer conduit simultaneously, and the product bottle also carries out air pressure balance by the exhaust needle and the external atmosphere pressure that have the aseptic filtration film; The product bottle places activity meter to measure in the tube, and activity meter is measured tube and placed in the radiation-safe lead protection tube.
Syringe places in the tungsten alloy protecting jacket, and the tungsten alloy protecting jacket is placed on the fixed support.
In the use, by touch-screen the PLC controller is sent operating order, peristaltic pump and air control unit are worked under the programming control of PLC controller, have both guaranteed the accuracy and the packing precision of packing, also have good protective.
The utlity model has that reasonable in design, easy to manufacture, flexible and convenient operation, barrier propterty are good, the characteristics of packing precision height, good reproducibility.
Description of drawings
Fig. 1 is the structured flowchart of the utility model packing instrument.
Fig. 2 is the structural representation of dilution packing pipeline in the utility model packing instrument.
Fig. 3 is the structural representation of air control unit in the utility model packing instrument.
Fig. 4 is the control program diagram of circuit of the utility model packing instrument.
Wherein, 1, the PLC controller, 2, touch-screen, 3, peristaltic pump, 4, contain the pipeline of aseptic filtration film, 5, activity meter measures tube, 6, chopping machine, 7, the product bottle, 8, the remaining returnable bottle of nucleic stoste, 9, dilution bottle, 10, the remaining returnable bottle of dilution, 11.1-11.5, anchor clamps, 12, syringe, 13, nucleic stoste effuser, 14, the peristaltic pump pump line, 15, dilution flows out pipe, 16, the remaining Through Flow Line (TFL) of nucleic stoste, 17, dilution raffinate Through Flow Line (TFL), 18, syringe connection tube, 19, cylinder, 20, source of the gas, 21, compression indicator, 22, threeway, 23, electromagnetic valve.
The specific embodiment
With specific embodiment radionuclide liquid medicine of the present utility model is diluted the packing instrument automatically and make the dilution method for filling with reference to Figure of description and explain below doing.
Embodiment:
As shown in Figure 1: radionuclide liquid medicine of the present utility model dilutes the packing instrument automatically and is made of PLC controller 1, touch-screen 2, peristaltic pump 3, air control unit A, activity meter measurement tube 5, chopping machine 6, product bottle 7 and dilution packing pipeline B.Touch-screen 2, peristaltic pump 3, air control unit A, activity meter measure tube 5 and chopping machine 6 is electrically connected with PLC controller 1 by control line respectively.Product bottle 7 is installed in activity meter and measures in the tube 5, and dilution packing pipeline B is connected with air control unit A.
As shown in Figure 2: described dilution packing pipeline B comprises that nucleic stoste effuser 13, dilution flow out pipe 15, the remaining Through Flow Line (TFL) 16 of nucleic stoste, peristaltic pump pump line 14, dilution raffinate Through Flow Line (TFL) 17 and syringe connection tube 18.Nucleic stoste effuser 13 is connected with product bottle 7, dilution flows out pipe 15 and is connected with dilution bottle 9, the remaining Through Flow Line (TFL) 16 of nucleic stoste is connected with the remaining returnable bottle 8 of nucleic stoste, peristaltic pump pump line 14 is connected with peristaltic pump 3, dilution raffinate Through Flow Line (TFL) 17 is connected with the remaining returnable bottle 10 of dilution, and syringe connection tube 18 is connected with syringe 12; Peristaltic pump pump line 14 1 ends are connected by four-way and nucleic stoste effuser 13, dilution outflow pipe 15, the remaining Through Flow Line (TFL) 16 of nucleic stoste; The other end links to each other with syringe connection tube 18 with dilution raffinate Through Flow Line (TFL) 17 by threeway; Above-mentioned pipeline is provided with pilot piping conducting and the anchor clamps 11.1-11.5 that closes, and anchor clamps 11.1-11.5 all is connected with air control unit A.
As shown in Figure 3: air control unit master A will be made of source of the gas 20, compression indicator 21, threeway 22, cylinder 19 and electromagnetic valve 23.Connect by vent line between each parts, electromagnetic valve 23 is electrically connected with PLC controller 1.
Syringe 12 places in the tungsten alloy protecting jacket, and the tungsten alloy protecting jacket is placed on the fixed support.
Described PLC controller 1 is the FX2N-32MT-001 Programmable Logic Controller; Five with the HDT-1020 cylinder of the miniature cylinder model of anchor clamps bonded assembly for Ya De, Taiwan gram company; It is that the CRC-15 activity meter that U.S. Capintec company produces is measured tube that activity meter is measured tube 5; Peristaltic pump is this import high precision peristaltic pump of Britain's water, is suitable for low discharge, single tube, application scenario that flow is adjustable, maximum speed of revolution 200rmp, and maximum flow 332ml/min is two elastic rotor pumps, properties of product are reliable and stable, are applicable to medical medicine equipment.
As shown in Figure 4: the using method that above-mentioned radionuclide liquid medicine dilutes the packing instrument automatically is:
1) connect product bottle, installation dilution packing pipeline, system powers on, and selects and definite nucleic soup title;
2) behind the initial volume and activity of input nucleic soup on the touch-screen, import the activity of the nucleic soup that needs again and need the time;
3) place needle tubing, the folding of each branch line of PLC control pneumatics clamping then, the beginning pump is got the nucleic soup;
4) after pump took away the beginning, peristaltic pump is just changeing first pump to be got and needs the nucleic of volume stoste in the product bottle, delays time 2 seconds; Peristaltic pump continues just to change pump again and gets normal saline, delays time 3 seconds; Air in peristaltic pump counter-rotating venting pipeline and the syringe is to nucleic soup raffinate returnable bottle then; Take dilution away and divide the syringe that installs; Last peristaltic pump is just changeing normal saline in the emptying pipeline once more to dilution remnants returnable bottle, finishes the extraction process of the packing and the dilution of a nucleic soup;
5) finish after for the first time soup extracts, delay time 5 seconds, PLC controls pneumatics makes the anchor clamps on each branch line be in initial condition, and system enters wait state, waits for that new dilution divides process of assembling.
(anchor clamps 11.1,11.2,11.3,11.4,11.5 in the accompanying drawing 4 in anchor clamps 1,2,3,4, the 5 difference respective figure 2)
Claims (6)
1, a kind of radionuclide liquid medicine dilutes the packing instrument automatically, it is characterized in that this packing instrument comprises PLC controller, peristaltic pump, air control unit, product bottle, activity meter measurement tube and dilution packing pipeline, peristaltic pump, air control unit and activity meter are measured tube and are electrically connected with the PLC controller by control line respectively, the product bottle is installed in activity meter and measures in the tube, and dilution packing pipeline is connected with air control unit.
2, radionuclide liquid medicine according to claim 1 dilutes the packing instrument automatically, it is characterized in that the PLC controller be have storage, actuating logic computing, sequence control, regularly, the Programmable Logic Controller of calculating and calculation function, the PLC controller is connected with touch-screen, chopping machine, peristaltic pump and air control unit.
3, radionuclide liquid medicine according to claim 1 dilutes the packing instrument automatically, it is characterized in that diluting the packing pipeline and comprise nucleic stoste effuser, dilution flows out pipe, the remaining Through Flow Line (TFL) of nucleic stoste, the peristaltic pump pump line, dilution raffinate Through Flow Line (TFL) and syringe connection tube, nucleic stoste effuser is connected with the product bottle, dilution flows out pipe and is connected with the dilution bottle, the remaining Through Flow Line (TFL) of nucleic stoste is connected with nucleic soup raffinate returnable bottle, the peristaltic pump pump line is connected with peristaltic pump, dilution raffinate Through Flow Line (TFL) is connected with the remaining returnable bottle of dilution, and syringe connection tube is connected with syringe; Peristaltic pump pump line one end is connected with nucleic stoste effuser, nucleic stoste effuser, the remaining Through Flow Line (TFL) of nucleic stoste by four-way; The other end links to each other with syringe connection tube with dilution raffinate Through Flow Line (TFL) by threeway; Above-mentioned pipeline is provided with pilot piping conducting and the anchor clamps of closing, and anchor clamps are connected with air control unit.
4, radionuclide liquid medicine according to claim 1 dilutes the packing instrument automatically, it is characterized in that air control unit mainly is made of source of the gas, compression indicator, threeway, cylinder and electromagnetic valve, connect by vent line between each parts, electromagnetic valve is electrically connected with the PLC controller.
5, radionuclide liquid medicine according to claim 1 dilutes the packing instrument automatically, it is characterized in that the product bottle is connected with the soup production facilities by the pipeline that contains the aseptic filtration film, also link to each other with soup dilution packing transfer conduit simultaneously, the product bottle also carries out air pressure balance by the exhaust needle and the external atmosphere pressure that have the aseptic filtration film; The product bottle places activity meter to measure in the tube, and activity meter is measured tube and placed in the radiation-safe lead protection tube.
6, radionuclide liquid medicine according to claim 1 dilutes the packing instrument automatically, it is characterized in that syringe places in the tungsten alloy protecting jacket, and the tungsten alloy protecting jacket is placed on the fixed support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200265741U CN201102889Y (en) | 2007-08-16 | 2007-08-16 | Automatic dilution split charging instrument of radionuclide liquid medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200265741U CN201102889Y (en) | 2007-08-16 | 2007-08-16 | Automatic dilution split charging instrument of radionuclide liquid medicine |
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| Publication Number | Publication Date |
|---|---|
| CN201102889Y true CN201102889Y (en) | 2008-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200265741U Expired - Fee Related CN201102889Y (en) | 2007-08-16 | 2007-08-16 | Automatic dilution split charging instrument of radionuclide liquid medicine |
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| CN (1) | CN201102889Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102923627A (en) * | 2011-08-10 | 2013-02-13 | 上海原子科兴药业有限公司 | Automatic loading method of radioactive medicines |
| CN108159907A (en) * | 2018-01-04 | 2018-06-15 | 四川汉辉盛世医疗科技有限公司 | A kind of liquid mixing system and method |
| CN110812222A (en) * | 2018-08-14 | 2020-02-21 | 北京森科医药有限公司 | Automatic radioactive drug subpackaging instrument and method |
-
2007
- 2007-08-16 CN CNU2007200265741U patent/CN201102889Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102923627A (en) * | 2011-08-10 | 2013-02-13 | 上海原子科兴药业有限公司 | Automatic loading method of radioactive medicines |
| CN102923627B (en) * | 2011-08-10 | 2015-02-11 | 上海原子科兴药业有限公司 | Automatic loading method of radioactive medicines |
| CN108159907A (en) * | 2018-01-04 | 2018-06-15 | 四川汉辉盛世医疗科技有限公司 | A kind of liquid mixing system and method |
| CN108159907B (en) * | 2018-01-04 | 2023-08-29 | 四川汉辉盛世医疗科技有限公司 | Liquid mixing system and method |
| CN110812222A (en) * | 2018-08-14 | 2020-02-21 | 北京森科医药有限公司 | Automatic radioactive drug subpackaging instrument and method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080820 Termination date: 20090916 |