CN201049110Y - Midazolam blood medicine concentration closed-loop feedback infusion/injection control device - Google Patents
Midazolam blood medicine concentration closed-loop feedback infusion/injection control device Download PDFInfo
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- CN201049110Y CN201049110Y CNU2007200510739U CN200720051073U CN201049110Y CN 201049110 Y CN201049110 Y CN 201049110Y CN U2007200510739 U CNU2007200510739 U CN U2007200510739U CN 200720051073 U CN200720051073 U CN 200720051073U CN 201049110 Y CN201049110 Y CN 201049110Y
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- infusion
- control device
- midazolam
- loop feedback
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Abstract
An imidazole diazepam blood drug level closed-loop feedback infusion control device comprises an infusion actuator (1) and a control device (2), wherein, the control device consists of an electric source, a microcomputer controls system, an electrical motor driving module, a display device and an input device; the electric source realizes power supply for each device through an electric source management module; the microcomputer controls system is in electrical connection with the electric source management module, the electrical motor driving module, a liquid crystal display device and the input device through data lines; the output of the electrical motor driving module is transmitted to the infusion actuator. The infusion control device realizes realtime calculation of administration rate according to the principle of pharmacokinetics and object drug concentration, and takes imidazole diazepam effect-site concentration as feedback index; moreover, the device can control the depth of anesthesia through adjusting object drug concentration to ensure the safety of a patient during an operation and avoid intraoperative awareness; meanwhile, the device is convenient for use and can complete automatic administration after the parameters of a patient and a predicted effect-site concentration are input; in addition, the device realizes stable control of blood drug level and avoids the pain of a patient resulting from postoperative recovery delay or intraoperative awareness caused by too high concentration or too low concentration.
Description
Technical field
It serves as that the feedback index is controlled the blood drug level of Midazolam and the infusion control device of sedation automatically with intravenous anesthesia medicine Midazolam effect compartment that this utility model relates to a kind of.
Background technology
Along with biotechnology and development of computer, all anesthesia all will be carried out remote control by computerized monitoring feedback system.Be head it off, seeking and establish the pharmacodynamic index of reliable intravenous anesthetic sensitivity and developing corresponding feedback device has become inevitable trend.Obtained certain progress at monitoring depth of anesthesia such as using neuroelectricity physiology, pharmacological method in recent years.But different intravenous anesthesia medicines there are differences brain electricity, pharmacology's index sensitivity.And clinical often the change according to hemodynamics judged the anesthesia depth.
Midazolam is a kind of newer potent intravenous anesthetic, because it is rapid-action, action time short, toxicity is extremely low and do not have advantage such as obvious complication of anesthesia, be widely used in clinical each section's tranquilization, induction of anesthesia and keep, ICU calmness, the short and small operation of outpatient service etc.The infusion time correlation half-life of Midazolam does not have obvious prolongation with the increase of infusion time, can be used for the intravenous anesthesia target controlled infusion and continue medication being used for the ICU calmness.But the excessive concentration of Midazolam can cause patient's post-operative recovery and postpone, and crosses low can causing in patient's art and knows, and causes suffering to patient.
Relatively infusion Midazolam patient's HR, MAP and calm relation of marking find that it changes and sedation depth does not have obviously relevant.The inventor confirms through a large amount of basic research: with the plasma drug level (Cp) of Midazolam, effect compartment concentration (Ce) and brain electricity bispectral index (BIS) predict that sedation depth and actual result are quite identical, prediction probability value (Pk) is quite desirable, the predictive value size order is Ce＞BIS＞Cp, illustrate that application effect compartment concentration can be reacted sedation depth preferably and predictive value is higher, can be used as the feedback index of Midazolam closed loop feedback prediction depth of anesthesia, by setting up the blood drug level closed-loop feedback arrangement, can control depth of anesthesia better, improve anesthesia control level.
Summary of the invention
The purpose of this utility model, just provide a kind of possess intelligence, serve as that the feedback index is controlled the injection speed of Midazolam automatically with intravenous anesthesia medicine Midazolam effect compartment, and then the blood drug level of control Midazolam and the infusion control device of sedation depth.
The purpose of this utility model is to realize by following technical scheme: a kind of Midazolam blood drug level closed loop feedback control device, comprise infusion actuator and control device, it is characterized in that: described control device is by power supply, microcomputer control system, motor drive module, display device and input equipment constitute, power supply is powered to each device by power management module, microcomputer control system respectively with power management module, motor drive module, liquid crystal indicator and input equipment have data wire to be electrically connected, motor drive module export the infusion actuator to.
Described infusion actuator can be by controllable motor, turn-screw and be placed in the syringe that Midazolam is housed on the fixed mount and constitute that the output of controllable motor drives turn-screw and promotes to lay the syringe of being furnished with the Midazolam medicinal liquid on the fixed mount.
Described infusion actuator can be controlled syringe pump.
Described microcomputer control system circuit is made up of single-chip microcomputer U1, data latches U2, memory chip U3, outside quartz crystal oscillator, system control program writes in the U1 internal processes memory block, program is by parameter setting and medicament selection, according to the pharmacokinetics Equation for Calculating, generate of the operation of corresponding control command by the actuator of communication interface control infusion.
Described communication interface circuit is made up of integrated circuit U5 (MAX202), peripheral capacitor C 5, C6, C7, C8, C9, U5 finishes the conversion of singlechip serial communication Transistor-Transistor Logic level to the RS232 level, by U8, U9 forms liquid crystal display circuit by U7, display memory U4, liquid crystal display malleation booster circuit.
Described display device is a LCDs.
Described input equipment is keyboard or touch screen.
Beneficial effect: this utility model is according to the principle of pharmacokinetics, calculating medicine-feeding rate in real time according to drug target concentration, serves as the feedback index with Midazolam effect compartment concentration, and can control depth of anesthesia by regulating drug target concentration, guarantee safety in patient's art, avoid knowing in the art.This utility model is easy to use, after input patient age, body weight, sex and the prediction effect compartment concentration, gets final product automatic chemical feeding.As adjusting concentration range, reconfigurable new effect compartment concentration gets final product.Blood drug level control is stable, has avoided excessive concentration or crossed to hang down causing that patient's post-operative recovery postpones to know in the art, causes suffering to patient.
Description of drawings
Fig. 1 is a principle assumption diagram of the present utility model.
Among the figure: the actuator of 1-infusion, 2-control device.
The specific embodiment
As shown in Figure 1, Midazolam blood drug level closed loop feedback control device embodiment of the present utility model, comprise infusion actuator 1 and control device 2, the infusion actuator is controlled syringe pump, control device is by power supply, microcomputer control system, motor drive module, liquid crystal indicator and keyboard or touch screen input equipment constitute, power supply is powered to each device by power management module, the microcomputer control system circuit is by single-chip microcomputer, data latches, memory chip, outside quartz crystal oscillator is formed, system control program writes in the internal processes memory block, program is by parameter setting and medicament selection, according to the pharmacokinetics Equation for Calculating, generate of the operation of corresponding control command by the actuator of communication interface control infusion, the communication interface circuit is by integrated circuit (MAX202), periphery electric capacity is formed, the communication interface circuit is finished the conversion of singlechip serial communication Transistor-Transistor Logic level to the RS232 level, and liquid crystal display circuit is by LCD controller SED1335, display memory, liquid crystal display malleation booster circuit is formed; Microcomputer control system has data wire to be electrically connected with power management module, motor drive module, liquid crystal indicator and input equipment respectively, motor drive module export the infusion actuator to.
Described infusion actuator also can be by controllable motor, turn-screw and be placed in the syringe that Midazolam is housed on the fixed mount and constitute that the output of controllable motor drives turn-screw and promotes to lay the syringe of being furnished with the Midazolam medicinal liquid on the fixed mount.
This device has following distinguishing feature:
1. confirmed that Midazolam effect compartment concentration can be reacted sedation depth and predictive value is higher, can be used as miaow The feedback index of the stable closed loop feedback prediction of azoles depth of anesthesia can be controlled anesthesia by regulating drug target concentration The degree of depth.
2. Midazolam effect compartment concentration shows at Intravenous Anesthesia controller display screen, does not affect operation and fiber crops Liquor-saturated enforcement easily obtains.
3. the control of Midazolam blood concentration closed loop feedback is easy to use, input patient age, body weight, sex After prediction effect compartment concentration, this device gets final product automatic chemical feeding, and all are finished automatically by device. Dense as adjusting The degree scope, reconfigurable new effect compartment concentration gets final product.
4. the control of Midazolam blood concentration is stable, has avoided excessive concentration or crossed to hang down causing that patient's postoperative is extensive Postpone again to know in the art, cause suffering to patient.
Claims (5)
1. Midazolam blood drug level closed loop feedback infusion control device, comprise infusion actuator (1) and control device (2), it is characterized in that: described infusion actuator (1) is for by controllable motor, turn-screw be placed in the syringe that Midazolam is housed on the fixed mount and constitute, and the output of controllable motor drives the turn-screw pushing syringe; Or controlled syringe pump; Described control device is made of power supply, microcomputer control system, motor drive module, display device and input equipment, power supply is powered to each device by power management module, microcomputer control system has data wire to be electrically connected with power management module, motor drive module, liquid crystal indicator and input equipment respectively, motor drive module export the infusion actuator to.
2. Midazolam blood drug level closed loop feedback infusion control device according to claim 1, it is characterized in that: described microcomputer control system circuit is made up of single-chip microcomputer U1, data latches U2, memory chip U3, outside quartz crystal oscillator, system control program writes in the U1 internal processes memory block, program is by parameter setting and medicament selection, according to the pharmacokinetics Equation for Calculating, generate of the operation of corresponding control command by the actuator of communication interface control infusion.
3. Midazolam blood drug level closed loop feedback infusion control device according to claim 2, it is characterized in that: described communication interface circuit is made up of integrated circuit U5 (MAX202), peripheral capacitor C 5, C6, C7, C8, C9, U5 finishes the conversion of singlechip serial communication Transistor-Transistor Logic level to the RS232 level, by U8, U9 forms liquid crystal display circuit by U7, display memory U4, liquid crystal display malleation booster circuit.
4. Midazolam blood drug level closed loop feedback infusion control device according to claim 3, it is characterized in that: described display device is a LCDs.
5. Midazolam blood drug level closed loop feedback infusion control device according to claim 4, it is characterized in that: described input equipment is keyboard or touch screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200510739U CN201049110Y (en) | 2007-04-30 | 2007-04-30 | Midazolam blood medicine concentration closed-loop feedback infusion/injection control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200510739U CN201049110Y (en) | 2007-04-30 | 2007-04-30 | Midazolam blood medicine concentration closed-loop feedback infusion/injection control device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201049110Y true CN201049110Y (en) | 2008-04-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200510739U Expired - Fee Related CN201049110Y (en) | 2007-04-30 | 2007-04-30 | Midazolam blood medicine concentration closed-loop feedback infusion/injection control device |
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| CN (1) | CN201049110Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212119A (en) * | 2013-04-09 | 2013-07-24 | 陕西君天行机电科技有限公司 | BIS (BispectralIndex) feedback-based anesthesia target controlled infusion pump controller |
| CN108273158A (en) * | 2018-03-21 | 2018-07-13 | 桑凤欣 | A kind of multi-functional clinical anesthesia section Supplementary Anesthesia device |
| CN108525070A (en) * | 2018-04-25 | 2018-09-14 | 上海应用技术大学 | A kind of superhigh precision magnetostriction syringe pump having from perceptional function |
-
2007
- 2007-04-30 CN CNU2007200510739U patent/CN201049110Y/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212119A (en) * | 2013-04-09 | 2013-07-24 | 陕西君天行机电科技有限公司 | BIS (BispectralIndex) feedback-based anesthesia target controlled infusion pump controller |
| CN103212119B (en) * | 2013-04-09 | 2015-11-18 | 陕西君天行机电科技有限公司 | A kind of anesthesia target controlled infusion pump controller based on BIS feedback |
| CN108273158A (en) * | 2018-03-21 | 2018-07-13 | 桑凤欣 | A kind of multi-functional clinical anesthesia section Supplementary Anesthesia device |
| CN108525070A (en) * | 2018-04-25 | 2018-09-14 | 上海应用技术大学 | A kind of superhigh precision magnetostriction syringe pump having from perceptional function |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080423 Termination date: 20110430 |