CN1979130A - Reflection type optical-fiber bio-chemical sensing module - Google Patents
Reflection type optical-fiber bio-chemical sensing module Download PDFInfo
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- CN1979130A CN1979130A CNA2005101257076A CN200510125707A CN1979130A CN 1979130 A CN1979130 A CN 1979130A CN A2005101257076 A CNA2005101257076 A CN A2005101257076A CN 200510125707 A CN200510125707 A CN 200510125707A CN 1979130 A CN1979130 A CN 1979130A
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Abstract
The invention relates to a reflection fiber biochemical sensing module that is made up of light source/probe section, light path section and test bar straining frame, which are accurately located by bolt hole and screw. Three combination modules are mutual independent that is easy to change component and maintain. Light path section adopts optical fiber. Light source, fiber and photo detector are directly coupling together. It has the advantages of small volume, high flexible, and widely application in sensor field.
Description
Technical field
The present invention relates to the optical sensor technology field, particularly a kind of reflection type optical fiber sensing module, in conjunction with different biochemical test bar sensors, can realize measurement to haemoglobin (HB) and glutamic-pyruvic transaminase biochemical parameters such as (ALT).
Background technology
Characteristics such as it is fast that optical sensor has corresponding speed, highly sensitive, and anti-electromagnetic interference capability is strong are the important branch in the sensor field.To be material to be detected have characteristic absorption to the light wave of a certain specific wavelength to the fundamental measurement principle of reflection type optical sensor, thing to be detected is after the rayed of corresponding wave band, its concentration difference, degree of absorption difference to light wave, cause the light reflection strength to change with detecting substrate concentration, utilize photoelectric sensor, light intensity is changed being converted to change in electric, can instead push away the concentration of thing to be detected according to particular kind of relationship.
Haemoglobin (HB) and glutamic-pyruvic transaminase (ALT) are two important biochemical parameters of human body, and its concentration determination has broad sense.The large-scale Biochemical Analyzer of the general employing of hospital, its shortcoming is that instrument is valuable, complicated operation is not easy to carry etc.At present, the research and development of portable optical biochemical analyzer receive much attention, and have Related product to emerge, but still come with some shortcomings:
1. the light path part of most miniature instruments adopts light emitting diode (LED) and integrating sphere combination, and advantage is that light is evenly distributed, and is beneficial to and monitors light source stability simultaneously; But shortcoming is the light intensity decreasing that shines the strip sensitizing range, and detection sensitivity is descended, and light source is integrated in the integrating sphere with photodetector, if any damage, be difficult for changing, and because the employing integrating sphere increases production cost.
2. the part instrument adopts micro-optical component, comprises lenticule, and little beam splitter etc. converge and beam splitting light wave, and advantage is simple in structure; Shortcoming is that stability of layout is poor, and sensitivity is low.
Summary of the invention
At above-mentioned analysis, the purpose of this invention is to provide a kind of small-sized, stable and dirigibility, highly sensitive reflection type optical fiber sensing module, it can be measured human body hemoglobin (HB) and glutamic-pyruvic transaminase biochemical parameters such as (ALT) fast in conjunction with corresponding biochemical test bar sensor.
For reaching above-mentioned purpose, technical solution of the present invention provides a kind of reflection type optical-fiber bio-chemical sensing module, adopts integrated module structure, is that three separate funtion parts are formed, be respectively light source/probe portion, light path part and strip loading frame part; Its light source/probe portion, by housing, light emitting diode, photodetector is formed, light path part, comprise second housing, complex root optical fiber and corresponding a plurality of fibre-optical probe, wherein, light emitting diode and photodetector are coupled with a plurality of fibre-optical probe one ends respectively, the other end of a plurality of fibre-optical probes is connected with the upper end of complex root optical fiber respectively, and the lower end of complex root optical fiber places strip loading frame part top;
Strip loading frame part is made up of the 3rd housing and detection groove, detects groove and links to each other with the determinand storage tank of biochemical test bar sensor;
Light source/probe portion be positioned at light path part directly over, light path part be positioned at strip loading frame part directly over, after the stack of three housings, connect, and to photoelectricity coupling location by screw.
Described reflection type optical-fiber bio-chemical sensing module, its described light source/probe portion is by housing, light emitting diode, photodetector is formed, wherein, and inverted T shape housing, upwards have four blind holes from the bottom surface, four blind holes can be arranged arbitrarily, and from left to right, order is equiped with photodetector, light emitting diode, light emitting diode and photodetector in each blind hole, light emitting diode and photodetector lead separately stretches out from the top, is electrically connected with associated components;
Light path part comprises second housing, complex root optical fiber and corresponding a plurality of fibre-optical probe, wherein, second housing has cavity for the cylinder of sealing in the cylinder, its upper surface has four holes, the size in hole and position, and four blind holes of the housing of light source/probe portion are suitable; Its lower surface has two holes; Be provided with six road optical fiber in the cavity of second housing, be installed with fibre-optical probe in the hole of the upper and lower end face of second housing, wherein, the probe connection of the second shell ends left side of face is coupled with first optical fiber upper end, the first probe connection in the middle of the second housing upper surface is coupled with second optical fiber, the 3rd optical fiber upper end, the second middle probe connection is coupled with the 4th optical fiber, the 5th optical fiber upper end, and the probe connection on right side, the second housing upper surface is coupled with the six fibers upper end; Wherein, first, second, the left side fibre-optical probe coupling of the 4th optical fiber lower end and lower surface links to each other, three, the 5th, the six fibers lower end links to each other with the right side fibre-optical probe coupling of lower surface, below the right side fibre-optical probe of lower surface, is installed with total reflective mirror at perforate end opening inwall;
Strip loading frame part, form by the 3rd housing and detection groove, concordant the matching of second housing left side of flat the 3rd housing left end and light path part, right-hand member protrudes from the second housing right side, the 3rd housing upper surface has the detection groove of level, and it is uncovered to detect the groove right-hand member, uncoveredly links to each other with the determinand storage tank of biochemical test bar sensor, detect the below that groove is positioned at two holes, the second housing lower surface, and be covered in two hole end openings from the below.
Described reflection type optical-fiber bio-chemical sensing module, its described two light emitting diodes are the light emitting diode of concentricity wavelength or different centre wavelengths.
Described reflection type optical-fiber bio-chemical sensing module, its described two photodetectors, model is identical, is photoresistance or photoelectricity two, triode, one of them is used for the reflected light signal of survey sensor strip, two stability that are used to monitor light source and whole device wherein.
Described reflection type optical-fiber bio-chemical sensing module, in the right side fibre-optical probe of its described second housing lower surface, two-way incident optical random alignment, and the optical fiber that is reflected surrounds the border outside; In first, second probe in the middle of the second housing upper surface, two-way optical fiber random alignment.
Described reflection type optical-fiber bio-chemical sensing module, four through holes that open its described second housing upper surface are with four blind hole center-aligned on first housing.
Described reflection type optical-fiber bio-chemical sensing module, direct coupling system is all adopted in its described light emitting diode, optical fiber, photodetector connection each other.
Described reflection type optical-fiber bio-chemical sensing module, the case material of its described three parts is all teflon.
Described reflection type optical-fiber bio-chemical sensing module, its described optical fiber is multimode optical fiber, the material of fibre core is a quartz glass.
Reflection type optical fiber sensing module of the present invention, LED and optical fiber and optical fiber and photodetector all adopt direct coupling system, and this mode has the highest coupling efficiency, when guaranteeing stability of layout, has also improved the sensitivity that detects.
The present invention adopts optical fiber as passing light and beam splitter, makes the easier adjusting of system; Adopt light emitting diode as light source, guaranteed the miniaturization of system; Adopt integrated module structure, make the present invention have more dirigibility.
In sum, characteristics of the present invention are that volume is little, and are highly sensitive, and have the modularization characteristics, make package unit have higher dirigibility and practicality.
Description of drawings
Fig. 1 is a reflection type optical-fiber bio-chemical sensing module structural representation of the present invention;
Fig. 2 is optical fiber structure synoptic diagram among the present invention;
Fig. 3 arranges synoptic diagram for fibre-optical probe inner fiber fibre core among the present invention, wherein:
Fig. 3 (a) is the incident optical random alignment, and mirror based fiber optica surrounds incident optical;
Fig. 3 (b) is signal optical fibre and reference optical fiber random alignment;
Fig. 4 uses the sensor of module of the present invention to hemoglobin concentration test result synoptic diagram in the whole blood.
Embodiment
As shown in Figure 1, reflection type optical-fiber bio-chemical sensing module of the present invention, be that three separate funtion parts are formed, be respectively light source/probe portion 1, light path part 2 and strip loading frame part 3, its light source/probe portion 1 be positioned at light path part 2 directly over, light path part 2 be positioned at strip loading frame part 3 directly over, after three's stack, connect by screw, and to photoelectricity coupling location.Light source/probe portion 1, by housing 1a, light emitting diode (LED) 4,5, photodetector 6,7 is formed, and wherein, inverted T shape housing 1a upwards has four blind holes from the bottom surface, and four blind holes can be arranged arbitrarily, and four blind holes are that in-line is arranged among Fig. 1.From left to right, order is equiped with photodetector 6, light emitting diode 4, light emitting diode 5 and photodetector 7 in each blind hole, two through holes are arranged at the blind hole bottom, photodetector 6, light emitting diode 4, light emitting diode 5 and photodetector 7 electrode cable 15 separately stretches out from the top through hole, is electrically connected with associated components.The model of two photodetectors 6,7 is identical, and wherein photodetector 6 is used for the reflected light signal of survey sensor strip, and photodetector 7 is used to monitor the stability of light source and whole device.
In the fibre-optical probe 10, two-way incident optical random alignment, and the optical fiber border encirclement outside that is reflected are shown in Fig. 3 (a); In the fibre- optical probe 11,13, two-way optical fiber random alignment is shown in Fig. 3 (b).
Strip loading frame part 3, form by housing 3a and detection groove 3b, concordant the matching of housing 2a left side of flat housing 3a left end and light path part 2, right-hand member protrudes from housing 2a right side, housing 3a upper surface has the detection groove 3b of level, and it is uncovered to detect groove 3b right-hand member, uncoveredly links to each other with the determinand storage tank of biochemical test bar sensor, detect the below that groove 3b is positioned at two holes, light path part 2 housing 2a lower surfaces, and be covered in two hole end openings from the below.
The material of above-mentioned housing 1a, 2a, 3a is all teflon; Optical fiber 8a, 8b, 8c, 8d, 8e, 8f are multimode optical fiber, and the material of fibre core is a quartz glass.
Adopt the said structure mode, can safeguard separately each funtion part easily, do not influence the operate as normal and the precision of other parts, thereby make whole optical-fiber bio-chemical sensing module have very high dirigibility.
Reflection type optical fiber sensing module of the present invention, according to haemoglobin (HB) and the different absorption characteristic of glutamic-pyruvic transaminase (ALT), select two light emitting diode (LED) 4,5 as light source, the then identical instability of photodetector with accurate reflection light source and system with different centre wavelengths.
Embodiments of the invention are the concentration of measuring haemoglobin in the whole blood.
Detection reaction principle such as equation (1) are described.Haemoglobin and potassium ferricyanide generation oxidation reaction in the whole blood generate methemoglobin.
HbFe
2++Fe(CN)
6 3-→Fe(CN)
6 4-+HbFe
3+ (1)
Utilize spectrometer to obtain the reflectance spectrum of methemoglobin at whole visible light wave range, analyze and find that methemoglobin has maximum reflectivity near the green-yellow light the 570nm, its reflective light intensity changes the graded with maximum with hemoglobin concentration.Therefore the present invention chooses the light emitting diode that centre wavelength is 570nm (LED) as light source.
During measurement, after sensor strip sensitizing range drips whole blood, insert in the strip loading frame module 3 of the present invention.Light emitting diode 4,5 sends the green-yellow light that centre wavelength is 570nm, through fibre- optical probe 11 or 13 direct coupled into optical fibres 8b, 8c, 8d, 8e.Coupling light is divided into two-way, and the light wave of one road optical fiber 8b, 8d wherein incides the sensitizing range of sensor strip through reflection type optical fiber probe 10, and fibre-optical probe 10 is gathered the strip reflected light simultaneously, and by photodetector 6 records, this is sample signal light; The light wave of another road optical fiber 8c, 8e, to total reflective mirror 9a reflection, through fibre-optical probe 14 and photodetector 7 couplings, this is a reference optical signal through fibre-optical probe 9.Reference signal light path and sample signal light path be symmetry fully, and photoelectric sensor is also identical, so reference signal can monitor light source and total system in real time, utilizes differential principle, eliminates the labile factor of each side, improves the stability and the sensitivity of system.The strength of differential signal value becomes the specific function relation with hemoglobin concentration in the whole blood, therefore can instead push away the concentration of haemoglobin in the whole blood according to the differential signal that obtains.Accompanying drawing 4 is the concentration and the actual concentrations degree of correlation relation of haemoglobin in the whole blood that uses the present invention's acquisition.
More than be the example explanation at haemoglobin test.The present invention includes two light emitting diodes 4,5, choose different wavelength,, can measure two kinds of different biochemical parameters simultaneously, do not limit with hemoglobin concentration and measure in conjunction with different sensing strips; In addition, because native system adopts modular design, light emitting diode 4,5 is easy to change, and therefore selects for use other different wave length light emitting diodes to realize the more measurement of multiparameter on the basis that does not influence total system stability, makes the present invention have more dirigibility.
Claims (9)
1. a reflection type optical-fiber bio-chemical sensing module adopts integrated module structure, is that three separate funtion parts are formed, and is respectively light source/probe portion, light path part and strip loading frame part; It is characterized in that,
Light source/probe portion, by housing, light emitting diode, photodetector is formed, light path part, comprise second housing, complex root optical fiber and corresponding a plurality of fibre-optical probe, wherein, light emitting diode and photodetector are coupled with a plurality of fibre-optical probe one ends respectively, the other end of a plurality of fibre-optical probes is connected with the upper end of complex root optical fiber respectively, and the lower end of complex root optical fiber places strip loading frame part top;
Strip loading frame part is made up of the 3rd housing and detection groove, detects groove and links to each other with the determinand storage tank of biochemical test bar sensor;
Light source/probe portion be positioned at light path part directly over, light path part be positioned at strip loading frame part directly over, after the stack of three housings, connect, and to photoelectricity coupling location by screw.
2. reflection type optical-fiber bio-chemical sensing module as claimed in claim 1, it is characterized in that, described light source/probe portion, by housing, light emitting diode, photodetector is formed, wherein, inverted T shape housing upwards has four blind holes from the bottom surface, and four blind holes can be arranged arbitrarily, from left to right, order is equiped with photodetector, light emitting diode, light emitting diode and photodetector in each blind hole, and light emitting diode and photodetector lead separately stretches out from the top, is electrically connected with associated components;
Light path part comprises second housing, complex root optical fiber and corresponding a plurality of fibre-optical probe, wherein, second housing has cavity for the cylinder of sealing in the cylinder, its upper surface has four holes, the size in hole and position, and four blind holes of the housing of light source/probe portion are suitable; Its lower surface has two holes; Be provided with six road optical fiber in the cavity of second housing, be installed with fibre-optical probe in the hole of the upper and lower end face of second housing, wherein, the probe connection of the second shell ends left side of face is coupled with first optical fiber upper end, the first probe connection in the middle of the second housing upper surface is coupled with second optical fiber, the 3rd optical fiber upper end, the second middle probe connection is coupled with the 4th optical fiber, the 5th optical fiber upper end, and the probe connection on right side, the second housing upper surface is coupled with the six fibers upper end; Wherein, first, second, the left side fibre-optical probe coupling of the 4th optical fiber lower end and lower surface links to each other, three, the 5th, the six fibers lower end links to each other with the right side fibre-optical probe coupling of lower surface, below the right side fibre-optical probe of lower surface, is installed with total reflective mirror at perforate end opening inwall;
Strip loading frame part, form by the 3rd housing and detection groove, concordant the matching of second housing left side of flat the 3rd housing left end and light path part, right-hand member protrudes from the second housing right side, the 3rd housing upper surface has the detection groove of level, and it is uncovered to detect the groove right-hand member, uncoveredly links to each other with the determinand storage tank of biochemical test bar sensor, detect the below that groove is positioned at two holes, the second housing lower surface, and be covered in two hole end openings from the below.
3. reflection type optical-fiber bio-chemical sensing module as claimed in claim 2 is characterized in that, described two light emitting diodes are the light emitting diode of concentricity wavelength or different centre wavelengths.
4. reflection type optical-fiber bio-chemical sensing module as claimed in claim 2, it is characterized in that, described two photodetectors, model is identical, be photoresistance or photoelectricity two, triode, one of them is used for the reflected light signal of survey sensor strip, two stability that are used to monitor light source and whole device wherein.
5. reflection type optical-fiber bio-chemical sensing module as claimed in claim 2 is characterized in that, in the right side fibre-optical probe of the described second housing lower surface, and two-way incident optical random alignment, and the optical fiber that is reflected surrounds the border outside; In first, second probe in the middle of the second housing upper surface, two-way optical fiber random alignment.
6. reflection type optical-fiber bio-chemical sensing module as claimed in claim 2 is characterized in that, four through holes that open the described second housing upper surface are with four blind hole center-aligned on first housing.
7. reflection type optical-fiber bio-chemical sensing module as claimed in claim 1 or 2 is characterized in that, direct coupling system is all adopted in the connection each other of described light emitting diode, optical fiber, photodetector.
8. reflection type optical-fiber bio-chemical sensing module as claimed in claim 1 or 2 is characterized in that the case material of described three parts is all teflon.
9. reflection type optical-fiber bio-chemical sensing module as claimed in claim 1 or 2 is characterized in that, described optical fiber is multimode optical fiber, and the material of fibre core is a quartz glass.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101806726A (en) * | 2010-03-29 | 2010-08-18 | 浙江大学 | Double-wavelength absorbance detection device for analyzing trace liquid |
| CN101461712B (en) * | 2007-12-19 | 2010-10-20 | 中国科学院电子学研究所 | Wearing type non-invasive instrument for quickly testing blood sugar |
| CN109073540A (en) * | 2016-02-26 | 2018-12-21 | 通用电气健康护理生物科学股份公司 | For measuring the device and method of the absorptance of the substance in solution |
| CN111504903A (en) * | 2020-04-30 | 2020-08-07 | 天津国科医工科技发展有限公司 | Photoelectric detection module |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032883C (en) * | 1991-08-20 | 1996-09-25 | 成都科技大学 | Optical-fibre gas chemical sensor |
| EP1301924A2 (en) * | 2000-07-19 | 2003-04-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for carrying out biochemical fluorescence tests |
| CN100396786C (en) * | 2003-06-11 | 2008-06-25 | 中国科学院电子学研究所 | Multiple parameter micro sensor |
| JP4360265B2 (en) * | 2004-05-06 | 2009-11-11 | 株式会社日立製作所 | Biochemical measuring chip and measuring device |
| CN100380099C (en) * | 2004-09-09 | 2008-04-09 | 武汉光迅科技股份有限公司 | Optical fiber sensor |
| CN2854577Y (en) * | 2005-12-01 | 2007-01-03 | 中国科学院电子学研究所 | Reflection fibre-optical biochemical sensing module |
-
2005
- 2005-12-01 CN CN200510125707A patent/CN100575926C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461712B (en) * | 2007-12-19 | 2010-10-20 | 中国科学院电子学研究所 | Wearing type non-invasive instrument for quickly testing blood sugar |
| CN101806726A (en) * | 2010-03-29 | 2010-08-18 | 浙江大学 | Double-wavelength absorbance detection device for analyzing trace liquid |
| CN109073540A (en) * | 2016-02-26 | 2018-12-21 | 通用电气健康护理生物科学股份公司 | For measuring the device and method of the absorptance of the substance in solution |
| US11543344B2 (en) | 2016-02-26 | 2023-01-03 | Cytiva Sweden Ab | Apparatus and method for measuring the light absorbance of a substance in a solution |
| CN111504903A (en) * | 2020-04-30 | 2020-08-07 | 天津国科医工科技发展有限公司 | Photoelectric detection module |
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| CN100575926C (en) | 2009-12-30 |
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