CN103212119B - A kind of anesthesia target controlled infusion pump controller based on BIS feedback - Google Patents
A kind of anesthesia target controlled infusion pump controller based on BIS feedback Download PDFInfo
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- CN103212119B CN103212119B CN201310122118.7A CN201310122118A CN103212119B CN 103212119 B CN103212119 B CN 103212119B CN 201310122118 A CN201310122118 A CN 201310122118A CN 103212119 B CN103212119 B CN 103212119B
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Abstract
The invention discloses a kind of anesthesia target controlled infusion pump controller based on BIS feedback, comprise control module, control module comprises communication unit, I/O unit, I2C unit, filter unit, fuzzy solve unit, output unit, alarm unit and clock unit.Invention increases BIS feedback, the BIS value benchmark adapted can be set the body constitution different according to each patient, and by BIS feedback loop, anesthetis dosage is adjusted in real time, overcome the shortcoming that open cycle system is unadjustable, precision is low, guarantee the safe and reliable of anaesthesia process, also hommization more.
Description
Technical field
The invention belongs to anesthesia target controlled infusion pump control technology field, relate to a kind of anesthesia target controlled infusion pump controller based on BIS feedback.
Background technology
Anaesthesia technology is widely used in medical industry, for the pain in the therapeutic processes such as reduction of patient operation, is convenient to therapeutic process and carries out smoothly.But the control for the paralysis degree of depth is a difficult problem of medical circle always, degree of paralysis is benumbed not or excessively all can cause serious or even fatal impact to patient.Because medicine has complicated distribution, metabolism and effect process in human body, common syringe pump can not realize stable drug influence.In order to overcome these shortcomings, start both at home and abroad to utilize target controlled infusion technical research to go out to be more suitable for target controlled infusion pump and the controller thereof of human body infusion, as document (1) Qu Xuefen, target controlled infusion pump and utilize the area of computer aided infusion system of this infusion pump, Chinese Patent Application No.: 200620061690.2; (2) Wu Qi, target control syringe pump, Chinese Patent Application No.: 02253495.4; (3) Satie Shi Sangdaer, Si Wa meter Na Tambala Clichy south, Ivan Mai Er Nico, high precision infusion pump controller, application number: CN200880115087.X; (4) Shi Jieyi, Xie Hongming, Yao Jianhui, electronic infusion pump and control method thereof, application number: CN200910215189.5; (5) Zhang Xingan, Chen Yuke, sufentanil intravenous anesthesia target controlled infusion control device, Chinese Patent Application No.: 200720053151.9.Document (1) adopts the main MCU module of the auxiliary monitoring of secondary MCU module, in case main MCU module is made mistakes, reduce due to the risk that control system internal fault causes in clinical anesthesia process, improve safety, this control system is opened loop control; Document (2) achieves the control of blood drug level target, the control of effective-site target, be provided with syringe to be in place detection, expand controlled speed scope, possess and carry out exchanges data and the crystal display that Chinesizes with PC, the open-loop control system that adopt step motor drive syringe pump same with document (1); Document (3) adopts closed-loop control system, uses spring, rotation motor and linear motor etc. to drive infusion pump, provides the multiple feasible control mode that infusion pump controls; Document (4) adopts two MCU chip real-time communication to improve the reliability of system, have employed redundancy, be configured with pressure transducer, air bubble sensor, magnetic switch box contact detection switch real-time monitoring system running status, improve the linear smoothing degree of infusion, reduce liquid pulse degree and noise, but the collection lacked human life signal and feedback; Document (5) adopts opened loop control, by controlling sufentanil blood drug level and then controlling depth of anesthesia, according to information realization automatic constant speed administrations such as Gender, age, heights.Because depth of anesthesia controls the life security that direct relation patient, the safe, stable and reliable of control performance must be ensured on links, operation risk drops to by the basis of existing control technology condition minimum.
The stepper motor driven open cycle system that above-mentioned controller adopts single-chip microcomputer to set up substantially, although the effective control having achieved to infusion pump, the stability of its control accuracy, system and safety can be further enhanced.
Summary of the invention
The problem that the present invention solves is to provide a kind of anesthesia target controlled infusion pump controller based on BIS feedback, makes anaesthesia process be in omnidistance controllable state, reduces anesthetic risks.
The present invention is achieved through the following technical solutions:
Based on an anesthesia target controlled infusion pump controller for BIS feedback, comprising:
Control module, control module comprises communication unit, I/O unit, I2C unit, filter unit, fuzzy solve unit, output unit, alarm unit and clock unit;
BIS setting module, is connected with communication unit, and will send to communication unit according to BIS reference value, communication unit sends it to fuzzy again and solves unit;
Power amplifier, is connected with output unit, is sent to brushless electric machine after the current signal exported by output unit amplifies; The electric current that current sensor monitoring power amplifier exports, and is sent to I2C unit by current signal, then unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Brushless electric machine, connects infusion pump by leading screw, and after brushless electric machine is driven, it is converted to the passing of leading screw, provides motive force to infusion pump; The velocity of rotation of encoders monitor brushless electric machine, and the forward travel distance of monitoring leading screw, then velocity of rotation signal and forward travel distance signal are sent to I/O unit, unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Electrode for encephalograms, the real-time BIS value detecting anesthesia object is sent to I/O unit, and unit is sent to fuzzy and solves unit after filtering;
Fuzzy solves unit to carry out fuzzy according to real-time BIS value, current signal, velocity of rotation signal and forward travel distance signal and solves, obtain dutycycle, generate the corresponding current signal driving brushless electric machine according to dutycycle again, send to power amplifier through output unit.
Described when current signal occur that fluctuation is abnormal, stall appears in brushless electric machine, the forward travel distance of leading screw exceeds in the ultimate value of setting a kind of time, alarm unit sends alarm signal.
Described control module also comprises the LCD cell be connected with display device, and various signals control module received show on the display apparatus accordingly;
When alarm unit sends alarm signal, also show accordingly on the display apparatus.
Described control module also comprises the date read-write cell be connected with memorizer, the various signal datas that record controls module receives.
Described display or the data of record comprise the anaesthesia dosage of the physiological feature of current anesthesia object, the infusion velocity of current infusion pump and infusion.
Described control module also comprises Power Management Unit, the power supply of Power Management Unit managing and communicating electricity and reserve battery, and monitors the electricity of reserve battery; When the electricity of reserve battery also sends corresponding alarm signal by alarm unit lower than during setting value.
Described control module is also connected with life monitor, reads the data detected by life monitor.
Described control module controls based on FPGA control chip.
Described fuzzy solves unit with the form output current signal of current duty cycle, power amplifier is sent to through output unit, drive brushless electric machine to move again, electric current, the rotating speed of brushless electric machine and the forward travel distance of leading screw that power amplifier exports is regulated.
Compared with prior art, the present invention has following useful technique effect:
Anesthesia target controlled infusion pump controller based on BIS feedback provided by the invention, add BIS feedback, the BIS value benchmark adapted can be set the body constitution different according to each patient, and by BIS feedback loop, anesthetis dosage is adjusted in real time, overcome the shortcoming that open cycle system is unadjustable, precision is low, guarantee the safe and reliable of anaesthesia process, also hommization more;
There is the inherent defects such as vibration & noise when considering that motor slowly runs, the present invention adopts brushless electric machine to drive infusion pump, shake little, noise is low, simultaneously high, the smooth movement of brushless electric machine good stability, reliability, improves infusion performance;
In addition, outer the present invention is fed back by parameters such as three control loops (electric current loop, speed ring and position ring) next real-time regulating and controlling driving pressure, motor speed and anesthesia injection amounts except increasing BIS.The present invention considerably improves the safety of anaesthesia technology, the stability of system and control accuracy on the basis of existing target control anesthesia infusion pump control technology.
Further, anesthesia target controlled infusion pump controller based on BIS feedback provided by the invention, adopt the special integrated circuit based on FPGA to realize control to infusion system, overcome single-chip microcomputer unstable properties, defect that control accuracy is low, improve from hardware the precision that anesthesia controls.
Anesthesia target controlled infusion pump controller based on BIS feedback provided by the invention, also there is good human-computer interaction function, the current duty of infusion pump can be read by LCD display, by the communication of external matrix keyboard finishing man-machine interaction, also can also can be read out other recorded informations in control procedure by internal memory simultaneously; Controller is by hardware circuit performing a programme, and reliability is high, and significantly improves disposal ability and the arithmetic speed of chip based on the parallel work-flow characteristic of FPGA; Adopt fuzzy-adaptation PID control to improve the control accuracy of system, and make system have good robustness.
Accompanying drawing explanation
Fig. 1 is the anesthesia target controlled infusion pump control module formation schematic diagram based on BIS feedback.
Fig. 2 is the connection diagram of the anesthesia target controlled infusion pump controller based on BIS feedback.
Fig. 3 is the control flow schematic diagram of the anesthesia target controlled infusion pump controller based on BIS feedback.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and the explanation of the invention is not limited.
Based on an anesthesia target controlled infusion pump controller for BIS feedback, it is characterized in that, comprising:
Control module, control module comprises communication unit, I/O unit, I2C unit, filter unit, fuzzy solve unit, output unit, alarm unit and clock unit;
BIS setting module, is connected with communication unit, and will send to communication unit according to BIS reference value, communication unit sends it to fuzzy again and solves unit;
Power amplifier, is connected with output unit, is sent to brushless electric machine after the current signal exported by output unit amplifies; The electric current that current sensor monitoring power amplifier exports, and is sent to I2C unit by current signal, then unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Brushless electric machine, connects infusion pump by leading screw, and after brushless electric machine is driven, it is converted to the passing of leading screw, provides motive force to infusion pump; The velocity of rotation of encoders monitor brushless electric machine, and the forward travel distance of monitoring leading screw, then velocity of rotation signal and forward travel distance signal are sent to I/O unit, unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Electrode for encephalograms, the real-time BIS value detecting anesthesia object is sent to I/O unit, and unit is sent to fuzzy and solves unit after filtering;
Fuzzy solves unit to carry out fuzzy according to real-time BIS value, current signal, velocity of rotation signal and forward travel distance signal and solves, obtain dutycycle, generate the corresponding current signal driving brushless electric machine according to dutycycle again, send to power amplifier through output unit.
Concrete, as shown in Figure 1, control module is subdivided into the processing unit of 11 mutual parallel work-flows: clock unit, I/O unit, I2C unit, filter unit, fuzzy solve unit, communication unit, output unit, date read-write cell, LCD display unit, alarm unit, Power Management Unit
Wherein I/O unit controls I/O mouth gather the measured value of digital sensor (encoder); I2C unit is by the current measurement value of current sensor collection after power amplifier amplifies; Filter unit carries out filtering post processing to acquired signal and the transmitting measured values after process is solved unit, alarm unit and LCD display unit to fuzzy;
Communication unit and host computer (computer, or can be inputted by the external connection keyboard of control system) communication, operator are according to body setting different B IS reference value and sent to fuzzy and solve unit;
Fuzzy solves unit and processes respectively according to the BIS value fed back, current signal, brushless motor speed signal and the angle of rake positional information of infusion pump, solve control dutycycle, and by the Duty ratio control amount that solves in the form of electric current, be sent to infusion actuator through output unit, electric current, the rotating speed of brushless electric machine and the forward travel distance of leading screw that power amplifier exports is regulated;
Output unit utilizes controlled quentity controlled variable after power amplifier, control brushless electric machine working speed, and rotating speed is the angle of rake rectilinear motion of syringe pump by convert rotational motion after decelerator, leading screw, controls the duty of anesthesia target controlled infusion pump;
Date read-write cell is read and write the duty of recording system and is saved to memorizer as preliminary data;
LCD cell is used for the duty that display infusion pump is current in real time;
Clock unit is used for the unified time sequential routine controlling each unit of control module.
Concrete, control module controls based on FPGA control chip, overcomes single-chip microcomputer unstable properties, defect that control accuracy is low, improves from hardware the precision that anesthesia controls.
Target controlled infusion pump controller work system of the present invention as shown in Figure 2, comprises four feedback loops altogether:
(1) electric current loop: output unit output signal feeds back to control module by current sensor after power amplifier, because infusion pump is subject to pressure in human body in infusion process, module provides the drive current of brushless electric machine according to the feedback signal of current sensor, adjusts infusion pressure;
(2) speed ring: by brushless electric machine, infusion pump motion is controlled after control signal exports, feed back its tach signal in motor output end collection, realize control chip and motor speed is controlled, thus realize the fine adjustment of infusion pump drug injection speed;
(3) position ring: motor output end is connected with lead screw guide rails, infusion pump propeller is driven to advance by leading screw, work as forward propeller displacement at leading screw place by encoder feedback, thus control the distance that leading screw drives infusion pump propelling, complete anesthetis infusion amount and accurately control;
(4) BIS ring: medical monitor shows patient physiology in real time, as blood pressure, brain electricity, heart rate etc., and current BIS value is fed back to module, solve by fuzzy the controlled quentity controlled variable that unit obtains electric current loop, speed ring and position ring, export with the form of current duty cycle; Ensure that patient is in narcotism effectively in operation process by implementing monitoring mode, it also avoid due to the physiological difference of individuality thus the phenomenon of the excessive anesthesia caused and either shallow anesthesia, thus reduction anesthetic risks, make anaesthesia process be in omnidistance controllable state.
As shown in Figure 3, step is as follows for target controlled infusion pump body running flow process:
(1) opening power starting device, completes initialization and the device interior self-inspection of target controlled infusion pump control module after powering on, determine that the various functions of each functional module is normal, completing circuit intercommunication;
(2) by sensor data acquisition, comprise the encoder information gathering the motion of monitoring brushless electric machine realize to brushless electric machine velocity of rotation and leading screw advance position control, to electrode for encephalograms data acquisition and to current sensor information collection.Filtering Processing is carried out to the sensor values collected and draws current duty, BIS value as current in patient, the current infusion velocity of infusion pump and infusion anesthetis dose etc.;
(3) communicate with host computer, the BIS reference value controlling depth of anesthesia is set according to the patient BIS value gathered and body feature (as height, body weight, age and sex etc.), this reference value is sent to control module communication unit, as the target setting parameter controlled by host computer;
(4) will the current duty and control objectives feeding control module that obtain be processed, and solve by fuzzy the deviation that unit draws target setting and actual motion state, and utilize fuzzy control to solve system control amount according to self stored parameter.Fuzzy-adaptation PID control combines the advantage of fuzzy control and PID control, has neutralized respective shortcoming, has improve control accuracy;
(5) output unit utilize fuzzy to solve controlled quentity controlled variable that unit solves drives brushless electric machine motion, and feed back to control module the rate signal that current motor moves by encoder.Meanwhile, LCD cell is shown to current duty and control objectives, the state variable utilizing date read-write cell record relevant and control effects;
(6) brushless electric machine will control lead screw guide rails motion after decelerator, and then change the duty of infusion pump, carry out Real-time Feedback by encoder to infusion pump forward displacement to control module simultaneously;
(7) be determine whether meet termination condition or receive the finish command, if do not terminate, continue redirect the 3rd step and perform, otherwise complete control procedure, terminate anesthetis infusion.
In operation when current signal occur that fluctuation is abnormal, stall appears in brushless electric machine, the forward travel distance of leading screw exceeds in the ultimate value of setting a kind of time; And when control system internal abnormality or backup battery without electricity when, also send alarm signal to alarm unit.When alarm unit sends alarm signal, also show accordingly on the display apparatus.
Described control module also comprises the date read-write cell be connected with memorizer, the various signal datas that record controls module receives.Data that are shown or record comprise the anaesthesia dosage of the physiological feature of current anesthesia object, the infusion velocity of current infusion pump and infusion.
BIS Propofol-targeted (BIS) has been acknowledged as a kind of efficiency index weighing anesthesia Depth of sleep.Control anesthesia target controlled infusion pump with BIS as feedback controling variable, infusion dose can be regulated effectively, quickly, shorten the recovery time of patient.As operation consent, according to the BIS value benchmark of patient, BIS feedback control amount is set to 55(deep anaesthesia), when also not reaching expection narcotism higher than patient during this value, infusion pump continues administration; Then stop administration lower than during this value, can perform the operation, and maintenance is anaesthetized in a more stable degree of depth all the time.Utilize the detected parameters such as blood pressure, heart rate, brain electricity as the switch of patient safety thresholding or anesthetis infusion, further ensure the safe and reliable of operation.
Claims (8)
1., based on an anesthesia target controlled infusion pump controller for BIS feedback, it is characterized in that, comprising:
Control module, control module comprises communication unit, I/O unit, I2C unit, filter unit, fuzzy solve unit, output unit, alarm unit and clock unit;
BIS setting module, is connected with communication unit, and will send to communication unit according to BIS reference value, communication unit sends it to fuzzy again and solves unit;
Power amplifier, is connected with output unit, is sent to brushless electric machine after the current signal exported by output unit amplifies; The electric current that current sensor monitoring power amplifier exports, and is sent to I2C unit by current signal, then unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Brushless electric machine, connects infusion pump by leading screw, and after brushless electric machine is driven, it is converted to the passing of leading screw, provides motive force to infusion pump; The velocity of rotation of encoders monitor brushless electric machine, and the forward travel distance of monitoring leading screw, then velocity of rotation signal and forward travel distance signal are sent to I/O unit, unit is sent to fuzzy respectively and solves unit and alarm unit after filtering;
Electrode for encephalograms, the real-time BIS value detecting anesthesia object is sent to I/O unit, and unit is sent to fuzzy and solves unit after filtering;
Fuzzy solves unit to carry out fuzzy according to real-time BIS value, current signal, velocity of rotation signal and forward travel distance signal and solves, obtain dutycycle, generate the corresponding current signal driving brushless electric machine according to dutycycle again, send to power amplifier through output unit;
Described control module also comprises the date read-write cell be connected with memorizer, the various signal datas that record controls module receives.
2. as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, when current signal occur that fluctuation is abnormal, stall appears in brushless electric machine, the forward travel distance of leading screw exceeds in the ultimate value of setting a kind of time, alarm unit sends alarm signal.
3. as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described control module also comprises the LCD cell be connected with display device, and various signals control module received show on the display apparatus accordingly;
When alarm unit sends alarm signal, also show accordingly on the display apparatus.
4. as claimed in claim 3 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described display or the data of record comprise the anaesthesia dosage of the physiological feature of current anesthesia object, the infusion velocity of current infusion pump and infusion.
5. as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described control module also comprises Power Management Unit, the power supply of Power Management Unit managing and communicating electricity and reserve battery, and monitors the electricity of reserve battery; When the electricity of reserve battery also sends corresponding alarm signal by alarm unit lower than during setting value.
6. as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described control module is also connected with life monitor, reads the data detected by life monitor.
7., as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described control module controls based on FPGA control chip.
8. as claimed in claim 1 based on the anesthesia target controlled infusion pump controller of BIS feedback, it is characterized in that, described fuzzy solves unit with the form output current signal of current duty cycle, power amplifier is sent to through output unit, drive brushless electric machine to move again, electric current, the rotating speed of brushless electric machine and the forward travel distance of leading screw that power amplifier exports is regulated.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104189983A (en) * | 2014-09-23 | 2014-12-10 | 深圳市安保科技有限公司 | Deep sedation closed-loop control method and system |
| RU2713972C1 (en) * | 2016-05-02 | 2020-02-11 | Фрезениус Виаль Сас | Control device for administering propofol for patient |
| CN109893709B (en) * | 2019-04-09 | 2020-05-15 | 广东嘉博制药有限公司 | Anesthesia depth automatic control system based on key vital sign parameters |
| ES2808969B2 (en) | 2020-04-23 | 2022-10-11 | Univ Madrid Politecnica | CLOSED LOOP DRUG PERFUSION SYSTEM WITH SYNERGIC CONTROL |
| CN111912066B (en) * | 2020-08-25 | 2021-04-30 | 无锡菲兰爱尔空气质量技术有限公司 | Radiant air conditioner terminal for adjusting thermal damping |
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