CN101618241A - Epidural target-control automatic-control pain-relieving pump - Google Patents
Epidural target-control automatic-control pain-relieving pump Download PDFInfo
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- CN101618241A CN101618241A CN200810012125A CN200810012125A CN101618241A CN 101618241 A CN101618241 A CN 101618241A CN 200810012125 A CN200810012125 A CN 200810012125A CN 200810012125 A CN200810012125 A CN 200810012125A CN 101618241 A CN101618241 A CN 101618241A
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Abstract
The invention relates to improvement of an analgesia pump structural device, in particular to an epidural pain-relieving pump. The epidural pain-relieving pump solves the technical problems of providing a pain-relieving pump capable of achieving target control and automatic control at the same time, and providing a safer and more reliable, economical and convenient analgesic apparatus for clinical use. In order to solve the technical problems, the technical scheme of the invention has the following structural features: the epidural pain-relieving pump comprises a power supply, an infusion executing mechanism and a control device, wherein the control device consists of a power supply management module, a control module of the infusion executing mechanism, a central control singlechip with a built-in control program, a display device and an input device; the power supply is controlled by the power supply management module to supply power to each device; the central control singlechip is electrically connected with the power supply management module, the control module of the infusion executing mechanism, the display device and the input device through data wires; and particularly, the control device further comprises an electroencephalogram monitoring module of a charged electrode, and an output signal is connected to a signal input end of the central control singlechip through a network interface.
Description
Technical field
The present invention relates to the analgesia pump constructional device and improve, particularly epidural pain-relieving pump.
Background technology
Vein postoperative controlled analgesia (IPCA) or automatic control Epidural analgesia (PCEA), two methods are by setting the parameter of PCA pump, and as single-dose dosage, locking time and background infusion amount reach analgesic purpose.But because the administration deficiency may cause the not good or polypharmacy of analgesic effect to cause the probability of untoward reaction such as respiration inhibition to increase, therefore how improving the safety of postoperative analgesic is that target level control infusion (TCI) is a kind of based on modern many compartment models of pharmacokinetics theory, adjusts infusion rates at any time and obtains the induction of anesthesia of corresponding target blood plasma or target effect compartment drug level and keep technology by computational analysis controlling infusion system in the population pharmacokinetics parameter embedding program.To the analgesia demand, self-administration has solved individual demand difference to patient-controlled analgesia (PCA) to greatest extent within the specific limits according to different patients self.Postoperative acute pain adopts automatic control anesthesia analgesia (IPCA) crucial more at present.Therefore according to the pharmacokinetics principle the relevant index of PCA such as drug level, loading dose be set, continue dosage, PCA dosage, locking time, unit interval maximum are limited the quantity of, injection speed etc. is more appropriate reasonable.At present the TCI apparatus system that uses clinically only is used for anesthesia, is not used for the postoperative analgesia, and especially epidural pain relieving does not have target control function and be used for postoperative analgesic analgesic pump, so we research and develop target control-automatic control Epidural analgesia pump and are used for the postoperative analgesia.Still there is not epidural epidural target-control analgesic pump at present both at home and abroad.Pharmacokinetic model and the computer-controlled infusion pump of setting up medicine are key to the issues.This case is developed the TCI-PCEA application software, and is developed novel TCI-PCEA analgesic pump (having target control and patient-controlled function simultaneously) by setting up pharmacokinetic model and parameter, is used for the treatment of postoperative patient acute pain.How improving the safety of postoperative analgesic is an important topic of current clinical research, now on the market or the analgesic pump of using clinically all is target control or automatic control.Target level control infusion (TCI) is a kind of based on modern many compartment models of pharmacokinetics theory, adjusts infusion rates at any time and obtains the induction of anesthesia of corresponding target blood plasma or target effect compartment drug level and keep technology by computational analysis controlling infusion system in the population pharmacokinetics parameter embedding program.To the analgesia demand, self-administration has solved individual demand difference to patient-controlled analgesia (PCA) to greatest extent within the specific limits according to different patients self.Postoperative acute pain adopts the automatic control anesthesia analgesia crucial more at present.Therefore according to the pharmacokinetics principle the relevant index of PCA such as drug level, loading dose be set, continue dosage, PCA dosage, locking time, unit interval maximum are limited the quantity of, injection speed etc. is more appropriate reasonable.The TCI apparatus system that uses clinically only is used for anesthesia at present, be not used for the postoperative analgesia, especially epidural pain relieving, do not have target control function and be used for postoperative analgesic analgesic pump, therefore the amount of control administration often appears being difficult to, sometimes giving given less, impacts for the healthy of patient.TCI technology prospect is along with the development of computer and other biomedical engineering, and the TCI technology will have breakthrough aspect following three and develop.
(1) medicine can be more careful with the chamberization of human body for the computer of the physiology high-speed computation of model, also can easily handle multivariable mathematical model, thereby will improve a lot on the accuracy of prediction concentrations.In addition, for the interative computation of model by repeatedly, also can improve its accuracy with the medicine of non-chamber by the upgrading of computer.
(2) portability of infusion pump will be controlled software as DIPRIFUSOR and be incorporated in the infusion pump, exempt promptly that to carry a large amount of computer equipments the same, and the miniaturization of TCI system and portability are another trend of its development.Along with going deep into of patient-controlled notion, need to realize the portability of TCI more.
(3) behind the automated setting target level of control system, TCI can reach automatically and keep stable target level, but the change that anaesthesia depth and operation stimulate all needs constantly to adjust the target level that sets, and present TCI system but can not finish this work.If effect information can feed back to target control system and finish the adjusting of concentration automatically, can form so-called closed circuit anesthesia (closed-loop control ofanesthesia).The source of effect information has two: one, and drug influence is as with BIS or EP being the anesthesia of feedback information formation closed circuit.The 2nd, drug level, present concentration monitor can't be measured at once to the blood drug level of intravenous anesthetic.But along with the development of biochemical technology, intravenous anesthetic is hopeful to resemble accomplishes to monitor at any time intravital online concentration the inhalation anesthetic, and controls depth of anesthesia by drug level.
Summary of the invention
Technical problem to be solved by this invention is, a kind of analgesic pump that can realize target control-automatic control simultaneously is provided, and clinical safety and reliability, a kind of easily pain-relieving instrument of economy again of providing is provided.
For solving the problems of the technologies described above, the structural feature of technical scheme of the present invention is, comprise power supply, infusion actuator and control device, control device is made of central control single chip computer, display device and the input equipment of power management module, the control module of infusion actuator, built-in control sequence, power supply is subjected to power management module control to each device power supply, and central control single chip computer has data wire to be electrically connected with control module, display device and the input equipment of power management module, infusion actuator respectively; Particularly described control device also comprises the brain electricity monitoring module of charged electrode, and its output signal is connected to the signal input part of central control single chip computer by network interface.
Described infusion actuator is the controlled syringe pump that analgesic is housed; Or by controlled TV, turn-screw guide rail, be placed in the syringe that analgesic is housed on the fixed mount and constitute, the output of controllable motor drives the turn-screw pushing syringe.
Described display device is a LCDs.
Described input equipment is keyboard or touch screen.
On the basis of the above, the present invention can do following improvement:
Described infusion actuator has also comprised infusion position sensor.
Described power supply also comprises backup battery, and it is connected with power management module by data wire.
After using the present invention, be provided with the safe concentration scope of the analgesic of locking, and press plasma drug level and effect compartment (cerebral tissue) aimed concn administering mode, all are finished automatically by device; LCDs shows multiple parameters such as needing concentration in injection process, have good real time performance, as long as input patient parameter and target blood drug level, the infusion velocity of control card pain medicine is to control its blood drug level and then to reach the analgesic effect automatically.Can certainly directly use automatic control to be good for and strengthen dosage, use for different personnel.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is done further explanation,
Fig. 1 is a structural representation of the present invention.
The specific embodiment
The structural feature of technical scheme of the present invention is, comprise power supply, infusion actuator and control device, control device is made of central control single chip computer, display device and the input equipment of power management module, the control module of infusion actuator, built-in control sequence, power supply is subjected to power management module control to each device power supply, and central control single chip computer has data wire to be electrically connected with control module, display device and the input equipment of power management module, infusion actuator respectively; Particularly described control device also comprises the brain electricity monitoring module of charged electrode, and its output signal is connected to the signal input part of central control single chip computer by network interface.
Described infusion actuator is the controlled syringe pump that analgesic is housed; Or by controlled TV, turn-screw guide rail, be placed in the syringe that analgesic is housed on the fixed mount and constitute, the output of controllable motor drives the turn-screw pushing syringe.
Described display device is a LCDs.
Described input equipment is keyboard or touch screen.
On the basis of the above, the present invention can do following improvement:
Described infusion actuator has also comprised infusion position sensor.
Described power supply also comprises backup battery, and it is connected with power management module by data wire.
With the blood drug level of high effective liquid chromatography for measuring local anaesthetics, and medication is for dynamics calculation program match compartment model.The pharmacokinetics of the surgical patient of research epidural local anaesthetics anesthesia.Before local anaesthetics is given in epidural (contrast), behind the local anaesthetics 10,20,30,60,90min and 2,8,24h extraction peripheric venous blood 1ml.Place the anticoagulant test tube of heparinization, centrifugal back profound hypothermia is preserved.The blood drug level of high effective liquid chromatography for measuring local anaesthetics.Make interior mark with bupivacaine, add in the extraction column.Local anaesthetics washs with methanol/ammonium salt solution, the mobile phase acetonitrile, and methanol and phosphate buffer, sample adds high performance liquid chromatograph, writes down peak time, reaches peak concentration.Set up the pharmacokinetic two-compartment model of local anaesthetics, need to measure the parameter of its epidural anesthesia injecting drug use, as the volume of central compartment, the elimination speed (k10) of central compartment and effect compartment and keo), between central compartment and the effect compartment, the speed constant (k21 between the effect compartment, k12, k10) etc.Continue medication according to peak concentration and steady plasma-drug concentration-time data, drug-time curve behind the drafting multiple dosing, try to achieve corresponding pharmacokinetic parameter, comprise peak time (Tmax), stable state peak concentration (Css_min), stable state peak concentration (Css_max), average steady state blood drug level (Css_av), eliminate under half-life (t1/2), clearance rate (CL or CL/F), the steady plasma-drug concentration-time graph area (AUCss) etc.Use the 3P97 program above-mentioned pharmacokinetic parameter is handled, set up its pharmacokinetic model.The pharmacokinetics of research special population (liver function injury, renal function injury, gerontal patient and child patient) is in the hope of illustrating the basic feature of pharmacokinetics.Our application software (NONMEM) is analyzed the population pharmacokinetics of local anaesthetics.Again model is carried out computer simulation, utilize MATLAB concentration-time catch cropping non-linear curve fitting.In MATLAB, introduced two orders and carried out the match definition nonlinear equation order and the order of matched curve equation of curve, carried out non-linear curve fitting, obtained each coefficient value and bring equation into and obtain local anaesthetics pharmacokinetic model equation according to its program.Coefficient of determination R2 approaches 1 more, and fitting effect is better.Be used for continuing the reasonable regulation and control of epidural infusion system local anaesthetics at last.
Claims (5)
1, a kind of epidural target-control automatic-control pain-relieving pump, structural feature is, comprise power supply (3), infusion actuator (1) and control device (2), control device (2) is by power supply (3) administration module (8), the control module of infusion actuator (9), the central control single chip computer (10) of built-in control sequence, display device (11) and input equipment (12) constitute, power supply is subjected to power management module control to each device power supply, central control single chip computer (10) respectively with power management module (8), the control module of infusion actuator (9), display device (11) and input equipment (12) have data wire to be electrically connected; Particularly described control device (2) also comprises the brain electricity monitoring module of charged electrode, and its output signal is connected to the signal input part of central control single chip computer (10) by network interface.
2, epidural target-control automatic-control pain-relieving pump according to claim 1, it is characterized in that, described infusion actuator also comprises infusion ultimate position pick off (7), and described power supply also comprises backup battery, and it is electrically connected with power management module by data wire.
3, epidural target-control automatic-control pain-relieving pump according to claim 1 is characterized in that, described infusion actuator is the controlled syringe pump that analgesic is housed; Or by controlled TV, turn-screw guide rail (5), be placed in the syringe (6) that analgesic is housed on the fixed mount and constitute, the output of controllable motor (4) drives the turn-screw pushing syringe.
4, epidural target-control automatic-control pain-relieving pump according to claim 1 is characterized in that, described display device (11) is a LCDs.
5, epidural target-control automatic-control pain-relieving pump according to claim 1 is characterized in that, described input equipment (12) is keyboard or touch screen.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810012125A CN101618241A (en) | 2008-07-03 | 2008-07-03 | Epidural target-control automatic-control pain-relieving pump |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810012125A CN101618241A (en) | 2008-07-03 | 2008-07-03 | Epidural target-control automatic-control pain-relieving pump |
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| CN101618241A true CN101618241A (en) | 2010-01-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106485092A (en) * | 2016-10-25 | 2017-03-08 | 上海市中医医院 | Application of the patient-controlled intrathecal analgesic techniques combining information management in Pain Treatment |
| CN106730110A (en) * | 2016-12-01 | 2017-05-31 | 谢言虎 | A kind of patient-controlled sedation target-controlled infusion system based on anesthesia depth monitoring |
| CN113648484A (en) * | 2021-09-06 | 2021-11-16 | 北京航空航天大学 | Portable target-controlled infusion intravenous anesthesia device and target-controlled infusion control method |
-
2008
- 2008-07-03 CN CN200810012125A patent/CN101618241A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106485092A (en) * | 2016-10-25 | 2017-03-08 | 上海市中医医院 | Application of the patient-controlled intrathecal analgesic techniques combining information management in Pain Treatment |
| CN106730110A (en) * | 2016-12-01 | 2017-05-31 | 谢言虎 | A kind of patient-controlled sedation target-controlled infusion system based on anesthesia depth monitoring |
| CN113648484A (en) * | 2021-09-06 | 2021-11-16 | 北京航空航天大学 | Portable target-controlled infusion intravenous anesthesia device and target-controlled infusion control method |
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Open date: 20100106 |